FI913137A0 - Förfarande för framställning av nya terapeutiskt användbara 4"-deoxi-4"epi-metylamino-avermektinsalter - Google Patents

Förfarande för framställning av nya terapeutiskt användbara 4"-deoxi-4"epi-metylamino-avermektinsalter

Info

Publication number
FI913137A0
FI913137A0 FI913137A FI913137A FI913137A0 FI 913137 A0 FI913137 A0 FI 913137A0 FI 913137 A FI913137 A FI 913137A FI 913137 A FI913137 A FI 913137A FI 913137 A0 FI913137 A0 FI 913137A0
Authority
FI
Finland
Prior art keywords
acid salt
deoxy
salts
epimethylamino
avermectin
Prior art date
Application number
FI913137A
Other languages
English (en)
Finnish (fi)
Other versions
FI97890B (sv
FI913137A (sv
FI97890C (sv
Inventor
Raymond Cvetovich
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI913137A0 publication Critical patent/FI913137A0/sv
Publication of FI913137A publication Critical patent/FI913137A/sv
Publication of FI97890B publication Critical patent/FI97890B/sv
Application granted granted Critical
Publication of FI97890C publication Critical patent/FI97890C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
FI913137A 1990-06-28 1991-06-27 Förfarande för framställning av nya terapeutiskt användbara 4"-deoxi-4"epi-metylamino-avermektinsalter FI97890C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54522990A 1990-06-28 1990-06-28
US54522990 1990-06-28

Publications (4)

Publication Number Publication Date
FI913137A0 true FI913137A0 (sv) 1991-06-27
FI913137A FI913137A (sv) 1991-12-29
FI97890B FI97890B (sv) 1996-11-29
FI97890C FI97890C (sv) 1997-03-10

Family

ID=24175383

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913137A FI97890C (sv) 1990-06-28 1991-06-27 Förfarande för framställning av nya terapeutiskt användbara 4"-deoxi-4"epi-metylamino-avermektinsalter

Country Status (21)

Country Link
US (1) US5288710A (sv)
EP (1) EP0465121B1 (sv)
JP (1) JPH0822870B2 (sv)
KR (1) KR100224292B1 (sv)
AT (1) ATE134377T1 (sv)
AU (1) AU641777B2 (sv)
CA (1) CA2045864C (sv)
CY (1) CY1949A (sv)
DE (1) DE69117223T2 (sv)
DK (1) DK0465121T3 (sv)
ES (1) ES2084110T3 (sv)
FI (1) FI97890C (sv)
GR (1) GR3019067T3 (sv)
HK (1) HK157096A (sv)
IE (1) IE71175B1 (sv)
IL (1) IL98599A (sv)
LV (1) LV5740B4 (sv)
NO (2) NO2001007I2 (sv)
NZ (1) NZ238705A (sv)
PT (1) PT98117B (sv)
ZA (1) ZA914961B (sv)

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EG23124A (en) 2001-02-27 2004-04-28 Syngenta Participations Ag Avermectins substituted in the 4-position having pesticidal properties
JP4701538B2 (ja) 2001-05-21 2011-06-15 住友化学株式会社 農業害虫防除剤組成物
AR036486A1 (es) 2001-08-28 2004-09-15 Syngenta Participations Ag Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion
DE10203688A1 (de) * 2002-01-31 2003-08-07 Bayer Cropscience Ag Synergistische insektizide Mischungen
DE10207241A1 (de) * 2002-02-21 2003-09-04 Bayer Cropscience Ag Synergistische insektizide Mischungen
DE10207242A1 (de) * 2002-02-21 2003-09-04 Bayer Cropscience Ag Synergistische insektizide Mischungen
US20050154229A1 (en) * 2002-03-22 2005-07-14 Aeri Kim Maleic acid salt of(2s)-n-{5-[amino(imino)methy]-2-thienyl}methyl-1-{(2r)-2-[(carboxymethyl)amino]-3,3-diphenylpropanoyl}-2-pyrrolidine carboxamide and a process for
AR040073A1 (es) 2002-05-07 2005-03-16 Syngenta Participations Ag Derivados de 4''-desoxi-4''-(s)-amido avermectina y su uso como plaguicidas
GB0302310D0 (en) 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties
GB0302308D0 (en) 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties
GB0320176D0 (en) 2003-08-28 2003-10-01 Syngenta Participations Ag Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties
EP1799636B1 (en) 2004-09-23 2008-08-27 Schering-Plough Ltd. Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
US7705038B2 (en) * 2004-11-19 2010-04-27 Intervet, Inc. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives
CA2609574A1 (en) * 2005-06-09 2006-12-21 Schering-Plough Ltd. Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
EP1849363A1 (en) * 2006-03-09 2007-10-31 Cheminova A/S Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
TWI422328B (zh) 2006-06-19 2014-01-11 Univ California 結合有殺線蟲之種子塗覆物的生物控制劑
FR2906469B1 (fr) * 2006-09-28 2008-11-28 Galderma Sa Utilisation de composes de la famille des avermectines pour le traitement de desordres dermatologiques chez l'homme
MX2009006467A (es) * 2006-12-13 2009-08-21 Schering Plough Ltd Profarmacos solubles en agua de cloranfenicol, tiamfenicol y analogos de los mismos.
WO2008076259A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
DE102007002872A1 (de) 2007-01-15 2008-07-17 Alpha-Biocare Gmbh Verwendung von Avermectin-Derivaten zur Behandlung gegen Parasiten von Fischen
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
MX368680B (es) 2007-06-27 2019-10-11 Du Pont Administración subcutánea de un derivado de isoxazol-benzamida para usarse en un método para proteger un mamífero de una pulga.
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
WO2010014566A2 (en) * 2008-07-30 2010-02-04 Intervet International B.V. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
MX2011009678A (es) 2009-03-17 2011-09-30 Intervet Int Bv Sistema de suministro de farmaco de lactona macrociclica.
MX2012001646A (es) 2009-08-05 2012-03-21 Du Pont Pesticidas mesoionicos.
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
JP2013501059A (ja) 2009-08-05 2013-01-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー メソイオン性殺虫剤
CA2799963C (en) 2010-05-27 2018-01-23 E. I. Du Pont De Nemours And Company Crystalline form of 4- [5 - [3 -chloro-5 - (trifluoromethyl) phenyl] -4,5 -dihydro-5 - (trifluoromethyl) -3 - isoxazolyl] -n- [2-0x0-2- [(2,2,2-trifluoroethyl)amino]ethyl] -1-naphthalenecarboxamide
AR081970A1 (es) 2010-06-24 2012-10-31 Intervet Int Bv Formulacion inyectable de una lactona macrociclica y levamisol, formulacion y uso veterinario
EP2629772B1 (en) 2010-10-20 2016-05-18 Galderma S.A. Ivermectin for use in the treatment of hemorrhoids
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
EP2658541B1 (en) 2010-12-27 2022-01-26 Intervet International B.V. Topical localized isoxazoline formulation comprising glycofurol
US9173870B2 (en) 2010-12-27 2015-11-03 Intervet Inc. Topical localized isoxazoline formulation
US9861105B2 (en) 2011-07-28 2018-01-09 Syngenta Participations Ag Methods and compositions for controlling nematode pests
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
US9643991B2 (en) * 2015-06-08 2017-05-09 Rotam Agrochem International Company Limited Process for preparing a novel crystalline form of emamectin benzoate and use the same
US9409920B1 (en) * 2015-06-08 2016-08-09 Rotam Agrochem International Company Limited Method for purifying emamectin benzoate and compositions comprising the same
CN107344954B (zh) * 2017-08-07 2020-08-11 河北蓝泰化工科技有限公司 增效型甲氨基阿维菌素b1或b2的盐及制备方法和应用
CN108840893A (zh) * 2018-07-01 2018-11-20 李万强 一种甲氨基阿维菌素苯甲酸盐的新晶型及其制备方法
CN108864230B (zh) * 2018-07-26 2021-05-14 河北威远生物化工有限公司 一种有机磷基团取代的阿维菌素衍生物及其制备方法和应用

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US4366309A (en) * 1980-03-14 1982-12-28 Schering Corporation Derivatives of antibiotic AR-5 components
US4321361A (en) * 1980-06-12 1982-03-23 Eli Lilly And Company Demycinosyltylosin and process for its production
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US4874749A (en) * 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb

Also Published As

Publication number Publication date
DK0465121T3 (da) 1996-03-18
FI97890B (sv) 1996-11-29
JPH05306294A (ja) 1993-11-19
NO178339B (no) 1995-11-27
IL98599A0 (en) 1992-07-15
CA2045864A1 (en) 1991-12-29
GR3019067T3 (en) 1996-05-31
IL98599A (en) 1995-06-29
NO178339C (no) 1996-03-06
DE69117223T2 (de) 1996-09-12
KR100224292B1 (ko) 1999-10-15
NZ238705A (en) 1993-07-27
LV5740B4 (lv) 1997-12-20
KR920000781A (ko) 1992-01-29
FI913137A (sv) 1991-12-29
ATE134377T1 (de) 1996-03-15
CY1949A (en) 1991-06-27
JPH0822870B2 (ja) 1996-03-06
NO912535D0 (no) 1991-06-27
ES2084110T3 (es) 1996-05-01
HK157096A (en) 1996-08-23
NO2001007I2 (no) 2007-02-26
CA2045864C (en) 2001-11-27
EP0465121B1 (en) 1996-02-21
PT98117B (pt) 1998-12-31
EP0465121A1 (en) 1992-01-08
FI97890C (sv) 1997-03-10
ZA914961B (en) 1992-07-29
DE69117223D1 (de) 1996-03-28
US5288710A (en) 1994-02-22
LV5740A4 (lv) 1996-08-20
AU641777B2 (en) 1993-09-30
IE912251A1 (en) 1992-01-01
NO912535L (no) 1991-12-30
PT98117A (pt) 1993-10-29
IE71175B1 (en) 1997-01-29
AU7939291A (en) 1992-01-02

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: MERCK & CO., INC.

BB Publication of examined application
SPCF Supplementary protection certificate application filed

Spc suppl protection certif: L20010007

SPCG Supplementary protection certificate granted

Spc suppl protection certif: L193

Extension date: 20150113

PC Transfer of assignment of patent

Owner name: MERCK SHARP & DOHME CORP.

Free format text: MERCK SHARP & DOHME CORP.

MA Patent expired