MX2011009678A - Sistema de suministro de farmaco de lactona macrociclica. - Google Patents

Sistema de suministro de farmaco de lactona macrociclica.

Info

Publication number
MX2011009678A
MX2011009678A MX2011009678A MX2011009678A MX2011009678A MX 2011009678 A MX2011009678 A MX 2011009678A MX 2011009678 A MX2011009678 A MX 2011009678A MX 2011009678 A MX2011009678 A MX 2011009678A MX 2011009678 A MX2011009678 A MX 2011009678A
Authority
MX
Mexico
Prior art keywords
drug delivery
delivery system
macrocyclic lactone
skin
rod
Prior art date
Application number
MX2011009678A
Other languages
English (en)
Inventor
Wouter De Graaff
Raymond Zeeman
Niels Honcoop
Original Assignee
Intervet Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet Int Bv filed Critical Intervet Int Bv
Publication of MX2011009678A publication Critical patent/MX2011009678A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se describe un sistema de suministro de fármaco del cual una lactona macrocíclica se puede liberar con un perfil de liberación de orden de cero deseable. El sistema se basa en el uso de polímeros termoplásticos, y particularmente de los copolímeros de acetato de polietilenvinilo (EVA). El sistema de suministro de fármaco de la invención comprende un depósito no poroso sólido en el cual la lactona macrocíclica está contenida, preferiblemente en una concentración muy por encima de la concentración de saturación, y una cubierta no porosa que cubre el depósito inicialmente no cargado con el fármaco. El sistema está preferiblemente en forma de barra, en donde el núcleo y la cubierta son concéntricos, y las superficies extremas de la barra no están cubiertas.
MX2011009678A 2009-03-17 2010-03-16 Sistema de suministro de farmaco de lactona macrociclica. MX2011009678A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16094209P 2009-03-17 2009-03-17
EP09155383 2009-03-17
PCT/EP2010/053339 WO2010106046A1 (en) 2009-03-17 2010-03-16 Macrocyclic lactone drug delivery system

Publications (1)

Publication Number Publication Date
MX2011009678A true MX2011009678A (es) 2011-09-30

Family

ID=40941503

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011009678A MX2011009678A (es) 2009-03-17 2010-03-16 Sistema de suministro de farmaco de lactona macrociclica.

Country Status (11)

Country Link
US (1) US9345686B2 (es)
EP (1) EP2408432A1 (es)
JP (1) JP2012520847A (es)
KR (1) KR20120006987A (es)
CN (1) CN102355891A (es)
AR (1) AR075846A1 (es)
AU (1) AU2010224918A1 (es)
BR (1) BRPI1009345A2 (es)
CA (1) CA2755753A1 (es)
MX (1) MX2011009678A (es)
WO (1) WO2010106046A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013002175A2 (pt) * 2010-07-30 2016-10-25 Ceva Sante Animale método para controlar a infestação por vermes do coração, composição de uma droga veterinária e kit útil para o controle de uma infestação parasitária por verme do coração em uma cobaia não humana
JP2013540693A (ja) * 2010-07-30 2013-11-07 セヴァ サンテ アニマレ ハートワーム感染を抑制するための組成物
CL2014000989A1 (es) * 2014-04-17 2014-10-17 Univ Santiago Chile Dispositivo subdermal de liberacion prolongada y lenta para prevencion, tratamiento y monitoreo de parasitos, que comprende al menos una lactona macrociclica tal como ivermectina y/o dormectina, opcionalmente nanoparticulas o microparticulas de zeolita, una matriz polimerica y medios de monitoreo, dentro de un circuito integrado.
US10406336B2 (en) * 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
US9980850B2 (en) 2016-09-29 2018-05-29 Gesea Biosciences, Inc. Bioerodible contraceptive implant and methods of use thereof
CN111971026A (zh) 2018-05-24 2020-11-20 塞拉尼斯伊娃高性能聚合物公司 用于持续释放大分子药物化合物的可植入器件
CN111989068A (zh) 2018-05-24 2020-11-24 塞拉尼斯伊娃高性能聚合物公司 用于持续释放大分子药物化合物的可植入器件
CA3104513A1 (en) * 2018-06-25 2020-01-02 Titan Pharmaceuticals, Inc. Implants for release of lipophilic or amphiphilic pharmaceutical substances

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3984564A (en) 1972-06-08 1976-10-05 Sankyo Company Limited Antibiotic substances B-41, their production and their use as insecticides and acaricides
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
ES8800986A1 (es) 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
US4916154A (en) 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
IL98599A (en) 1990-06-28 1995-06-29 Merck & Co Inc Stable salts of "4-deoxy-" 4-epi-methylamino abramectin and insecticides containing them
US5399717A (en) 1993-09-29 1995-03-21 Merck & Co., Inc. Glycosidation route to 4"-epi-methylamino-4"-deoxyavermectin B1
AUPR602501A0 (en) 2001-06-29 2001-07-26 Smart Drug Systems Inc Sustained release pharmaceutical composition
AUPR610501A0 (en) 2001-07-04 2001-07-26 Smart Drug Systems Inc Treatment of parasitic disease
AUPR951501A0 (en) * 2001-12-14 2002-01-24 Smart Drug Systems Inc Modified sustained release pharmaceutical system
MXPA06010905A (es) * 2004-03-24 2007-03-08 Organon Nv Sistema para el suministro de farmacos basados en copolimeros de polietileno y acetato de vinilo.
BRPI0504244A (pt) 2005-09-29 2007-09-25 Clarion Biociencias Ltda implantes subdérmicos de etilenovilacetato (eva) e polydimethylsiloxane (silicone) que consiste na utilização de eva ou silicone para uso como matriz plástica endectocida, associado ou não a um ectoparasiticida e/ou igr, para confecções de implantes subdérmicos para utilização em bovinos, cães e gatos e respectivo método de produção

Also Published As

Publication number Publication date
EP2408432A1 (en) 2012-01-25
BRPI1009345A2 (pt) 2016-03-08
KR20120006987A (ko) 2012-01-19
AU2010224918A1 (en) 2011-10-06
US20120052108A1 (en) 2012-03-01
AR075846A1 (es) 2011-04-27
JP2012520847A (ja) 2012-09-10
US9345686B2 (en) 2016-05-24
CN102355891A (zh) 2012-02-15
WO2010106046A1 (en) 2010-09-23
CA2755753A1 (en) 2010-09-23

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