AR075846A1 - Sistema de administracion de farmaco de lactona macrociclica.uso. metodo de tratamiento - Google Patents

Sistema de administracion de farmaco de lactona macrociclica.uso. metodo de tratamiento

Info

Publication number
AR075846A1
AR075846A1 ARP100100817A ARP100100817A AR075846A1 AR 075846 A1 AR075846 A1 AR 075846A1 AR P100100817 A ARP100100817 A AR P100100817A AR P100100817 A ARP100100817 A AR P100100817A AR 075846 A1 AR075846 A1 AR 075846A1
Authority
AR
Argentina
Prior art keywords
drug delivery
delivery system
macrocyclic lactone
administration system
macrociclica
Prior art date
Application number
ARP100100817A
Other languages
English (en)
Inventor
Wouter De Graaff
Niels Honcoop
Original Assignee
Organon Nv
Intervet Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv, Intervet Int Bv filed Critical Organon Nv
Publication of AR075846A1 publication Critical patent/AR075846A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Reivindicacion 1: Un sistema de administracion de fármaco para la liberacion controlada de una lactona macrocíclica como ingrediente activo, que comprende un deposito no poroso solido de un copolímero de polietileno acetato de vinilo farmacéuticamente aceptable, cargado con la lactona macrocíclica y un recubrimiento no poroso que cubre el deposito, el recubrimiento comprende un copolímero de polietileno acetato de vinilo, donde la lactona macrocíclica es liberada sustancialmente por difusion a través del recubrimiento del sistema de administracion de fármaco. Reivindicacion 7: Un sistema de administracion de fármaco de acuerdo con cualquiera de las reivindicaciones anteriores, caracterizado porque la lactona macrocíclica se selecciona entre el grupo que comprende ivermectina, moxidectina, selamectina, doramectina, abamectina y mezclas de ellos. Reivindicacion 8: Un sistema de administracion de fármaco de acuerdo con cualquiera de las reivindicaciones anteriores, caracterizado porque el deposito comprende un agente de radiocontraste, preferentemente, sulfato de bario. Reivindicacion 10: Un sistema de administracion de fármaco de acuerdo con cualquiera de las reivindicaciones anteriores, caracterizado porque el sistema de administracion se presenta en forma de implante.
ARP100100817A 2009-03-17 2010-03-16 Sistema de administracion de farmaco de lactona macrociclica.uso. metodo de tratamiento AR075846A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16094209P 2009-03-17 2009-03-17
EP09155383 2009-03-17

Publications (1)

Publication Number Publication Date
AR075846A1 true AR075846A1 (es) 2011-04-27

Family

ID=40941503

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100100817A AR075846A1 (es) 2009-03-17 2010-03-16 Sistema de administracion de farmaco de lactona macrociclica.uso. metodo de tratamiento

Country Status (11)

Country Link
US (1) US9345686B2 (es)
EP (1) EP2408432A1 (es)
JP (1) JP2012520847A (es)
KR (1) KR20120006987A (es)
CN (1) CN102355891A (es)
AR (1) AR075846A1 (es)
AU (1) AU2010224918A1 (es)
BR (1) BRPI1009345A2 (es)
CA (1) CA2755753A1 (es)
MX (1) MX2011009678A (es)
WO (1) WO2010106046A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140012013A (ko) * 2010-07-30 2014-01-29 세바 상뜨 아니말르 사상충 체내 감염증을 치료하기 위한 조성물
EP3682887A1 (en) * 2010-07-30 2020-07-22 Ceva Sante Animale Compositions comprising ivermectin for treating heartworm infestation
CL2014000989A1 (es) * 2014-04-17 2014-10-17 Univ Santiago Chile Dispositivo subdermal de liberacion prolongada y lenta para prevencion, tratamiento y monitoreo de parasitos, que comprende al menos una lactona macrociclica tal como ivermectina y/o dormectina, opcionalmente nanoparticulas o microparticulas de zeolita, una matriz polimerica y medios de monitoreo, dentro de un circuito integrado.
US10406336B2 (en) 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
WO2018064556A1 (en) 2016-09-29 2018-04-05 Gesea Biosciences Inc. Bioerodible implant for long-term drug delivery and associated methods of manufacture and use
JP2021524841A (ja) 2018-05-24 2021-09-16 セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー 高分子薬剤化合物の持続放出用の埋め込み型デバイス
CN111989068A (zh) 2018-05-24 2020-11-24 塞拉尼斯伊娃高性能聚合物公司 用于持续释放大分子药物化合物的可植入器件
CA3104513A1 (en) * 2018-06-25 2020-01-02 Titan Pharmaceuticals, Inc. Implants for release of lipophilic or amphiphilic pharmaceutical substances

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US3984564A (en) 1972-06-08 1976-10-05 Sankyo Company Limited Antibiotic substances B-41, their production and their use as insecticides and acaricides
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
ES8800986A1 (es) 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
US4916154A (en) 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
IL98599A (en) 1990-06-28 1995-06-29 Merck & Co Inc Stable salts of "4-deoxy-" 4-epi-methylamino abramectin and insecticides containing them
US5399717A (en) 1993-09-29 1995-03-21 Merck & Co., Inc. Glycosidation route to 4"-epi-methylamino-4"-deoxyavermectin B1
AUPR602501A0 (en) 2001-06-29 2001-07-26 Smart Drug Systems Inc Sustained release pharmaceutical composition
AUPR610501A0 (en) * 2001-07-04 2001-07-26 Smart Drug Systems Inc Treatment of parasitic disease
AUPR951501A0 (en) * 2001-12-14 2002-01-24 Smart Drug Systems Inc Modified sustained release pharmaceutical system
CA2559224C (en) * 2004-03-24 2011-12-13 N.V. Organon Drug delivery system based on polyethylene vinylacetate copolymers
BRPI0504244A (pt) 2005-09-29 2007-09-25 Clarion Biociencias Ltda implantes subdérmicos de etilenovilacetato (eva) e polydimethylsiloxane (silicone) que consiste na utilização de eva ou silicone para uso como matriz plástica endectocida, associado ou não a um ectoparasiticida e/ou igr, para confecções de implantes subdérmicos para utilização em bovinos, cães e gatos e respectivo método de produção

Also Published As

Publication number Publication date
US9345686B2 (en) 2016-05-24
EP2408432A1 (en) 2012-01-25
AU2010224918A1 (en) 2011-10-06
JP2012520847A (ja) 2012-09-10
US20120052108A1 (en) 2012-03-01
WO2010106046A1 (en) 2010-09-23
KR20120006987A (ko) 2012-01-19
CN102355891A (zh) 2012-02-15
CA2755753A1 (en) 2010-09-23
BRPI1009345A2 (pt) 2016-03-08
MX2011009678A (es) 2011-09-30

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