FI97686B - Förfarande för framställning av korn för tillverkning av produkter med kontrollerad frisättning - Google Patents

Förfarande för framställning av korn för tillverkning av produkter med kontrollerad frisättning Download PDF

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Publication number
FI97686B
FI97686B FI881657A FI881657A FI97686B FI 97686 B FI97686 B FI 97686B FI 881657 A FI881657 A FI 881657A FI 881657 A FI881657 A FI 881657A FI 97686 B FI97686 B FI 97686B
Authority
FI
Finland
Prior art keywords
beads
active compound
pharmaceutically active
release
methylene chloride
Prior art date
Application number
FI881657A
Other languages
English (en)
Finnish (fi)
Other versions
FI881657A0 (sv
FI97686C (sv
FI881657A (sv
Inventor
John Anders Sandberg
John Albert Sjoegren
Lars-Erik David Dahlinder
Mats Ove Johansson
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of FI881657A0 publication Critical patent/FI881657A0/sv
Publication of FI881657A publication Critical patent/FI881657A/sv
Application granted granted Critical
Publication of FI97686B publication Critical patent/FI97686B/sv
Publication of FI97686C publication Critical patent/FI97686C/sv

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Claims (9)

1. Förfarande för framställning av korn för tillverkning av produkter med kontrollerad frisättning, kännetecknat av att en farmaceutiskt aktiv förening upplöst i ett lösnings-medel appliceras pä ett kompakt, olösligt kärnmaterial med en porositet av mindre än 15 % och med en storlek av 0,1-2 mm, lösningsmedlet torkas bort och korn belagda med ett kompakt skikt av den aktiva föreningen och uppvisande en storlek av 0,2-3,0 mm erhdlls, varefter de erhällna kornen yt-terligare belägges med ett polymermembran som kontrollerar frisättningen.
2. Förfarande enligt patentkrav l för framställning av korn, kännetecknat av att kärnmaterialet har en storlek pa 0,1-0,5 mm och kärnmaterialet belagt med den farmaceutiskt aktiva föreningen har en storlek av 0,3-1,0 mm.
3. Förfarande enligt patentkrav l för framställning av korn, kännetecknat av att kärnmaterialet är kiseldioxid.
4. Förfarande enligt patentkrav 1 för framställning av korn, kännetecknat av att kärnmaterialet är smä partiklar av glas.
5. Förfarande enligt patentkrav l för framställning av korn, kännetecknat av att kornen innehäller en farmaceutiskt aktiv förening för vilken en icke omedelbar frisättning av läkemedel önskas. . iu.i a»*; i.i i «e 97686
6. Förfarande enligt patentkrav 1 för framställning av korn, kännetecknat av att den i kornen ingäende farmaceu-tiskt aktiva föreningen är avsedd att administreras oralt eller parenteralt.
7. Förfarande enligt patentkrav 1 för framställning av korn, kännetecknat av att den i kornen ingäende farmaceu-tiskt aktiva föreningen används i det kardiovaskulära, gas-trointestinala eller kemoterapeutiska omrädet.
8. Förfarande enligt patentkrav 1 för framställning av korn, kännetecknat av att den i kornen ingäende farmaceu-tiskt aktiva föreningen är ett sait av en adrenergisk beta-blockare.
9. Förfarande enligt patentkrav 1 för framställning av korn, kännetecknat av att den i kornen ingäende farmaceu-tiskt aktiva föreningen är ett antibiotikum. >
FI881657A 1985-10-11 1988-04-08 Förfarande för framställning av korn för tillverkning av produkter med kontrollerad frisättning FI97686C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE8504720 1985-10-11
SE8504720A SE450087B (sv) 1985-10-11 1985-10-11 Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial
PCT/SE1986/000400 WO1987002240A1 (en) 1985-10-11 1986-09-10 New drug preparation with controlled release of the active compound, a method for the manufacture thereof and the use of the new preparation
SE8600400 1986-09-10

Publications (4)

Publication Number Publication Date
FI881657A0 FI881657A0 (sv) 1988-04-08
FI881657A FI881657A (sv) 1988-04-08
FI97686B true FI97686B (sv) 1996-10-31
FI97686C FI97686C (sv) 1997-02-10

Family

ID=20361705

Family Applications (1)

Application Number Title Priority Date Filing Date
FI881657A FI97686C (sv) 1985-10-11 1988-04-08 Förfarande för framställning av korn för tillverkning av produkter med kontrollerad frisättning

Country Status (24)

Country Link
US (1) US4927640A (sv)
EP (1) EP0277127B1 (sv)
JP (1) JP2560019B2 (sv)
KR (1) KR940000098B1 (sv)
CN (1) CN1025283C (sv)
AU (1) AU593038B2 (sv)
CS (1) CS268819B2 (sv)
CY (1) CY1764A (sv)
DD (1) DD266734A5 (sv)
DK (1) DK175592B1 (sv)
ES (1) ES2003139A6 (sv)
FI (1) FI97686C (sv)
GR (1) GR862526B (sv)
HU (1) HU199677B (sv)
IE (1) IE58967B1 (sv)
IS (1) IS1530B (sv)
NZ (1) NZ217697A (sv)
PH (1) PH24739A (sv)
PL (1) PL148624B1 (sv)
PT (1) PT83508B (sv)
SE (1) SE450087B (sv)
SU (1) SU1706373A3 (sv)
WO (1) WO1987002240A1 (sv)
ZA (1) ZA866861B (sv)

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DD266734A5 (de) 1989-04-12
AU593038B2 (en) 1990-02-01
WO1987002240A1 (en) 1987-04-23
CS729486A2 (en) 1989-08-14
EP0277127A1 (en) 1988-08-10
PL148624B1 (en) 1989-11-30
ZA866861B (en) 1987-05-27
DK287687A (da) 1987-06-04
JP2560019B2 (ja) 1996-12-04
KR870700344A (ko) 1987-12-28
EP0277127B1 (en) 1991-04-10
SE8504720D0 (sv) 1985-10-11
CN1025283C (zh) 1994-07-06
CS268819B2 (en) 1990-04-11
FI881657A0 (sv) 1988-04-08
PT83508B (pt) 1989-05-31
FI97686C (sv) 1997-02-10
SE8504720L (sv) 1987-04-12
GR862526B (en) 1987-02-09
NZ217697A (en) 1989-04-26
IS1530B (is) 1993-02-23
PT83508A (en) 1986-11-01
SE450087B (sv) 1987-06-09
ES2003139A6 (es) 1988-10-16
KR940000098B1 (ko) 1994-01-05
IS3152A7 (is) 1987-04-12
CN86106651A (zh) 1987-04-15
JPS63501080A (ja) 1988-04-21
DK175592B1 (da) 2004-12-13
CY1764A (en) 1994-07-15
IE862493L (en) 1987-04-11
PL261801A1 (en) 1987-08-10
SU1706373A3 (ru) 1992-01-15
HUT47843A (en) 1989-04-28
AU6529686A (en) 1987-05-05
HU199677B (en) 1990-03-28
FI881657A (sv) 1988-04-08
DK287687D0 (da) 1987-06-04
US4927640A (en) 1990-05-22
IE58967B1 (en) 1993-12-01
PH24739A (en) 1990-10-01

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