FI953358A0 - Uudet paksusuolelle- ja sykkyräsuolelle spesifiset steroidijohdannaiset - Google Patents

Uudet paksusuolelle- ja sykkyräsuolelle spesifiset steroidijohdannaiset

Info

Publication number
FI953358A0
FI953358A0 FI953358A FI953358A FI953358A0 FI 953358 A0 FI953358 A0 FI 953358A0 FI 953358 A FI953358 A FI 953358A FI 953358 A FI953358 A FI 953358A FI 953358 A0 FI953358 A0 FI 953358A0
Authority
FI
Finland
Prior art keywords
small intestine
specific derivatives
colon
compounds
new colon
Prior art date
Application number
FI953358A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI953358L (fi
FI953358A7 (fi
Inventor
Ralph Lennart Brattsand
Peter Edman
Thomas Hoegberg
Stinabritt Nilsson
Bror Arne Thalen
Jan Erik Ulmius
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9300030A external-priority patent/SE9300030D0/xx
Priority claimed from SE9300082A external-priority patent/SE9300082D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of FI953358L publication Critical patent/FI953358L/fi
Publication of FI953358A0 publication Critical patent/FI953358A0/fi
Publication of FI953358A7 publication Critical patent/FI953358A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI953358A 1993-01-08 1993-12-17 Uudet paksusuolelle- ja sykkyräsuolelle spesifiset steroidijohdannaise t FI953358A7 (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9300030A SE9300030D0 (sv) 1993-01-08 1993-01-08 Novel colon- or ileum-specific steroid derivatives
SE9300082A SE9300082D0 (sv) 1993-01-14 1993-01-14 Novel colon- or ileum-specific steroid derivatives
PCT/SE1993/001081 WO1994015947A1 (en) 1993-01-08 1993-12-17 Novel colon- or ileum-specific steroid derivatives

Publications (3)

Publication Number Publication Date
FI953358L FI953358L (fi) 1995-07-07
FI953358A0 true FI953358A0 (fi) 1995-07-07
FI953358A7 FI953358A7 (fi) 1995-07-07

Family

ID=26661623

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953358A FI953358A7 (fi) 1993-01-08 1993-12-17 Uudet paksusuolelle- ja sykkyräsuolelle spesifiset steroidijohdannaise t

Country Status (22)

Country Link
US (2) US5908833A (enExample)
EP (1) EP0678097B1 (enExample)
JP (1) JP3366640B2 (enExample)
KR (1) KR960700266A (enExample)
AT (1) ATE183192T1 (enExample)
BR (1) BR9307746A (enExample)
CA (1) CA2152374A1 (enExample)
CZ (1) CZ171095A3 (enExample)
DK (1) DK0678097T3 (enExample)
ES (1) ES2137353T3 (enExample)
FI (1) FI953358A7 (enExample)
GR (1) GR3031789T3 (enExample)
HU (1) HU221584B (enExample)
IS (1) IS4111A (enExample)
LV (1) LV10961B (enExample)
NO (1) NO305367B1 (enExample)
NZ (1) NZ259596A (enExample)
PL (1) PL178307B1 (enExample)
RU (1) RU95115547A (enExample)
SK (1) SK87295A3 (enExample)
TW (1) TW261615B (enExample)
WO (1) WO1994015947A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3366640B2 (ja) * 1993-01-08 2003-01-14 アストラ・アクチエボラーグ 新規な結腸−または回腸−特異的ステロイド誘導体
WO1995009177A1 (en) * 1993-09-29 1995-04-06 Nissin Shokuhin Kabushiki Kaisha 21-substituted steroid compound
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
WO1999047541A1 (fr) * 1998-03-19 1999-09-23 Nissin Food Products Co., Ltd. Composes steroides glycosyles a substitution en position 21
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
DE60021720T2 (de) 1999-05-04 2006-06-01 Strakan International Ltd. Androgen glykoside und die androgenische aktivität davon
JP4790950B2 (ja) 1999-06-14 2011-10-12 コスモ・テクノロジーズ・リミテッド 制御放出および味感遮蔽経口医薬組成物
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
WO2001051057A2 (en) * 2000-01-14 2001-07-19 Strakan Limited Glycosides and orthoester glycosides of glucocorticoids and uses thereof
SE0101220D0 (sv) * 2001-04-04 2001-04-04 Astrazeneca Ab New use
DE602004017164D1 (de) * 2004-08-09 2008-11-27 Deutsches Krebsforsch Albuminkonjugate, die eine Glucuron-Verknüpfung enthalten
WO2008100560A2 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators, associated pharmaceutical compositions and methods of use
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
KR20190074310A (ko) 2016-11-08 2019-06-27 리제너론 파마슈티칼스 인코포레이티드 스테로이드 및 이의 단백질-접합체
US11491232B2 (en) 2017-03-30 2022-11-08 Fruithy Holdings Limited Lactuloside compounds and preparation and use thereof
JP7364471B2 (ja) 2017-05-18 2023-10-18 レゲネロン ファーマシューティカルス，インコーポレーテッド シクロデキストリンタンパク質薬物コンジュゲート
CA3080857A1 (en) 2017-11-07 2019-05-16 Regeneron Pharmaceuticals, Inc. Hydrophilic linkers for antibody drug conjugates
MA50259A1 (fr) * 2018-01-08 2021-07-29 Regeneron Pharma Stéroïdes et leurs conjugués-anticorps
CN118955710A (zh) 2018-05-09 2024-11-15 里珍纳龙药品有限公司 抗msr1抗体及其使用方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE378110B (enExample) * 1972-05-19 1975-08-18 Bofors Ab
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378109B (enExample) * 1972-05-19 1975-08-18 Bofors Ab
US3938233A (en) * 1974-08-12 1976-02-17 Cannon Robert B Heat transfer apparatus
BG33738A3 (bg) * 1978-01-25 1983-04-15 Schering Aktiengesellschaft Метод за получаване на заместени в 17-а позиция стероиди на прегнановия ред
DE2803660A1 (de) * 1978-01-25 1979-07-26 Schering Ag Neue in 17-position substituierte steroide der pregnanreihe, ihre herstellung und verwendung
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
US4469689A (en) * 1983-03-30 1984-09-04 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
WO1984004041A1 (en) * 1983-04-14 1984-10-25 Univ California Colon-specific drug delivery system
US4959358A (en) * 1983-06-06 1990-09-25 Beth Israel Hospital Assn. Drug administration
US4548922A (en) * 1983-06-06 1985-10-22 Beth Israel Hospital Drug administration
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
US5215979A (en) * 1985-12-19 1993-06-01 Aktiebolaget Draco 16,17-acetalsubstituted pregnane 21-oic acid derivatives
GB8600489D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside steroids
GB8600491D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid derivatives
GB8600490D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid lactams
EP0267297B1 (en) * 1986-05-12 1993-09-15 Mect Corporation Sialosylcholesterol, process for its preparation, and drug for treating diseases of nervous system
CA1299653C (en) * 1988-07-07 1992-04-28 Markwell Medical Institute, Inc. Biological fluid measuring device
SE8903914D0 (sv) * 1989-11-22 1989-11-22 Draco Ab Oral composition for the treatment of inflammatory bowel diseases
US5643602A (en) * 1989-11-22 1997-07-01 Astra Aktiebolag Oral composition for the treatment of inflammatory bowel disease
US5888995A (en) * 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
WO1993022334A1 (en) * 1992-05-04 1993-11-11 Sri International Pharmaceutical compositions and methods for colonic delivery of corticosteroids
JP3366640B2 (ja) * 1993-01-08 2003-01-14 アストラ・アクチエボラーグ 新規な結腸−または回腸−特異的ステロイド誘導体

Also Published As

Publication number Publication date
JP3366640B2 (ja) 2003-01-14
US5908833A (en) 1999-06-01
TW261615B (enExample) 1995-11-01
US6140308A (en) 2000-10-31
PL178307B1 (pl) 2000-04-28
HU9502087D0 (en) 1995-09-28
FI953358L (fi) 1995-07-07
DK0678097T3 (da) 2000-02-07
HUT73227A (en) 1996-07-29
HU221584B (hu) 2002-11-28
NO952683D0 (no) 1995-07-06
NO952683L (no) 1995-07-06
SK87295A3 (en) 1996-04-03
ES2137353T3 (es) 1999-12-16
CZ171095A3 (en) 1996-01-17
EP0678097B1 (en) 1999-08-11
EP0678097A1 (en) 1995-10-25
PL309777A1 (en) 1995-11-13
RU95115547A (ru) 1997-06-10
CA2152374A1 (en) 1994-07-21
ATE183192T1 (de) 1999-08-15
BR9307746A (pt) 1995-11-14
GR3031789T3 (en) 2000-02-29
WO1994015947A1 (en) 1994-07-21
LV10961B (en) 1996-08-20
AU678803B2 (en) 1997-06-12
IS4111A (is) 1994-07-09
LV10961A (lv) 1995-12-20
FI953358A7 (fi) 1995-07-07
AU5844794A (en) 1994-08-15
JPH08505616A (ja) 1996-06-18
NZ259596A (en) 1997-04-24
KR960700266A (ko) 1996-01-19
NO305367B1 (no) 1999-05-18

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