DE3750913D1 - Karbostyrilderivate, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Zusammensetzungen und ihre Verwendung. - Google Patents

Karbostyrilderivate, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Zusammensetzungen und ihre Verwendung.

Info

Publication number
DE3750913D1
DE3750913D1 DE3750913T DE3750913T DE3750913D1 DE 3750913 D1 DE3750913 D1 DE 3750913D1 DE 3750913 T DE3750913 T DE 3750913T DE 3750913 T DE3750913 T DE 3750913T DE 3750913 D1 DE3750913 D1 DE 3750913D1
Authority
DE
Germany
Prior art keywords
processes
preparation
pharmaceutical compositions
compositions containing
carbostyril derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3750913T
Other languages
English (en)
Other versions
DE3750913T2 (de
Inventor
Takao - Nishi
Tetsuyuki - Uno
Yasuo - Koga
Gil-Namg Chu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP62043457A external-priority patent/JPH0681727B2/ja
Priority claimed from JP62060770A external-priority patent/JPH0681752B2/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE3750913D1 publication Critical patent/DE3750913D1/de
Publication of DE3750913T2 publication Critical patent/DE3750913T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE3750913T 1986-04-02 1987-04-02 Karbostyrilderivate, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Zusammensetzungen und ihre Verwendung. Expired - Fee Related DE3750913T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP7608986 1986-04-02
JP62043457A JPH0681727B2 (ja) 1986-04-02 1987-02-25 血小板粘着抑制剤
JP62060770A JPH0681752B2 (ja) 1986-04-02 1987-03-16 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
DE3750913D1 true DE3750913D1 (de) 1995-02-09
DE3750913T2 DE3750913T2 (de) 1995-06-01

Family

ID=27291549

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3750913T Expired - Fee Related DE3750913T2 (de) 1986-04-02 1987-04-02 Karbostyrilderivate, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Zusammensetzungen und ihre Verwendung.

Country Status (5)

Country Link
US (1) US5008274A (de)
EP (1) EP0240015B1 (de)
DE (1) DE3750913T2 (de)
DK (1) DK167187A (de)
ES (1) ES2068807T3 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
US5064837A (en) * 1989-11-13 1991-11-12 Schering Corporation 3-substituted-1-aryl-2(h)-quinolones and their pharmaceutical compositions
EP0505481A1 (de) * 1989-12-12 1992-09-30 Rhone-Poulenc Sante 2-substituierte 4,5-diphenylimidazole
AU7066191A (en) * 1990-01-12 1991-08-05 Rhone-Poulenc Rorer S.A. 2-substituted 4,5-diphenyl-imidazoles
EP0544958A1 (de) * 1990-08-09 1993-06-09 Tanabe Seiyaku Co., Ltd. Cephalosporinverbindungen und Verfahren zu ihrer Herstellung
KR930702307A (ko) * 1991-08-23 1993-09-08 오오쓰까 아끼히꼬 카르보스티릴 유도체 및 혈소판 응집 억제제
JP3141051B2 (ja) * 1992-10-09 2001-03-05 日清製粉株式会社 抗動脈硬化剤
WO1994022826A1 (en) * 1993-04-07 1994-10-13 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing n-acylated 4-amino piperidine derivatives as active ingredients
TW289019B (de) * 1993-05-19 1996-10-21 Otsuka Pharma Co Ltd
IL110280A0 (en) * 1993-07-27 1994-10-21 Zeneca Ltd Thiazole derivatives
EP0636624A1 (de) * 1993-07-27 1995-02-01 Zeneca Limited Thiazolederivative als Lipoxygenasehemmer
ZA945250B (en) * 1993-07-27 1995-01-27 Zeneca Ltd Thiazole derivatives
US5780480A (en) * 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
WO1998046593A1 (en) * 1997-04-16 1998-10-22 Otsuka Pharmaceutical Co., Ltd. Novel carbostyril derivative
FR2812548B1 (fr) * 2000-08-01 2002-09-20 Sanofi Synthelabo Utilisation de derives de quinolein-2(1h)-one ou un de leurs sels pharmaceutiquement acceptable pour la preparation d'un medicament destine au traitement de l'insuffisance renale
US6660864B2 (en) 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6531603B1 (en) 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en) 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en) 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6657061B2 (en) 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
MY142362A (en) * 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
TW201039822A (en) 2009-02-06 2010-11-16 Taisho Pharmaceutical Co Ltd Dihydroquinolinone derivatives
GB202019475D0 (en) 2020-12-10 2021-01-27 Cancer Research Tech Ltd Therapeutic compounds and their use
CN115974850A (zh) * 2023-02-16 2023-04-18 中国药科大学 一类作为akr1c3抑制剂的化合物及其制备方法与用途

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1496768A (en) 1973-12-26 1978-01-05 Otsuka Pharma Co Ltd 5-substituted ethyl-8-hydroxycarbostyril derivatives and production thereof
US4026897A (en) 1974-01-31 1977-05-31 Otsuka Pharmaceutical Company 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxycarbostyril derivatives
GB1496875A (en) 1974-06-13 1978-01-05 Otsuka Pharma Co Ltd 5-substituted alkanoyl-8-hydroxycarbostyril derivatives and production thereof
US3994901A (en) 1974-06-13 1976-11-30 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
US4070470A (en) 1974-06-24 1978-01-24 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting carbostyrils, their compositions and method of use
GB1496770A (en) 1974-11-08 1978-01-05 Otsuka Pharma Co Ltd 5-substituted alkyl-8-substituted-carbostyrils and-3,4-dihydrocarbostyril derivatives and production thereof
GB1496871A (en) 1974-11-08 1978-01-05 Otsuka Pharma Co Ltd 5-(alpha-aminoalkanoyl)-8-substituted-carbostyrils and their preparation
JPS5412384A (en) 1977-06-24 1979-01-30 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5430180A (en) 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative
JPS5430183A (en) 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative
US4329347A (en) * 1978-02-17 1982-05-11 Boehringer Ingelheim Gmbh Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril
DE2806721A1 (de) 1978-02-17 1979-08-23 Thomae Gmbh Dr K Neue carbostyril-derivate
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS5535019A (en) 1978-09-01 1980-03-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
DE2928583A1 (de) * 1979-07-14 1981-01-29 Thomae Gmbh Dr K Verfahren zur herstellung von carbostyrilderivaten
JPS5645414A (en) * 1979-09-19 1981-04-25 Otsuka Pharmaceut Co Ltd Phosphodiesterase inhibitor
PH17194A (en) 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
JPS5632471A (en) * 1980-05-08 1981-04-01 Otsuka Pharmaceut Co Ltd Tetrazole derivative
JPS56156263A (en) * 1980-05-08 1981-12-02 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS579780A (en) 1980-06-21 1982-01-19 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS57154129A (en) 1981-03-16 1982-09-22 Otsuka Pharmaceut Co Ltd Cardiotonic drug
JPS57159778A (en) 1981-03-27 1982-10-01 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5859980A (ja) * 1981-10-05 1983-04-09 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JPS5877880A (ja) * 1981-11-05 1983-05-11 Otsuka Pharmaceut Co Ltd テトラゾ−ル誘導体
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
FR2539413A1 (fr) * 1983-01-17 1984-07-20 Pos Lab Carbostyriloximinopropanolamines utiles comme medicaments et procede pour leur preparation
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors

Also Published As

Publication number Publication date
EP0240015B1 (de) 1994-12-28
DE3750913T2 (de) 1995-06-01
EP0240015A3 (en) 1990-10-24
EP0240015A2 (de) 1987-10-07
US5008274A (en) 1991-04-16
DK167187D0 (da) 1987-04-01
ES2068807T3 (es) 1995-05-01
DK167187A (da) 1987-10-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee