ES2068807T3 - Derivados de carboestirilo, procedimiento para prepararlos, composicion farmaceutica, y uso. - Google Patents

Derivados de carboestirilo, procedimiento para prepararlos, composicion farmaceutica, y uso.

Info

Publication number
ES2068807T3
ES2068807T3 ES87104873T ES87104873T ES2068807T3 ES 2068807 T3 ES2068807 T3 ES 2068807T3 ES 87104873 T ES87104873 T ES 87104873T ES 87104873 T ES87104873 T ES 87104873T ES 2068807 T3 ES2068807 T3 ES 2068807T3
Authority
ES
Spain
Prior art keywords
group
zinyl
alkyl
formula
substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87104873T
Other languages
English (en)
Inventor
Takao - Aza Sotobiraki Nishi
Tetsuyuki - Aza Kitahari Uno
Yasuo - Aza Hachikami Koga
Gil-Namg Chu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP62043457A external-priority patent/JPH0681727B2/ja
Priority claimed from JP62060770A external-priority patent/JPH0681752B2/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2068807T3 publication Critical patent/ES2068807T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La utilización de un derivado de carboestirilo o una sal del mismo representado mediante la fórmula general (1), **fórmula** donde R es un grupo residual heterocíclico insaturado seleccionado entre los grupos 1,2,4 -triazolilo, imidazolilo, 1,2,3,5 - tetrazolilo, 1,2,3,4 - tetrazolilo, pirrolilo, benzimidazolilo, 1,3,4 -triazolilo, imidazolinilo, piridilo, pirimidinilo, pirazolilo, pirazolinilo, tiazolilo, tiazolinilo, 1,3,4 -oxadiazolilo, 1,3,4 - tiadiazolilo, tienilo, furilo, piranilo, isotiazolilo, isoxazolilo, pirazinilo, piridazinilo, indolilo, isoindolilo, 3H - indolilo, indolizinilo, indazolilo, quinolilo, isoquinolilo, ftalazinilo, naftiridinilo, quinoxalinilo, quinazolinilo, cinolinilo, pirrolinilo, pirazolinilo, indolinilo e isoindolinilo, dicho grupo residual heterocíclico insaturado puede tener de 1 a 3 sustituyentes,sobreelanillo residual heterocíclico, seleccionados entre un grupo oxo; un grupo tio; ungrupofenilo;ungrupofeniloquepuedetenerde1 a 3 sustituyentes,sobreelanillo defenilo, seleccionados entre un grupo alquilo C1-C6, un grupo haloalquilo C1-C6, un átomo de halógeno, un grupo hidroxi, un grupo amino, un grupo alquil(C1-C6)amino, un grupo carboxi y un grupo alcoxi C1-C6; un grupo cicloalquilo C3-C8; un grupo feniltio; un grupo alquilo C1-C6; un grupo alquilo C1-C6 quetienede1 a 2 sustituyentesseleccionados entre un grupo amino, un grupo alquil(C1-C6)amino y un grupo carboxilo; un grupo amino; un grupo hidroxilo; un grupo ciano; un grupo carboxilo; un grupo alcoxi(C1-C6)carbonilo; un grupo fenilalquilo C1-C6 que puede tener grupos hidroxilo como sustituyentes en el anillo de fenilo; un grupo fenilsulfonilo que puede tener grupos alquilo C1-C6 como sustituyentes en el anillo de fenilo; un grupo fenilalquilo C1-C6 sustituido con alcoxi C1-C6; un grupo alquil(C1-C6)tio; un grupo alquenilo C2-C6; un grupo alcoxi C1-C6 y un grupo piridilo; R1 es un átomo de hidrógeno, un grupo alquilo C1-C6 o un grupo fenilalquilo C1-C6; R2 es un átomo de hidrógeno, un átomode halógeno, un grupo alquil(C1-C6)sulfoniloxi, un grupo alcoxi C1-C6 o un grupo hidroxilo; Z es un átomo de oxígeno, un átomo de azufre, un grupo de fórmula -C - !! O, un grupo de fórmula -C - !! N -OH un grupo de fórmula -CH - !! OR3 (donde R3 es un átomo de hidrógeno o un grupo alquilo C1-C6) o un grupo de fórmula -NH-; A es un grupo alquileno C2-C6; X esun átomo de oxígeno, un átomo de azufre, un grupo de fórmula - SO - o un grupo de fórmula - SO2- ; n es 0 o 1; y el enlace carbono - carbono entre las posiciones 3 y 4 del esqueleto de carboestirilo es un enlace sencillo o doble en la preparación de un medicamento para el tratamiento y la prevención de la arteriosclerosis, las enfermedades cardíacas isquémicas, la obstrucción arterial crónica, la nefritis aguda o crónica y el tratamiento durante la diálisis artificial y la implantación de un órgano artificial.
ES87104873T 1986-04-02 1987-04-02 Derivados de carboestirilo, procedimiento para prepararlos, composicion farmaceutica, y uso. Expired - Lifetime ES2068807T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP7608986 1986-04-02
JP62043457A JPH0681727B2 (ja) 1986-04-02 1987-02-25 血小板粘着抑制剤
JP62060770A JPH0681752B2 (ja) 1986-04-02 1987-03-16 カルボスチリル誘導体

Publications (1)

Publication Number Publication Date
ES2068807T3 true ES2068807T3 (es) 1995-05-01

Family

ID=27291549

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87104873T Expired - Lifetime ES2068807T3 (es) 1986-04-02 1987-04-02 Derivados de carboestirilo, procedimiento para prepararlos, composicion farmaceutica, y uso.

Country Status (5)

Country Link
US (1) US5008274A (es)
EP (1) EP0240015B1 (es)
DE (1) DE3750913T2 (es)
DK (1) DK167187A (es)
ES (1) ES2068807T3 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
US5064837A (en) * 1989-11-13 1991-11-12 Schering Corporation 3-substituted-1-aryl-2(h)-quinolones and their pharmaceutical compositions
CA2071497A1 (en) * 1989-12-12 1991-06-13 Andrew William Bridge 2-substituted 4,5-diphenyl-imidazoles
MX9203711A (es) * 1990-01-12 1992-07-01 Rhone Poulenc Rorer Sa Derivados de imidazol y composiciones farmaceuticas que los contienen.
EP0544958A1 (en) * 1990-08-09 1993-06-09 Tanabe Seiyaku Co., Ltd. Cephalosporin compounds and processes for preparing the same
EP0569592A4 (en) * 1991-08-23 1994-12-07 Otsuka Pharma Co Ltd CARBOSTYRILE DERIVATIVE AND PLATELET ANTIAGGREGATOR.
JP3141051B2 (ja) * 1992-10-09 2001-03-05 日清製粉株式会社 抗動脈硬化剤
EP0650476B1 (en) * 1993-04-07 2002-06-26 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing n-acylated 4-amino piperidine derivatives as active ingredients
TW289019B (es) * 1993-05-19 1996-10-21 Otsuka Pharma Co Ltd
IL110280A0 (en) * 1993-07-27 1994-10-21 Zeneca Ltd Thiazole derivatives
ZA945250B (en) * 1993-07-27 1995-01-27 Zeneca Ltd Thiazole derivatives
EP0636624A1 (en) * 1993-07-27 1995-02-01 Zeneca Limited Thiazole derivatives as lipoxygenase inhibitors
US5780480A (en) * 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
WO1998046593A1 (en) * 1997-04-16 1998-10-22 Otsuka Pharmaceutical Co., Ltd. Novel carbostyril derivative
FR2812548B1 (fr) * 2000-08-01 2002-09-20 Sanofi Synthelabo Utilisation de derives de quinolein-2(1h)-one ou un de leurs sels pharmaceutiquement acceptable pour la preparation d'un medicament destine au traitement de l'insuffisance renale
US6596871B2 (en) 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6657061B2 (en) 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en) 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6531603B1 (en) 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6660864B2 (en) 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
MY142362A (en) * 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
TW201039822A (en) 2009-02-06 2010-11-16 Taisho Pharmaceutical Co Ltd Dihydroquinolinone derivatives
GB202019475D0 (en) 2020-12-10 2021-01-27 Cancer Research Tech Ltd Therapeutic compounds and their use
CN115974850B (zh) * 2023-02-16 2024-08-06 中国药科大学 一类作为akr1c3抑制剂的化合物及其制备方法与用途

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GB1496768A (en) 1973-12-26 1978-01-05 Otsuka Pharma Co Ltd 5-substituted ethyl-8-hydroxycarbostyril derivatives and production thereof
US4026897A (en) 1974-01-31 1977-05-31 Otsuka Pharmaceutical Company 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxycarbostyril derivatives
US3994901A (en) 1974-06-13 1976-11-30 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
GB1496875A (en) 1974-06-13 1978-01-05 Otsuka Pharma Co Ltd 5-substituted alkanoyl-8-hydroxycarbostyril derivatives and production thereof
FI59246C (fi) 1974-06-24 1981-07-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin
GB1496770A (en) 1974-11-08 1978-01-05 Otsuka Pharma Co Ltd 5-substituted alkyl-8-substituted-carbostyrils and-3,4-dihydrocarbostyril derivatives and production thereof
GB1496871A (en) 1974-11-08 1978-01-05 Otsuka Pharma Co Ltd 5-(alpha-aminoalkanoyl)-8-substituted-carbostyrils and their preparation
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JPS5430180A (en) 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative
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US4329347A (en) * 1978-02-17 1982-05-11 Boehringer Ingelheim Gmbh Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril
DE2806721A1 (de) 1978-02-17 1979-08-23 Thomae Gmbh Dr K Neue carbostyril-derivate
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
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DE2928583A1 (de) * 1979-07-14 1981-01-29 Thomae Gmbh Dr K Verfahren zur herstellung von carbostyrilderivaten
JPS5645414A (en) * 1979-09-19 1981-04-25 Otsuka Pharmaceut Co Ltd Phosphodiesterase inhibitor
PH17194A (en) 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
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JPS5859980A (ja) * 1981-10-05 1983-04-09 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JPS5877880A (ja) * 1981-11-05 1983-05-11 Otsuka Pharmaceut Co Ltd テトラゾ−ル誘導体
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
FR2539413A1 (fr) * 1983-01-17 1984-07-20 Pos Lab Carbostyriloximinopropanolamines utiles comme medicaments et procede pour leur preparation
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors

Also Published As

Publication number Publication date
EP0240015B1 (en) 1994-12-28
DE3750913D1 (de) 1995-02-09
DE3750913T2 (de) 1995-06-01
DK167187A (da) 1987-10-03
EP0240015A3 (en) 1990-10-24
US5008274A (en) 1991-04-16
EP0240015A2 (en) 1987-10-07
DK167187D0 (da) 1987-04-01

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