JPS57159778A - Carbostyril derivative - Google Patents
Carbostyril derivativeInfo
- Publication number
- JPS57159778A JPS57159778A JP4584281A JP4584281A JPS57159778A JP S57159778 A JPS57159778 A JP S57159778A JP 4584281 A JP4584281 A JP 4584281A JP 4584281 A JP4584281 A JP 4584281A JP S57159778 A JPS57159778 A JP S57159778A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- lower alkyl
- preventive
- formula
- carbostyril derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:The compound of formulaI(R is H, lower alkyl, or cycloalkyl; A is lower alkylene; the dotted line represents single or double bond) and its salt.
EXAMPLE: 5-[(2-Cyclohexyl-imidazol-1-yl)]-3,4-dihydrocarbostyril.
USE: Preventive for thrombosis, and remedy or preventive for ischemic cardiopathy such as hypertension, stenocardia, cardiac infaction, etc., and cerebral diseases such as cerebral apoplexy, transient ischemic attack, migraine, etc.
PROCESS: The compound of formulaIcan be prepared e.g. by reacting the compound of formula II[X is halogen, -OSO2R1 (R1 is lower alkyl or aryl), or -+N(R2)3 (R2 is lower alkyl)]with the compound of formula III preferably in the presence of a basic compound (e.g. NaOH) at room temperature W100°C.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4584281A JPS57159778A (en) | 1981-03-27 | 1981-03-27 | Carbostyril derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4584281A JPS57159778A (en) | 1981-03-27 | 1981-03-27 | Carbostyril derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57159778A true JPS57159778A (en) | 1982-10-01 |
JPS6366318B2 JPS6366318B2 (en) | 1988-12-20 |
Family
ID=12730467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4584281A Granted JPS57159778A (en) | 1981-03-27 | 1981-03-27 | Carbostyril derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57159778A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0240015A2 (en) | 1986-04-02 | 1987-10-07 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use |
JPS6345220A (en) * | 1986-04-02 | 1988-02-26 | Otsuka Pharmaceut Co Ltd | Platelet adhesion suppresser |
US4792561A (en) * | 1986-05-29 | 1988-12-20 | Syntex (U.S.A.) Inc. | Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors |
JPS646271A (en) * | 1986-04-02 | 1989-01-10 | Otsuka Pharma Co Ltd | Carbostyril derivative |
WO1994026732A1 (en) * | 1993-05-19 | 1994-11-24 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
US5434164A (en) * | 1986-04-02 | 1995-07-18 | Otsuka Pharmaceutical Co. Ltd. | Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5430183A (en) * | 1977-08-10 | 1979-03-06 | Otsuka Pharmaceut Co Ltd | 3,4-dihydrocarbostyril derivative |
-
1981
- 1981-03-27 JP JP4584281A patent/JPS57159778A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5430183A (en) * | 1977-08-10 | 1979-03-06 | Otsuka Pharmaceut Co Ltd | 3,4-dihydrocarbostyril derivative |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0240015A2 (en) | 1986-04-02 | 1987-10-07 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use |
JPS6345220A (en) * | 1986-04-02 | 1988-02-26 | Otsuka Pharmaceut Co Ltd | Platelet adhesion suppresser |
JPS646271A (en) * | 1986-04-02 | 1989-01-10 | Otsuka Pharma Co Ltd | Carbostyril derivative |
US5008274A (en) * | 1986-04-02 | 1991-04-16 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and pharmaceutical composition for inhibiting adhesion of thrombocytes |
US5434164A (en) * | 1986-04-02 | 1995-07-18 | Otsuka Pharmaceutical Co. Ltd. | Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes |
US4792561A (en) * | 1986-05-29 | 1988-12-20 | Syntex (U.S.A.) Inc. | Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors |
WO1994026732A1 (en) * | 1993-05-19 | 1994-11-24 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
US5541198A (en) * | 1993-05-19 | 1996-07-30 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS6366318B2 (en) | 1988-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS55136266A (en) | Derivatives of 2-imidazoline | |
JPS5519250A (en) | Cephalosporin analog, or its salts, their preparation, and preventive and remedy for microbism | |
JPS57159778A (en) | Carbostyril derivative | |
JPS55127371A (en) | Carbostyril derivative | |
JPS5649364A (en) | Carbostyril derivative | |
GB1301505A (en) | ||
JPS55133366A (en) | Thiazole derivative | |
IE41256B1 (en) | An ether of 1-(2-hydrooxyethyl)-o-methyl-pyrazolin-5-one processes for its preparation and its use as an antithrombotic agent | |
JPS5754177A (en) | Substituted thiazole derivative | |
JPS57144269A (en) | Triazine derivative and its preparation | |
JPS5716852A (en) | Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same | |
JPS57165369A (en) | Pyrazole derivative and its preparation | |
GB1447954A (en) | Process for the preparation of 1,2,4-triazole derivative | |
JPS56164186A (en) | Carbostyril derivative | |
JPS57122061A (en) | Novel cyclohexanecarboxylic acid derivative and its preparation | |
JPS5754175A (en) | Novel 3-aminoindazole derivative | |
JPS5651483A (en) | 1-azaxanthone 3-carboxylic acid derivative and its preparation | |
JPS57130979A (en) | 4-amino-1,3-benzoxazine derivative and its preparation | |
JPS57144253A (en) | Preparation of crude aminoalkylthiol | |
JPS54106498A (en) | Carbostyril derivative | |
JPS572277A (en) | Quinoxalinone derivative, its preparation, and fungicide for agricultural and horticultural use | |
JPS5643280A (en) | Carbostyril derivative | |
JPS53111078A (en) | Carbostyril derivative | |
JPS552655A (en) | Quinoline derivative | |
JPS57116012A (en) | Preventive and remedy for mycosis of fish |