JPS57159778A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS57159778A
JPS57159778A JP4584281A JP4584281A JPS57159778A JP S57159778 A JPS57159778 A JP S57159778A JP 4584281 A JP4584281 A JP 4584281A JP 4584281 A JP4584281 A JP 4584281A JP S57159778 A JPS57159778 A JP S57159778A
Authority
JP
Japan
Prior art keywords
compound
lower alkyl
preventive
formula
carbostyril derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4584281A
Other languages
Japanese (ja)
Other versions
JPS6366318B2 (en
Inventor
Takao Nishi
Fujio Tafusa
Tatsuyoshi Tanaka
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP4584281A priority Critical patent/JPS57159778A/en
Publication of JPS57159778A publication Critical patent/JPS57159778A/en
Publication of JPS6366318B2 publication Critical patent/JPS6366318B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:The compound of formulaI(R is H, lower alkyl, or cycloalkyl; A is lower alkylene; the dotted line represents single or double bond) and its salt.
EXAMPLE: 5-[(2-Cyclohexyl-imidazol-1-yl)]-3,4-dihydrocarbostyril.
USE: Preventive for thrombosis, and remedy or preventive for ischemic cardiopathy such as hypertension, stenocardia, cardiac infaction, etc., and cerebral diseases such as cerebral apoplexy, transient ischemic attack, migraine, etc.
PROCESS: The compound of formulaIcan be prepared e.g. by reacting the compound of formula II[X is halogen, -OSO2R1 (R1 is lower alkyl or aryl), or -+N(R2)3 (R2 is lower alkyl)]with the compound of formula III preferably in the presence of a basic compound (e.g. NaOH) at room temperature W100°C.
COPYRIGHT: (C)1982,JPO&Japio
JP4584281A 1981-03-27 1981-03-27 Carbostyril derivative Granted JPS57159778A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4584281A JPS57159778A (en) 1981-03-27 1981-03-27 Carbostyril derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4584281A JPS57159778A (en) 1981-03-27 1981-03-27 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS57159778A true JPS57159778A (en) 1982-10-01
JPS6366318B2 JPS6366318B2 (en) 1988-12-20

Family

ID=12730467

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4584281A Granted JPS57159778A (en) 1981-03-27 1981-03-27 Carbostyril derivative

Country Status (1)

Country Link
JP (1) JPS57159778A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240015A2 (en) 1986-04-02 1987-10-07 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use
JPS6345220A (en) * 1986-04-02 1988-02-26 Otsuka Pharmaceut Co Ltd Platelet adhesion suppresser
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
JPS646271A (en) * 1986-04-02 1989-01-10 Otsuka Pharma Co Ltd Carbostyril derivative
WO1994026732A1 (en) * 1993-05-19 1994-11-24 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US5434164A (en) * 1986-04-02 1995-07-18 Otsuka Pharmaceutical Co. Ltd. Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5430183A (en) * 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5430183A (en) * 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240015A2 (en) 1986-04-02 1987-10-07 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use
JPS6345220A (en) * 1986-04-02 1988-02-26 Otsuka Pharmaceut Co Ltd Platelet adhesion suppresser
JPS646271A (en) * 1986-04-02 1989-01-10 Otsuka Pharma Co Ltd Carbostyril derivative
US5008274A (en) * 1986-04-02 1991-04-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and pharmaceutical composition for inhibiting adhesion of thrombocytes
US5434164A (en) * 1986-04-02 1995-07-18 Otsuka Pharmaceutical Co. Ltd. Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
WO1994026732A1 (en) * 1993-05-19 1994-11-24 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US5541198A (en) * 1993-05-19 1996-07-30 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Also Published As

Publication number Publication date
JPS6366318B2 (en) 1988-12-20

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