JPS579780A - Carbostyril derivative - Google Patents
Carbostyril derivativeInfo
- Publication number
- JPS579780A JPS579780A JP8425080A JP8425080A JPS579780A JP S579780 A JPS579780 A JP S579780A JP 8425080 A JP8425080 A JP 8425080A JP 8425080 A JP8425080 A JP 8425080A JP S579780 A JPS579780 A JP S579780A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- phenyl
- carbostyril
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Carbostyril derivatives of formula I (R1 is H, lower alkyl, cycloalkyl, phenyl, phenyl-lower-alkyl, lower alkylthio; R2 is H, lower alkyl, phenyl- lower- alkyl, lower alkenyl; A is lower alkylene; B, Z are O, S; the carbon-carbon bond between the 3- and 4-positions in the carbostyril skelton is single or double) and their salts.
EXAMPLE: 6-[3-(1,3,4-Oxadiazol-5-yl)propoxy]carbostyril.
USE: Blood platelet coagulation ingibitor (prophylactic or remedy for thrombosis), phosphodiesterase inhibitor, antitumor agent, cardiotoner (positive cardiac muscle stimulator), anti-inflammatory, hypotensor, central nervous system depressant (tranquilizer).
PREPARATION: The reaction of a compound of formula IVb with another compound of formula V (R4 is lower alkyl) affords the compound of formula Ib.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8425080A JPS579780A (en) | 1980-06-21 | 1980-06-21 | Carbostyril derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8425080A JPS579780A (en) | 1980-06-21 | 1980-06-21 | Carbostyril derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS579780A true JPS579780A (en) | 1982-01-19 |
JPS6254308B2 JPS6254308B2 (en) | 1987-11-13 |
Family
ID=13825209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8425080A Granted JPS579780A (en) | 1980-06-21 | 1980-06-21 | Carbostyril derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS579780A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0240015A2 (en) | 1986-04-02 | 1987-10-07 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use |
JPS62265966A (en) * | 1986-05-12 | 1987-11-18 | Deijii Shokuhin Kogyo Kk | Production of formed crab meat product |
US4721721A (en) * | 1984-12-18 | 1988-01-26 | Rorer Pharmaceutical Corporation | 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses |
JPS6345220A (en) * | 1986-04-02 | 1988-02-26 | Otsuka Pharmaceut Co Ltd | Platelet adhesion suppresser |
JPS646271A (en) * | 1986-04-02 | 1989-01-10 | Otsuka Pharma Co Ltd | Carbostyril derivative |
US5424434A (en) * | 1992-09-02 | 1995-06-13 | Dainippon Pharmaceutical Co., Ltd. | Production on 3-oxadiazolyl-1,6-naphthyridine derivatives |
US5434164A (en) * | 1986-04-02 | 1995-07-18 | Otsuka Pharmaceutical Co. Ltd. | Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0742871U (en) * | 1993-12-31 | 1995-08-11 | 株式会社ブレスト工業研究所 | Long object support |
-
1980
- 1980-06-21 JP JP8425080A patent/JPS579780A/en active Granted
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4721721A (en) * | 1984-12-18 | 1988-01-26 | Rorer Pharmaceutical Corporation | 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses |
EP0240015A2 (en) | 1986-04-02 | 1987-10-07 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use |
JPS6345220A (en) * | 1986-04-02 | 1988-02-26 | Otsuka Pharmaceut Co Ltd | Platelet adhesion suppresser |
JPS646271A (en) * | 1986-04-02 | 1989-01-10 | Otsuka Pharma Co Ltd | Carbostyril derivative |
US5008274A (en) * | 1986-04-02 | 1991-04-16 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and pharmaceutical composition for inhibiting adhesion of thrombocytes |
US5434164A (en) * | 1986-04-02 | 1995-07-18 | Otsuka Pharmaceutical Co. Ltd. | Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes |
JPS62265966A (en) * | 1986-05-12 | 1987-11-18 | Deijii Shokuhin Kogyo Kk | Production of formed crab meat product |
US5424434A (en) * | 1992-09-02 | 1995-06-13 | Dainippon Pharmaceutical Co., Ltd. | Production on 3-oxadiazolyl-1,6-naphthyridine derivatives |
US5424433A (en) * | 1992-09-02 | 1995-06-13 | Dainippon Pharmaceutical Co., Ltd. | Intermediates for 3-oxadiazoly-1,6-naphthyridine derivatives |
CN1039010C (en) * | 1992-09-02 | 1998-07-08 | 大日本制药株式会社 | Novel 3-oxadiazolyl-1,6-naphthyridine derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS6254308B2 (en) | 1987-11-13 |
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