GB1496770A - 5-substituted alkyl-8-substituted-carbostyrils and-3,4-dihydrocarbostyril derivatives and production thereof - Google Patents

5-substituted alkyl-8-substituted-carbostyrils and-3,4-dihydrocarbostyril derivatives and production thereof

Info

Publication number
GB1496770A
GB1496770A GB5592974A GB5592974A GB1496770A GB 1496770 A GB1496770 A GB 1496770A GB 5592974 A GB5592974 A GB 5592974A GB 5592974 A GB5592974 A GB 5592974A GB 1496770 A GB1496770 A GB 1496770A
Authority
GB
United Kingdom
Prior art keywords
compound
alkyl
substituted
carbostyrils
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5592974A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP12938374A external-priority patent/JPS5156458A/en
Priority claimed from JP12938174A external-priority patent/JPS5156456A/en
Priority claimed from JP12938274A external-priority patent/JPS5156457A/en
Priority claimed from JP12938474A external-priority patent/JPS5156459A/en
Priority claimed from JP49130729A external-priority patent/JPS5156475A/en
Priority claimed from JP13072674A external-priority patent/JPS5156472A/en
Priority claimed from JP13072774A external-priority patent/JPS5156473A/en
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of GB1496770A publication Critical patent/GB1496770A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1496770 Carbostyril derivatives OTSUKA PHARMACEUTICAL CO Ltd 27 Dec 1974 [8 Nov 1974 (4) 11 Nov 1974 (3)] 55929/74 Heading C2C Novel compounds Ia and Ib (R<SP>1</SP>, R<SP>4</SP> and R<SP>5</SP> are H or 1-4 C alkyl, at least one of R<SP>4</SP> and R<SP>5</SP> being alkyl; and R<SP>2</SP> and R<SP>3</SP> are H, 1-4 C alkyl, aryl-1-4 C alkyl or 4-6 C cycloalkyl; or -NR<SP>2</SP>R<SP>3</SP> is a 5- or 6-membered, optionally substituted, heterocyclic ring containing 1 or 2 N, O or S atoms as heteroatoms) and acid addition salts thereof are prepared by: (i) catalytic hydrogenation of a compound Ia to give a compound Ib; (ii) catalytic hydrogenation of a compound II or VIIb or (iii) alkylation of a compound VIIIa or VIIIb Compounds of Formulae II, VIIb, Villa and VIIIb are described and claimed in Specifications 1,496,871; 1,496,873; 1,496,875; 1,496,766 and 1,496,767 respectively. Pharmaceutical compositions, useful as bronchodilators, peripheral vasodilators and antihypertensives, comprise a compound I together with a suitable diluent and/or carrier.
GB5592974A 1974-11-08 1974-12-22 5-substituted alkyl-8-substituted-carbostyrils and-3,4-dihydrocarbostyril derivatives and production thereof Expired GB1496770A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP12938374A JPS5156458A (en) 1974-11-08 1974-11-08 KARUBOSUCHIRIRU JUDOTAINOSEIZOHO
JP12938174A JPS5156456A (en) 1974-11-08 1974-11-08 KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
JP12938274A JPS5156457A (en) 1974-11-08 1974-11-08 KARUBOSUCHIRIRU JUDOTAINOSEIZOHO
JP12938474A JPS5156459A (en) 1974-11-08 1974-11-08 KARUBOSUCHIRIRU JUDOTAINOSEIZOHO
JP49130729A JPS5156475A (en) 1974-11-11 1974-11-11 Karubosuchirirujudotaino seizoho
JP13072674A JPS5156472A (en) 1974-11-11 1974-11-11 KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
JP13072774A JPS5156473A (en) 1974-11-11 1974-11-11 KARUBOSUCHIRIRU JUDOTAINO SEIZOHO

Publications (1)

Publication Number Publication Date
GB1496770A true GB1496770A (en) 1978-01-05

Family

ID=27565968

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5592974A Expired GB1496770A (en) 1974-11-08 1974-12-22 5-substituted alkyl-8-substituted-carbostyrils and-3,4-dihydrocarbostyril derivatives and production thereof

Country Status (3)

Country Link
GB (1) GB1496770A (en)
HK (1) HK19981A (en)
MY (1) MY8200094A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240015A2 (en) 1986-04-02 1987-10-07 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use
EP0264951A2 (en) * 1986-10-24 1988-04-27 Warner-Lambert Company Process for stabilising procaterol

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240015A2 (en) 1986-04-02 1987-10-07 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use
EP0264951A2 (en) * 1986-10-24 1988-04-27 Warner-Lambert Company Process for stabilising procaterol
EP0264951A3 (en) * 1986-10-24 1988-09-14 Warner-Lambert Company Procaterol-derivatives

Also Published As

Publication number Publication date
MY8200094A (en) 1982-12-31
HK19981A (en) 1981-05-22

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Legal Events

Date Code Title Description
PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19941226