CZ171095A3 - Novel steroidal derivatives specific for colon or ilium - Google Patents

Novel steroidal derivatives specific for colon or ilium Download PDF

Info

Publication number
CZ171095A3
CZ171095A3 CZ951710A CZ171095A CZ171095A3 CZ 171095 A3 CZ171095 A3 CZ 171095A3 CZ 951710 A CZ951710 A CZ 951710A CZ 171095 A CZ171095 A CZ 171095A CZ 171095 A3 CZ171095 A3 CZ 171095A3
Authority
CZ
Czechia
Prior art keywords
compound
sugar
formula
gcs
epimer
Prior art date
Application number
CZ951710A
Other languages
Czech (cs)
English (en)
Inventor
Ralph Lennart Brattsand
Peter Edman
Thomas Hogberg
Stinabritt Nilsson
Bror Arne Thalen
Jan Erik Ulmius
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9300030A external-priority patent/SE9300030D0/xx
Priority claimed from SE9300082A external-priority patent/SE9300082D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of CZ171095A3 publication Critical patent/CZ171095A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CZ951710A 1993-01-08 1993-12-17 Novel steroidal derivatives specific for colon or ilium CZ171095A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9300030A SE9300030D0 (sv) 1993-01-08 1993-01-08 Novel colon- or ileum-specific steroid derivatives
SE9300082A SE9300082D0 (sv) 1993-01-14 1993-01-14 Novel colon- or ileum-specific steroid derivatives

Publications (1)

Publication Number Publication Date
CZ171095A3 true CZ171095A3 (en) 1996-01-17

Family

ID=26661623

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ951710A CZ171095A3 (en) 1993-01-08 1993-12-17 Novel steroidal derivatives specific for colon or ilium

Country Status (22)

Country Link
US (2) US5908833A (enExample)
EP (1) EP0678097B1 (enExample)
JP (1) JP3366640B2 (enExample)
KR (1) KR960700266A (enExample)
AT (1) ATE183192T1 (enExample)
BR (1) BR9307746A (enExample)
CA (1) CA2152374A1 (enExample)
CZ (1) CZ171095A3 (enExample)
DK (1) DK0678097T3 (enExample)
ES (1) ES2137353T3 (enExample)
FI (1) FI953358L (enExample)
GR (1) GR3031789T3 (enExample)
HU (1) HU221584B (enExample)
IS (1) IS4111A (enExample)
LV (1) LV10961B (enExample)
NO (1) NO305367B1 (enExample)
NZ (1) NZ259596A (enExample)
PL (1) PL178307B1 (enExample)
RU (1) RU95115547A (enExample)
SK (1) SK87295A3 (enExample)
TW (1) TW261615B (enExample)
WO (1) WO1994015947A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2137353T3 (es) * 1993-01-08 1999-12-16 Astra Ab Nuevos derivados esteroides especificos del colon o del ileon.
ATE195127T1 (de) * 1993-09-29 2000-08-15 Nissin Food Products Ltd In stellung 21 substituierte steroide
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
WO1999047541A1 (fr) * 1998-03-19 1999-09-23 Nissin Food Products Co., Ltd. Composes steroides glycosyles a substitution en position 21
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
IL146284A0 (en) 1999-05-04 2002-07-25 Strakan Ltd Androgen glycosides and pharmaceutical compositions containing the same
RU2246293C2 (ru) 1999-06-14 2005-02-20 Космо С.П.А. Фармацевтические композиции для перорального введения с регулируемым высвобождением активного ингредиента и маскируемым вкусом
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
WO2001051057A2 (en) * 2000-01-14 2001-07-19 Strakan Limited Glycosides and orthoester glycosides of glucocorticoids and uses thereof
SE0101220D0 (sv) * 2001-04-04 2001-04-04 Astrazeneca Ab New use
EP1625854B1 (en) * 2004-08-09 2008-10-15 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Albumin conjugates containing a glucuronic linker
WO2008100560A2 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators, associated pharmaceutical compositions and methods of use
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
KR20190074310A (ko) 2016-11-08 2019-06-27 리제너론 파마슈티칼스 인코포레이티드 스테로이드 및 이의 단백질-접합체
US11491232B2 (en) 2017-03-30 2022-11-08 Fruithy Holdings Limited Lactuloside compounds and preparation and use thereof
JP7364471B2 (ja) 2017-05-18 2023-10-18 レゲネロン ファーマシューティカルス，インコーポレーテッド シクロデキストリンタンパク質薬物コンジュゲート
WO2019094395A2 (en) 2017-11-07 2019-05-16 Regeneron Pharmaceuticals, Inc. Hydrophilic linkers for antibody drug conjugates
AU2019205542B2 (en) 2018-01-08 2025-10-23 Regeneron Pharmaceuticals, Inc. Steroids and antibody-conjugates thereof
SG11202010909RA (en) 2018-05-09 2020-12-30 Regeneron Pharma Anti-msr1 antibodies and methods of use thereof

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
SE378109B (enExample) * 1972-05-19 1975-08-18 Bofors Ab
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378110B (enExample) * 1972-05-19 1975-08-18 Bofors Ab
US3938233A (en) * 1974-08-12 1976-02-17 Cannon Robert B Heat transfer apparatus
DE2803660A1 (de) * 1978-01-25 1979-07-26 Schering Ag Neue in 17-position substituierte steroide der pregnanreihe, ihre herstellung und verwendung
BG33738A3 (bg) * 1978-01-25 1983-04-15 Schering Aktiengesellschaft Метод за получаване на заместени в 17-а позиция стероиди на прегнановия ред
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
US4469689A (en) * 1983-03-30 1984-09-04 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
WO1984004041A1 (en) * 1983-04-14 1984-10-25 Univ California Colon-specific drug delivery system
US4959358A (en) * 1983-06-06 1990-09-25 Beth Israel Hospital Assn. Drug administration
US4548922A (en) * 1983-06-06 1985-10-22 Beth Israel Hospital Drug administration
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
US5215979A (en) * 1985-12-19 1993-06-01 Aktiebolaget Draco 16,17-acetalsubstituted pregnane 21-oic acid derivatives
GB8600490D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid lactams
GB8600491D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid derivatives
GB8600489D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside steroids
AU594468B2 (en) * 1986-05-12 1990-03-08 Mect Corporation Sialosylcholesterol, process for its preparation, and drug for treating diseases of nervous system
CA1299653C (en) * 1988-07-07 1992-04-28 Markwell Medical Institute, Inc. Biological fluid measuring device
US5643602A (en) * 1989-11-22 1997-07-01 Astra Aktiebolag Oral composition for the treatment of inflammatory bowel disease
SE8903914D0 (sv) * 1989-11-22 1989-11-22 Draco Ab Oral composition for the treatment of inflammatory bowel diseases
US5888995A (en) * 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
WO1993022334A1 (en) * 1992-05-04 1993-11-11 Sri International Pharmaceutical compositions and methods for colonic delivery of corticosteroids
ES2137353T3 (es) * 1993-01-08 1999-12-16 Astra Ab Nuevos derivados esteroides especificos del colon o del ileon.

Also Published As

Publication number Publication date
NO952683D0 (no) 1995-07-06
PL309777A1 (en) 1995-11-13
BR9307746A (pt) 1995-11-14
FI953358A0 (fi) 1995-07-07
CA2152374A1 (en) 1994-07-21
HUT73227A (en) 1996-07-29
SK87295A3 (en) 1996-04-03
NO305367B1 (no) 1999-05-18
AU5844794A (en) 1994-08-15
JPH08505616A (ja) 1996-06-18
US6140308A (en) 2000-10-31
NO952683L (no) 1995-07-06
IS4111A (is) 1994-07-09
LV10961B (en) 1996-08-20
HU221584B (hu) 2002-11-28
ES2137353T3 (es) 1999-12-16
GR3031789T3 (en) 2000-02-29
LV10961A (lv) 1995-12-20
EP0678097B1 (en) 1999-08-11
JP3366640B2 (ja) 2003-01-14
HU9502087D0 (en) 1995-09-28
TW261615B (enExample) 1995-11-01
KR960700266A (ko) 1996-01-19
FI953358A7 (fi) 1995-07-07
EP0678097A1 (en) 1995-10-25
DK0678097T3 (da) 2000-02-07
US5908833A (en) 1999-06-01
AU678803B2 (en) 1997-06-12
ATE183192T1 (de) 1999-08-15
NZ259596A (en) 1997-04-24
PL178307B1 (pl) 2000-04-28
WO1994015947A1 (en) 1994-07-21
RU95115547A (ru) 1997-06-10
FI953358L (fi) 1995-07-07

Similar Documents

Publication Publication Date Title
CZ171095A3 (en) Novel steroidal derivatives specific for colon or ilium
CN1917886B (zh) 核心2GlcNAc-T抑制剂
CZ287877B6 (cs) Prednisolonové deriváty a farmaceutické prostředky s jejich obsahem
JP2013063993A (ja) コア２ｇｌｃｎａｃ−ｔ阻害剤
JP2783560B2 (ja) 新規なアンドロスタン１７−カルボン酸エステル、その製法及びそれを含む薬剤
WO1993022334A1 (en) Pharmaceutical compositions and methods for colonic delivery of corticosteroids
WO1995010527A1 (en) 3,17-dihydroxy-3,7,16 and/or 17-methyl-androst-5-ene compounds, derivatives thereof, and their use
HRP941012A2 (en) Steroidal glycosides
US6150336A (en) Steroidal glycosides
CN102796159B (zh) 一类达玛烷糖苷及其制备方法与应用
SI9400203A (en) Spirostanyl glycosidal crystalline monohydrate
EP3604322B1 (en) Lactulose glycoside compound and preparation method and use thereof
AU678803C (en) Novel colon- or ileum-specific steroid derivatives
WO1984004041A1 (en) Colon-specific drug delivery system
DE69326023T2 (de) Neue colon-oder ilean-spezifische steroid derivate
Pis et al. Analysis of ecdysteroid conjugates: chromatographic characterization of sulfates, phosphates and glucosides
WO2002080931A1 (en) New use of glyconjugates of glucocorticosteroids as a targeting to the colon
CN1114654A (zh) 新的结肠或回肠专一性类固醇衍生物
KR100472303B1 (ko) 결장표적성 프로드럭으로서의 코티코스테로이드21-설페이트 소듐 유도체
HUT76831A (en) Dammara-steroids, their prodution, pharmaceutical compositions containing them and use thereof
CS197245B2 (en) Method of producing novel 2-brom-6-beta,9alpha-difluor-pregna-1,4-diene-3,20 diones or 17,21-esters,17-21-alkylorthoesters or 17,21-cyclic acetals or ketals thereof
PL97346B1 (pl) Sposob wytwarzania 2-bromo-6 beta-fluoropregnadien-1,4-dionow-3,20
JPH0673084A (ja) グリコシド及びこれを含有する抗肝炎剤
JPH0439480B2 (enExample)

Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic