FI943208A7 - Bisyklisiä tetrahydropyratsolopyridiinejä - Google Patents

Bisyklisiä tetrahydropyratsolopyridiinejä Download PDF

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Publication number
FI943208A7
FI943208A7 FI943208A FI943208A FI943208A7 FI 943208 A7 FI943208 A7 FI 943208A7 FI 943208 A FI943208 A FI 943208A FI 943208 A FI943208 A FI 943208A FI 943208 A7 FI943208 A7 FI 943208A7
Authority
FI
Finland
Prior art keywords
tetrahydropyrazolopyridines
bicyclic
bicyclic tetrahydropyrazolopyridines
Prior art date
Application number
FI943208A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI943208L (fi
FI943208A0 (fi
Inventor
Allen Jacob Duplantier
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI943208A0 publication Critical patent/FI943208A0/fi
Publication of FI943208L publication Critical patent/FI943208L/fi
Publication of FI943208A7 publication Critical patent/FI943208A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI943208A 1993-07-06 1994-07-05 Bisyklisiä tetrahydropyratsolopyridiinejä FI943208A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8829293A 1993-07-06 1993-07-06

Publications (3)

Publication Number Publication Date
FI943208A0 FI943208A0 (fi) 1994-07-05
FI943208L FI943208L (fi) 1995-01-07
FI943208A7 true FI943208A7 (fi) 1995-01-07

Family

ID=22210524

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943208A FI943208A7 (fi) 1993-07-06 1994-07-05 Bisyklisiä tetrahydropyratsolopyridiinejä

Country Status (20)

Country Link
EP (1) EP0707585A1 (enrdf_load_html_response)
JP (1) JP2944048B2 (enrdf_load_html_response)
KR (1) KR100228949B1 (enrdf_load_html_response)
CN (1) CN1048015C (enrdf_load_html_response)
AU (1) AU695301B2 (enrdf_load_html_response)
BR (1) BR9406946A (enrdf_load_html_response)
CA (1) CA2166721C (enrdf_load_html_response)
CZ (1) CZ3696A3 (enrdf_load_html_response)
EG (1) EG20513A (enrdf_load_html_response)
FI (1) FI943208A7 (enrdf_load_html_response)
HU (1) HUT74170A (enrdf_load_html_response)
IL (1) IL110175A (enrdf_load_html_response)
MX (1) MX9405132A (enrdf_load_html_response)
NO (1) NO305029B1 (enrdf_load_html_response)
NZ (1) NZ266525A (enrdf_load_html_response)
PL (1) PL312426A1 (enrdf_load_html_response)
RU (1) RU2131876C1 (enrdf_load_html_response)
TW (1) TW316904B (enrdf_load_html_response)
WO (1) WO1995001980A1 (enrdf_load_html_response)
ZA (1) ZA944844B (enrdf_load_html_response)

Families Citing this family (38)

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CZ120097A3 (cs) * 1994-10-20 1998-01-14 Pfizer Inc. Bicyklické tetrahydropyrazolopyridiny a farmaceutické prostředky na jejich bázi
SK282167B6 (sk) * 1995-06-06 2001-11-06 Pfizer Inc. Tricyklické 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-a] pyridíny a farmaceutický prostriedok na ich báze
AP932A (en) * 1996-08-26 2001-02-02 Pfizer Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines.
WO1998009961A1 (en) * 1996-09-04 1998-03-12 Pfizer Inc. Indazole derivatives and their use as inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf)
BR9812682A (pt) * 1997-09-26 2000-08-22 Asta Medica Ag Compostos à base de azabenzimidazol para modulação de função de cinase de proteìna de serina/treonina
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
SI1140941T1 (en) 1998-12-23 2005-04-30 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor xa inhibitors
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
IL147688A0 (en) 1999-08-21 2002-08-14 Byk Gulden Lomberg Chem Fab Synergistic combination
TWI243055B (en) * 2000-04-13 2005-11-11 Nippon Zoki Pharmaceutical Co Pharmaceutical composition for use in treatment of dermatitis
AU8765401A (en) * 2000-08-10 2002-02-18 Pharmacia Italia Spa Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation andpharmaceutical compositions comprising them
JP5049447B2 (ja) * 2000-08-14 2012-10-17 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 置換ピラゾール
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
WO2002085356A1 (en) 2001-04-18 2002-10-31 Bristol-Myers Squibb Company 1, 4, 5, 6-tetrahydropyrazolo-[3, 4-c]-pyrid in-7-ones as factor xa inhibitors
WO2002085353A1 (en) 2001-04-18 2002-10-31 Bristol-Myers Squibb Company 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor xa inhibitors
US7902179B2 (en) 2001-04-26 2011-03-08 Ajinomoto Co., Inc. Heterocyclic compounds
JP4249621B2 (ja) * 2001-09-21 2009-04-02 ブリストル−マイヤーズ スクイブ カンパニー 第Ｘａ因子阻害剤としてのラクタム含有化合物およびその誘導体
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
AU2004215644B2 (en) 2003-02-27 2010-09-02 Palau Pharma, S.A. Pyrazolopyridine derivates
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
WO2004087211A2 (en) 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
AR050188A1 (es) * 2004-08-03 2006-10-04 Uriach Y Compania S A J Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen
DE102005031580A1 (de) * 2005-07-06 2007-01-11 Aicuris Gmbh & Co. Kg Substituierte Sulfolanylpyrazole und ihre Verwendung
AR065804A1 (es) * 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN103601792B (zh) 2007-06-04 2016-06-29 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2913737A1 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス，インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
CN110357888A (zh) * 2018-04-09 2019-10-22 南京药捷安康生物科技有限公司 杂环磷酸二酯酶抑制剂及其用途
EP3972599A1 (en) 2019-05-21 2022-03-30 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1463883A (fr) * 1964-09-08 1966-07-22 Ciba Geigy Procédé de préparation de triaza-composés bicycliques
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
HU183325B (en) * 1981-02-11 1984-04-28 Richter Gedeon Vegyeszet Process for preparing new apovincaminol-3',4',5'-trimethoxy-benzoates substituted with a nitro group
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
FR2525602A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

Also Published As

Publication number Publication date
CA2166721A1 (en) 1995-01-19
TW316904B (enrdf_load_html_response) 1997-10-01
ZA944844B (en) 1996-01-05
PL312426A1 (en) 1996-04-29
JP2944048B2 (ja) 1999-08-30
BR9406946A (pt) 1996-08-06
MX9405132A (es) 1995-01-31
RU2131876C1 (ru) 1999-06-20
HUT74170A (en) 1996-11-28
NO305029B1 (no) 1999-03-22
HU9503934D0 (en) 1996-03-28
EP0707585A1 (en) 1996-04-24
KR960703852A (ko) 1996-08-31
FI943208L (fi) 1995-01-07
AU695301B2 (en) 1998-08-13
NO960056L (no) 1996-01-05
EG20513A (en) 1999-06-30
KR100228949B1 (ko) 1999-11-01
AU6805794A (en) 1995-02-06
JPH08507084A (ja) 1996-07-30
IL110175A (en) 2000-01-31
NZ266525A (en) 1997-10-24
IL110175A0 (en) 1994-10-07
CN1048015C (zh) 2000-01-05
CN1129940A (zh) 1996-08-28
CA2166721C (en) 1999-07-27
CZ3696A3 (en) 1997-06-11
FI943208A0 (fi) 1994-07-05
WO1995001980A1 (en) 1995-01-19
NO960056D0 (no) 1996-01-05

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