FI93356B - Förfarande för framställning av terapeutiskt användbara heterocykliska föreningar - Google Patents

Förfarande för framställning av terapeutiskt användbara heterocykliska föreningar Download PDF

Info

Publication number
FI93356B
FI93356B FI883064A FI883064A FI93356B FI 93356 B FI93356 B FI 93356B FI 883064 A FI883064 A FI 883064A FI 883064 A FI883064 A FI 883064A FI 93356 B FI93356 B FI 93356B
Authority
FI
Finland
Prior art keywords
mol
compound
methyl
mixture
het
Prior art date
Application number
FI883064A
Other languages
English (en)
Finnish (fi)
Other versions
FI93356C (sv
FI883064A (sv
FI883064A0 (sv
Inventor
Klaus Gundertofte Jensen
Klaus Peter Boegesoe
Henrik Pedersen
Ejner Knud Moltzen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of FI883064A0 publication Critical patent/FI883064A0/sv
Publication of FI883064A publication Critical patent/FI883064A/sv
Application granted granted Critical
Publication of FI93356B publication Critical patent/FI93356B/sv
Publication of FI93356C publication Critical patent/FI93356C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (2)

1. Förfarande för framställning av terapeutiskt an-vändbara föreningar med formeln I och stereoisomera former 5 och farmaceutiskt godtagbara syraadditionssalter av dessa ^X^het-R4 r2-T j 10 R1 väri den streckade Iinjen betecknar en eventuell bindning, het betecknar tetrazolyl, triazolyl, oxazolyl, tiazoyl, 15 oxazolinyl eller pyrazolyl, R1 betecknar väte eller lägre alkyl; R2 betecknar väte eller lägre alkyl; R4 betecknar väte, lägre alkyl, lägre alkenyl, lägre alky-nyl, lägre alkyltio eller lägre alkyloxi; 20 förutsatt att, R1 och R2 ej beteckna väte dä het betecknar pyrazolyl och den streckade Iinjen ej betecknar en bindning, kännetecknat därav, att a) man hydrolyserar eller hydrogenolyserar en fö-rening med formeln II 25 « t t · het-R4 R2-p T ^ N S I p R8 30 väri het, R2 och R4 är definierade ovan och R8 betecknar en * lätt avspjälkbar aminoskyddsgrupp, eller 46 93356 b) man reducerar en förening med formeln III het-R4 +,A Ry väri het, R2 och R4 är definierade ovan och R9 betecknar samma som R1, förutom väte, och A betecknar en bas svarande 10 mot en oorgaanisk syra, med ett reduktionsmedel, eller c) man behandlar en förening med formeln VI het-R4 r2-4 '' 15 CO-R10 väri het, R2 och R4 är definierade ovan och R10 betecknar väte, lägre alkyl eller lägre alkyloxi, med ett reduk-20 tionsmedel; eller d) man hydrogenerar katalytiskt en förening med formeln VII eller VIII . . 25 het-R4 het-R4 r40 *2-f T ^nAa- A1 il 30 väri het, R1, R2, R4 och A är definierade ovan, varefter . föreningen med formeln I isoleras som fri bas eller farma- "*‘ ceutiskt godtagbart syraadditionssalt, och om sä önskas isoleras de separata stereoisomererna. II 47 93356
2. Förening, kännetecknad därav, att den har formeln ^ het-R^ 5 «2-f T t C COORb väri R2, R4 och het är definierade i patentkrav 1, och R6 10 betecknar en förgrenad eller oförgrenad lägre alkyl. Ψ r • c » 1 · »-
FI883064A 1987-06-24 1988-06-23 Förfarande för framställning av terapeutiskt användbara heterocykliska föreningar FI93356C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878714789A GB8714789D0 (en) 1987-06-24 1987-06-24 Heterocyclic compounds
GB8714789 1987-06-24

Publications (4)

Publication Number Publication Date
FI883064A0 FI883064A0 (sv) 1988-06-23
FI883064A FI883064A (sv) 1988-12-25
FI93356B true FI93356B (sv) 1994-12-15
FI93356C FI93356C (sv) 1995-03-27

Family

ID=10619472

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883064A FI93356C (sv) 1987-06-24 1988-06-23 Förfarande för framställning av terapeutiskt användbara heterocykliska föreningar

Country Status (19)

Country Link
US (3) US4866077A (sv)
EP (1) EP0296721B1 (sv)
JP (1) JP2703268B2 (sv)
AU (1) AU615917B2 (sv)
BR (1) BR1100658A (sv)
CA (1) CA1340458C (sv)
DE (1) DE3881970T2 (sv)
DK (1) DK168600B1 (sv)
ES (1) ES2056928T3 (sv)
FI (1) FI93356C (sv)
GB (1) GB8714789D0 (sv)
HK (1) HK84194A (sv)
HU (1) HU210809A9 (sv)
IE (1) IE61694B1 (sv)
IL (1) IL86618A (sv)
NO (1) NO174051C (sv)
NZ (1) NZ224868A (sv)
PT (1) PT87820B (sv)
ZA (1) ZA884339B (sv)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307141B1 (en) * 1987-09-10 1993-01-13 MERCK SHARP & DOHME LTD. Oxazoles and thiazoles for the treatment of senile dementia
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
ES2055036T3 (es) * 1988-02-19 1994-08-16 Lilly Co Eli Antagonistas tetrazolicos de receptores de aminoacidos excitadores.
DK162892C (da) * 1988-07-04 1992-05-11 Novo Nordisk As 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse
IT1229491B (it) * 1988-12-28 1991-09-03 Roussel Maestretti S P A Ora R Derivati della 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro impiego come sostanze medicinali
JP3003148B2 (ja) * 1989-01-05 2000-01-24 藤沢薬品工業株式会社 チアゾール化合物、その製造法およびそれを含有する医薬組成物
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5264444A (en) * 1989-02-22 1993-11-23 Novo Nordisk A/S Piperidine compounds and use
US5260311A (en) * 1989-02-22 1993-11-09 Novo Nordisk A/S Piperidine compounds and their use
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
US5328925A (en) * 1989-02-22 1994-07-12 Novo Nordisk A/S Piperidine compounds and their use
EP0402056A3 (en) * 1989-06-06 1991-09-04 Beecham Group p.l.c. Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
EP0427390B1 (en) * 1989-10-07 1996-03-27 Beecham Group Plc Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them
US5200419A (en) * 1990-05-21 1993-04-06 Warner-Lambert Company Substituted tetrazoles and derivatives thereof acting at muscarinic receptors
IE911994A1 (en) * 1990-07-03 1992-01-15 Akzo Nv 5-isothiazolamine derivatives
USRE35822E (en) * 1990-08-21 1998-06-09 Novo Nordisk A/S Heterocyclic compounds
US5376668A (en) * 1990-08-21 1994-12-27 Novo Nordisk A/S Heterocyclic compounds
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
ES2113939T3 (es) * 1990-11-29 1998-05-16 Allergan Inc Uso de derivados de piridina en el tratamiento de la hipertension ocular.
JPH06510021A (ja) * 1991-03-13 1994-11-10 ザ リージェンツ オブ ザ ユニバーシティ オブ ミネソタ アルツハイマー病検出用の放射性薬剤
IE922270A1 (en) * 1991-07-26 1993-01-27 Akzo Nv Pyrazole derivatives
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
US5175166A (en) * 1991-08-27 1992-12-29 The University Of Toledo Muscarinic agonists
WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5330994A (en) * 1992-03-24 1994-07-19 Warner-Lambert Company Tetrahydropyridine isoxazoline derivatives
DE69325662T2 (de) * 1992-10-23 2000-02-10 Merck Sharp & Dohme Ltd., Hoddesdon Dopamin rezeptor subtyp liganden
US5753683A (en) * 1993-08-19 1998-05-19 Novo Nordisk A/S Antipsychotic method
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
US5668148A (en) * 1995-04-20 1997-09-16 Merck & Co., Inc. Alpha1a adrenergic receptor antagonists
AU6299296A (en) * 1995-06-29 1997-01-30 Novo Nordisk A/S Novel substituted azacyclic compounds
CA2234824A1 (en) * 1995-11-06 1997-05-15 Brian R. Pike Treatment of traumatic brain injury
WO1997040045A1 (en) * 1996-04-24 1997-10-30 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
US6297262B1 (en) 1997-05-29 2001-10-02 H. Lundbeck A/S Treatment of schizophrenia and psychosis
AR013096A1 (es) * 1997-07-01 2000-12-13 Lundbeck & Co As H Sal de adicion de acido maleico de 5-(2-etil-2-h-tetrazol-5-il)-1-metil- 1,2,3,6-tetrahidropiridina, composicion farmaceutica que la contiene, su usoen terapia y metodo de preparacion de la misma.
AU9432498A (en) * 1997-10-02 1999-04-27 H. Lundbeck A/S Granular preparations of 5-(2-ethyl- 2(h)-tetrazol- 5-yl)-1-methyl-1, 2,3,6-tetrahydropyridine
KR20010072064A (ko) * 1998-07-27 2001-07-31 피터 지. 스트링거 불안 장애 치료법
AU6686700A (en) * 1999-08-23 2001-03-19 H. Lundbeck A/S Treatment of urinary incontinence
JP2003530438A (ja) * 2000-04-12 2003-10-14 スミスクライン・ビーチャム・コーポレイション 化合物および方法
DK1373263T3 (da) * 2001-04-05 2005-03-07 Torrent Pharmaceuticals Ltd Heterocycliske forbindelser til aldringsrelaterede og diabetesbetingede vaskulære sygdomme
US20030069597A1 (en) * 2001-10-10 2003-04-10 Scimed Life Systems, Inc. Loading tool
AU2002360403A1 (en) * 2001-11-19 2003-06-10 Elan Pharmaceuticals, Inc. (4-phenyl) piperidin-3-yl-phenylcarboxylate derivatives and related compounds as beta-secretase inhibitors for the treatment of Alzheimer's disease
JP2006511621A (ja) 2002-12-18 2006-04-06 エフ　エム　シー　コーポレーション Ｎ―（置換アリールメチル）―４―（二置換メチル）ピペリジン及びピペラジン
EP1581497A4 (en) * 2002-12-20 2009-03-18 Merck & Co Inc INHIBITORS OF MITOTIC KINESINE
EP1720874A4 (en) * 2004-02-24 2010-03-03 Bioaxone Therapeutique Inc SUBSTITUTED PIPERIDINE DERIVATIVES IN POSITION 4
US20060224175A1 (en) * 2005-03-29 2006-10-05 Vrba Anthony C Methods and apparatuses for disposition of a medical device onto an elongate medical device
WO2007025177A2 (en) * 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2009002496A (es) 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US8084473B2 (en) 2007-04-24 2011-12-27 Solvay Pharmaceuticals B.V. Heterocyclic compounds with affinity to muscarinic receptors
RU2446166C2 (ru) * 2007-04-24 2012-03-27 Солвей Фармасьютикалс Б.В. Гетероциклические соединения, имеющие сродство к мускариновым рецепторам
WO2009140483A1 (en) 2008-05-15 2009-11-19 University Of Toledo Muscarinic agonists as cognitive enhancers
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
SG175422A1 (en) * 2009-05-07 2011-11-28 Torrent Pharmaceuticals Ltd Piperidine derivatives useful for treatment of diebetes
CN104086528A (zh) 2010-07-15 2014-10-08 拜耳知识产权有限责任公司 作为杀虫剂的新杂环化合物
JP5953308B2 (ja) 2010-10-22 2016-07-20 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 殺害虫剤としての新規ヘテロ環式化合物
US9549928B2 (en) 2011-04-29 2017-01-24 The University Of Toledo Muscarinic agonists as enhancers of cognitive flexibility
CN103848850B (zh) * 2013-08-28 2016-03-23 沈阳东瑞精细化工有限公司 一种舒巴坦的制备方法
US10857157B2 (en) 2015-01-26 2020-12-08 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US10106525B2 (en) 2015-01-26 2018-10-23 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
US10149856B2 (en) 2015-01-26 2018-12-11 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US11198680B2 (en) 2016-12-21 2021-12-14 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
WO2019014322A1 (en) 2017-07-11 2019-01-17 BioAxone BioSciences, Inc. KINASE INHIBITORS FOR THE TREATMENT OF DISEASES

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2659739A (en) 1950-04-14 1953-11-17 Eastman Kodak Co 1-hydroxy-4-beta-cyanopropylamino-anthraquinone and process for preparing same
BE845612A (fr) * 1976-03-23 1977-02-28 Derives de tetrazole-5-carboxamide et leur preparation
US4431653A (en) 1982-03-18 1984-02-14 Hoffmann-La Roche Inc. Penicillanic acid derivatives
DE3421072A1 (de) * 1984-06-06 1985-12-12 Heinrich Mack Nachf., 7918 Illertissen 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4650805A (en) * 1985-12-02 1987-03-17 Warner-Lambert Company 4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines having anti-psychotic activity
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
GB8610432D0 (en) * 1986-04-29 1986-06-04 Akzo Nv Amino-thiazole & oxazole derivatives
IL83275A (en) * 1986-09-08 1994-02-27 Novo Nordisk As Compounds 1,2, 4-Oxadiazolyl Pipridine Transformed, their preparation and pharmaceutical preparations containing them
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
EP0372125A1 (en) * 1988-11-08 1990-06-13 Akzo N.V. Oxazole and thiazole derivatives

Also Published As

Publication number Publication date
AU615917B2 (en) 1991-10-17
CA1340458C (en) 1999-03-23
GB8714789D0 (en) 1987-07-29
US4866077A (en) 1989-09-12
NO882799D0 (no) 1988-06-23
ZA884339B (en) 1989-05-30
PT87820A (pt) 1989-05-31
NO174051B (no) 1993-11-29
BR1100658A (pt) 1999-08-31
HK84194A (en) 1994-08-26
HU210809A9 (en) 1995-08-28
FI93356C (sv) 1995-03-27
IL86618A (en) 1992-07-15
IE61694B1 (en) 1994-11-16
ES2056928T3 (es) 1994-10-16
JP2703268B2 (ja) 1998-01-26
DK321688A (da) 1988-12-25
JPS6422869A (en) 1989-01-25
FI883064A (sv) 1988-12-25
US4925858A (en) 1990-05-15
IE881631L (en) 1988-12-24
EP0296721A2 (en) 1988-12-28
DK321688D0 (da) 1988-06-13
DK168600B1 (da) 1994-05-02
IL86618A0 (en) 1988-11-30
DE3881970D1 (de) 1993-07-29
FI883064A0 (sv) 1988-06-23
PT87820B (pt) 1992-10-30
AU1828288A (en) 1989-01-05
NO174051C (no) 1994-03-09
USRE36374E (en) 1999-11-02
DE3881970T2 (de) 1993-11-11
NZ224868A (en) 1990-07-26
NO882799L (no) 1988-12-27
EP0296721A3 (en) 1990-04-25
EP0296721B1 (en) 1993-06-23

Similar Documents

Publication Publication Date Title
FI93356B (sv) Förfarande för framställning av terapeutiskt användbara heterocykliska föreningar
CA2010578C (en) Piperidine compounds and their preparation and use
KR100755577B1 (ko) 타키키닌 수용체 길항제로서의 트리아졸 유도체
CA1341370C (en) Fused polycyclic compounds, methods of manufacture, and their use as paf antagonists, antihistamines and/or antiinflammatory agents
EP0544756B1 (en) 1,2,5,6-tetrahydro-1-methylpyridines, their preparation and use
EP2086983A2 (en) Fused ring compounds for inflammation and immune-related uses
EP0040639A1 (en) Isoxazole derivatives
JPH07291964A (ja) 新規ベンズイミダゾ−ルのピペリジン誘導体
HU194208B (en) Process for preparing piperidine derivatives and pharmaceuticals comprising these compounds
US20030212012A1 (en) Pharmaceutically active pyrrolidine derivatives
JPH06502146A (ja) チアゾリジンジオン誘導体
US4490527A (en) Benzo-fused heterocyclic anti-ulcer agents
US5194440A (en) Substituted cyclic sulphamide derivatives
HUT71132A (en) Bis-aryl-carbinol derivatives, pharmaceutical compositions containing them and process for producing
US5789425A (en) Imidazolidinone derivatives, their acid adducts and therapeutic drugs for senile dementia
DE69523595T2 (de) Aryl und heteroaryl alkoxynaphtalen derivate
WO1997010214A1 (fr) Nouveaux derives d'acide phenylacetique et compositions medicinales les contenant
JP3114996B2 (ja) ヘテロ環式化合物及びそれを有効成分とする強心剤
KR100399541B1 (ko) 3-알콕시카르보닐-티아디아지논유도체
FR2499991A1 (fr) Nouveaux 2,1,3-benzothiadiazoles et 2,1,3-benzoxadiazoles, leur preparation et leur application comme medicaments
US20020103235A1 (en) Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists
HU188328B (en) Process for preparing 3'-substituted-5'-/2-amino-4-pyridyl/-1',2',4'-triazole derivatives
ES2236672T3 (es) Derivados de imidazolina, su proceso de preparacion y composiciones farmaceuticas que los contienen.
JPH04308589A (ja) チアジアジノン誘導体
US6339083B1 (en) Multiheterocyclic pharmAceuticals

Legal Events

Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: H. LUNDBECK A/S