FI93356B - Förfarande för framställning av terapeutiskt användbara heterocykliska föreningar - Google Patents

Förfarande för framställning av terapeutiskt användbara heterocykliska föreningar Download PDF

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Publication number
FI93356B
FI93356B FI883064A FI883064A FI93356B FI 93356 B FI93356 B FI 93356B FI 883064 A FI883064 A FI 883064A FI 883064 A FI883064 A FI 883064A FI 93356 B FI93356 B FI 93356B
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FI
Finland
Prior art keywords
mol
compound
methyl
mixture
het
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Application number
FI883064A
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English (en)
Finnish (fi)
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FI883064A (sv
FI883064A0 (sv
FI93356C (sv
Inventor
Klaus Gundertofte Jensen
Klaus Peter Boegesoe
Henrik Pedersen
Ejner Knud Moltzen
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Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of FI883064A0 publication Critical patent/FI883064A0/sv
Publication of FI883064A publication Critical patent/FI883064A/sv
Publication of FI93356B publication Critical patent/FI93356B/sv
Application granted granted Critical
Publication of FI93356C publication Critical patent/FI93356C/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (2)

1. Förfarande för framställning av terapeutiskt an-vändbara föreningar med formeln I och stereoisomera former 5 och farmaceutiskt godtagbara syraadditionssalter av dessa ^X^het-R4 r2-T j 10 R1 väri den streckade Iinjen betecknar en eventuell bindning, het betecknar tetrazolyl, triazolyl, oxazolyl, tiazoyl, 15 oxazolinyl eller pyrazolyl, R1 betecknar väte eller lägre alkyl; R2 betecknar väte eller lägre alkyl; R4 betecknar väte, lägre alkyl, lägre alkenyl, lägre alky-nyl, lägre alkyltio eller lägre alkyloxi; 20 förutsatt att, R1 och R2 ej beteckna väte dä het betecknar pyrazolyl och den streckade Iinjen ej betecknar en bindning, kännetecknat därav, att a) man hydrolyserar eller hydrogenolyserar en fö-rening med formeln II 25 « t t · het-R4 R2-p T ^ N S I p R8 30 väri het, R2 och R4 är definierade ovan och R8 betecknar en * lätt avspjälkbar aminoskyddsgrupp, eller 46 93356 b) man reducerar en förening med formeln III het-R4 +,A Ry väri het, R2 och R4 är definierade ovan och R9 betecknar samma som R1, förutom väte, och A betecknar en bas svarande 10 mot en oorgaanisk syra, med ett reduktionsmedel, eller c) man behandlar en förening med formeln VI het-R4 r2-4 '' 15 CO-R10 väri het, R2 och R4 är definierade ovan och R10 betecknar väte, lägre alkyl eller lägre alkyloxi, med ett reduk-20 tionsmedel; eller d) man hydrogenerar katalytiskt en förening med formeln VII eller VIII . . 25 het-R4 het-R4 r40 *2-f T ^nAa- A1 il 30 väri het, R1, R2, R4 och A är definierade ovan, varefter . föreningen med formeln I isoleras som fri bas eller farma- "*‘ ceutiskt godtagbart syraadditionssalt, och om sä önskas isoleras de separata stereoisomererna. II 47 93356
2. Förening, kännetecknad därav, att den har formeln ^ het-R^ 5 «2-f T t C COORb väri R2, R4 och het är definierade i patentkrav 1, och R6 10 betecknar en förgrenad eller oförgrenad lägre alkyl. Ψ r • c » 1 · »-
FI883064A 1987-06-24 1988-06-23 Förfarande för framställning av terapeutiskt användbara heterocykliska föreningar FI93356C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8714789 1987-06-24
GB878714789A GB8714789D0 (en) 1987-06-24 1987-06-24 Heterocyclic compounds

Publications (4)

Publication Number Publication Date
FI883064A0 FI883064A0 (sv) 1988-06-23
FI883064A FI883064A (sv) 1988-12-25
FI93356B true FI93356B (sv) 1994-12-15
FI93356C FI93356C (sv) 1995-03-27

Family

ID=10619472

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883064A FI93356C (sv) 1987-06-24 1988-06-23 Förfarande för framställning av terapeutiskt användbara heterocykliska föreningar

Country Status (19)

Country Link
US (3) US4866077A (sv)
EP (1) EP0296721B1 (sv)
JP (1) JP2703268B2 (sv)
AU (1) AU615917B2 (sv)
BR (1) BR1100658A (sv)
CA (1) CA1340458C (sv)
DE (1) DE3881970T2 (sv)
DK (1) DK168600B1 (sv)
ES (1) ES2056928T3 (sv)
FI (1) FI93356C (sv)
GB (1) GB8714789D0 (sv)
HK (1) HK84194A (sv)
HU (1) HU210809A9 (sv)
IE (1) IE61694B1 (sv)
IL (1) IL86618A (sv)
NO (1) NO174051C (sv)
NZ (1) NZ224868A (sv)
PT (1) PT87820B (sv)
ZA (1) ZA884339B (sv)

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Also Published As

Publication number Publication date
PT87820B (pt) 1992-10-30
PT87820A (pt) 1989-05-31
ES2056928T3 (es) 1994-10-16
US4925858A (en) 1990-05-15
DE3881970T2 (de) 1993-11-11
IE61694B1 (en) 1994-11-16
IL86618A (en) 1992-07-15
NO882799D0 (no) 1988-06-23
DK168600B1 (da) 1994-05-02
DE3881970D1 (de) 1993-07-29
IL86618A0 (en) 1988-11-30
NO882799L (no) 1988-12-27
NO174051C (no) 1994-03-09
EP0296721B1 (en) 1993-06-23
US4866077A (en) 1989-09-12
AU615917B2 (en) 1991-10-17
CA1340458C (en) 1999-03-23
BR1100658A (pt) 1999-08-31
JPS6422869A (en) 1989-01-25
IE881631L (en) 1988-12-24
FI883064A (sv) 1988-12-25
NZ224868A (en) 1990-07-26
USRE36374E (en) 1999-11-02
DK321688D0 (da) 1988-06-13
EP0296721A2 (en) 1988-12-28
GB8714789D0 (en) 1987-07-29
JP2703268B2 (ja) 1998-01-26
FI883064A0 (sv) 1988-06-23
NO174051B (no) 1993-11-29
AU1828288A (en) 1989-01-05
EP0296721A3 (en) 1990-04-25
ZA884339B (en) 1989-05-30
DK321688A (da) 1988-12-25
HK84194A (en) 1994-08-26
FI93356C (sv) 1995-03-27
HU210809A9 (en) 1995-08-28

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