DK168600B1 - Piperidin-3-yl eller (1,2,5,6-tetrahydro-pyrid-3-yl)-substituerede heterocykliske forbindelser, farmaceutiske kompositioner deraf, og fremgangsmåder til deres fremstilling - Google Patents

Piperidin-3-yl eller (1,2,5,6-tetrahydro-pyrid-3-yl)-substituerede heterocykliske forbindelser, farmaceutiske kompositioner deraf, og fremgangsmåder til deres fremstilling Download PDF

Info

Publication number
DK168600B1
DK168600B1 DK321688A DK321688A DK168600B1 DK 168600 B1 DK168600 B1 DK 168600B1 DK 321688 A DK321688 A DK 321688A DK 321688 A DK321688 A DK 321688A DK 168600 B1 DK168600 B1 DK 168600B1
Authority
DK
Denmark
Prior art keywords
mol
methyl
compound
tetrahydro
pyridyl
Prior art date
Application number
DK321688A
Other languages
Danish (da)
English (en)
Other versions
DK321688D0 (da
DK321688A (da
Inventor
Ges Klaus Peter B
Klaus Gundertofte Jensen
Ejner Knud Moltzen
Henrik Pedersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of DK321688D0 publication Critical patent/DK321688D0/da
Publication of DK321688A publication Critical patent/DK321688A/da
Application granted granted Critical
Publication of DK168600B1 publication Critical patent/DK168600B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK321688A 1987-06-24 1988-06-13 Piperidin-3-yl eller (1,2,5,6-tetrahydro-pyrid-3-yl)-substituerede heterocykliske forbindelser, farmaceutiske kompositioner deraf, og fremgangsmåder til deres fremstilling DK168600B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8714789 1987-06-24
GB878714789A GB8714789D0 (en) 1987-06-24 1987-06-24 Heterocyclic compounds

Publications (3)

Publication Number Publication Date
DK321688D0 DK321688D0 (da) 1988-06-13
DK321688A DK321688A (da) 1988-12-25
DK168600B1 true DK168600B1 (da) 1994-05-02

Family

ID=10619472

Family Applications (1)

Application Number Title Priority Date Filing Date
DK321688A DK168600B1 (da) 1987-06-24 1988-06-13 Piperidin-3-yl eller (1,2,5,6-tetrahydro-pyrid-3-yl)-substituerede heterocykliske forbindelser, farmaceutiske kompositioner deraf, og fremgangsmåder til deres fremstilling

Country Status (19)

Country Link
US (3) US4866077A (sv)
EP (1) EP0296721B1 (sv)
JP (1) JP2703268B2 (sv)
AU (1) AU615917B2 (sv)
BR (1) BR1100658A (sv)
CA (1) CA1340458C (sv)
DE (1) DE3881970T2 (sv)
DK (1) DK168600B1 (sv)
ES (1) ES2056928T3 (sv)
FI (1) FI93356C (sv)
GB (1) GB8714789D0 (sv)
HK (1) HK84194A (sv)
HU (1) HU210809A9 (sv)
IE (1) IE61694B1 (sv)
IL (1) IL86618A (sv)
NO (1) NO174051C (sv)
NZ (1) NZ224868A (sv)
PT (1) PT87820B (sv)
ZA (1) ZA884339B (sv)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2053748T3 (es) * 1987-09-10 1994-08-01 Merck Sharp & Dohme Oxazoles y tiazoles para el tratamiento de la demencia senil.
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
ZA891113B (en) * 1988-02-19 1990-10-31 Lilly Co Eli Tetrazole excitatory amino acid receptor antagonists
DK162892C (da) * 1988-07-04 1992-05-11 Novo Nordisk As 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse
IT1229491B (it) * 1988-12-28 1991-09-03 Roussel Maestretti S P A Ora R Derivati della 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro impiego come sostanze medicinali
JP3003148B2 (ja) * 1989-01-05 2000-01-24 藤沢薬品工業株式会社 チアゾール化合物、その製造法およびそれを含有する医薬組成物
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5260311A (en) * 1989-02-22 1993-11-09 Novo Nordisk A/S Piperidine compounds and their use
US5264444A (en) * 1989-02-22 1993-11-23 Novo Nordisk A/S Piperidine compounds and use
US5328925A (en) * 1989-02-22 1994-07-12 Novo Nordisk A/S Piperidine compounds and their use
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
EP0402056A3 (en) * 1989-06-06 1991-09-04 Beecham Group p.l.c. Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
EP0427390B1 (en) * 1989-10-07 1996-03-27 Beecham Group Plc Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them
US5200419A (en) * 1990-05-21 1993-04-06 Warner-Lambert Company Substituted tetrazoles and derivatives thereof acting at muscarinic receptors
IE911994A1 (en) * 1990-07-03 1992-01-15 Akzo Nv 5-isothiazolamine derivatives
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
USRE35822E (en) * 1990-08-21 1998-06-09 Novo Nordisk A/S Heterocyclic compounds
US5376668A (en) * 1990-08-21 1994-12-27 Novo Nordisk A/S Heterocyclic compounds
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
ES2113939T3 (es) * 1990-11-29 1998-05-16 Allergan Inc Uso de derivados de piridina en el tratamiento de la hipertension ocular.
WO1992016239A1 (en) * 1991-03-13 1992-10-01 The Regents Of The University Of Minnesota Radiopharmaceutical agents for the detection of alzheimer's disease
IE922270A1 (en) * 1991-07-26 1993-01-27 Akzo Nv Pyrazole derivatives
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
US5175166A (en) * 1991-08-27 1992-12-29 The University Of Toledo Muscarinic agonists
WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5330994A (en) * 1992-03-24 1994-07-19 Warner-Lambert Company Tetrahydropyridine isoxazoline derivatives
AU678186B2 (en) * 1992-10-23 1997-05-22 Merck Sharp & Dohme Limited Dopamine receptor subtype ligands
US5753683A (en) * 1993-08-19 1998-05-19 Novo Nordisk A/S Antipsychotic method
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
US5668148A (en) * 1995-04-20 1997-09-16 Merck & Co., Inc. Alpha1a adrenergic receptor antagonists
AU6299296A (en) * 1995-06-29 1997-01-30 Novo Nordisk A/S Novel substituted azacyclic compounds
JPH11514654A (ja) * 1995-11-06 1999-12-14 ハー・ルンドベック・アクチェゼルスカベット 外傷による脳損傷の治療方法
WO1997040045A1 (en) * 1996-04-24 1997-10-30 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
ES2227836T3 (es) * 1997-05-29 2005-04-01 H. Lundbeck A/S Tratamiento de esquizofrenia y psicosis.
AR013096A1 (es) * 1997-07-01 2000-12-13 Lundbeck & Co As H Sal de adicion de acido maleico de 5-(2-etil-2-h-tetrazol-5-il)-1-metil- 1,2,3,6-tetrahidropiridina, composicion farmaceutica que la contiene, su usoen terapia y metodo de preparacion de la misma.
AU9432498A (en) * 1997-10-02 1999-04-27 H. Lundbeck A/S Granular preparations of 5-(2-ethyl- 2(h)-tetrazol- 5-yl)-1-methyl-1, 2,3,6-tetrahydropyridine
HUP0102886A3 (en) * 1998-07-27 2002-12-28 Lilly Co Eli Treatment of anxiety disorders
CO5440228A1 (es) * 1999-08-23 2004-09-30 Lunbeck As H Tratamiento de la incontinencia urinaria
AU2001253418A1 (en) * 2000-04-12 2001-10-30 Smith Kline Beecham Corporation Compounds and methods
DK1373263T3 (da) * 2001-04-05 2005-03-07 Torrent Pharmaceuticals Ltd Heterocycliske forbindelser til aldringsrelaterede og diabetesbetingede vaskulære sygdomme
US20030069597A1 (en) * 2001-10-10 2003-04-10 Scimed Life Systems, Inc. Loading tool
AP2004003052A0 (en) * 2001-11-19 2004-06-30 Elan Pharm Inc 3,4-Disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines and piperazines.
AU2003296373A1 (en) 2002-12-18 2004-07-29 Bayer Cropscience Ag N-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and piperazines
US7622468B2 (en) * 2002-12-20 2009-11-24 Merck & Co. Inc. Mitotic kinesin inhibitors
CN1980929A (zh) * 2004-02-24 2007-06-13 比奥阿克松医疗技术股份有限公司 4-取代哌啶衍生物
US20060224175A1 (en) * 2005-03-29 2006-10-05 Vrba Anthony C Methods and apparatuses for disposition of a medical device onto an elongate medical device
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
US7678363B2 (en) * 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス,インコーポレイティド 4−アシルアミノピリジン誘導体を含む組み合わせ
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US8084473B2 (en) 2007-04-24 2011-12-27 Solvay Pharmaceuticals B.V. Heterocyclic compounds with affinity to muscarinic receptors
JP2010525020A (ja) * 2007-04-24 2010-07-22 ソルベイ・フアーマシユーチカルズ・ベー・ブイ ムスカリン性受容体への親和性を有する複素環式化合物
EP2296471A4 (en) 2008-05-15 2012-03-14 Univ Toledo MUSCARIC ACID AGONISTS AS COGNITIVE ENHANCERS
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
AU2010245596A1 (en) * 2009-05-07 2011-12-22 Torrent Pharmaceuticals Limited Piperidine derivatives useful for treatment of diebetes
CN103140483B (zh) 2010-07-15 2015-06-24 拜耳知识产权有限责任公司 作为杀虫剂的新杂环化合物
WO2012052412A1 (de) 2010-10-22 2012-04-26 Bayer Cropscience Ag Neue heterocylische verbindungen als schädlingsbekämpfungsmittel
US9549928B2 (en) 2011-04-29 2017-01-24 The University Of Toledo Muscarinic agonists as enhancers of cognitive flexibility
CN103848850B (zh) * 2013-08-28 2016-03-23 沈阳东瑞精细化工有限公司 一种舒巴坦的制备方法
US10857157B2 (en) 2015-01-26 2020-12-08 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US10106525B2 (en) 2015-01-26 2018-10-23 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
US10149856B2 (en) 2015-01-26 2018-12-11 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US11198680B2 (en) 2016-12-21 2021-12-14 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
WO2019014322A1 (en) 2017-07-11 2019-01-17 BioAxone BioSciences, Inc. KINASE INHIBITORS FOR THE TREATMENT OF DISEASES

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2659739A (en) 1950-04-14 1953-11-17 Eastman Kodak Co 1-hydroxy-4-beta-cyanopropylamino-anthraquinone and process for preparing same
BE845612A (fr) * 1976-03-23 1977-02-28 Derives de tetrazole-5-carboxamide et leur preparation
US4431653A (en) 1982-03-18 1984-02-14 Hoffmann-La Roche Inc. Penicillanic acid derivatives
DE3421072A1 (de) * 1984-06-06 1985-12-12 Heinrich Mack Nachf., 7918 Illertissen 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4650805A (en) * 1985-12-02 1987-03-17 Warner-Lambert Company 4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines having anti-psychotic activity
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
GB8610432D0 (en) * 1986-04-29 1986-06-04 Akzo Nv Amino-thiazole & oxazole derivatives
IL83275A (en) * 1986-09-08 1994-02-27 Novo Nordisk As Compounds 1,2, 4-Oxadiazolyl Pipridine Transformed, their preparation and pharmaceutical preparations containing them
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
EP0372125A1 (en) * 1988-11-08 1990-06-13 Akzo N.V. Oxazole and thiazole derivatives

Also Published As

Publication number Publication date
PT87820B (pt) 1992-10-30
PT87820A (pt) 1989-05-31
ES2056928T3 (es) 1994-10-16
US4925858A (en) 1990-05-15
DE3881970T2 (de) 1993-11-11
IE61694B1 (en) 1994-11-16
IL86618A (en) 1992-07-15
NO882799D0 (no) 1988-06-23
DE3881970D1 (de) 1993-07-29
IL86618A0 (en) 1988-11-30
NO882799L (no) 1988-12-27
NO174051C (no) 1994-03-09
EP0296721B1 (en) 1993-06-23
US4866077A (en) 1989-09-12
AU615917B2 (en) 1991-10-17
CA1340458C (en) 1999-03-23
BR1100658A (pt) 1999-08-31
JPS6422869A (en) 1989-01-25
IE881631L (en) 1988-12-24
FI883064A (sv) 1988-12-25
NZ224868A (en) 1990-07-26
USRE36374E (en) 1999-11-02
DK321688D0 (da) 1988-06-13
EP0296721A2 (en) 1988-12-28
FI93356B (sv) 1994-12-15
GB8714789D0 (en) 1987-07-29
JP2703268B2 (ja) 1998-01-26
FI883064A0 (sv) 1988-06-23
NO174051B (no) 1993-11-29
AU1828288A (en) 1989-01-05
EP0296721A3 (en) 1990-04-25
ZA884339B (en) 1989-05-30
DK321688A (da) 1988-12-25
HK84194A (en) 1994-08-26
FI93356C (sv) 1995-03-27
HU210809A9 (en) 1995-08-28

Similar Documents

Publication Publication Date Title
DK168600B1 (da) Piperidin-3-yl eller (1,2,5,6-tetrahydro-pyrid-3-yl)-substituerede heterocykliske forbindelser, farmaceutiske kompositioner deraf, og fremgangsmåder til deres fremstilling
CA2010578C (en) Piperidine compounds and their preparation and use
JP6116245B2 (ja) 神経変性疾患治療における使用のためのインドールアミン誘導体および関連化合物
AU2003230829B2 (en) Triazole derivatives as tachykinin receptor antagonists
US5496833A (en) Piperidine tachykinin receptor antagonists
CA2218391A1 (en) Alpha 1a adrenergic receptor antagonists
AU2006283884B2 (en) (Indol-3-yl)-heterocycle derivatives as agonists of the cannabinoid CB1 receptor
JPH11508540A (ja) 新規の置換アザ環式またはアザ二環式化合物
JP6130383B2 (ja) ピリジン誘導体
US5194440A (en) Substituted cyclic sulphamide derivatives
KR920008819B1 (ko) 옥사디아졸릴-1,4-디히드로피리딘 유도체 및 그의 산부가염의 제조방법
KR20210130757A (ko) 파르네소이드 x 수용체 조정제로서의 치환된 비시클릭 화합물
NO177145B (no) Analogifremgangsmåte for fremstilling av 4,5,6,7-tetrahydroisotiazolo[4,5-cÅ-pyridinderivater og isomere
JP2000504700A (ja) 5―ht1aレセプターリガンドとしての複素環式エルゴリン誘導体
JPH08504801A (ja) スクアレンシンターゼ阻害剤としてのキヌクリジン誘導体
IL291418B2 (en) Substances that function as modulators of cMYC-mRNA translation and their uses for cancer treatment
NO880167L (no) Fremgangsmaate for fremstilling av benzotiazindioksyd-derivater.
JPH11508539A (ja) 新規の置換アザ環式化合物

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired