FI93013B - Förfarande för framställning av terapeutiskt användbara pyridopyrazinonderivat - Google Patents
Förfarande för framställning av terapeutiskt användbara pyridopyrazinonderivat Download PDFInfo
- Publication number
- FI93013B FI93013B FI902335A FI902335A FI93013B FI 93013 B FI93013 B FI 93013B FI 902335 A FI902335 A FI 902335A FI 902335 A FI902335 A FI 902335A FI 93013 B FI93013 B FI 93013B
- Authority
- FI
- Finland
- Prior art keywords
- pyrido
- oxo
- acid
- pyridazin
- ylmethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Claims (2)
1. Förfarande för framställning av ett terapeutiskt användbart pyridopyridazinonättiksyraderivat med formeln 5 ^COOH ^COOH ch2 ch2 M \ eller Γ jj | I II eller dess C^-alkylesterderivat eller för framställning av ett bassalt av nämnda syra med en farmakologiskt godtagbar 15 katjon, väri z är fenyl, bensotiofenyl, bensoxazolyl, ben-sotiazolyl eller fenyloxadiazolyl, varvid fenyl-, bensotiofenyl-, bensoxazolyl-, bensotiazolyl- och fenyloxadi-azolylgrupperna var och en valbart är substituerad i ben-senringen med en eller tvä substituenter, varvid substi-20 tuenterna är valda är gruppen fluor, klor, brom och tri-fluormetyl, kännetecknat därav, att motsvaran-de substituerade pyridopyridazinonättiksyra-C^-alkyles-ter med formeln 25 yCOOR' COOR' s / / 9h2 ch2 eller
30. S m IV väri R' är Cj_6-alkyl, bringas att reagera med motsvarande aralkyl- eller heteroaralkylhalogenid med formeln HalCH2Z, 35 väri Z betecknar samma som ovan i strukturformlerna I och II och Hai är klor, brom eller jod, i närvaro av ett ba- li 93013 23 siskt kondensationsmedel till en C^-alkyl-S-oxo-öH-pyrido-[2,3-d]pyridazin-8-ylättiksyraester eller en C^-alkyl-e-oxo-7H-pyrido[2,3-d]pyridazin-5-ylättiksyraester varefter nämnda ester hydrolyseras tili motsvarande fria syraföre-5 ning med strukturformeln I eller II och om s& önskas om-vandlas nämnda syra tili ett C^g-alkylesterderivat eller tili ett bassalt av nämnda syra med en farmakologiskt god-tagbar katjon.
2. Förfarande enligt patentkrav 1, k ä n n e -10 tecknat därav, att man framställer 6-(5-fluorbenso-tiazol-2-ylmetyl)-5-oxo-6H-pyrido[2,3-d]pyridazin-8-ylät-tiksyra. ! *
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35041789 | 1989-05-11 | ||
| US07/350,417 US4996204A (en) | 1989-05-11 | 1989-05-11 | Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI902335A0 FI902335A0 (sv) | 1990-05-10 |
| FI93013B true FI93013B (sv) | 1994-10-31 |
| FI93013C FI93013C (sv) | 1995-02-10 |
Family
ID=23376622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI902335A FI93013C (sv) | 1989-05-11 | 1990-05-10 | Förfarande för framställning av terapeutiskt användbara pyridopyrazinonderivat |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4996204A (sv) |
| EP (1) | EP0401981B1 (sv) |
| JP (1) | JPH0631235B2 (sv) |
| KR (1) | KR920003559B1 (sv) |
| AT (1) | ATE121743T1 (sv) |
| AU (1) | AU611610B2 (sv) |
| CA (1) | CA2016326C (sv) |
| DE (1) | DE69018876T2 (sv) |
| DK (1) | DK0401981T3 (sv) |
| ES (1) | ES2071016T3 (sv) |
| FI (1) | FI93013C (sv) |
| HU (1) | HU206714B (sv) |
| IE (1) | IE66029B1 (sv) |
| IL (1) | IL94302A (sv) |
| NO (1) | NO173938C (sv) |
| NZ (1) | NZ233599A (sv) |
| PT (1) | PT93984B (sv) |
| ZA (1) | ZA903564B (sv) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4954629A (en) * | 1989-05-11 | 1990-09-04 | Pfizer Inc. | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof |
| US5716954A (en) * | 1991-10-09 | 1998-02-10 | Syntex U.S.A. Inc. | Benzopyridazinone and pyridopyridazinone compounds |
| KR950703539A (ko) * | 1992-09-28 | 1995-09-20 | 알렌 제이. 스피겔 | 당뇨병 합병증 치료용 치환된 피리미딘(substituted pyrimidines for control or diabetic complications) |
| GB9314412D0 (en) * | 1993-07-13 | 1993-08-25 | Rhone Poulenc Agriculture | New compositions of matter |
| MXPA02003122A (es) | 1998-03-31 | 2004-04-21 | Inst For Pharm Discovery Inc | Acidos indolalcanoicos substituidos. |
| TNSN99224A1 (fr) | 1998-12-01 | 2005-11-10 | Inst For Pharm Discovery Inc | Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique |
| PL365378A1 (en) * | 2000-11-30 | 2005-01-10 | Pfizer Products Inc. | Combination of gaba agonists and aldose reductase inhibitors |
| DE60204611T2 (de) | 2001-02-28 | 2006-05-11 | Pfizer Products Inc., Groton | Sulfonyl-pyridazinon-derivate zur Verwendung als Aldose-reduktase-inhibitoren |
| AU2002226634B2 (en) | 2001-03-30 | 2007-01-25 | Pfizer Products Inc. | Pyridazinone aldose reductase inhibitors |
| AU2002236131B2 (en) * | 2001-04-30 | 2005-04-14 | Pfizer Products Inc. | Combinations of aldose reductase inhibitors and cyclooxygenase-2 inhibitors |
| AU761191B2 (en) | 2001-05-24 | 2003-05-29 | Pfizer Products Inc. | Therapies for tissue damage resulting from ischemia |
| US7572910B2 (en) * | 2003-02-20 | 2009-08-11 | Pfizer, Inc. | Pyridazinone aldose reductase inhibitors |
| PT3597650T (pt) * | 2010-07-16 | 2022-12-16 | Univ Columbia | Inibidores da aldose redutase e utilizações dos mesmos |
| US8916563B2 (en) | 2010-07-16 | 2014-12-23 | The Trustees Of Columbia University In The City Of New York | Aldose reductase inhibitors and uses thereof |
| IL283809B2 (en) | 2016-06-21 | 2024-01-01 | Univ Columbia | Compounds for use in a method for treating neuropathy, retinopathy, nephropathy or cardiomyopathy |
| AU2018307964B2 (en) | 2017-07-28 | 2023-11-16 | Applied Therapeutics Inc. | Compositions and methods for treating galactosemia |
| JP2022531466A (ja) | 2019-05-07 | 2022-07-06 | ユニバーシティ オブ マイアミ | 遺伝性ニューロパチーおよび関連障害の処置および検出 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3821383A (en) * | 1972-07-10 | 1974-06-28 | Ayerst Mckenna & Harrison | Compositions for and a method of treating diabetic complications |
| DE2708187A1 (de) * | 1977-02-25 | 1978-08-31 | Thomae Gmbh Dr K | Neue pyrido-pyridazin-one |
| IE47592B1 (en) * | 1977-12-29 | 1984-05-02 | Ici Ltd | Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture |
| US4209527A (en) * | 1979-05-16 | 1980-06-24 | Pfizer Inc. | Benzimidazolone derivatives |
| CA1160518A (en) * | 1979-07-06 | 1984-01-17 | E. I. Du Pont De Nemours And Company | Coated cookware with fep topcoat |
| IL80475A (en) * | 1985-11-07 | 1993-01-31 | Pfizer | Heterocyclic-substituted 4-oxo (or thio)-3h- phthalazinyl-acetic acid derivatives and pharmaceutical compositions containing them |
| US4954629A (en) * | 1989-05-11 | 1990-09-04 | Pfizer Inc. | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof |
-
1989
- 1989-05-11 US US07/350,417 patent/US4996204A/en not_active Expired - Lifetime
-
1990
- 1990-05-06 IL IL9430290A patent/IL94302A/en not_active IP Right Cessation
- 1990-05-08 NZ NZ233599A patent/NZ233599A/en unknown
- 1990-05-09 CA CA002016326A patent/CA2016326C/en not_active Expired - Fee Related
- 1990-05-09 PT PT93984A patent/PT93984B/pt not_active IP Right Cessation
- 1990-05-10 AU AU54905/90A patent/AU611610B2/en not_active Ceased
- 1990-05-10 DE DE69018876T patent/DE69018876T2/de not_active Expired - Fee Related
- 1990-05-10 ZA ZA903564A patent/ZA903564B/xx unknown
- 1990-05-10 EP EP90305015A patent/EP0401981B1/en not_active Expired - Lifetime
- 1990-05-10 KR KR1019900006808A patent/KR920003559B1/ko not_active IP Right Cessation
- 1990-05-10 NO NO902070A patent/NO173938C/no unknown
- 1990-05-10 AT AT90305015T patent/ATE121743T1/de not_active IP Right Cessation
- 1990-05-10 HU HU902996A patent/HU206714B/hu not_active IP Right Cessation
- 1990-05-10 DK DK90305015.1T patent/DK0401981T3/da active
- 1990-05-10 ES ES90305015T patent/ES2071016T3/es not_active Expired - Lifetime
- 1990-05-10 FI FI902335A patent/FI93013C/sv not_active IP Right Cessation
- 1990-05-11 IE IE170190A patent/IE66029B1/en unknown
- 1990-05-11 JP JP2122832A patent/JPH0631235B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL94302A (en) | 1994-01-25 |
| FI93013C (sv) | 1995-02-10 |
| EP0401981B1 (en) | 1995-04-26 |
| DK0401981T3 (da) | 1995-09-04 |
| HUT54683A (en) | 1991-03-28 |
| JPH0631235B2 (ja) | 1994-04-27 |
| US4996204A (en) | 1991-02-26 |
| EP0401981A1 (en) | 1990-12-12 |
| KR920003559B1 (ko) | 1992-05-04 |
| NO902070D0 (no) | 1990-05-10 |
| HU206714B (en) | 1992-12-28 |
| ES2071016T3 (es) | 1995-06-16 |
| DE69018876T2 (de) | 1995-08-24 |
| KR900018092A (ko) | 1990-12-20 |
| AU5490590A (en) | 1990-11-15 |
| DE69018876D1 (de) | 1995-06-01 |
| NO173938B (no) | 1993-11-15 |
| ATE121743T1 (de) | 1995-05-15 |
| JPH035481A (ja) | 1991-01-11 |
| PT93984A (pt) | 1991-01-08 |
| ZA903564B (en) | 1992-08-26 |
| IE66029B1 (en) | 1995-11-29 |
| HU902996D0 (en) | 1990-09-28 |
| FI902335A0 (sv) | 1990-05-10 |
| IL94302A0 (en) | 1991-03-10 |
| CA2016326C (en) | 1995-05-30 |
| IE901701L (en) | 1990-11-11 |
| NO902070L (no) | 1990-11-12 |
| NZ233599A (en) | 1991-07-26 |
| NO173938C (no) | 1994-02-23 |
| CA2016326A1 (en) | 1990-11-11 |
| AU611610B2 (en) | 1991-06-13 |
| PT93984B (pt) | 1996-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Owner name: PFIZER INC. |
|
| BB | Publication of examined application | ||
| MM | Patent lapsed |
Owner name: PFIZER INC. |