FI91861C - Menetelmä 2-/2-/4-/(4-kloorifenyyli)fenyylimetyyli/-1-piperatsinyyli/etoksi/-etikkahapon ja sen dihydrokloridin valmistamiseksi - Google Patents

Menetelmä 2-/2-/4-/(4-kloorifenyyli)fenyylimetyyli/-1-piperatsinyyli/etoksi/-etikkahapon ja sen dihydrokloridin valmistamiseksi Download PDF

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Publication number
FI91861C
FI91861C FI895563A FI895563A FI91861C FI 91861 C FI91861 C FI 91861C FI 895563 A FI895563 A FI 895563A FI 895563 A FI895563 A FI 895563A FI 91861 C FI91861 C FI 91861C
Authority
FI
Finland
Prior art keywords
chlorophenyl
phenylmethyl
dihydrochloride
piperazinyl
alkali metal
Prior art date
Application number
FI895563A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI91861B (fi
FI895563A0 (fi
Inventor
Jean Gobert
Guy Bodson
Eric Cossement
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of FI895563A0 publication Critical patent/FI895563A0/fi
Application granted granted Critical
Publication of FI91861B publication Critical patent/FI91861B/fi
Publication of FI91861C publication Critical patent/FI91861C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI895563A 1988-11-23 1989-11-22 Menetelmä 2-/2-/4-/(4-kloorifenyyli)fenyylimetyyli/-1-piperatsinyyli/etoksi/-etikkahapon ja sen dihydrokloridin valmistamiseksi FI91861C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8827390 1988-11-23
GB888827390A GB8827390D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Publications (3)

Publication Number Publication Date
FI895563A0 FI895563A0 (fi) 1989-11-22
FI91861B FI91861B (fi) 1994-05-13
FI91861C true FI91861C (fi) 1994-08-25

Family

ID=10647346

Family Applications (1)

Application Number Title Priority Date Filing Date
FI895563A FI91861C (fi) 1988-11-23 1989-11-22 Menetelmä 2-/2-/4-/(4-kloorifenyyli)fenyylimetyyli/-1-piperatsinyyli/etoksi/-etikkahapon ja sen dihydrokloridin valmistamiseksi

Country Status (17)

Country Link
KR (1) KR970009727B1 (ko)
AT (1) AT398970B (ko)
CA (1) CA1320732C (ko)
CY (1) CY1696A (ko)
DK (1) DK174289B1 (ko)
ES (1) ES2018967A6 (ko)
FI (1) FI91861C (ko)
GB (2) GB8827390D0 (ko)
GR (1) GR1000576B (ko)
HK (1) HK45493A (ko)
HU (1) HU208002B (ko)
NO (1) NO172287C (ko)
PH (1) PH26334A (ko)
PL (1) PL161374B1 (ko)
PT (1) PT92363B (ko)
RU (1) RU1838306C (ko)
SG (1) SG12793G (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE177636T1 (de) * 1992-09-24 1999-04-15 Sepracor Inc Transdermale behandlung der nesselsucht mit optisch reinem (+)-cetirizin
DE69320975T2 (de) * 1992-09-24 1999-05-12 Sepracor,Inc., Marlborough, Ma. Verwendung von (-) Cetirizin zur Behandlung allergischer Rhinitis und und Asthma
BE1010094A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
CA2180993A1 (en) * 1996-07-11 1998-01-12 Yong Tao Methods for the manufacture of cetirizine
EP0919550A1 (en) 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
DK176706B1 (da) * 1999-03-04 2009-03-30 Sandoz As Fremgangsmåde til fremstilling af 2-{2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy}-eddikesyre-forbindelser eller salte deraf
US6265579B1 (en) * 1999-10-29 2001-07-24 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
WO2003104211A2 (en) * 2002-06-05 2003-12-18 Dr. Reddy's Laboratories Limited Crystalline [2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl] ethoxy] acetic acid dihydrochloride
CA2514145A1 (en) * 2003-01-23 2004-08-05 Ucb Farchim Sa Piperazine derivatives and their use as synthesis intermediates
US20060258684A1 (en) * 2003-05-21 2006-11-16 Singh Prasad S 2-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl]ethoxy]acetic acid monohydrochloride as anti-allergenic compound and process for its production
WO2010046908A2 (en) 2008-09-17 2010-04-29 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB817231A (en) * 1956-01-27 1959-07-29 Henri Morren New derivatives of n-mono-benzhydryl-piperazine and process for the preparation thereof
US3090725A (en) * 1960-02-29 1963-05-21 Burroughs Wellcome Co Phosphorylated quaternary ammonium compounds of improved oral absorption
DK154078C (da) * 1981-02-06 1989-05-22 Ucb Sa Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf

Also Published As

Publication number Publication date
GB8827390D0 (en) 1988-12-29
HU208002B (en) 1993-07-28
GR1000576B (el) 1992-08-26
GB2225320A (en) 1990-05-30
NO894650D0 (no) 1989-11-22
ES2018967A6 (es) 1991-05-16
GB2225320B (en) 1992-09-02
RU1838306C (ru) 1993-08-30
DK586589D0 (da) 1989-11-22
PT92363A (pt) 1990-05-31
KR970009727B1 (ko) 1997-06-17
KR900007824A (ko) 1990-06-02
SG12793G (en) 1993-04-16
HK45493A (en) 1993-05-21
GB8926242D0 (en) 1990-01-10
AT398970B (de) 1995-02-27
FI91861B (fi) 1994-05-13
HUT53626A (en) 1990-11-28
CY1696A (en) 1994-01-14
GR890100771A (en) 1990-12-31
PL161374B1 (pl) 1993-06-30
DK174289B1 (da) 2002-11-18
PH26334A (en) 1992-04-29
ATA266489A (de) 1994-07-15
HU896130D0 (en) 1990-02-28
NO172287B (no) 1993-03-22
PT92363B (pt) 1995-07-18
NO172287C (no) 1993-06-30
FI895563A0 (fi) 1989-11-22
NO894650L (no) 1990-05-25
CA1320732C (en) 1993-07-27
DK586589A (da) 1990-05-24

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Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: UCB S.A.

MA Patent expired