FI891361A0 - Menetelmä farmaseuttisesti vaikuttavien aryylihydratsonien valmistamiseksi - Google Patents

Menetelmä farmaseuttisesti vaikuttavien aryylihydratsonien valmistamiseksi

Info

Publication number
FI891361A0
FI891361A0 FI891361A FI891361A FI891361A0 FI 891361 A0 FI891361 A0 FI 891361A0 FI 891361 A FI891361 A FI 891361A FI 891361 A FI891361 A FI 891361A FI 891361 A0 FI891361 A0 FI 891361A0
Authority
FI
Finland
Prior art keywords
arylhydrazones
preparation
pharmaceutically active
compounds
prepared
Prior art date
Application number
FI891361A
Other languages
English (en)
Swedish (sv)
Other versions
FI91397B (fi
FI891361A (fi
FI91397C (fi
Inventor
Jaroslav Stanek
Giorgio Caravatti
Joerg Frei
Hans-Georg Capraro
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI891361A0 publication Critical patent/FI891361A0/fi
Publication of FI891361A publication Critical patent/FI891361A/fi
Publication of FI91397B publication Critical patent/FI91397B/fi
Application granted granted Critical
Publication of FI91397C publication Critical patent/FI91397C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C337/00Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C337/06Compounds containing any of the groups, e.g. thiosemicarbazides
    • C07C337/08Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Centrifugal Separators (AREA)
  • Steroid Compounds (AREA)
  • Luminescent Compositions (AREA)
FI891361A 1988-03-25 1989-03-22 Menetelmä farmaseuttisesti vaikuttavien aryylihydratsonien valmistamiseksi FI91397C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH113988 1988-03-25
CH113988 1988-03-25

Publications (4)

Publication Number Publication Date
FI891361A0 true FI891361A0 (fi) 1989-03-22
FI891361A FI891361A (fi) 1989-09-26
FI91397B FI91397B (fi) 1994-03-15
FI91397C FI91397C (fi) 1994-06-27

Family

ID=4203401

Family Applications (1)

Application Number Title Priority Date Filing Date
FI891361A FI91397C (fi) 1988-03-25 1989-03-22 Menetelmä farmaseuttisesti vaikuttavien aryylihydratsonien valmistamiseksi

Country Status (23)

Country Link
US (2) US4971986A (fi)
EP (1) EP0335832B1 (fi)
JP (1) JP2664241B2 (fi)
KR (1) KR890014479A (fi)
AT (1) ATE85607T1 (fi)
AU (1) AU627719B2 (fi)
CA (1) CA1340962C (fi)
DD (1) DD283601A5 (fi)
DE (1) DE58903483D1 (fi)
DK (1) DK175234B1 (fi)
ES (1) ES2046527T3 (fi)
FI (1) FI91397C (fi)
GR (1) GR3007512T3 (fi)
HU (1) HU204778B (fi)
IE (1) IE63164B1 (fi)
IL (1) IL89841A (fi)
MX (1) MX15387A (fi)
NO (1) NO176314C (fi)
NZ (1) NZ228478A (fi)
PH (1) PH27574A (fi)
PT (1) PT90105B (fi)
YU (1) YU59189A (fi)
ZA (1) ZA892205B (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5238941A (en) * 1988-03-25 1993-08-24 Ciba-Geigy Corporation Arylhydrazones and pharmaceutical compositions thereof
US5395855A (en) * 1990-05-07 1995-03-07 Ciba-Geigy Corporation Hydrazones
AU4486796A (en) * 1995-01-26 1996-08-14 Novartis Ag Imidazole derivatives, their preparation and their use as sadenosylmethionine decarboxylase (=samdc) inhibitors
US6020139A (en) * 1995-04-25 2000-02-01 Oridigm Corporation S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy
EP1221615A2 (en) 1995-04-25 2002-07-10 Oridigm Corporation S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy
WO1998047869A1 (en) 1997-04-22 1998-10-29 Cocensys, Inc. Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof
DOP2002000332A (es) * 2001-02-14 2002-08-30 Warner Lambert Co Inhibidores de piridina de metaloproteinasas de la matriz
WO2002098420A1 (en) * 2001-06-01 2002-12-12 Cytovia, Inc. 4-substituted-1-(arylmethylidene)thiosemicarbazide, 4-substituted-1-(arylcarbonyl)thiosemicarbazide and analogs as activators of caspases and inducers of apoptosis and the use thereof
EP1408028A1 (en) * 2002-10-09 2004-04-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) S-adenosyl methionine decarboxylase inhibition for the treatment of a herpes simplex virus infection
WO2004060308A2 (en) * 2002-12-27 2004-07-22 Chiron Corporation Thiosemicarbazones as anti-virals and immunopotentiators
US7045632B2 (en) * 2003-03-04 2006-05-16 Chevron Phillips Chemical Company, Lp Composition and method for a hexadentate ligand and bimetallic complex for polymerization of olefins
US20050187418A1 (en) * 2004-02-19 2005-08-25 Small Brooke L. Olefin oligomerization
US7384886B2 (en) * 2004-02-20 2008-06-10 Chevron Phillips Chemical Company Lp Methods of preparation of an olefin oligomerization catalyst
US20050187098A1 (en) * 2004-02-20 2005-08-25 Knudsen Ronald D. Methods of preparation of an olefin oligomerization catalyst
US20070043181A1 (en) * 2005-08-19 2007-02-22 Knudsen Ronald D Methods of preparation of an olefin oligomerization catalyst
US9550841B2 (en) 2004-02-20 2017-01-24 Chevron Phillips Chemical Company Lp Methods of preparation of an olefin oligomerization catalyst
US7456284B2 (en) * 2004-12-10 2008-11-25 Chevron Phillips Chemical Company Lp Methods for producing a hexadentate bimetallic complex
US7271121B2 (en) * 2005-07-21 2007-09-18 Chevron Phillips Chemical Company Lp Diimine metal complexes, methods of synthesis, and methods of using in oligomerization and polymerization
US7129304B1 (en) 2005-07-21 2006-10-31 Chevron Phillips Chemical Company Lp Dimine metal complexes, methods of synthesis, and methods of using in oligomerization and polymerization
US7727926B2 (en) * 2005-07-21 2010-06-01 Chevron Phillips Chemical Company Lp Diimine metal complexes, methods of synthesis, and method of using in oligomerization and polymerization
US7268096B2 (en) * 2005-07-21 2007-09-11 Chevron Phillips Chemical Company Lp Diimine metal complexes, methods of synthesis, and methods of using in oligomerization and polymerization
KR100807403B1 (ko) * 2006-07-26 2008-02-28 동아대학교 산학협력단 식물 잿빛 곰팡이병 방제용 바실러스 아밀로리퀘페이션스lp03 균주 및 이를 이용한 미생물 제제의 제조방법
US7902415B2 (en) * 2007-12-21 2011-03-08 Chevron Phillips Chemical Company Lp Processes for dimerizing or isomerizing olefins
US9586872B2 (en) 2011-12-30 2017-03-07 Chevron Phillips Chemical Company Lp Olefin oligomerization methods
CN102627593A (zh) * 2012-02-23 2012-08-08 河南师范大学 具有抗癌活性的1,4-二羟基-2-甲酰基-9,10蒽醌缩氨硫脲新化合物及制备方法
CN102942431B (zh) * 2012-10-26 2014-07-23 青岛正大海尔制药有限公司 一种利用分子筛分离手性化合物的方法
EP2818641A1 (de) 2013-06-26 2014-12-31 Siemens Aktiengesellschaft Turbinenschaufel mit gestufter und abgeschrägter Plattformkante
US9975860B2 (en) 2014-01-17 2018-05-22 University College Dublin, National University Of Ireland, Dublin Anti-angiogenic compounds
US9944661B2 (en) 2016-08-09 2018-04-17 Chevron Phillips Chemical Company Lp Olefin hydroboration

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH383948A (de) * 1959-07-22 1964-11-15 Ciba Geigy Verfahren zur Herstellung neuer Hydrazone
CH396881A (de) * 1961-01-16 1965-08-15 Ciba Geigy Verfahren zur Herstellung neuer Hydrazone
US3206478A (en) * 1961-10-05 1965-09-14 Ciba Geigy Corp Aminoarylalkanone
CH430694A (de) * 1962-04-03 1967-02-28 Ciba Geigy Verfahren zur Herstellung neuer Guanylhydrazone
CH474486A (de) * 1965-11-19 1969-06-30 Ciba Geigy Verfahren zur Herstellung neuer Diphenylharnstoffe
US3673241A (en) * 1968-04-04 1972-06-27 Ciba Geigy Corp Substituted benzaldehyde guanylhydrazones
CH496671A (de) * 1968-04-04 1970-09-30 Ciba Geigy Verfahren zur Herstellung von neuen Guanylhydrazonen
US3753680A (en) * 1970-05-14 1973-08-21 Stauffer Chemical Co Arylidene semicarbazones and their utility as herbicides
DE2309260A1 (de) * 1973-02-24 1974-08-29 Beiersdorf Ag Substituierte guanylhydrazone von alkylarylketonen
US4321274A (en) * 1980-10-06 1982-03-23 Merck & Co., Inc. Substituted 1-(cinnamylideneamino)-3-benzyli-deneaminoguanidines active against Giardia lamblia and Trichomonas vaginalis
EP0087218B1 (en) * 1982-02-10 1985-05-02 Beecham Group Plc Guanidine derivatives

Also Published As

Publication number Publication date
DD283601A5 (de) 1990-10-17
NO891232D0 (no) 1989-03-21
IL89841A (en) 1994-05-30
US4971986A (en) 1990-11-20
DK175234B1 (da) 2004-07-19
FI91397B (fi) 1994-03-15
EP0335832B1 (de) 1993-02-10
DK147089D0 (da) 1989-03-22
ATE85607T1 (de) 1993-02-15
ZA892205B (en) 1989-11-29
FI891361A (fi) 1989-09-26
DE58903483D1 (en) 1993-03-25
AU3162989A (en) 1989-09-28
IL89841A0 (en) 1989-12-15
AU627719B2 (en) 1992-09-03
IE63164B1 (en) 1995-03-22
NO176314C (no) 1995-03-15
YU59189A (en) 1991-02-28
US5118709A (en) 1992-06-02
HU204778B (en) 1992-02-28
EP0335832A3 (en) 1989-10-18
DK147089A (da) 1989-09-26
EP0335832A2 (de) 1989-10-04
PH27574A (en) 1993-08-18
CA1340962C (en) 2000-04-18
PT90105B (pt) 1994-06-30
FI91397C (fi) 1994-06-27
HUT51241A (en) 1990-04-28
NO891232L (no) 1989-09-26
NO176314B (no) 1994-12-05
PT90105A (pt) 1989-11-10
JPH024761A (ja) 1990-01-09
GR3007512T3 (fi) 1993-08-31
NZ228478A (en) 1991-08-27
ES2046527T3 (es) 1994-02-01
MX15387A (es) 1994-01-31
IE890933L (en) 1989-09-25
KR890014479A (ko) 1989-10-23
JP2664241B2 (ja) 1997-10-15

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Legal Events

Date Code Title Description
BB Publication of examined application
PC Transfer of assignment of patent

Owner name: NOVARTIS AG

FG Patent granted

Owner name: NOVARTIS AG

MA Patent expired