FI890282A - Förfarande för framställning av terapeutiskt användbara 23,24-didehydro-25-hydroxikalciferolderivat - Google Patents

Förfarande för framställning av terapeutiskt användbara 23,24-didehydro-25-hydroxikalciferolderivat Download PDF

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Publication number
FI890282A
FI890282A FI890282A FI890282A FI890282A FI 890282 A FI890282 A FI 890282A FI 890282 A FI890282 A FI 890282A FI 890282 A FI890282 A FI 890282A FI 890282 A FI890282 A FI 890282A
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FI
Finland
Prior art keywords
ciferol
hydroxy
derivatives
preparation
therapeutically useful
Prior art date
Application number
FI890282A
Other languages
English (en)
Finnish (fi)
Other versions
FI92193B (sv
FI890282A0 (sv
FI92193C (sv
Inventor
Enrico Giuseppe Baggiolini
John Joseph Partridge
Shian-Jan Shiuey
Gary Arthur Truitt
Milan Radoje Uskokovic
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI890282A0 publication Critical patent/FI890282A0/sv
Publication of FI890282A publication Critical patent/FI890282A/sv
Publication of FI92193B publication Critical patent/FI92193B/sv
Application granted granted Critical
Publication of FI92193C publication Critical patent/FI92193C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
FI890282A 1988-01-20 1989-01-19 Förfarande för framställning av terapeutiskt användbara 23,24-didehydro-25-hydroxikalciferolderivat FI92193C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14586788 1988-01-20
US07/145,867 US4804502A (en) 1988-01-20 1988-01-20 Vitamin D compounds

Publications (4)

Publication Number Publication Date
FI890282A0 FI890282A0 (sv) 1989-01-19
FI890282A true FI890282A (sv) 1989-07-21
FI92193B FI92193B (sv) 1994-06-30
FI92193C FI92193C (sv) 1994-10-10

Family

ID=22514903

Family Applications (1)

Application Number Title Priority Date Filing Date
FI890282A FI92193C (sv) 1988-01-20 1989-01-19 Förfarande för framställning av terapeutiskt användbara 23,24-didehydro-25-hydroxikalciferolderivat

Country Status (23)

Country Link
US (1) US4804502A (sv)
EP (1) EP0326875B1 (sv)
JP (1) JPH0764805B2 (sv)
KR (1) KR960009118B1 (sv)
AR (1) AR246253A1 (sv)
AT (1) ATE74125T1 (sv)
AU (1) AU621851B2 (sv)
CA (1) CA1314906C (sv)
DE (1) DE58901003D1 (sv)
DK (1) DK171966B1 (sv)
ES (1) ES2032613T3 (sv)
FI (1) FI92193C (sv)
GR (1) GR3004785T3 (sv)
HU (1) HU201736B (sv)
IE (1) IE60920B1 (sv)
IL (1) IL88988A (sv)
MC (1) MC1997A1 (sv)
NO (1) NO174547C (sv)
NZ (1) NZ227642A (sv)
PH (1) PH24442A (sv)
PT (1) PT89485B (sv)
YU (1) YU47204B (sv)
ZA (1) ZA8922B (sv)

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US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
ATE99942T1 (de) * 1989-05-18 1994-01-15 Hoffmann La Roche Dehydrocholecalciferolderivate.
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
US5258559A (en) * 1990-11-27 1993-11-02 Hoffmann-La Roche Inc. Process for the preparation of [1R-(1β(R*), 3aα, 4β, 7aβ)] octahydro-1-(5-hydroxy-1,5-dimethylhexyl)-7a-methyl-4H-inden-4-one
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
AU1247592A (en) * 1991-01-08 1992-08-17 Lunar Corporation Methods for preparation and use of 1alpha,24-dihydroxy vitamin d2
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
DK0521550T3 (da) * 1991-07-05 1996-11-04 Duphar Int Res Vitamin D forbindelse, fremgangsmåde til fremstilling af denne forbindelse og mellemprodukt derfor
IL99368A (en) * 1991-09-02 1996-01-19 Teva Pharma Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine
US5200536A (en) * 1992-02-10 1993-04-06 Daikin Industries Ltd. Fluorine-containing vitamin D3 analogues
ES2091515T3 (es) * 1992-05-20 1996-11-01 Hoffmann La Roche Analogos fluorados de la vitamina d3.
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE4221961A1 (de) * 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
GB9223061D0 (en) * 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
TW267161B (sv) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
GB9314400D0 (en) * 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US6121469A (en) 1993-12-23 2000-09-19 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
US6103709A (en) * 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
AU7295696A (en) * 1995-10-27 1997-05-22 F. Hoffmann-La Roche Ag Pharmaceutical composition for treating osteoporosis
US5696103A (en) * 1995-11-17 1997-12-09 Syntex (U.S.A.) Inc. Method for treating osteoporosis
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
AU743514B2 (en) * 1997-05-16 2002-01-24 Women & Infants Hospital Cyclic ether vitamin D3 compounds, 1alpha (OH) 3-EPI-vitamin D3 compounds and uses thereof
AU7497798A (en) * 1997-05-16 1998-12-08 F. Hoffmann-La Roche Ag 3-epi compounds of vitamin d3 and uses thereof
JP2002506429A (ja) * 1997-05-16 2002-02-26 ウィメン アンド インファンツ ホスピタル ３−エピビタミンｄ２化合物及びその使用法
US6087350A (en) * 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
CA2303248A1 (en) * 1997-09-08 1999-03-18 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
EP1064000B1 (en) 1998-03-27 2011-07-06 Oregon Health & Science University Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders
WO2006120681A2 (en) * 2005-05-10 2006-11-16 Dermipsor Ltd. Compositions and methods for skin care
WO2002013832A1 (fr) * 2000-08-17 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Agent therapeutique destine au traitement de l'osteoporose
GB0305332D0 (en) * 2003-03-10 2003-04-09 Leuven K U Res & Dev Biological evaluation of novel vitamin D analogues
GB0422929D0 (en) * 2004-10-15 2004-11-17 Leuven K U Res & Dev Bioactive vitamin D analogues
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
EP1812011A1 (en) 2004-11-12 2007-08-01 Bioxell S.p.a. Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
US9173835B2 (en) 2005-05-10 2015-11-03 Dermipsor Ltd. Compositions and methods for treating hyperproliferative epidermal diseases
JP4882050B2 (ja) 2006-03-15 2012-02-22 日本マイクロバイオファーマ株式会社 インデン誘導体の製造方法およびその製造中間体
EP2085380A1 (en) 2006-11-02 2009-08-05 Mercian Corporation Process for production of 1-hydroxy-19-norcyclovitamin d derivative and intermediate for the production
WO2010088304A1 (en) 2009-01-27 2010-08-05 Cytotech Labs, Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
MX338746B (es) 2009-08-14 2016-04-29 Berg Llc Vitamina d3 y analogos de la misma para tratar alopecia.
SG189427A1 (en) * 2010-10-25 2013-05-31 Teijin Pharma Ltd 23-yne-vitamin d3 derivative
JP6608810B2 (ja) 2013-05-29 2019-11-20 バーグ エルエルシー ビタミンｄを使用する化学療法誘発性脱毛症の予防又は軽減
WO2017209934A1 (en) 2016-05-13 2017-12-07 Case Western Reserve University Autophagy activators for treating or preventing skin injury

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GB2021115B (en) * 1978-05-19 1982-10-06 Wisconsin Alumni Res Found Vitamin d derivatives
US4358406A (en) * 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4689180A (en) * 1984-01-30 1987-08-25 Wisconsin Alumni Research Foundation 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound
US4521410A (en) * 1984-05-03 1985-06-04 The General Hospital Corporation Vitamin D glycosyl orthoesters
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives

Also Published As

Publication number Publication date
US4804502A (en) 1989-02-14
FI92193B (sv) 1994-06-30
HU201736B (en) 1990-12-28
YU47204B (sh) 1995-01-31
JPH0764805B2 (ja) 1995-07-12
JPH029860A (ja) 1990-01-12
KR890011837A (ko) 1989-08-22
KR960009118B1 (en) 1996-07-13
PH24442A (en) 1990-06-25
NZ227642A (en) 1991-06-25
PT89485A (pt) 1989-10-04
NO890240D0 (no) 1989-01-19
DK171966B1 (da) 1997-09-01
EP0326875A1 (de) 1989-08-09
FI890282A0 (sv) 1989-01-19
CA1314906C (en) 1993-03-23
IL88988A (en) 1993-08-18
IE60920B1 (en) 1994-08-24
NO174547C (no) 1994-05-25
DK19689A (da) 1989-07-21
AU2864389A (en) 1989-07-20
PT89485B (pt) 1993-12-31
DE58901003D1 (de) 1992-04-30
YU11889A (en) 1991-04-30
EP0326875B1 (de) 1992-03-25
AR246253A1 (es) 1994-07-29
IL88988A0 (en) 1989-08-15
FI92193C (sv) 1994-10-10
HUT49316A (en) 1989-09-28
ZA8922B (en) 1989-09-27
DK19689D0 (da) 1989-01-17
AU621851B2 (en) 1992-03-26
IE890156L (en) 1989-07-20
ATE74125T1 (de) 1992-04-15
ES2032613T3 (es) 1993-02-16
NO174547B (no) 1994-02-14
GR3004785T3 (sv) 1993-04-28
MC1997A1 (fr) 1990-01-26
NO890240L (no) 1989-07-21

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Owner name: F. HOFFMANN-LA ROCHE AG