MX338746B - Vitamina d3 y analogos de la misma para tratar alopecia. - Google Patents

Vitamina d3 y analogos de la misma para tratar alopecia.

Info

Publication number
MX338746B
MX338746B MX2012001885A MX2012001885A MX338746B MX 338746 B MX338746 B MX 338746B MX 2012001885 A MX2012001885 A MX 2012001885A MX 2012001885 A MX2012001885 A MX 2012001885A MX 338746 B MX338746 B MX 338746B
Authority
MX
Mexico
Prior art keywords
vitamin
pharmaceutical compositions
chemotherapy
analogs
treating alopecia
Prior art date
Application number
MX2012001885A
Other languages
English (en)
Other versions
MX2012001885A (es
Inventor
John Patrick Mccook
Joaquin J Jimenez
Niven Rajin Narain
Original Assignee
Berg Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berg Llc filed Critical Berg Llc
Publication of MX2012001885A publication Critical patent/MX2012001885A/es
Publication of MX338746B publication Critical patent/MX338746B/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5929,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

La invención provee métodos y composiciones farmacéuticas para prevenir o tratar la alopecia, tal como alopecia inducida por quimioterapia (CIA). Las composiciones farmacéuticas de la invención comprenden una cantidad efectiva de un compuesto de vitamina D en una formulación que administra tópicamente el compuesto de vitamina D a la capa de la epidermis pero evita sustancialmente la capa de la dermis. En pacientes de quimioterapia, las composiciones farmacéuticas de la invención se pueden administrar ya sea antes o simultáneas con la medicación de la quimioterapia.
MX2012001885A 2009-08-14 2010-08-06 Vitamina d3 y analogos de la misma para tratar alopecia. MX338746B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23417809P 2009-08-14 2009-08-14
PCT/US2010/044765 WO2011019617A2 (en) 2009-08-14 2010-08-06 Vitamin d3 and analogs thereof for treating alopecia

Publications (2)

Publication Number Publication Date
MX2012001885A MX2012001885A (es) 2012-06-01
MX338746B true MX338746B (es) 2016-04-29

Family

ID=43586756

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015014509A MX366076B (es) 2009-08-14 2010-08-06 Vitamina d3 y analogos de la misma para tratar alopecia.
MX2012001885A MX338746B (es) 2009-08-14 2010-08-06 Vitamina d3 y analogos de la misma para tratar alopecia.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015014509A MX366076B (es) 2009-08-14 2010-08-06 Vitamina d3 y analogos de la misma para tratar alopecia.

Country Status (18)

Country Link
US (2) US9901637B2 (es)
EP (2) EP3603646B1 (es)
JP (2) JP5978130B2 (es)
KR (2) KR101880032B1 (es)
CN (3) CN102655869B (es)
AR (1) AR077922A1 (es)
AU (3) AU2010282731C1 (es)
BR (1) BR112012003372A2 (es)
CA (1) CA2770683C (es)
EA (1) EA201270226A1 (es)
ES (1) ES2742750T3 (es)
IL (1) IL218043B (es)
IN (1) IN2012DN02137A (es)
MX (2) MX366076B (es)
SG (2) SG178382A1 (es)
TW (2) TW201733593A (es)
WO (1) WO2011019617A2 (es)
ZA (2) ZA201702812B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX339746B (es) * 2009-01-27 2016-06-08 Berg Llc Vitamina d3 y análogos de la misma para aliviar efectos secundarios asociados con la quimioterapia.
JP5978130B2 (ja) 2009-08-14 2016-08-24 バーグ エルエルシー 脱毛症を治療するためのビタミンd3およびその類似体
JP5654808B2 (ja) * 2010-09-09 2015-01-14 花王株式会社 毛成長制御剤の評価又は選択方法
JP5537352B2 (ja) * 2010-09-09 2014-07-02 花王株式会社 毛成長抑制剤
US9005898B2 (en) 2010-09-09 2015-04-14 Kao Corporation Method for controlling hair growth, method for selecting or evaluating hair growth control agent, and hair growth suppression agent
FR2996128B1 (fr) * 2012-09-28 2015-01-02 Inneov Lab Utilisation d'une association de taurine ou un de ses derives, et d'extrait de raisins pour ameliorer la qualite des ongles.
CN118105365A (zh) * 2013-03-15 2024-05-31 马斯公司 化合物在制备预防或治疗伴侣动物的特发性呕吐的药物中的用途
WO2014194133A1 (en) * 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
WO2017147420A1 (en) * 2016-02-25 2017-08-31 The University Of Florida Research Foundation, Inc. Methods and compositions with vitamin d compounds for treatment of cystic fibrosis and respiratory disorders
CN105842459A (zh) * 2016-03-24 2016-08-10 泰州海路生物技术有限公司 快速定量检测粪便钙卫蛋白的免疫层析试剂盒
AU2017278257B2 (en) * 2016-06-05 2024-04-18 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D
US10500217B2 (en) 2018-04-30 2019-12-10 Leslie Ray Matthews, M.D., Llc Vitamin D3, heat shock proteins, and glutathione for the treatment of chronic inflammation and chronic diseases
MX2021014028A (es) * 2019-05-17 2022-02-21 Univ Pennsylvania Métodos y composiciones para tratar obesidad y/o trastornos de la piel.
CN110604098B (zh) * 2019-09-23 2021-09-07 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) 一种类风湿关节炎合并间质性肺病动物模型的构建方法

Family Cites Families (169)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4425916A (en) 1979-06-01 1984-01-17 Therapeutic Products, Inc. Cap structure for creating temperature controlled environment for reducing alopecia
US4248791A (en) 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4307231A (en) 1980-07-18 1981-12-22 Wisconsin Alumni Research Foundation Vitamin D-lactone derivative and process for preparing same
US4336193A (en) 1980-08-04 1982-06-22 Wisconsin Alumni Research Foundation Process for preparing vitamin D-lactones
US4367177A (en) 1981-04-15 1983-01-04 Wisconsin Alumni Research Foundation Process for preparing 23,25-dihydroxyvitamin D3
US4279826A (en) 1980-09-22 1981-07-21 Wisconsin Alumni Research Foundation 23,25-Dihydroxyvitamin D3
US4305880A (en) 1980-09-22 1981-12-15 Wisconsin Alumni Research Foundation Process for preparing 24-fluoro-25-hydroxycholecalciferol
US4307025A (en) 1981-02-17 1981-12-22 Wisconsin Alumni Research Foundation 1α, 25-dihydroxy-2β-fluorovitamin D3
JPS57149224A (en) 1981-03-13 1982-09-14 Chugai Pharmaceut Co Ltd Tumor-suppressing agent
US4358406A (en) 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US4360471A (en) 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4360472A (en) 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation Trihydroxyvitamin D3 compounds
US4411833A (en) 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4428946A (en) 1982-07-26 1984-01-31 Wisconsin Alumni Research Foundation Method of preventing milk fever in dairy cattle
US4448721A (en) 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
US5036061A (en) 1983-05-09 1991-07-30 Deluca Hector F Process for the preparation of 1 alpha,25-dihydroxylated vitamin D2 and related compounds
US4448726A (en) 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
US4564474A (en) 1983-08-18 1986-01-14 Wisconsin Alumni Research Foundation 23,23-Difluoro-25-hydroxy-vitamin D3 and process for preparing same
US4502991A (en) 1983-08-18 1985-03-05 Wisconsin Alumni Research Foundation 23,23-Difluoro-1α,25-dihydroxy-vitamin D3
US4769181A (en) 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
US4689180A (en) 1984-01-30 1987-08-25 Wisconsin Alumni Research Foundation 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound
US4719205A (en) 1984-01-30 1988-01-12 Wisconsin Alumini Research Foundation Side-chain unsaturated 1-hydroxyvitamin D compounds
US4505906A (en) 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US5120722A (en) 1984-02-08 1992-06-09 Hoffmann-La Roche Inc. Trihydroxy-cholecacliferol and trihydroxy-ergocalciferol for treating leukemia
US4481198A (en) 1984-02-13 1984-11-06 Wisconsin Alumni Research Foundation Vitamin D metabolism inhibitor
US4719204A (en) 1984-03-05 1988-01-12 Wisconsin Alumni Research Foundation Fowl bone mineralization with 28-NOR 1α-hydroxyvitamin D2 analogs
US4566455A (en) 1984-03-27 1986-01-28 H. Mervin Hughes, II Skin temperature control
US4588716A (en) 1984-05-04 1986-05-13 Wisconsin Alumni Research Foundation Method for treating metabolic bone disease in mammals
US4588528A (en) 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
US4857518A (en) 1984-10-04 1989-08-15 Wisconsin Alumni Research Foundation Hydroxylated 24-homo-vitamin D derivatives and methods for preparing same
US4717721A (en) 1985-05-30 1988-01-05 Howard W. Bremer Sidechain homo-vitamin D compounds with preferential anti-cancer activity
JPS62501505A (ja) 1985-01-17 1987-06-18 ウイスコンシン アラムナイ リサ−チ フオンデ−シヨン ビタミンd誘導体
US4594192A (en) 1985-03-20 1986-06-10 Wisconsin Alumni Research Foundation 2α-fluorovitamin D3
JPS62502545A (ja) 1985-04-23 1987-10-01 ウイスコンシン アラムナイ リサ−チ フオンデ−シヨン セコステロール化合物
US4755329A (en) 1985-06-10 1988-07-05 Wisconsin Alumni Research Foundation Process and intermediates for preparing 1α-hydroxyvitamin D compounds
AU603340B2 (en) 1985-08-02 1990-11-15 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues
US4619920A (en) 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
US5017371A (en) 1988-01-06 1991-05-21 Amarillo Cell Culture Company, Incorporated Method for reducing side effects of cancer therapy
US5145846A (en) 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US4804502A (en) 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5342411A (en) 1988-04-16 1994-08-30 Greater Glasgow Health Board Scalp cooling device
US4847012A (en) 1988-04-29 1989-07-11 Wisconsin Alumni Research Foundation Vitamin D related compounds and processes for their preparation
US4927815A (en) 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
US5354744A (en) 1988-04-29 1994-10-11 Wisconsin Alumni Research Foundation Side chain unsaturated 1 alpha-hydroxyvitamin D analogs
US5250523A (en) 1988-04-29 1993-10-05 Wisconsin Alumni Research Foundation Side chain unsaturated 1α-hydroxyvitanim D homologs
US5232836A (en) 1988-05-04 1993-08-03 Ire-Medgenix S.A. Vitamin D derivatives: therapeutic applications and applications to assays of metabolites of vitamin D
US4851401A (en) 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
US5321018A (en) 1989-03-09 1994-06-14 Wisconsin Alumni Research Foundation Use of 1α-hydroxylated-19-nor-vitamin D compounds to treat psoriasis
US4973584A (en) 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
US5246925A (en) 1989-03-09 1993-09-21 Wisconsin Alumni Research Foundation 19-nor-vitamin D compounds for use in treating hyperparathyroidism
CA1333616C (en) 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
DE3933034A1 (de) 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
US5254538A (en) 1989-10-04 1993-10-19 Trustees Of Boston University Method of treating periodontal disease
US5532228A (en) 1990-02-06 1996-07-02 Schering Aktiengesellschaft Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents
US5030772A (en) 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5260290A (en) 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
GB9007236D0 (en) 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
GB9017890D0 (en) 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
US5185150A (en) 1990-08-24 1993-02-09 Wisconsin Alumni Research Fdn. Cosmetic compositions containing 19-nor-vitamin D compounds
DE4101953A1 (de) 1991-01-19 1992-07-23 Schering Ag 23-oxa-derivate in der vitamin-d-reihe, verfahren zu ihrer herstellung diese derivate enthaltende pharmazeutische praeparate sowie deren verwendung als arzneimittel
US5086191A (en) 1991-05-28 1992-02-04 Wisconsin Alumni Research Foundation Intermediates for the synthesis of 19-nor vitamin D compounds
AU650751B2 (en) 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
PT100638B (pt) 1991-06-28 1999-09-30 Univ Miami Metodo para evitar e tratar a alopecia induzida por quimioterapia
US5486509A (en) * 1991-06-28 1996-01-23 University Of Miami Method of preventing and treating chemotherapy-induced alopecia
EP0521550B1 (en) 1991-07-05 1996-09-18 Duphar International Research B.V Vitamin D compound, method of preparing this compound and intermediate therefor
DE4141746A1 (de) 1991-12-13 1993-06-17 Schering Ag 20-methyl-substituierte vitamin d-derivate
EP0549318B1 (en) 1991-12-26 1996-10-16 Wisconsin Alumni Research Foundation 26,27-Dimethylene-1 alpha, 25-dihydroxyvitamin D2 and 26,27-dihydroxyvitamin D2 and methods for preparing same
GB9201920D0 (en) * 1992-01-29 1992-03-18 Leo Pharm Prod Ltd Novel treatment i
US5830885A (en) 1992-03-12 1998-11-03 The Johns Hopkins University Antiproliferative vitamin D3 hybrids
GB9206648D0 (en) 1992-03-26 1992-05-06 Leo Pharm Prod Ltd Chemical compounds
KR960013798B1 (ko) 1992-04-24 1996-10-10 재단법인 한국전자통신연구소 평면 도파로형 공간 스위치
AU666529B2 (en) 1992-04-24 1996-02-15 Wisconsin Alumni Research Foundation Method of treating osteoporosis with 1 alpha, 24 (R)-dihydroxy-22 (E)-dehydro-vitamin D3
JP2876547B2 (ja) 1992-06-23 1999-03-31 呉羽化学工業株式会社 抗クル病剤
DE4220757A1 (de) 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE4221961A1 (de) 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
GB9214202D0 (en) 1992-07-03 1992-08-12 Leo Pharm Prod Ltd Chemical compounds
US5194431A (en) 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives
AU666563B2 (en) 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
IL103224A (en) 1992-09-18 1998-08-16 Teva Pharma Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3
GB9220272D0 (en) 1992-09-25 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
GB9220439D0 (en) 1992-09-28 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
IL107185A (en) 1992-10-06 1998-02-22 Schering Ag History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them
US5247104A (en) 1992-11-04 1993-09-21 Wisconsin Alumni Research Foundation Preparation of 1α, 24-dihydroxyvitamin D analogs
GB9223061D0 (en) 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
WO1994013280A1 (en) 1992-12-04 1994-06-23 Mayor Pharmaceutical Laboratories, Inc. Sprayable analgesic composition and method of use
GB9226877D0 (en) 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Chemical compounds
DK0676951T3 (da) 1992-12-29 2002-06-03 Michael F Holick Anvendelse af vitamin-D-glycosider til behandling eller forebyggelse af osteoporose
US5547947A (en) 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
GB9309422D0 (en) 1993-05-07 1993-06-23 Res Inst Medicine Chem Chemical compounds
US5371249A (en) 1993-05-11 1994-12-06 Wisconsin Alumni Research Foundation Iodo vitamin D3 compounds and method for preparing same
US5449668A (en) 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds
CA2166898C (en) 1993-07-09 2004-09-07 Roger Bouillon Novel structural analogues of vitamin d
GB9314400D0 (en) 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
GB9315253D0 (en) 1993-07-23 1993-09-08 Res Inst Medicine Chem Chemical compounds
US5565589A (en) 1993-11-03 1996-10-15 Wisconsin Alumni Research Foundation 17-formyl-5,6-trans-vitamin D compounds
US5552392A (en) 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5384313A (en) 1993-11-24 1995-01-24 Wisconsin Alumni Research Foundation 21-norvitamin D compounds
US5373004A (en) 1993-11-24 1994-12-13 Wisconsin Alumni Research Foundation 26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds
GB9325415D0 (en) 1993-12-13 1994-02-16 Res Inst Medicine Chem Chemical compounds
US6103709A (en) 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
GB9405715D0 (en) 1994-03-23 1994-05-11 Res Inst Medicine Chem Chemical compounds
US5824811A (en) 1994-04-11 1998-10-20 Chugai Seiyaku Kabushiki Kaisha 22-Thiavitamin D3 derivatives
DE69507714D1 (de) 1994-11-21 1999-03-18 Wisconsin Alumni Res Found 18,19-dinor-vitamin-d-derivate
US5661140A (en) 1994-11-21 1997-08-26 Wisconsin Alumni Research Foundation 18-nor-vitamin D compounds
ES2130522T3 (es) 1994-12-14 1999-07-01 Duphar Int Res Compuestos de vitamina d y metodo para preparar estos compuestos.
EP0806413B1 (en) 1995-01-23 2001-12-12 Chugai Seiyaku Kabushiki Kaisha 2-substituted vitamin d3 derivatives
US5877168A (en) 1995-02-10 1999-03-02 Chugai Seiyaku Kabushiki Kaisha Vitamin D derivative with substituent at the 2β-position
JPH08295628A (ja) * 1995-04-27 1996-11-12 Teijin Ltd 脱毛症外用治療剤
DE19519273A1 (de) * 1995-05-22 1996-11-28 Schering Ag Topisch applizierbare Mittel zur Behandlung und Prophylaxe der Alopezie
US6844326B2 (en) 1995-06-07 2005-01-18 Anticancer, Inc. Treatment of alopecia
US6372731B1 (en) 1995-06-14 2002-04-16 Schering Aktiengesellschaft Vitamin D derivatives with C-25 substituents, process for their preparation, intermediate products and their use in preparing medicaments
DE69606680T2 (de) 1995-10-30 2000-08-17 F. Hoffmann-La Roche Ag, Basel 1-Alpha, 26-dihydroxy-D-homo-vitamin D3
GB9524812D0 (en) 1995-12-05 1996-02-07 Leo Pharm Prod Ltd Chemical compounds
GB9526208D0 (en) 1995-12-21 1996-02-21 Res Inst Medicine Chem Chemical compounds
GB9607034D0 (en) 1996-04-03 1996-06-05 Leo Pharm Prod Ltd Chemical compounds
AU2953697A (en) 1996-05-02 1997-11-26 Duphar International Research B.V. Vitamin d analogs and methods of preparing these compounds
JPH09299484A (ja) 1996-05-10 1997-11-25 Maeda Sangyo Kk シリンジ・スプレーポンプ
GB9611603D0 (en) 1996-06-04 1996-08-07 Leo Pharm Prod Ltd Chemical compounds
US5976784A (en) 1996-09-20 1999-11-02 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
GB9622590D0 (en) 1996-10-30 1997-01-08 Leo Pharm Prod Ltd Chemical compounds
IL130484A (en) 1996-12-20 2004-07-25 Chugai Pharmaceutical Co Ltd History of -16N-Vitamin-D
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6392071B1 (en) 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US5945410A (en) 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds
JPH10316652A (ja) 1997-05-02 1998-12-02 Duphar Internatl Res Bv 16−デヒドロビタミンd化合物の製造方法
EP0981514B1 (en) 1997-05-16 2006-04-05 Woman & Infants Hospital 3-epi vitamin d2 compounds and uses thereof
KR20010012770A (ko) 1997-05-22 2001-02-26 세파론, 인코포레이티드 비타민 d 유사체 및 그 뉴런 효과
WO1998055104A1 (fr) 1997-06-06 1998-12-10 Shionogi & Co., Ltd. Perfectionnement d'un systeme d'administration de medicament
AUPO727097A0 (en) 1997-06-10 1997-07-03 Unisearch Limited Method of treatment of hepatoma and pharmaceutical compositions for use therein
US5936105A (en) 1997-06-13 1999-08-10 Tetrionics, Inc. 14-EPI-19-nor-vitamin D compounds and methods
US5939406A (en) 1997-07-21 1999-08-17 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
US6359152B2 (en) 1997-07-21 2002-03-19 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
GB9721156D0 (en) 1997-10-06 1997-12-03 Leo Pharm Prod Ltd Novel vitamin d analogues
US5919986A (en) 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
US6043385A (en) 1997-12-16 2000-03-28 Hoffman-La Roche Inc. Vitamin D derivatives
JP2002508383A (ja) * 1997-12-17 2002-03-19 シエーリング アクチエンゲゼルシャフト 側鎖中にリン原子を有するビタミンd誘導体
US6184422B1 (en) 1998-02-26 2001-02-06 Hoffman-La Roche Inc. Cyclohexanediol derivatives
AU762481C (en) 1998-03-27 2004-08-19 Oregon Health Sciences University Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders
EP1070704A4 (en) 1998-04-10 2001-11-07 Chugai Pharmaceutical Co Ltd VITAMIN D DERIVATIVES SUBSTITUTED IN THE 2 BETA POSITION
US6114317A (en) 1998-05-21 2000-09-05 Wisconsin Alumni Research Foundation Method of locking 1α-OH of vitamin D compounds in axial orientation
CA2333256A1 (en) 1998-05-29 1999-12-02 Bone Care International, Inc. Method for making hydroxy-25-ene-vitamin d compounds
US5972917A (en) 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
US20010002396A1 (en) 1998-07-16 2001-05-31 Charles Achkar Compositions and methods of treating skin conditions
US6218430B1 (en) 1998-08-24 2001-04-17 Ligand Pharmaceuticals Incorporated Vitamin D3 mimics
WO2000024712A1 (fr) * 1998-10-23 2000-05-04 Teijin Limited Derives de vitamine d3 et medicaments contre des maladies respiratoires inflammatoires les contenant
FR2785284B1 (fr) 1998-11-02 2000-12-01 Galderma Res & Dev Analogues de la vitamine d
US6238683B1 (en) * 1998-12-04 2001-05-29 Johnson & Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
KR200257098Y1 (ko) * 1999-01-21 2001-12-24 신석균 양면투시용 입체 투시기
FR2801307B1 (fr) 1999-11-24 2002-12-06 Galderma Res & Dev Analogues de la vitamine d
FR2801305B1 (fr) 1999-11-24 2002-12-06 Galderma Res & Dev Analogues de la vitamine d
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
WO2002030430A1 (en) * 2000-10-06 2002-04-18 Abbott Laboratories Use of vitamin d2 compounds for alopecia
FR2825087B1 (fr) * 2001-05-22 2005-01-14 Galderma Res & Dev Analogues de la vitamine d
GB0128628D0 (en) 2001-11-29 2002-01-23 Univ Sheffield Disease treatment
AU2003211496A1 (en) 2002-02-20 2003-09-09 Teijin Limited Vitamin d3 derivatives and remedies using the same
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
AR041696A1 (es) * 2002-10-23 2005-05-26 Leo Pharm Prod Ltd Compuestos analogos de vitamina d, composiciones que comprenden dichos compuestos analogos y su uso
KR20050055784A (ko) * 2002-10-23 2005-06-13 레오 파마 에이/에스 비타민 디 유사체, 이 유사체를 포함하는 조성물 및 이들의용도
JP2007501865A (ja) 2003-06-11 2007-02-01 ノバセア インコーポレイティッド 放射線治療薬および放射線治療と併用した、活性ビタミンd化合物による癌の治療法
US7863298B2 (en) 2003-10-14 2011-01-04 Exelixis, Inc. Bridged ring structures as pharmaceutical agents
FR2862540B1 (fr) 2003-11-21 2007-03-30 Galderma Res & Dev Composition sous forme de spray comprenant un actif pharmaceutique, au moins un silicone volatile et une phase non polaire non volatile
PL1686972T3 (pl) 2003-11-21 2008-09-30 Galderma Res & Dev Kompozycja możliwa do rozpylania dla podawania pochodnych witaminy D
US8034788B2 (en) 2005-05-10 2011-10-11 Dermipsor Ltd. Composition and methods for skin care
CN1732902A (zh) 2005-09-01 2006-02-15 晏四平 含有维生素类物质的喷雾剂
US8530463B2 (en) 2007-05-07 2013-09-10 Hale Biopharma Ventures Llc Multimodal particulate formulations
EP2262507A1 (en) * 2008-03-06 2010-12-22 Wisconsin Alumni Research Foundation Methods of increasing epidermal skin thickness by topical administration of a 19-nor containing vitamin d compound
JP5978130B2 (ja) * 2009-08-14 2016-08-24 バーグ エルエルシー 脱毛症を治療するためのビタミンd3およびその類似体
WO2014194133A1 (en) 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
AU2017278257B2 (en) 2016-06-05 2024-04-18 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D

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