FI862370A - Monoklonala antikroppar mot cyclosporiner - Google Patents

Monoklonala antikroppar mot cyclosporiner Download PDF

Info

Publication number
FI862370A
FI862370A FI862370A FI862370A FI862370A FI 862370 A FI862370 A FI 862370A FI 862370 A FI862370 A FI 862370A FI 862370 A FI862370 A FI 862370A FI 862370 A FI862370 A FI 862370A
Authority
FI
Finland
Prior art keywords
cyclosporins
monoclonal antibodies
cyclosporine
succinimidooxysuccinyl
conjugates
Prior art date
Application number
FI862370A
Other languages
English (en)
Finnish (fi)
Other versions
FI862370A0 (sv
FI93965B (sv
FI93965C (sv
Inventor
Joachim Rosenthaler
Roland Wenger
Philipp E Ball
Max H Schreier
Valerie Quesniaux
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848425040A external-priority patent/GB8425040D0/en
Priority claimed from GB858515673A external-priority patent/GB8515673D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of FI862370A0 publication Critical patent/FI862370A0/sv
Publication of FI862370A publication Critical patent/FI862370A/sv
Publication of FI93965B publication Critical patent/FI93965B/sv
Application granted granted Critical
Publication of FI93965C publication Critical patent/FI93965C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
FI862370A 1984-10-04 1986-06-03 Monoklonala antikroppar mot cyclosporiner FI93965C (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB848425040A GB8425040D0 (en) 1984-10-04 1984-10-04 Organic compounds
GB8425040 1984-10-04
GB858515673A GB8515673D0 (en) 1985-06-20 1985-06-20 Organic compounds
GB8515673 1985-06-20
PCT/EP1985/000501 WO1986002080A1 (en) 1984-10-04 1985-09-27 Monoclonal antibodies to cyclosporings
EP8500501 1985-09-27

Publications (4)

Publication Number Publication Date
FI862370A0 FI862370A0 (sv) 1986-06-03
FI862370A true FI862370A (sv) 1986-06-03
FI93965B FI93965B (sv) 1995-03-15
FI93965C FI93965C (sv) 1995-06-26

Family

ID=26288301

Family Applications (1)

Application Number Title Priority Date Filing Date
FI862370A FI93965C (sv) 1984-10-04 1986-06-03 Monoklonala antikroppar mot cyclosporiner

Country Status (15)

Country Link
EP (4) EP0198026B1 (sv)
JP (1) JPH074269B2 (sv)
KR (1) KR910002691B1 (sv)
AT (1) ATE92501T1 (sv)
AU (4) AU589917B2 (sv)
CA (1) CA1309671C (sv)
CY (2) CY1915A (sv)
DE (2) DE3587505T2 (sv)
DK (1) DK172037B1 (sv)
ES (1) ES8702949A1 (sv)
FI (1) FI93965C (sv)
HK (2) HK78696A (sv)
NO (1) NO173557C (sv)
NZ (1) NZ213680A (sv)
WO (1) WO1986002080A1 (sv)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5239057A (en) * 1987-03-27 1993-08-24 Abbott Laboratories Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
US5427960A (en) * 1987-03-27 1995-06-27 Abbott Laboratories Fluorescence polarization assay for cyclosporin A and metabolites and related immunogens and antibodies
EP0283801A3 (en) * 1987-03-27 1990-05-30 Abbott Laboratories Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
US5698448A (en) * 1988-12-02 1997-12-16 Soldin; Steven J. Immunosuppressive drug binding proteins and use
CA2004626A1 (en) * 1988-12-05 1990-06-05 Bernard F. Erlanger Derivatives of cyclosporine a, antibodies directed thereto and uses thereof
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
DK0473961T3 (da) * 1990-08-15 1996-07-01 Abbott Lab Immunoassay-reagenser og fremgangsmåde til bestemmelse af cyklosporin
CA2048302A1 (en) * 1990-08-15 1992-02-16 Victoria P. Meucci Solubilization reagent for biological test samples
DE69133095T2 (de) * 1990-11-20 2003-03-27 Dade Behring Marburg Gmbh Cyclosporin-Immunoassay
GB9307491D0 (en) 1993-04-08 1993-06-02 Sandoz Ltd Organic compounds
USRE40596E1 (en) * 1993-04-08 2008-12-02 Novartis Ag Rapamycin assay
WO1999010373A1 (en) * 1997-08-26 1999-03-04 Wisconsin Alumni Research Foundation Non-immunosuppressive cyclosporins and their use in the prevention and treatment of hiv infection
US6270957B1 (en) 1997-08-26 2001-08-07 Wisconsin Alumni Research Foundation Non-Imuunosuppressive cyclosporins and their use in the prevention and treatment of HIV infection
US5990274A (en) 1997-11-25 1999-11-23 Dade Behring Inc. Cyclosporine derivatives and uses thereof
BR9911724A (pt) 1998-07-01 2001-03-20 Debiopharm Sa Ciclosporina que tem um perfil de atividade melhorado
US6686454B1 (en) 1998-10-09 2004-02-03 Isotechnika, Inc. Antibodies to specific regions of cyclosporine related compounds
AU763822B2 (en) * 1998-10-09 2003-07-31 Isotechnika, Inc. Methods for the production of antibodies to specific regions of cyclosporine and cyclosporine metabolites
AU2002331509B2 (en) 2001-10-19 2007-12-06 Aurinia Pharmaceuticals Inc. Synthesis of cyclosporin analogs
JP5174898B2 (ja) 2007-05-24 2013-04-03 アボット・ラボラトリーズ 疎水性薬物検体代謝産物との交差反応性が低下している免疫アッセイ
TW200932240A (en) 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
CA2910133C (en) * 2008-05-23 2018-02-27 The University Of British Columbia Modified drugs for use in liposomal nanoparticles
KR101476626B1 (ko) 2009-01-30 2014-12-26 이난타 파마슈티칼스, 인코포레이티드 Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8623814B2 (en) 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
WO2012145426A1 (en) 2011-04-18 2012-10-26 The Trustees Of Columbia University In The City Of New York Methods to treat cancer using cyclosporine and cyclosporine derivatives
WO2014085623A1 (en) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
CA2921961A1 (en) 2013-08-26 2015-03-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c
US9669095B2 (en) 2014-11-03 2017-06-06 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection
WO2016112295A1 (en) 2015-01-09 2016-07-14 Warp Drive Bio, Inc. Compounds that participate in cooperative binding and uses thereof
US9989535B2 (en) 2015-10-01 2018-06-05 Warp Drive Bio, Inc. Methods and reagents for analyzing protein-protein interfaces
CA3020594A1 (en) 2016-04-12 2017-10-19 Warp Drive Bio, Inc. Compositions and methods for the production of compounds
CN110506120A (zh) 2016-10-28 2019-11-26 银杏生物制品公司 用于生产化合物的组合物和方法
EP4054719A1 (en) 2019-11-04 2022-09-14 Revolution Medicines, Inc. Ras inhibitors
CR20220243A (es) 2019-11-04 2022-08-04 Revolution Medicines Inc Inhibidores de ras
TW202132315A (zh) 2019-11-04 2021-09-01 美商銳新醫藥公司 Ras 抑制劑
EP4214209A1 (en) 2020-09-15 2023-07-26 Revolution Medicines, Inc. Indole derivatives as ras inhibitors in the treatment of cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB211526A (en) 1922-09-22 1924-02-22 John Fletcher Holliday Improvements in and relating to chain grate stokers
US4210581A (en) 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
CH614931A5 (sv) * 1975-11-04 1979-12-28 Sandoz Ag
DE2819094A1 (de) 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
EP0098457B1 (en) 1980-02-14 1987-08-05 Sandoz Ag (1s,2r,3r)- and (1r,2s,3s)-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes useful in the total synthesis of cyclosporins and processes for their production
IL62965A0 (en) 1980-07-17 1981-07-31 Scripps Miles Lab Inc Monoclonal antibodies to drugs and theri production
EP0056782B1 (en) 1981-01-09 1984-08-01 Sandoz Ag Novel cyclosporins
GB8407618D0 (en) 1984-03-23 1984-05-02 Sandoz Ltd Organic compounds
CH667274A5 (de) 1984-03-23 1988-09-30 Sandoz Ag Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Also Published As

Publication number Publication date
DK261386D0 (da) 1986-06-03
NO862177L (no) 1986-08-04
EP0198026B1 (en) 1993-08-04
FI862370A0 (sv) 1986-06-03
EP0290762B1 (en) 1993-05-12
JPH074269B2 (ja) 1995-01-25
AU3914289A (en) 1989-10-26
HK78696A (en) 1996-05-10
FI93965B (sv) 1995-03-15
ES547495A0 (es) 1987-01-16
AU3914389A (en) 1989-11-16
DE3587505D1 (de) 1993-09-09
KR910002691B1 (ko) 1991-05-03
KR870700637A (ko) 1987-12-30
JPS62500383A (ja) 1987-02-19
NO173557B (no) 1993-09-20
DE3587342D1 (en) 1993-06-17
WO1986002080A1 (en) 1986-04-10
CA1309671C (en) 1992-11-03
ES8702949A1 (es) 1987-01-16
CY1915A (en) 1985-09-27
NZ213680A (en) 1990-05-28
DK172037B1 (da) 1997-09-22
CY1927A (en) 1997-05-16
EP0290762A1 (en) 1988-11-17
NO173557C (no) 1993-12-29
DK261386A (da) 1986-06-03
EP0198026A1 (en) 1986-10-22
FI93965C (sv) 1995-06-26
NO862177D0 (no) 1986-06-02
DE3587505T2 (de) 1994-01-05
EP0314861A1 (en) 1989-05-10
AU589917B2 (en) 1989-10-26
AU3914189A (en) 1989-11-16
DE3587342T2 (de) 1993-12-02
ATE92501T1 (de) 1993-08-15
EP0314862A1 (en) 1989-05-10
AU4967185A (en) 1986-04-17
HK124696A (en) 1996-07-19

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BB Publication of examined application
PC Transfer of assignment of patent

Owner name: NOVARTIS AG

FG Patent granted

Owner name: NOVARTIS AG

MA Patent expired