FI86062B - Foerfarande foer framstaellning av 5-klor-3-klorsulfonyl-2-tiofenkarboksylsyraestrar. - Google Patents
Foerfarande foer framstaellning av 5-klor-3-klorsulfonyl-2-tiofenkarboksylsyraestrar. Download PDFInfo
- Publication number
- FI86062B FI86062B FI892051A FI892051A FI86062B FI 86062 B FI86062 B FI 86062B FI 892051 A FI892051 A FI 892051A FI 892051 A FI892051 A FI 892051A FI 86062 B FI86062 B FI 86062B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- iron
- chlorine gas
- chloro
- per mole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (4)
1. Förfarande för framställnin9 av 5-klor-3-klorsulfonyl-2-tiofenkarboxy1syraester med formeln (I) 5 SO?Cl ,_V il {I)
10 JL JK C00R där
15 R är C1-c4 alkyl, kännetecknat därav, att en förening med formeln (II) S02C1 20 --/ ΓΊί ^ s COOK 25 där R avser det samma som ovan, kloreras i närvaro av aktiverat järn i ett organiskt 1ösningsmedel, som i reaktionsförhäl- landen är inert, eller i en blandning av sädana lösningsme- del, varvid klorgas mätäs tills 50 - 70 % av den önskade 5-klor-3-klorsulfonyl-2-tiofenkarboxylsyraestern med ; formeln I bildats, varvid nämnda aktiverade järn fram- : : ställts genom att suspendera 0,1 - 1,0 mol metalliskt järn : per mol av en förening med formeln II i 0,5 - 5 liter :./35 organiskt 1ösningsmedel, som i aktiveringsförhäl1anden är * inert, eller i en blandning av sädana 1 ösningsmedel och :V: 100 - 500 g klorgas per mol järn mätäs under 1-5 timmar.
« * , 2. Förfarande enligt patentkravet 1, känneteck- 40. a t därav, att det metalliska järnet aktiveras med klorgas i en 1 ösningssuspension, varvid 0,2 - 0,4 mol * metalliskt järn per mol utgängsämne med formeln II akti-veras i 1 - 3 liter mety 1 enklorid eller tetraklorkolväte * · 4 · » · · »IM» 11 86062 eller i deras blandning genom att leda 200 - 300 g klorgas per mol jam in i suspensionen under 2-3 timmar.
3. För f a rand I* enligt patentkravet 1, kanneteck-5 n a t. därav, att järnets aktivering och kloreringen av föreningarna med formeln II utförs i samma 1ösningsmedel eller 1ösningsblandning.
4. Förfarande enligt patentkravet 1, känneteck-10 n a t därav, att kloreringen av föreningar med formeln II genom matning av 5 - 50 g klorgas per timme och mol av en förening med formeln utförs vid 20 - 50°C, tills 50 - 70 % av den önskade 5 — k 1or-3-klorsulfonyl-2-tiofenkarboxy1syra-estern bildats och därefter halls reaktionsblandningen i 15 isvatten. • · *
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT112388 | 1988-05-02 | ||
| AT0112388A AT390060B (de) | 1988-05-02 | 1988-05-02 | Verfahren zur herstellung von 5-chlor-3chlorsulfonyl-2-thiophencarbonsaeureestern |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI892051A0 FI892051A0 (fi) | 1989-04-28 |
| FI892051A FI892051A (fi) | 1989-11-03 |
| FI86062B true FI86062B (fi) | 1992-03-31 |
| FI86062C FI86062C (sv) | 1992-07-10 |
Family
ID=3507085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI892051A FI86062C (sv) | 1988-05-02 | 1989-04-28 | Förfarande för framställning av 5-klor-3-klorsulfonyl-2-tiofenkarboksy lsyraestrar |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5138072A (sv) |
| EP (1) | EP0340472B1 (sv) |
| JP (1) | JP2785132B2 (sv) |
| KR (1) | KR970000685B1 (sv) |
| CN (1) | CN1028101C (sv) |
| AT (2) | AT390060B (sv) |
| AU (1) | AU614058B2 (sv) |
| CA (1) | CA1333177C (sv) |
| CS (1) | CS275851B6 (sv) |
| CY (1) | CY1756A (sv) |
| DD (1) | DD283818A5 (sv) |
| DE (1) | DE58905010D1 (sv) |
| DK (1) | DK172655B1 (sv) |
| EG (1) | EG20136A (sv) |
| ES (1) | ES2058372T3 (sv) |
| FI (1) | FI86062C (sv) |
| GR (1) | GR3008623T3 (sv) |
| HK (1) | HK128193A (sv) |
| HU (1) | HU202518B (sv) |
| IL (1) | IL89902A0 (sv) |
| MY (1) | MY103874A (sv) |
| NO (1) | NO171912C (sv) |
| NZ (1) | NZ228772A (sv) |
| PH (1) | PH27581A (sv) |
| SA (1) | SA89100027B1 (sv) |
| SU (1) | SU1704632A3 (sv) |
| YU (1) | YU48507B (sv) |
| ZA (1) | ZA892791B (sv) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4232417A1 (de) * | 1992-09-28 | 1994-03-31 | Bayer Ag | Substituierte Thienylsulfonylharnstoffe |
| DE19540737A1 (de) * | 1995-11-02 | 1997-05-07 | Bayer Ag | Substituierte Sulfonylamino(thio)carbonylverbindungen |
| CN103356636A (zh) | 2004-05-23 | 2013-10-23 | 杰勒德·M·豪斯 | Theramutein调节剂 |
| US8431110B2 (en) | 2005-05-23 | 2013-04-30 | Hmi Medical Innovations, Llc. | Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators |
| EP4424838A2 (en) * | 2005-11-23 | 2024-09-04 | Gerard M. Housey | Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators |
| CN116693498B (zh) * | 2023-05-30 | 2024-01-30 | 湖北广济医药科技有限公司 | 一种利用连续流动反应合成5-氯-3-(氯磺酰基)-2-噻吩羧酸甲酯的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE698778C (de) * | 1934-11-11 | 1941-07-10 | I G Farbenindustrie Akt Ges | Verfahren zur Herstellung von organischen Monochlor- oder Monobromverbindungen |
| DE2227439B2 (de) * | 1972-06-06 | 1977-05-05 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Chlorierung oder bromierung phenolischer verbindungen |
| DE2534689B2 (de) * | 1974-09-16 | 1979-03-01 | Basf Ag, 6700 Ludwigshafen | 23-Dihydro-3-oxo-thieno-isothiazol-1,1-dioxide |
| AU518216B2 (en) * | 1977-09-06 | 1981-09-17 | Hafslund Nycomed Pharma Aktiengesellschaft | Thienothiazine derivatives |
| FR2564834A1 (fr) * | 1984-05-24 | 1985-11-29 | Du Pont | Procede de preparation de 3-chlorosulfonylthiophene-2-carboxylate d'alcoyle |
| FI862513A (fi) * | 1985-07-04 | 1987-01-05 | Chemie Linz Ag | Nya tieno-1,2-tiazolderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska preparat. |
| DE3785694T2 (de) * | 1986-05-13 | 1993-09-16 | Seitetsu Kagaku Co Ltd | Thiophenderivate und verfahren zu ihrer herstellung. |
-
1988
- 1988-05-02 AT AT0112388A patent/AT390060B/de not_active IP Right Cessation
-
1989
- 1989-04-07 CA CA000596140A patent/CA1333177C/en not_active Expired - Lifetime
- 1989-04-07 ES ES89106153T patent/ES2058372T3/es not_active Expired - Lifetime
- 1989-04-07 DE DE8989106153T patent/DE58905010D1/de not_active Expired - Lifetime
- 1989-04-07 AT AT89106153T patent/ATE92056T1/de not_active IP Right Cessation
- 1989-04-07 EP EP89106153A patent/EP0340472B1/de not_active Expired - Lifetime
- 1989-04-10 IL IL89902A patent/IL89902A0/xx unknown
- 1989-04-11 MY MYPI89000456A patent/MY103874A/en unknown
- 1989-04-17 ZA ZA892791A patent/ZA892791B/xx unknown
- 1989-04-17 NZ NZ228772A patent/NZ228772A/xx unknown
- 1989-04-19 YU YU81089A patent/YU48507B/sh unknown
- 1989-04-24 NO NO891679A patent/NO171912C/no not_active IP Right Cessation
- 1989-04-25 SU SU894613917A patent/SU1704632A3/ru active
- 1989-04-26 EG EG21189A patent/EG20136A/xx active
- 1989-04-27 AU AU33801/89A patent/AU614058B2/en not_active Expired
- 1989-04-27 HU HU892021A patent/HU202518B/hu unknown
- 1989-04-27 PH PH38579A patent/PH27581A/en unknown
- 1989-04-27 DD DD89328037A patent/DD283818A5/de not_active IP Right Cessation
- 1989-04-28 FI FI892051A patent/FI86062C/sv not_active IP Right Cessation
- 1989-04-28 CS CS892634A patent/CS275851B6/cs not_active IP Right Cessation
- 1989-04-29 CN CN89102950A patent/CN1028101C/zh not_active Expired - Lifetime
- 1989-05-01 JP JP1109261A patent/JP2785132B2/ja not_active Expired - Lifetime
- 1989-05-01 KR KR1019890005804A patent/KR970000685B1/ko not_active IP Right Cessation
- 1989-05-01 DK DK198902111A patent/DK172655B1/da not_active IP Right Cessation
- 1989-10-07 SA SA89100027A patent/SA89100027B1/ar unknown
-
1991
- 1991-12-02 US US07/800,702 patent/US5138072A/en not_active Expired - Lifetime
-
1993
- 1993-07-29 GR GR930400602T patent/GR3008623T3/el unknown
- 1993-11-18 HK HK1281/93A patent/HK128193A/xx not_active IP Right Cessation
-
1994
- 1994-06-03 CY CY175694A patent/CY1756A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Transfer of assignment of patent |
Owner name: NYCOMED DANMARK A/S |
|
| FG | Patent granted |
Owner name: NYCOMED DANMARK A/S |
|
| MA | Patent expired |