KR890017240A - 5-클로로-3-클로로설포닐-2-티오펜카복실산 에스테르의 제조방법 - Google Patents

5-클로로-3-클로로설포닐-2-티오펜카복실산 에스테르의 제조방법 Download PDF

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Publication number
KR890017240A
KR890017240A KR1019890005804A KR890005804A KR890017240A KR 890017240 A KR890017240 A KR 890017240A KR 1019890005804 A KR1019890005804 A KR 1019890005804A KR 890005804 A KR890005804 A KR 890005804A KR 890017240 A KR890017240 A KR 890017240A
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South Korea
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chlorine gas
compound
iron
formula
solvent
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KR1019890005804A
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KR970000685B1 (ko
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페터 바그너 한스
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클라우스 로덴, 페터 자이델
체엘 마라 아크티엔게젤샤프트
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Publication of KR890017240A publication Critical patent/KR890017240A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

5-클로로-3-클로로설포닐-2-티오펜카복실산 에스테르의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 금속 철을 염소 가스로 활성화시키고 활성 철의 존재하에 염소 가스를 도입하여 일반식(Ⅱ)의 화합물을 염소화시킴을 포함함을 특징으르 하는 일반식(Ⅰ)의 5-클로로-3-클로로설포닐-2-티오펜카복실산 에스테르를 제조하는 방법.
    상기식에서 R은 C1-C4-알킬을 나타낸다.
  2. 제 1 항에 있어서, 금속 철을 염소 가스 대기하에 염소가스로 활성화시킴을 특징으로 하는 방법.
  3. 제 1 항에 있어서, 활성 금속 철을 염소 가스 대기하에 약 12 내지 48시간 동안 활성화시킴을 특징으로 하는 방법.
  4. 제 1 항에 있어서, 금속 철을 염소 가스 대기하에서 약 24시간 동안 활성화시킴을 특징으로 하는 방법.
  5. 제 1 항에 있어서, 반응 조건하에서 불활성인 유기용매 0.5 내지 5ℓ에 현탁된 일반식(Ⅱ)의 화합물 1몰당 금속 철 0.1 내지 1.0몰의 용매 현탁액 또는 당해 용매들이 혼합물 속에서 염소가스로 금속 철을 활성화시키고 철 1몰당 염소 가스 1OO 내지 500g을 1 내지 5시간 걸쳐 도입하여 철을 활성화시킴을 특징으로 하는 방법.
  6. 제 1 항에 있어서, 염화 메틸렌 또는 사염화탄소 1 내지 3ℓ을 현탁된 일반식(Ⅱ)의 화합물 1몰당 금속 철 0.2 내지 0.4몰의 용매 현탁액 또는 당해 용매들의 혼합물 속에서 염소 가스로 금속 철을 활성화시키고 철 1몰당 염소 가스 200 내지 300g을 2 내지 3시간에 걸쳐 도입하여 철을 활성화시킴을 특징으로 하는 방법.
  7. 제 1 항에 있어서, 동일한 용매 또는 용매 혼합물 속에서 철을 활성화시키고 일반식(Ⅱ)의 화합물을 염소화시킴을 특징으로 하는 방법.
  8. 제 1 항에 있어서, 모노클로로 화합물이 50 내지 70%가 생성될때까지 20 내지 50℃에서 1시간당 일반식(Ⅱ)화합물 1몰당 염소 가스를 5 내지 50g 도입한 다음, 반응 혼합물을 빙수 속에 부어넣음을 특징으로하는 방법.
  9. 제 1 항에 있어서, 모노클로로 화합물이 62 내지 65%가 생성될때까지, 30 내지 32℃에서 1시간당 일반식(Ⅱ)의 화합물 1몰당 염소가스를 15 내지 35g 도입하여 일반식(Ⅱ)의 화합물을 염소화시킨 다음 반응혼합물을 빙수속에 부어넣음을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890005804A 1988-05-02 1989-05-01 5-클로로-3-클로로설포닐-2-티오펜카복실산 에스테르의 제조방법 KR970000685B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA1123/88 1988-05-02
AT0112388A AT390060B (de) 1988-05-02 1988-05-02 Verfahren zur herstellung von 5-chlor-3chlorsulfonyl-2-thiophencarbonsaeureestern

Publications (2)

Publication Number Publication Date
KR890017240A true KR890017240A (ko) 1989-12-15
KR970000685B1 KR970000685B1 (ko) 1997-01-18

Family

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KR1019890005804A KR970000685B1 (ko) 1988-05-02 1989-05-01 5-클로로-3-클로로설포닐-2-티오펜카복실산 에스테르의 제조방법

Country Status (28)

Country Link
US (1) US5138072A (ko)
EP (1) EP0340472B1 (ko)
JP (1) JP2785132B2 (ko)
KR (1) KR970000685B1 (ko)
CN (1) CN1028101C (ko)
AT (2) AT390060B (ko)
AU (1) AU614058B2 (ko)
CA (1) CA1333177C (ko)
CS (1) CS275851B6 (ko)
CY (1) CY1756A (ko)
DD (1) DD283818A5 (ko)
DE (1) DE58905010D1 (ko)
DK (1) DK172655B1 (ko)
EG (1) EG20136A (ko)
ES (1) ES2058372T3 (ko)
FI (1) FI86062C (ko)
GR (1) GR3008623T3 (ko)
HK (1) HK128193A (ko)
HU (1) HU202518B (ko)
IL (1) IL89902A0 (ko)
MY (1) MY103874A (ko)
NO (1) NO171912C (ko)
NZ (1) NZ228772A (ko)
PH (1) PH27581A (ko)
SA (1) SA89100027B1 (ko)
SU (1) SU1704632A3 (ko)
YU (1) YU48507B (ko)
ZA (1) ZA892791B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4232417A1 (de) * 1992-09-28 1994-03-31 Bayer Ag Substituierte Thienylsulfonylharnstoffe
DE19540737A1 (de) * 1995-11-02 1997-05-07 Bayer Ag Substituierte Sulfonylamino(thio)carbonylverbindungen
CN103356636A (zh) 2004-05-23 2013-10-23 杰勒德·M·豪斯 Theramutein调节剂
US8431110B2 (en) 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
EP4424838A2 (en) * 2005-11-23 2024-09-04 Gerard M. Housey Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators
CN116693498B (zh) * 2023-05-30 2024-01-30 湖北广济医药科技有限公司 一种利用连续流动反应合成5-氯-3-(氯磺酰基)-2-噻吩羧酸甲酯的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE698778C (de) * 1934-11-11 1941-07-10 I G Farbenindustrie Akt Ges Verfahren zur Herstellung von organischen Monochlor- oder Monobromverbindungen
DE2227439B2 (de) * 1972-06-06 1977-05-05 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Chlorierung oder bromierung phenolischer verbindungen
DE2534689B2 (de) * 1974-09-16 1979-03-01 Basf Ag, 6700 Ludwigshafen 23-Dihydro-3-oxo-thieno-isothiazol-1,1-dioxide
AU518216B2 (en) * 1977-09-06 1981-09-17 Hafslund Nycomed Pharma Aktiengesellschaft Thienothiazine derivatives
FR2564834A1 (fr) * 1984-05-24 1985-11-29 Du Pont Procede de preparation de 3-chlorosulfonylthiophene-2-carboxylate d'alcoyle
FI862513A (fi) * 1985-07-04 1987-01-05 Chemie Linz Ag Nya tieno-1,2-tiazolderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska preparat.
DE3785694T2 (de) * 1986-05-13 1993-09-16 Seitetsu Kagaku Co Ltd Thiophenderivate und verfahren zu ihrer herstellung.

Also Published As

Publication number Publication date
HUT49869A (en) 1989-11-28
NO171912C (no) 1993-05-19
HU202518B (en) 1991-03-28
CY1756A (en) 1994-06-03
EP0340472A1 (de) 1989-11-08
NO171912B (no) 1993-02-08
ES2058372T3 (es) 1994-11-01
SA89100027B1 (ar) 2003-04-09
NO891679L (no) 1989-11-03
HK128193A (en) 1993-11-26
EP0340472B1 (de) 1993-07-28
YU48507B (sh) 1998-09-18
FI86062B (fi) 1992-03-31
CN1028101C (zh) 1995-04-05
CS275851B6 (en) 1992-03-18
NZ228772A (en) 1990-09-26
DK172655B1 (da) 1999-04-12
YU81089A (en) 1990-06-30
SU1704632A3 (ru) 1992-01-07
AT390060B (de) 1990-03-12
EG20136A (en) 1997-07-31
ATE92056T1 (de) 1993-08-15
PH27581A (en) 1993-08-18
FI892051A0 (fi) 1989-04-28
FI86062C (fi) 1992-07-10
CA1333177C (en) 1994-11-22
US5138072A (en) 1992-08-11
ZA892791B (en) 1989-12-27
DD283818A5 (de) 1990-10-24
JPH01313474A (ja) 1989-12-18
CN1037511A (zh) 1989-11-29
NO891679D0 (no) 1989-04-24
IL89902A0 (en) 1989-12-15
JP2785132B2 (ja) 1998-08-13
AU614058B2 (en) 1991-08-15
DK211189A (da) 1989-11-03
DK211189D0 (da) 1989-05-01
ATA112388A (de) 1989-08-15
DE58905010D1 (de) 1993-09-02
KR970000685B1 (ko) 1997-01-18
MY103874A (en) 1993-09-30
GR3008623T3 (ko) 1993-10-29
AU3380189A (en) 1989-11-02
FI892051A (fi) 1989-11-03

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