FI77448C - Foerfarande foer framstaellning av terapeutiskt anvaendbara 1-fenyl-2-piperidinopropanolderivat. - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara 1-fenyl-2-piperidinopropanolderivat. Download PDF

Info

Publication number
FI77448C
FI77448C FI833713A FI833713A FI77448C FI 77448 C FI77448 C FI 77448C FI 833713 A FI833713 A FI 833713A FI 833713 A FI833713 A FI 833713A FI 77448 C FI77448 C FI 77448C
Authority
FI
Finland
Prior art keywords
group
mixture
added
evaporated
carbon atoms
Prior art date
Application number
FI833713A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI833713A0 (fi
FI833713L (fi
FI77448B (fi
Inventor
Alexander Wick
Jonathan Frost
Jean Bertin
Bernard Gaudilliere
Regis Dupont
Jean Rousseau
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of FI833713A0 publication Critical patent/FI833713A0/fi
Publication of FI833713L publication Critical patent/FI833713L/fi
Application granted granted Critical
Publication of FI77448B publication Critical patent/FI77448B/fi
Publication of FI77448C publication Critical patent/FI77448C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
FI833713A 1982-10-13 1983-10-12 Foerfarande foer framstaellning av terapeutiskt anvaendbara 1-fenyl-2-piperidinopropanolderivat. FI77448C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8217187A FR2534580A1 (fr) 1982-10-13 1982-10-13 Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
FR8217187 1982-10-13

Publications (4)

Publication Number Publication Date
FI833713A0 FI833713A0 (fi) 1983-10-12
FI833713L FI833713L (fi) 1984-04-14
FI77448B FI77448B (fi) 1988-11-30
FI77448C true FI77448C (fi) 1989-03-10

Family

ID=9278253

Family Applications (1)

Application Number Title Priority Date Filing Date
FI833713A FI77448C (fi) 1982-10-13 1983-10-12 Foerfarande foer framstaellning av terapeutiskt anvaendbara 1-fenyl-2-piperidinopropanolderivat.

Country Status (22)

Country Link
US (1) US4690931A (en, 2012)
EP (1) EP0109317B1 (en, 2012)
JP (1) JPS5989660A (en, 2012)
AR (1) AR241267A1 (en, 2012)
AT (1) ATE24490T1 (en, 2012)
AU (1) AU559698B2 (en, 2012)
CA (1) CA1228855A (en, 2012)
CS (1) CS357791A3 (en, 2012)
DE (1) DE3368610D1 (en, 2012)
DK (1) DK164593C (en, 2012)
ES (1) ES526381A0 (en, 2012)
FI (1) FI77448C (en, 2012)
FR (1) FR2534580A1 (en, 2012)
GR (1) GR78949B (en, 2012)
HU (1) HU190509B (en, 2012)
IE (1) IE56085B1 (en, 2012)
IL (1) IL69955A (en, 2012)
MX (1) MX156053A (en, 2012)
NO (1) NO158461C (en, 2012)
NZ (1) NZ205938A (en, 2012)
PT (1) PT77488B (en, 2012)
ZA (1) ZA837598B (en, 2012)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2581993B1 (fr) * 1985-05-14 1988-03-18 Synthelabo Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique
ZA864772B (en) * 1985-07-02 1987-02-25 Merrell Dow Pharma Novel chemical compounds
WO1987000433A1 (en) * 1985-07-24 1987-01-29 Grelan Pharmaceutical Co., Ltd. Circulation improving agent
JPS6345230A (ja) * 1986-04-01 1988-02-26 Central Glass Co Ltd ブロモベンゾトリフルオリドの製造方法
JP2573195B2 (ja) * 1986-09-30 1997-01-22 エーザイ株式会社 環状アミン誘導体
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
FR2654341B1 (fr) * 1989-11-14 1994-09-23 Synthelabo Utilisation d'ifenprodil et de ses derives pour la fabrication de medicaments antipsychotiques.
DK0554247T3 (da) * 1990-05-10 2000-08-07 Pfizer Neurobeskyttende indolon og beslægtede derivater
FR2672286B1 (fr) * 1991-01-31 1994-11-18 Synthelabo Derives de 1-(4-chlorophenyl)-2-[4-(phenylmethyl)piperidin-1-yl]ethanol, leur preparation et leur application en therapeutique.
WO1992018502A1 (en) * 1991-04-18 1992-10-29 Pfizer Inc. Prodrug esters of phenolic 2-piperidino-1-alkanols
ES2060547B1 (es) * 1992-06-04 1995-06-16 Ferrer Int Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina".
FR2694555A1 (fr) * 1992-08-05 1994-02-11 Synthelabo Procédé de péparation des énantiomères du 1-(4-chloro-2-hydroxyphényl)-2-[4-[(4-fluorophényl)méthyl]-piperidin-1-yl]éthanol.
FR2696741B1 (fr) * 1992-10-12 1994-11-25 Synthelabo Dérivés de 1-(4-chlorophényl)-2-[4-[(4-fluorophényl)méthyl]piperidin-1-yl] éthanol, leur préparation et leur application en thérapeutique.
FR2697251B1 (fr) * 1992-10-22 1994-12-02 Synthelabo N-oxydes de dérivés de 1-(4-chlorophényl)-2-[4-[(4-fluorophényl)méthyl] pipéridin-1-yl]éthanol, leur procédé de préparation et leur application en thérapeutique.
BR9307331A (pt) * 1992-10-30 1999-05-25 Pfizer Compostos neuroprotetores 3,4-dihidro-2(1ho-quinolona
FR2699534B1 (fr) * 1992-12-21 1995-02-03 Synthelabo Dérivés de alpha-thiényl-pipéridine-1-éthanol, leur préparation et leur application en thérapeutique.
FR2717080B1 (fr) * 1994-03-09 1996-12-13 Synthelabo Utilisation de l'éliprodil et de ses énantiomères pour la préparation de médicaments utiles dans le traitement des neuropathies périphériques et des maladies neurodégénératives centrales.
DE4410822A1 (de) * 1994-03-24 1995-09-28 Schering Ag Neue Piperidin-Derivate
US5710165A (en) * 1994-07-06 1998-01-20 Synthelabo Use of polyamine antagonists for the treatment of glaucoma
FR2722497B1 (fr) * 1994-07-13 1996-08-14 Synthelabo Esters de alpha-4-chlorophenyl)-4-(4-fluorophenyl)methyl) piperidine-1-ethanol, leur preparation et leur application en therapeutique
FR2722987B1 (fr) * 1994-07-29 1997-05-16 Synthelabo Utilisation de l'eliprodil et de ses enantiomeres pour la preparation de medicaments utiles dans la prevention des neuropathiesinduites par des agentsanticancereux
FR2728568B1 (fr) 1994-12-23 1997-04-11 Synthelabo Intermediaires de synthese des enantiomeres de l'eliprodil et leur procede de preparation
FR2733422B1 (fr) * 1995-04-28 1997-05-30 Synthelabo Compositions pharmaceutiques a base d'eliprodil et d'un agent thrombolytique et leur application en therapeutique
US5604244A (en) * 1995-06-07 1997-02-18 Alcon Laboratories, Inc. Intraocular irrigating solution containing a polyamine antagonist
FR2738567B1 (fr) * 1995-09-08 1997-10-17 Synthelabo Derives de alpha-phenylpiperidine-1-propanol, leur preparation et leur application en therapeutique
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
WO1997018812A1 (en) * 1995-11-17 1997-05-29 Alcon Laboratories, Inc. Combination therapy for treating glaucoma
AU716670B2 (en) * 1996-01-02 2000-03-02 Sanofi-Aventis Use of polyamine site antagonist for the manufacture of a medicament for the treatment of ischemic disorders of the eye
DE69614577D1 (de) * 1996-11-06 2001-09-20 Alcon Lab Inc Polyamin-antagonisten enthaltende intraokulare irrigationslösung
US6380261B1 (en) * 1997-06-30 2002-04-30 Allergan Sales, Inc. Calcium blockers to treat proliferative vitreoretinopathy
GB9804885D0 (en) 1998-03-06 1998-04-29 Merck Sharp & Dohme Therapeutic combination
KR20020002356A (ko) 1998-10-27 2002-01-09 제임스 에이. 아노 외부 망막 손상의 치료
US6200990B1 (en) 1998-12-21 2001-03-13 Alcon Laboratories, Inc. Neuroprotective agents having antioxidant and NMDA antagonist activity
US6806285B1 (en) 2000-03-17 2004-10-19 Alcon, Inc. 5-Hydroxyl indole derivatives for treating glaucoma
US7005443B1 (en) 2000-03-17 2006-02-28 Alcon, Inc. 5-Hydroxy indazole derivatives for treating glaucoma
US6927233B1 (en) 2000-03-17 2005-08-09 Alcon, Inc. 5ht2 agonists for controlling IOP and treating glaucoma
US7012090B1 (en) 2000-03-17 2006-03-14 Alcon, Inc. Pyranoindoles for treating glaucoma
AU2001219185A1 (en) 2000-03-17 2001-10-03 Alcon, Inc. 2-acylaminobenzimidazole derivatives for treating glaucoma
US6956036B1 (en) 2000-03-17 2005-10-18 Alcon, Inc. 6-hydroxy-indazole derivatives for treating glaucoma
US20030119846A1 (en) * 2000-03-17 2003-06-26 Collier Jr Robert J. Compounds with 5-ht activity useful for controlling visual field loss
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
WO2004098807A1 (en) * 2000-11-21 2004-11-18 Barsplice Products, Inc. Method of making steel couplers for joining concrete reinforcing bars
US6833457B1 (en) * 2001-01-18 2004-12-21 Takeda Chemical Industries, Ltd. Process for preparation of benzylpiperidine compounds
US20030212107A1 (en) * 2001-05-10 2003-11-13 Kapin Michael A. R-reliprodil for treating glaucoma
CA2447156A1 (en) * 2001-06-01 2002-12-12 Alcon, Inc. Novel fused indazoles and indoles and their use for the treatment of glaucoma
CA2447479A1 (en) * 2001-06-01 2002-12-12 Alcon, Inc. Novel arylaminopropane analogues and their use for the treatment of glaucoma
BR0210241A (pt) * 2001-06-01 2004-08-10 Alcon Inc Piranoindazóis e seu uso no tratamento de glaucoma
US6884816B2 (en) * 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
US20040254230A1 (en) * 2001-12-03 2004-12-16 Ogidigben Miller J. Method for treating ocular hypertension
US20040110776A1 (en) * 2002-02-22 2004-06-10 Iok-Hou Pang Use of propentofylline to control intraocular pressure
JP4766875B2 (ja) 2002-06-06 2011-09-07 メルク フロスト カナダ リミテツド Ｅｐ４受容体作動薬、組成物及びその方法
JP2005534653A (ja) * 2002-06-06 2005-11-17 メルク フロスト カナダ アンド カンパニー 眼及び骨疾患の治療に於いてｅｐ４受容体作動薬として使用するための１，５−二置換イミダゾリジン−２−オン誘導体
WO2004019938A1 (en) * 2002-08-28 2004-03-11 Merck Frosst Canada & Co. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
WO2004043354A2 (en) * 2002-11-08 2004-05-27 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
US7196082B2 (en) 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
MXPA05004738A (es) * 2002-11-12 2005-08-03 Alcon Inc Inhibidores de histona deacetilasa para tratar enfermedades degenerativas del ojo.
US20080004311A1 (en) * 2002-11-12 2008-01-03 Alcon, Inc. Histone deacetylase inhibitors for treating degenerative diseases of the eye
US7053085B2 (en) * 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
CA2506204A1 (en) * 2002-12-13 2004-07-01 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
AU2004253543B2 (en) * 2003-07-01 2009-02-19 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
EP1664011A4 (en) * 2003-09-02 2009-02-25 Merck & Co Inc OPHTHALMIC COMPOSITIONS FOR THE TREATMENT OF OCCULAR HYPERTONIA
CN102558231B (zh) * 2003-09-04 2015-05-27 默沙东公司 用于治疗高眼压的眼用组合物
CA2537430A1 (en) * 2003-09-04 2005-03-24 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
US7476687B2 (en) * 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
WO2005051919A1 (en) * 2003-11-26 2005-06-09 Pfizer Products Inc. Aminopyrazole derivatives as gsk-3 inhibitors
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
AR046890A1 (es) * 2003-12-15 2005-12-28 Alcon Inc [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma.
KR20110091600A (ko) * 2004-04-26 2011-08-11 알콘, 인코퍼레이티드 고안압증과 녹내장의 치료용 스타틴
AU2005274972A1 (en) 2004-07-20 2006-02-23 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
US7425572B2 (en) * 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
US20060293378A1 (en) * 2005-06-28 2006-12-28 Mcintire Gregory Method of lowering intraocular pressure
GB2428675A (en) * 2005-07-29 2007-02-07 Arakis Ltd Ifenprodil derivatives
CA2616608A1 (en) * 2005-08-03 2007-02-08 Merck Frosst Canada Ltd. Ep4 receptor agonist, compositions and methods thereof
GB2430433A (en) * 2005-09-21 2007-03-28 Arakis Ltd Preparation & purification of 1-[4-(4-benzyloxy)phenyl]-2-(4-benzylpiperidin-1-yl)-1-propanone, & use thereof in stereospecific preparation of ifenprodil
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
JP2009533326A (ja) * 2006-03-13 2009-09-17 メルク エンド カムパニー インコーポレーテッド 高眼圧症の治療用眼科用組成物
AU2007258527A1 (en) * 2006-06-12 2007-12-21 Merck Sharp & Dohme Corp. Ophthalmic compositions for treating ocular hypertension
CN100448846C (zh) * 2006-12-04 2009-01-07 清华大学 一种催化氢化酰基吡啶为取代哌啶化合物盐酸盐的方法
UY30883A1 (es) * 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
WO2010112615A1 (en) 2009-04-03 2010-10-07 Dsm Ip Assets B.V. Lysine derivatives functionalised with lipids
US8648198B2 (en) * 2011-01-19 2014-02-11 Cold Spring Harbor Laboratory Phenylethanolamine-based NMDA receptor antagonists
EP3223793B1 (en) 2014-11-25 2023-06-28 Eximore Ltd. Compositions and methods for delivering a bio-active agent or bio-active agents
WO2017093354A1 (en) 2015-11-30 2017-06-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Nmdar antagonists for the treatment of diseases associated with angiogenesis
CN108623491B (zh) * 2017-03-24 2020-12-22 联化科技股份有限公司 一种卤代苯甲酰胺化合物的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5733M (en, 2012) * 1966-09-27 1968-01-22
GB1321701A (en) * 1969-10-01 1973-06-27 Continental Pharma Amino-alcohols their salts and process for prepairing the same
IE34545B1 (en) * 1969-10-01 1975-06-11 Continental Pharma Amino-alcohols,their salts and process for preparing the same
US3867455A (en) * 1970-06-02 1975-02-18 Allen & Hanburys Ltd Preparation of phenylaminoethanols
FR2105119A1 (en) * 1970-09-29 1972-04-28 Synthelabo Analgesic piperidino ethanol deriv - 1-parabenzyloxyphenyl -2-4-benzylpiperidinoethanol
AT310146B (de) * 1971-04-26 1973-09-25 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen N,N'-Bis-(β-hydroxyaryläthyl)-diaminoalkanen und deren Säureadditionssalzen
FR2163358A1 (en) * 1971-12-15 1973-07-27 Synthelabo Phenylalkanolamine derivs - with effects on the smooth musculature
US3870715A (en) * 1972-03-09 1975-03-11 Nikolaus R Hansl Substituted amino ethyl meta benzoic acid esters
US4018825A (en) * 1972-07-27 1977-04-19 Warner-Lambert Company 5-Hydroxy-α-(substituted aminomethyl)-m-xylene-α,α'-diols
FR2208901A1 (en) * 1972-12-04 1974-06-28 Rhone Poulenc Sa Alpha-(4-substd pyridino)-4-benzyloxypropiophenones - as inters for cardiovascular 1-(4-hydroxy-phenyl)-2-(4-substd piperidino) propan-1-ols
GB1390748A (en) * 1973-04-09 1975-04-16 Continental Pharma Alkyl and cycloalkylthiophenylalkylaminoalkanols their salts and the preparation thereof
US4011258A (en) * 1973-06-21 1977-03-08 Aktiebolaget Draco Orally active bronchospasmolytic compounds
GB2067187B (en) * 1979-12-07 1983-11-30 Cosmos Enterprise Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid addition salts thereof
IT1148741B (it) * 1980-11-28 1986-12-03 Zambeletti Spa L Procedimento per la preparazione dell'1-(3,5-dimetossi-4-idrossifenil)-2-(n-metilammino)etanolo cloridrato
FR2503705A1 (fr) * 1981-04-14 1982-10-15 Synthelabo Derives de phenethanolamine, leur preparation et leur application en therapeutique
JPS5896067A (ja) * 1981-12-01 1983-06-07 Hamari Yakuhin Kogyo Kk エリスロ１−（４−ヒドロキシフエニル）−２−（４−ベンジルピペリジノ）−１−プロパノ−ルの製造法およびその中間体

Also Published As

Publication number Publication date
FR2534580B1 (en, 2012) 1985-05-17
NZ205938A (en) 1985-11-08
JPS6158472B2 (en, 2012) 1986-12-11
FI833713A0 (fi) 1983-10-12
AU559698B2 (en) 1987-03-19
IL69955A (en) 1987-01-30
IE56085B1 (en) 1991-04-10
CA1228855A (en) 1987-11-03
ZA837598B (en) 1984-06-27
US4690931A (en) 1987-09-01
EP0109317A3 (en) 1984-08-08
PT77488B (fr) 1986-05-07
HU190509B (en) 1986-09-29
NO158461C (no) 1988-09-14
NO158461B (no) 1988-06-06
IL69955A0 (en) 1984-01-31
DE3368610D1 (en) 1987-02-05
AR241267A1 (es) 1992-04-30
DK470583D0 (da) 1983-10-12
DK164593B (da) 1992-07-20
DK470583A (da) 1984-04-14
DK164593C (da) 1992-12-07
FR2534580A1 (fr) 1984-04-20
CS357791A3 (en) 1992-04-15
ES8405766A1 (es) 1984-06-16
EP0109317B1 (fr) 1986-12-30
AU2011183A (en) 1984-04-19
ES526381A0 (es) 1984-06-16
FI833713L (fi) 1984-04-14
GR78949B (en, 2012) 1984-10-02
ATE24490T1 (de) 1987-01-15
PT77488A (fr) 1983-11-01
JPS5989660A (ja) 1984-05-23
MX156053A (es) 1988-06-22
FI77448B (fi) 1988-11-30
IE832405L (en) 1984-04-13
EP0109317A2 (fr) 1984-05-23
NO833705L (no) 1984-04-16

Similar Documents

Publication Publication Date Title
FI77448C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 1-fenyl-2-piperidinopropanolderivat.
US4711899A (en) 2-(4-benzoyl-1-piperidyl)-1-phenylalkanol derivatives
US4259338A (en) Benzofuranyl-tetrahydropyridines and -piperidines, their acid addition salts and antidepressant preparations thereof
Moffett Central nervous system depressants. VII. 1 pyridyl coumarins
JPS582936B2 (ja) ５↓−アロイルピロ−ル酢酸およびその塩類の製法
BG60270B2 (bg) Метод за получаване на 5н-2,3-бензодиазепинови производни
US4294841A (en) Derivatives of 1-phenyl 3-(4-piperidyl) 1-propanone usable as drugs
HU199425B (en) Process for producing alpha-alkyl-/4-amino-3-quinolinyl/-methanols and 1-square brackets open 4-/aralkylamino/-3-quinolinyl square brackets closed -alkanones, as well as pharmaceutical compositions comprising such compounds as active ingredient
GB1592996A (en) Acylated pyrrole carboxylic acids and derivatives thereof
FI77224B (fi) Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara aminopropanolderivat av 2-hydroxi- -fenylpropiofenoner.
AU644296B2 (en) 2-(1-piperidyl)ethanol derivatives, their preparation and their therapeutic application
CA2043136C (en) N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them
HK78895A (en) Substituted 1H-imidazoles
CA1119613A (en) Process for preparing benzylidene derivatives
US4598086A (en) α2 antagonistic 2-(4,5-dihydro-2-1H-imidazolyl)-2,3-dihydro-1H-indoles
HU189765B (en) Process for preparing n-substituted 1-(bis (hydroxy-metiol)-methyl)-isoquinoline-derivatives
JPH07119188B2 (ja) カルコン誘導体
US4101660A (en) 2-Aminomethyl-5-phenyloxazoles and the pharmaceutically acceptable acid addition salts thereof
US4432984A (en) Anti-hypertensive benzodioxan derivatives
US4283404A (en) Aroylethenylpiperidinobutyrophenone antipsychotic agents
JPS6026387B2 (ja) シンナミルモラノリン誘導体
DK167921B1 (da) 4-arylcarbonyl-1-oe(4-morpholinyl)-lavere alkylaa-1h-indoler, fremgangsmaade til fremstilling heraf, analgetiske praeparater indeholdende saadanne forbindelser og anvendelsen af disse forbindelser til fremstilling af farmaceutiske praeparater mod smerte
US4123541A (en) 2-Aminomethyl-5-phenyloxazoles and the pharmaceutically acceptable salts thereof
JPS62190156A (ja) ベンゼン融合β−ジケトシクロアルキレンの対称性Ｏ−置換ジオキシム、それらの調製方法およびそれらの薬物への適用
CA2197811C (en) Intermediates in process for the preparation of n-substituted trifluoromethylphenyltetrahy-dropydrines

Legal Events

Date Code Title Description
MA Patent expired

Owner name: SANOFI-SYNTHELABO