FI77228B - Foerfarande foer framstaellning av farmaceutiskt anvaendbara indolderivat. - Google Patents

Foerfarande foer framstaellning av farmaceutiskt anvaendbara indolderivat. Download PDF

Info

Publication number
FI77228B
FI77228B FI842615A FI842615A FI77228B FI 77228 B FI77228 B FI 77228B FI 842615 A FI842615 A FI 842615A FI 842615 A FI842615 A FI 842615A FI 77228 B FI77228 B FI 77228B
Authority
FI
Finland
Prior art keywords
hydrogen
compound
alkyl
formula
compounds
Prior art date
Application number
FI842615A
Other languages
English (en)
Finnish (fi)
Other versions
FI842615A (fi
FI77228C (sv
FI842615A0 (fi
Inventor
Faizulla Gulamhusein Kathawala
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of FI842615A publication Critical patent/FI842615A/fi
Publication of FI842615A0 publication Critical patent/FI842615A0/fi
Publication of FI77228B publication Critical patent/FI77228B/fi
Application granted granted Critical
Publication of FI77228C publication Critical patent/FI77228C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (9)

1. Förfarande för framställning av farmaceutiskt an-vändbara indolderivat med formeln I :p:V 10 / [ R3 % väri den ena av grupperna R och Rq är 15 rc 5a och den andra är en primär eller sekundär Ci_6~alkyl/
20 C3_g-sykloalkyl eller fenyl-(CH2)m~, väri R4 är vätef C-^-alkyl, trifluormetyl, fluor, klor eller fenoxi, R^ är väte, C^^-alkyl, trif luormetyl, fluor, klor eller fenoxi,
25 R^a är väte, C^_2_alkyl, fluor eller klor, och m är 1 eller 2, förutsatt, att högst den ena av grupperna R4 och R^ är trifluormetyl och högst den ena av grupperna R4 och R^ är fenoxi,
30 R2 är väte, C1_4~alkyl, C3_g-cykloalkyl, C-L_4~alkoxi (med undantag av t-butoxi), fluor, klor eller bensyloxi, och R3 är väte, C3_3~alkyl, C-L_3-alkoxi, fluor, klor eller bensyloxi, förutsatt, att högst den ena av grupperna R2 och R3 är bensyloxi,
35 X är -CH=CH- eller ”(CH2^n~' var^ n är 2 eller 3, och 68 7 7 2 2 8 Z är R- |6 -CH-CH~-C-CHo-C00H II I 2 I 2 OH OH väri Rg är väte eller C^_3~alkyl, i form av fria syror 5 eller fysiologiskt hydrolyserbara godtagbara estrar eller &-laktoner eller salter därav, kännetecknat därav, att man a) dii Rg är väte, reducerar en förening med formeln V R R 10 ff X\— X-CH-XH--C-CH--COOR, , V U 1 / I 2 ii 2 11 oh 0 15 väri R^ är en radikal som bildar en fysiologiskt hydroly-serbar och godtagbar ester och X, R, Rq ooh R^ är som ovan definierats, b) dä Rg är C1_2~alkyl, hydrolyserar en förening med formeln XII
20 R ? WV l6i I X-CH-CH2-C-CH2-COOR11 P7^Y ? R3 1 C=0 R I
25. R12 väri Rga är C1_3~alkyl, R12 är en esterbildande grupp och X, R, R , R, och R,, är som ovan definierats, o 3 11 c) dä X är -CH=CH-, avlägsnar skyddet i en förening 30 med formeln XXVIII R VyVc.-<. — XXVI11 r3 k Λ^Γ
FI842615A 1982-11-22 1984-06-28 Förfarande för framställning av farmaceutiskt användbara indolderivat FI77228C (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US44366882A 1982-11-22 1982-11-22
US44366882 1982-11-22
US54885083A 1983-11-04 1983-11-04
US54885083 1983-11-04
PCT/EP1983/000308 WO1984002131A1 (en) 1982-11-22 1983-11-18 Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
EP8300308 1983-11-18

Publications (4)

Publication Number Publication Date
FI842615A FI842615A (fi) 1984-06-28
FI842615A0 FI842615A0 (fi) 1984-06-28
FI77228B true FI77228B (fi) 1988-10-31
FI77228C FI77228C (sv) 1989-02-10

Family

ID=27033614

Family Applications (1)

Application Number Title Priority Date Filing Date
FI842615A FI77228C (sv) 1982-11-22 1984-06-28 Förfarande för framställning av farmaceutiskt användbara indolderivat

Country Status (18)

Country Link
EP (1) EP0114027B1 (sv)
JP (1) JPH0347167A (sv)
AT (1) ATE31718T1 (sv)
AU (1) AU570021B2 (sv)
CA (1) CA1210405A (sv)
CY (1) CY1579A (sv)
DE (2) DE19475017I2 (sv)
DK (2) DK359284A (sv)
FI (1) FI77228C (sv)
GR (1) GR79042B (sv)
HK (1) HK11191A (sv)
HU (1) HU204253B (sv)
IE (1) IE56262B1 (sv)
IL (1) IL70286A (sv)
LU (1) LU88670I2 (sv)
NL (1) NL950022I2 (sv)
NZ (1) NZ206338A (sv)
WO (1) WO1984002131A1 (sv)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5354772A (en) * 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
US4613610A (en) * 1984-06-22 1986-09-23 Sandoz Pharmaceuticals Corp. Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
US5001255A (en) * 1984-12-04 1991-03-19 Sandoz Pharm. Corp. Idene analogs of mevalonolactone and derivatives thereof
JPS62501009A (ja) * 1984-12-04 1987-04-23 サンド・アクチエンゲゼルシヤフト メバロノラクトンのインデン同族体及びその誘導体
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
WO1987002662A2 (en) * 1985-10-25 1987-05-07 Sandoz Ag Heterocyclic analogs of mevalonolactone and derivatives thereof, processes for their production and their use as pharmaceuticals
US4851427A (en) * 1985-10-25 1989-07-25 Sandoz Pharm. Corp. Pyrrole analogs of mevalonolactone, derivatives thereof and pharmaceutical use
NZ221717A (en) * 1986-09-10 1990-08-28 Sandoz Ltd Azaindole and indolizine derivatives and pharmaceutical compositions
US4751235A (en) * 1986-12-23 1988-06-14 Sandoz Pharm. Corp. Anti-atherosclerotic indolizine derivatives
US4735958A (en) * 1986-12-22 1988-04-05 Warner-Lambert Company Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-substituted-1H-pyrrol-1-yl]-ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one inhibitors of cholesterol biosynthesis
US4898949A (en) * 1987-02-25 1990-02-06 Bristol-Myers Company Intermediates for the preparation of antihypercholesterolemic tetrazole compounds
US4897490A (en) * 1987-02-25 1990-01-30 Bristol-Meyers Company Antihypercholesterolemic tetrazole compounds
US4894386A (en) * 1987-04-15 1990-01-16 Ici Americas Inc. Aliphatic carboxamides
US4904646A (en) * 1987-05-22 1990-02-27 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-COA reductase inhibitors
US5091378A (en) * 1987-05-22 1992-02-25 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method
US5185328A (en) * 1987-08-20 1993-02-09 Nissan Chemical Industries Ltd. Quinoline type mevalonolactones useful for treating hyperlipidemia, hyperlipoproteinemia or atherosclerosis
JP2569746B2 (ja) * 1987-08-20 1997-01-08 日産化学工業株式会社 キノリン系メバロノラクトン類
CA1336714C (en) * 1987-08-20 1995-08-15 Yoshihiro Fujikawa Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
DE3739882A1 (de) * 1987-11-25 1989-06-08 Bayer Ag Substituierte hydroxylamine
US4868185A (en) * 1987-12-10 1989-09-19 Warner-Lambert Company 6-[[Substituted)pyrimidinyl)ethyl]- and ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4822799A (en) * 1988-01-27 1989-04-18 Sandoz Pharm. Corp. Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals
KR890011876A (ko) * 1988-01-27 1989-08-23 메이 앤드 베이커 리미팃드 신규한 이소퀴놀린 유도체 그의 제조방법 및 그를 함유하는 제약학적 조성물
NO890522L (no) * 1988-02-25 1989-08-28 Bayer Ag Substituerte imidazolinoner og imidazolinthioner.
JP2890448B2 (ja) * 1988-04-26 1999-05-17 日産化学工業株式会社 ピラゾロピリジン系メバロノラクトン類
US5024999A (en) * 1988-04-26 1991-06-18 Nissan Chemical Industries Ltd. Pyrazolopyridine type mevalonolactones useful as pharmaeuticals
US5010205A (en) * 1988-08-23 1991-04-23 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl intermediates
US4870187A (en) * 1988-08-23 1989-09-26 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl compounds
NZ230121A (en) * 1988-08-29 1993-08-26 Squibb & Sons Inc Pyridine and quinoline terminal groups for hmg-coenzyme a reductase inhibitors and pharmaceutical compositions for lowering blood serum cholesterol levels
US5506219A (en) * 1988-08-29 1996-04-09 E. R. Squibb & Sons, Inc. Pyridine anchors for HMG-CoA reductase inhibitors
JP2853227B2 (ja) * 1988-10-13 1999-02-03 ノバルテイス・アクチエンゲゼルシヤフト ７置換‐ヘプト‐６‐エン酸、ヘプタン酸及び誘導体並びにそれらの中間体の製法
JPH04270285A (ja) * 1988-11-14 1992-09-25 Nissan Chem Ind Ltd ピラゾロピリミジン系メバロノラクトン類
DE3911064A1 (de) * 1989-04-06 1990-10-11 Bayer Ag Substituierte 1,8-naphthyridine
FI94339C (sv) 1989-07-21 1995-08-25 Warner Lambert Co Förfarande för framställning av farmaceutiskt användbar /R-(R*,R*)/-2-(4-fluorfenyl)- , -dihydroxi-5-(1-metyletyl)-3-fenyl-4-/(fenylamino)karbonyl/-1H-pyrrol-1-heptansyra och farmaceutiskt användbara salter därav
GB8919091D0 (en) * 1989-08-22 1989-10-04 Fujisawa Pharmaceutical Co Pyrroloquinoline compounds
IT1237792B (it) * 1989-12-21 1993-06-17 Zambon Spa Composti attivi come inibitori dell'enzima hmg-coa reduttasi
HU9203780D0 (en) * 1991-12-12 1993-03-29 Sandoz Ag Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
DE4243279A1 (de) * 1992-12-21 1994-06-23 Bayer Ag Substituierte Triole
JP2736599B2 (ja) * 1993-07-23 1998-04-02 株式会社キッツ ボールバルブのシート構造
US6425881B1 (en) 1994-10-05 2002-07-30 Nitrosystems, Inc. Therapeutic mixture useful in inhibiting lesion formation after vascular injury
WO1997049681A1 (en) * 1996-06-24 1997-12-31 Astra Aktiebolag (Publ) Polymorphic compounds
CA2291026A1 (en) 1997-06-05 1998-12-10 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
US7939105B2 (en) 1998-11-20 2011-05-10 Jagotec Ag Process for preparing a rapidly dispersing solid drug dosage form
US6242003B1 (en) 2000-04-13 2001-06-05 Novartis Ag Organic compounds
US6743926B2 (en) 2000-05-26 2004-06-01 Ciba Specialty Chemicals Corporation Process for the preparation of indole derivatives and intermediates of the process
US20060127474A1 (en) 2001-04-11 2006-06-15 Oskar Kalb Pharmaceutical compositions comprising fluvastatin
MXPA03009562A (es) 2001-04-18 2004-02-12 Genzyme Corp METODO PARA TRATAR EL SiNDROME X CON POLIAMINAS ALIFATICAS.
CN102516150A (zh) * 2001-08-03 2012-06-27 西巴特殊化学品控股有限公司 氟伐他汀钠的晶形
US6696473B2 (en) 2001-12-21 2004-02-24 X-Ceptor Therapeutics, Inc. Heterocyclic modulators of nuclear receptors
JP2005528392A (ja) 2002-04-12 2005-09-22 メルク　エンド　カムパニー　インコーポレーテッド チロシンキナーゼ阻害剤
US7312353B2 (en) 2003-08-21 2007-12-25 Merck Frost Canada & Co. Cathespin cysteine protease inhibitors
EP1510208A1 (en) 2003-08-22 2005-03-02 Fournier Laboratories Ireland Limited Pharmaceutical composition comprising a combination of metformin and statin
CN100404479C (zh) * 2003-08-27 2008-07-23 住友化学株式会社 芳族不饱和化合物的制备方法
US8227434B1 (en) 2003-11-04 2012-07-24 H. Lee Moffitt Cancer Center & Research Institute, Inc. Materials and methods for treating oncological disorders
US7709508B2 (en) 2004-12-09 2010-05-04 Merck Sharp & Dohme Estrogen receptor modulators
AU2005314230B2 (en) * 2004-12-09 2011-05-19 Merck Sharp & Dohme Corp. Estrogen receptor modulators
JP2008531691A (ja) 2005-03-02 2008-08-14 メルク エンド カムパニー インコーポレーテッド カテプシンｋ阻害組成物
AU2006261845C1 (en) 2005-06-27 2013-05-16 Exelixis Patent Company Llc Imidazole based LXR modulators
EP1912953B1 (en) 2005-07-28 2016-08-17 LEK Pharmaceuticals d.d. Process for the synthesis of rosuvastatin calcium
WO2007059372A2 (en) 2005-11-09 2007-05-24 St. Jude Children's Research Hospital Use of chloroquine to treat metabolic syndrome
US7553854B2 (en) 2006-04-19 2009-06-30 Novartis Vaccines And Diagnostics, Inc. 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling
DE602006006899D1 (de) 2006-04-20 2009-07-02 Italiana Sint Spa Verfahren zur Herstellung von Fluvastatin-Natrium
RS53461B (en) 2006-07-05 2014-12-31 Takeda Gmbh COMBINATION OF HMG-COA REDUCTASE INHIBITOR OR SIMVASTATIN WITH PHOSPHODIESTERASE 4 INHIBITOR AS A ROFLUMILAST FOR THE TREATMENT OF INFLAMMATORY PULMONARY DISEASES
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
MX2009009304A (es) 2007-03-01 2009-11-18 Novartis Ag Inhibidores de cinasa pim y metodos para su uso.
US8293769B2 (en) 2007-05-21 2012-10-23 Novartis Ag CSF-1R inhibitors, compositions, and methods of use
ES2330184B1 (es) 2008-06-03 2010-07-05 Neuron Biopharma, S.A. Uso de estatinas como anticonvulsivantes, antiepilepticos y neuroprotectores.
SI2373609T1 (sl) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
CA2761934C (en) 2009-05-28 2018-01-09 Exelixis Patent Company Llc Substituted 1-(biphenyl-4-yl)-2-benzyl-4-hydroxyalkyl-1h-imidazole compounds and their use as lxr modulators
WO2010144909A1 (en) 2009-06-12 2010-12-16 Novartis Ag Fused heterocyclic compounds and their uses
AU2010343102B2 (en) 2009-12-29 2016-03-24 Dana-Farber Cancer Institute, Inc. Type II Raf kinase inhibitors
US8987275B2 (en) 2010-03-16 2015-03-24 Dana-Farber Cancer Institute, Inc. Indazole compounds and their uses
US8372877B2 (en) 2010-04-16 2013-02-12 Cumberland Pharmaceuticals Stabilized statin formulations
EP2626069A4 (en) 2010-10-06 2014-03-19 Univ Tokyo A MEDICINAL PRODUCT FOR THE PREVENTION AND TREATMENT OF A DERY LYMPH
US8791162B2 (en) 2011-02-14 2014-07-29 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
TW201242953A (en) 2011-03-25 2012-11-01 Bristol Myers Squibb Co Imidazole prodrug LXR modulators
AU2012340200B2 (en) 2011-11-17 2017-10-12 Dana-Farber Cancer Institute, Inc. Inhibitors of c-Jun-N-Terminal Kinase (JNK)
BR112014016154A8 (pt) 2011-12-29 2017-07-04 Tufts College funcionalização de biomateriais para controlar respostas à regeneração e inflamação
US10112927B2 (en) 2012-10-18 2018-10-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
WO2014063061A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
US10000483B2 (en) 2012-10-19 2018-06-19 Dana-Farber Cancer Institute, Inc. Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
US9834542B2 (en) 2013-03-15 2017-12-05 Bristo-Myers Squibb Company LXR modulators
EP2810644A1 (en) 2013-06-06 2014-12-10 Ferrer Internacional, S.A. Oral formulation for the treatment of cardiovascular diseases
CA2923272A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
CA2927917C (en) 2013-10-18 2022-08-09 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of proliferative diseases
US10047070B2 (en) 2013-10-18 2018-08-14 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015164604A1 (en) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015164614A1 (en) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
JO3589B1 (ar) 2014-08-06 2020-07-05 Novartis Ag مثبطات كيناز البروتين c وطرق استخداماتها
JP6854762B2 (ja) 2014-12-23 2021-04-07 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤
EP3273966B1 (en) 2015-03-27 2023-05-03 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. ASSOCIATION THERAPY USING TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS
JP7028766B2 (ja) 2015-09-09 2022-03-02 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼの阻害剤

Also Published As

Publication number Publication date
JPH0347167A (ja) 1991-02-28
AU570021B2 (en) 1988-03-03
DK165244C (da) 1993-03-22
DK359284D0 (da) 1984-07-20
EP0114027B1 (en) 1988-01-07
NL950022I1 (sv) 1996-01-02
IL70286A0 (en) 1984-02-29
NZ206338A (en) 1987-08-31
HK11191A (en) 1991-02-13
GR79042B (sv) 1984-10-02
AU2261283A (en) 1984-06-18
HUT35642A (en) 1985-07-29
DK97890A (da) 1990-04-19
HU204253B (en) 1991-12-30
CY1579A (en) 1991-12-20
DE19475017I2 (de) 2003-02-20
IL70286A (en) 1987-08-31
FI842615A (fi) 1984-06-28
ATE31718T1 (de) 1988-01-15
DE3375137D1 (en) 1988-02-11
FI77228C (sv) 1989-02-10
FI842615A0 (fi) 1984-06-28
CA1210405A (en) 1986-08-26
LU88670I2 (fr) 1996-04-29
DK165244B (da) 1992-10-26
EP0114027A1 (en) 1984-07-25
NL950022I2 (nl) 1996-12-02
WO1984002131A1 (en) 1984-06-07
JPH0440343B2 (sv) 1992-07-02
DK97890D0 (da) 1990-04-19
IE832713L (en) 1984-05-22
IE56262B1 (en) 1991-06-05
DK359284A (da) 1984-07-20

Similar Documents

Publication Publication Date Title
FI77228B (fi) Foerfarande foer framstaellning av farmaceutiskt anvaendbara indolderivat.
US4739073A (en) Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
KR100192134B1 (ko) 융합된 페놀 유도체
US5354772A (en) Indole analogs of mevalonolactone and derivatives thereof
DK157543B (da) Pyrazolanaloge af mevalonolacton og derivater deraf samt deres anvendelse
JPH10505584A (ja) インドリジンｓＰＬＡ▲下２▼インヒビター
US4863957A (en) Novel HMG-CoA reductase inhibitors
JPH02250870A (ja) コレステロール生合成抑制性化合物
KR20040081161A (ko) ＨＭＧ-ＣｏＡ 환원효소 억제제의 제조 방법
EP0117228B1 (en) Analogs of mevalonolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
KR900009006B1 (ko) 메발로락톤의 동족체 및 그것의 유도체의 제조방법
US5093363A (en) 2,4,6-substituted phenol derivatives
US4870187A (en) Antihypercholesterolemic tetrazol-1-yl compounds
US5177104A (en) 6-α-hydroxy derivatives of mevinic acids
JP2965610B2 (ja) 置換されたフエニル類
US4892884A (en) Novel hmg-coa reductase inhibitors
FI96600B (sv) Som mellanprodukter användbara tetrazolföreningar
JPH0366668A (ja) イミノ置換ピリジン類
EP0658550A2 (en) Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds
FI96953B (sv) Tetrazolderivat och förfarande för deras framställning
FI103886B (sv) Förfarande för framställning av en aldehydmellanprodukt
US5010205A (en) Antihypercholesterolemic tetrazol-1-yl intermediates
US5070206A (en) Tetrazol-1-yl containing intermediates
WO1996019484A1 (fr) Nouveaux phosphonates derives de carboxamides, leur procede de fabrication et les compositions pharmaceutiques les contenant
EP0468974A1 (en) NOVEL HMG-CoA REDUCTASE INHIBITORS

Legal Events

Date Code Title Description
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L67

Extension date: 20080823

ND Supplementary protection certificate (spc) granted
PC Transfer of assignment of patent

Owner name: NOVARTIS AG

MA Patent expired

Owner name: NOVARTIS AG