FI68626B - Foerfarande foer framstaellning av nya terapeutiskt aktiva hydroxikarbonylfosfonsyraderivat - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt aktiva hydroxikarbonylfosfonsyraderivat Download PDF

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Publication number
FI68626B
FI68626B FI783932A FI783932A FI68626B FI 68626 B FI68626 B FI 68626B FI 783932 A FI783932 A FI 783932A FI 783932 A FI783932 A FI 783932A FI 68626 B FI68626 B FI 68626B
Authority
FI
Finland
Prior art keywords
viruses
viral
virus
nmr
mol
Prior art date
Application number
FI783932A
Other languages
English (en)
Finnish (fi)
Other versions
FI68626C (fi
FI783932A (fi
Inventor
Aoke John Erik Helgstrand
Karl Nils-Gunnar Johansson
Alfons Misiorny
Jan-Olof Noren
Goeran Bertil Stening
Original Assignee
Astra Laekemedel Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Laekemedel Ab filed Critical Astra Laekemedel Ab
Publication of FI783932A publication Critical patent/FI783932A/fi
Publication of FI68626B publication Critical patent/FI68626B/fi
Application granted granted Critical
Publication of FI68626C publication Critical patent/FI68626C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
    • C07F9/3891—Acids containing the structure -C(=X)-P(=X)(XH)2, (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4062—Esters of acids containing the structure -C(=X)-P(=X)(XR)2 or NC-P(=X)(XR)2, (X = O, S, Se)
    • C07F9/4065—Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (2)

1 I OH väri är Cg-Cg-cykloalkyl, C^-Cg-cykloalkyl-alkyl, adamant-1-yl eller adamant-2-yl, samt fysiologiskt acceptabla salter och optiska antipoder därav, kännetecknat av att en möjligen i ren stereoisomerisk eller racemisk form föreliggande hydroxikarbonylfosfonsyratriester med formeln
0. M R..O-P-C-OR., II i , J or2 väri R1 har ovan angiven betydelse, och R2 och Rg är oberoende av varandra och betecknar hydrolyserbara grupper, sasom C^-Cg-alkyl, Cg-Cg-cykloalkyl, C^-Cg-cykloalkyl-alkyl, adamant-1-yl, adamant-2-yl, bensyl, möjligen substituerad aryl eller en substituerad silylgrupp med formeln R. / 4 -Si-R.' \ 4 R4 n väri R4, R^' och R^" är lika eller olika och envar betecknar en inert organisk rest, sasom lägrealkyl eller fenyl, hydro-lyseras eller hydreras för avspjälkning av grupperna R2 och Rg, varefter en sälunda erhällen förening med formeln I om sä önskas överförs tili ett sait eller frigöres frän ett sait och/eller en erhällen racemisk blandning upplöses i sinä optiska antipoder.
1. Förfarande för framställning av nya terapeutiskt aktiva hydroxikarbonylfosfonsyraderivat med formeln 0 0 /y m R,0-P-C-0H I
2. Förfarande enligt patentkravet 1,kännetecknat av att R.j är adamant-1-yl eller adamant-2-yl.
FI783932A 1977-12-22 1978-12-20 Foerfarande foer framstaellning av nya terapeutiskt aktiva hydroxikarbonylfosfonsyraderivat FI68626C (fi)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
GB5358177 1977-12-22
GB5358077 1977-12-22
GB5358277 1977-12-22
GB5358077 1977-12-22
GB5358177 1977-12-22
GB5358277 1977-12-22
GB5358377 1977-12-22
GB5358377 1977-12-22
GB7828548 1978-07-03
GB7828552 1978-07-03
GB7828552 1978-07-03
GB7828553 1978-07-03
GB7828555 1978-07-03
GB7828553 1978-07-03
GB7828555 1978-07-03
GB7828548 1978-07-03

Publications (3)

Publication Number Publication Date
FI783932A FI783932A (fi) 1979-06-23
FI68626B true FI68626B (fi) 1985-06-28
FI68626C FI68626C (fi) 1985-10-10

Family

ID=27571200

Family Applications (2)

Application Number Title Priority Date Filing Date
FI783932A FI68626C (fi) 1977-12-22 1978-12-20 Foerfarande foer framstaellning av nya terapeutiskt aktiva hydroxikarbonylfosfonsyraderivat
FI783931A FI65438C (fi) 1977-12-22 1978-12-20 Foerfarande foer framstaellning av farmakologiskt aktiva estrar av fosfonomyrsyra

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI783931A FI65438C (fi) 1977-12-22 1978-12-20 Foerfarande foer framstaellning av farmakologiskt aktiva estrar av fosfonomyrsyra

Country Status (14)

Country Link
US (4) US4386081A (sv)
EP (2) EP0003007B1 (sv)
JP (2) JPS54106431A (sv)
AT (1) AT369017B (sv)
AU (1) AU530031B2 (sv)
CA (2) CA1140049A (sv)
DE (2) DE2861045D1 (sv)
DK (2) DK148631C (sv)
FI (2) FI68626C (sv)
HK (1) HK33584A (sv)
IE (1) IE48011B1 (sv)
MY (1) MY8500058A (sv)
NO (2) NO154751C (sv)
SG (1) SG82383G (sv)

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US5025003A (en) * 1989-09-18 1991-06-18 E. R. Squibb & Sons, Inc. Isoprenoid phosphinylformic acid squalene synthetase inhibitors
US5463092A (en) * 1989-11-22 1995-10-31 Vestar, Inc. Lipid derivatives of phosphonacids for liposomal incorporation and method of use
US5132414A (en) * 1990-05-10 1992-07-21 Dana-Farber Cancer Institute, Inc. Dideoxynucleoside-5'-phosphonoformic acid compounds
US5696277A (en) * 1994-11-15 1997-12-09 Karl Y. Hostetler Antiviral prodrugs
US7517858B1 (en) 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
US6096730A (en) * 1997-07-24 2000-08-01 University Of Kentucky Research Foundation Phosphonated agents and their antiangiogenic and antitumorigenic use
US5869469A (en) * 1997-08-18 1999-02-09 Queen's University At Kingston Phosphonocarboxylate compounds for treating amyloidosis
NZ550116A (en) * 1997-08-18 2008-03-28 Neurochem Int Ltd Phosphono-carboxylate compounds for treating amyloidosis
US20020022657A1 (en) * 1998-02-11 2002-02-21 Francine Gervais Methods for modulating neuronal cell death
US20040002079A1 (en) * 1998-02-11 2004-01-01 Gunn Robert B. Sodium-phosphate cotransporter in lithium therapy for the treatment of mental illness
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US6329356B1 (en) 1998-04-10 2001-12-11 Neurochem, Inc. Phosphono-carboxylate compounds for treating amyloidosis
US6310073B1 (en) * 1998-07-28 2001-10-30 Queen's University At Kingston Methods and compositions to treat glycosaminoglycan-associated molecular interactions
MXPA01010835A (es) * 1999-04-28 2003-07-14 Univ Kingston Composiciones y metodos para tratar amiloidosis.
US6562836B1 (en) 1999-05-24 2003-05-13 Queen's University Of Kingston Methods and compounds for inhibiting amyloid deposits
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DOP2003000641A (es) * 2002-05-10 2003-11-15 Pfizer Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan
US7148226B2 (en) * 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
US20040214178A1 (en) * 2003-04-24 2004-10-28 Agouron Pharmaceuticals, Inc. Reporter-selectable Hepatitis C virus replicon
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US7244764B2 (en) * 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US7414076B2 (en) 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
WO2006018725A1 (en) * 2004-08-18 2006-02-23 Pfizer Inc. Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same
ITMI20041822A1 (it) * 2004-09-24 2004-12-24 Pharmaproducts Uk Ltd "agente terapeutico utile per il trattamento di neoplasie plasmacellulari"
EP1817305A2 (en) * 2004-11-16 2007-08-15 Neurochem (International) Limited Compounds for the treatment of cns and amyloid associated diseases
CA2592320C (en) 2004-12-22 2015-11-24 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US8372886B2 (en) * 2005-12-22 2013-02-12 Kiacta Sarl Treatment of renal disorders, diabetic nephropathy and dyslipidemias
PL3851447T3 (pl) 2006-10-12 2024-03-04 Bellus Health Inc. Sposoby, związki, kompozycje i nośniki dostarczające kwas 3-amino-1-propanosulfonowy
CA2673022A1 (en) * 2006-12-22 2008-07-03 Bellus Health (International) Limited Methods, compounds, and compositions for treating metabolic disorders and diabetes
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DE102012103717A1 (de) * 2012-04-27 2013-11-14 Westfälische Wilhelms-Universität Münster Arzneimittel zur Behandlung von Tumorerkrankungen
CN105830271B (zh) * 2013-12-19 2018-11-16 宇部兴产株式会社 非水电解液、使用了其的蓄电装置及其中使用的膦酰基甲酸化合物
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Also Published As

Publication number Publication date
DE2861729D1 (en) 1982-05-19
NO784331L (no) 1979-06-25
NO156611B (no) 1987-07-13
DK148632C (da) 1986-03-03
IE782493L (en) 1979-06-22
JPS54106431A (en) 1979-08-21
AT369017B (de) 1982-11-25
MY8500058A (en) 1985-12-31
FI783931A (fi) 1979-06-23
NO784330L (no) 1979-06-25
EP0003275B1 (en) 1981-09-02
CA1140049A (en) 1983-01-25
CA1144937A (en) 1983-04-19
EP0003007A2 (en) 1979-07-11
DE2861045D1 (en) 1981-11-26
DK148631C (da) 1986-03-03
NO154751C (no) 1986-12-17
DK564178A (da) 1979-06-23
JPS6330885B2 (sv) 1988-06-21
DK564278A (da) 1979-06-23
US4536400A (en) 1985-08-20
FI65438C (fi) 1984-05-10
SG82383G (en) 1985-03-08
US4386081A (en) 1983-05-31
DK148631B (da) 1985-08-19
FI65438B (fi) 1984-01-31
EP0003275A1 (en) 1979-08-08
NO156611C (no) 1987-10-21
JPS54109951A (en) 1979-08-29
IE48011B1 (en) 1984-09-05
FI68626C (fi) 1985-10-10
DK148632B (da) 1985-08-19
FI783932A (fi) 1979-06-23
HK33584A (en) 1984-04-27
NO154751B (no) 1986-09-08
EP0003007A3 (en) 1979-08-08
AU530031B2 (en) 1983-06-30
JPS6254118B2 (sv) 1987-11-13
US4372894A (en) 1983-02-08
EP0003007B1 (en) 1982-04-07
US4591583A (en) 1986-05-27
ATA921778A (de) 1982-04-15
AU4268278A (en) 1979-06-28

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Owner name: ASTRA LAEKEMEDEL AB