FI66842C - Foerfarande foer framstaellning av som analgetiska medel anvaendbara enkelfalinanaloger - Google Patents

Foerfarande foer framstaellning av som analgetiska medel anvaendbara enkelfalinanaloger Download PDF

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Publication number
FI66842C
FI66842C FI782971A FI782971A FI66842C FI 66842 C FI66842 C FI 66842C FI 782971 A FI782971 A FI 782971A FI 782971 A FI782971 A FI 782971A FI 66842 C FI66842 C FI 66842C
Authority
FI
Finland
Prior art keywords
mixture
acid
added
butyloxycarbonyl
stirred
Prior art date
Application number
FI782971A
Other languages
English (en)
Finnish (fi)
Other versions
FI782971A (fi
FI66842B (fi
Inventor
Jr Edward Lee Smithwick
Robert Curtis Art Frederickson
Robert Theodore Shuman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI782971A publication Critical patent/FI782971A/fi
Application granted granted Critical
Publication of FI66842B publication Critical patent/FI66842B/fi
Publication of FI66842C publication Critical patent/FI66842C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
FI782971A 1977-10-03 1978-09-29 Foerfarande foer framstaellning av som analgetiska medel anvaendbara enkelfalinanaloger FI66842C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83851677 1977-10-03
US05/838,516 US4264491A (en) 1977-10-03 1977-10-03 Analgesic compounds

Publications (3)

Publication Number Publication Date
FI782971A FI782971A (fi) 1979-04-04
FI66842B FI66842B (fi) 1984-08-31
FI66842C true FI66842C (fi) 1984-12-10

Family

ID=25277291

Family Applications (1)

Application Number Title Priority Date Filing Date
FI782971A FI66842C (fi) 1977-10-03 1978-09-29 Foerfarande foer framstaellning av som analgetiska medel anvaendbara enkelfalinanaloger

Country Status (33)

Country Link
US (1) US4264491A (es)
EP (1) EP0001684B1 (es)
JP (1) JPS5459247A (es)
AR (1) AR224238A1 (es)
AT (1) AT367028B (es)
AU (1) AU520315B2 (es)
BE (1) BE870819A (es)
BG (1) BG31224A3 (es)
CA (1) CA1156219A (es)
CH (1) CH635571A5 (es)
CS (1) CS235072B2 (es)
DD (1) DD139710A5 (es)
DE (1) DE2861019D1 (es)
DK (1) DK149231C (es)
EG (1) EG13636A (es)
ES (1) ES473925A1 (es)
FI (1) FI66842C (es)
FR (1) FR2404629B1 (es)
GB (1) GB2005688B (es)
GR (1) GR71651B (es)
HU (1) HU182866B (es)
IE (1) IE47378B1 (es)
IL (1) IL55650A (es)
IT (1) IT1100839B (es)
LU (1) LU80316A1 (es)
NZ (1) NZ188521A (es)
PH (1) PH14660A (es)
PL (1) PL114271B1 (es)
PT (1) PT68598A (es)
RO (1) RO76176A (es)
SU (1) SU908246A3 (es)
YU (1) YU231578A (es)
ZA (1) ZA785564B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2702711A1 (de) 1976-02-02 1977-08-04 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
US4331593A (en) * 1977-10-03 1982-05-25 Smithwick Jr Edward L Analgesic compounds
US4265808A (en) * 1979-12-17 1981-05-05 Eli Lilly And Company Pharmacologically active peptides
US4283330A (en) * 1979-12-17 1981-08-11 Eli Lilly And Company Pharmacologically active peptides
US4333873A (en) 1979-12-17 1982-06-08 Eli Lilly And Company Pharmacologically active peptides
JPS5692846A (en) * 1979-12-27 1981-07-27 Takeda Chem Ind Ltd Tetrapeptide derivative and its preparation
FR2488253A1 (fr) * 1980-08-08 1982-02-12 Roques Bernard Nouveaux peptides et leur application en therapeutique
JPS5738756A (en) * 1980-08-18 1982-03-03 Earth Chem Corp Ltd Tripeptide alkylamide derivative
JPS5785349A (en) * 1980-11-14 1982-05-28 Earth Chem Corp Ltd Tripeptide alkylamide derivative
US4322340A (en) * 1980-10-20 1982-03-30 Eli Lilly And Company Pharmacologically active peptides
JPS5772950A (en) * 1980-10-24 1982-05-07 Takeda Chem Ind Ltd Tetrapeptide derivative, its preparation and analgesic agent
EP0076557B1 (en) * 1981-06-22 1985-11-13 Imperial Chemical Industries Plc Peptides and pseudopeptides in which the n terminus bears two substituents
US4448717A (en) * 1982-11-12 1984-05-15 Eli Lilly And Company Pharmacologically active peptides
US4495178A (en) * 1983-10-06 1985-01-22 G. D. Searle & Co. Enkephalin analogs

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1042487A (en) * 1964-06-25 1966-09-14 Ici Ltd Polypeptide derivatives
FR2338925A1 (fr) * 1976-01-26 1977-08-19 Wellcome Found Nouveaux peptides et medicament contenant ces substances
DE2702711A1 (de) * 1976-02-02 1977-08-04 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
GB1532181A (en) * 1976-02-02 1978-11-15 Beckman Instruments Inc Pentapetides and a method of preparing them
US4028319A (en) * 1976-05-07 1977-06-07 G. D. Searle & Co. 2 and 3-substituted enkephalins
DE2732451A1 (de) * 1976-07-27 1978-02-02 Reckitt & Colmann Prod Ltd Peptidverbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate
FR2359817A1 (fr) * 1976-07-27 1978-02-24 Reckitt & Colmann Prod Ltd Nouveaux peptides, leur procede de preparation et composition therapeutique les contenant
US4259234A (en) * 1976-09-27 1981-03-31 Eli Lilly And Company Analgesic compounds

Also Published As

Publication number Publication date
EP0001684A2 (en) 1979-05-02
SU908246A3 (ru) 1982-02-23
PL114271B1 (en) 1981-01-31
GB2005688A (en) 1979-04-25
CH635571A5 (fr) 1983-04-15
YU231578A (en) 1982-10-31
PH14660A (en) 1981-10-20
PL210045A1 (pl) 1979-06-18
LU80316A1 (fr) 1979-03-16
BG31224A3 (en) 1981-11-16
NZ188521A (en) 1981-07-13
US4264491A (en) 1981-04-28
IT7828359A0 (it) 1978-10-02
AR224238A1 (es) 1981-11-13
DD139710A5 (de) 1980-01-16
AT367028B (de) 1982-05-25
FR2404629A1 (fr) 1979-04-27
GB2005688B (en) 1982-02-24
DK149231C (da) 1986-08-18
ZA785564B (en) 1980-05-28
DE2861019D1 (en) 1981-11-26
JPS5459247A (en) 1979-05-12
IE781926L (en) 1979-04-03
RO76176A (ro) 1981-11-04
HU182866B (en) 1984-03-28
EP0001684A3 (en) 1979-06-27
IL55650A (en) 1982-02-28
ES473925A1 (es) 1980-01-16
DK434778A (da) 1979-04-04
EP0001684B1 (en) 1981-09-02
BE870819A (fr) 1979-03-28
EG13636A (en) 1982-03-31
IE47378B1 (en) 1984-03-07
AU520315B2 (en) 1982-01-28
FR2404629B1 (fr) 1985-12-27
CA1156219A (en) 1983-11-01
AU4024778A (en) 1980-04-03
PT68598A (en) 1978-10-01
CS235072B2 (en) 1985-04-16
ATA708778A (de) 1981-10-15
FI782971A (fi) 1979-04-04
DK149231B (da) 1986-03-24
FI66842B (fi) 1984-08-31
IT1100839B (it) 1985-09-28
GR71651B (es) 1983-06-20

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MM Patent lapsed

Owner name: ELI LILLY AND CO