FI65624C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara acylerade etanolaminfosfat - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara acylerade etanolaminfosfat Download PDFInfo
- Publication number
- FI65624C FI65624C FI771425A FI771425A FI65624C FI 65624 C FI65624 C FI 65624C FI 771425 A FI771425 A FI 771425A FI 771425 A FI771425 A FI 771425A FI 65624 C FI65624 C FI 65624C
- Authority
- FI
- Finland
- Prior art keywords
- framework
- formula
- phosphate
- compound
- group
- Prior art date
Links
- 239000002253 acid Substances 0.000 title claims description 3
- ARPJZLLWCWXWJQ-UHFFFAOYSA-N dihydrogen phosphate;ethylazanium Chemical compound CCN.OP(O)(O)=O ARPJZLLWCWXWJQ-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 6
- -1 phenyl ester Chemical class 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- SUHOOTKUPISOBE-UHFFFAOYSA-N O-phosphoethanolamine Chemical class NCCOP(O)(O)=O SUHOOTKUPISOBE-UHFFFAOYSA-N 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims description 3
- 230000007062 hydrolysis Effects 0.000 claims description 3
- 238000006460 hydrolysis reaction Methods 0.000 claims description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 125000006239 protecting group Chemical group 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 150000001408 amides Chemical class 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
- 235000021317 phosphate Nutrition 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000011719 vitamin A Substances 0.000 description 4
- 229940045997 vitamin a Drugs 0.000 description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 235000019155 vitamin A Nutrition 0.000 description 3
- VBIJCBOMFUAELO-UHFFFAOYSA-N 2-(4-aminobutanoylamino)ethyl dihydrogen phosphate Chemical compound NCCCC(=O)NCCOP(O)(O)=O VBIJCBOMFUAELO-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 206010018691 Granuloma Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- KRQFWXDSIWPJRF-UHFFFAOYSA-N (4-nitrophenyl) 4-(phenylmethoxycarbonylamino)butanoate Chemical compound C1=CC([N+](=O)[O-])=CC=C1OC(=O)CCCNC(=O)OCC1=CC=CC=C1 KRQFWXDSIWPJRF-UHFFFAOYSA-N 0.000 description 1
- 229910014572 C—O—P Inorganic materials 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000033687 granuloma formation Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUCI001662 | 1976-05-06 | ||
| HU76CI1662A HU178199B (en) | 1976-05-06 | 1976-05-06 | New process for producing amides of omega-amino-carboxylic acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI771425A FI771425A (no) | 1977-11-07 |
| FI65624B FI65624B (fi) | 1984-02-29 |
| FI65624C true FI65624C (fi) | 1984-06-11 |
Family
ID=10994613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI771425A FI65624C (fi) | 1976-05-06 | 1977-05-05 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara acylerade etanolaminfosfat |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4102948A (no) |
| JP (2) | JPS6055506B2 (no) |
| AR (2) | AR212468A1 (no) |
| AT (1) | AT353762B (no) |
| AU (1) | AU508792B2 (no) |
| BE (1) | BE854347A (no) |
| BG (1) | BG27739A3 (no) |
| CA (1) | CA1089485A (no) |
| CH (1) | CH638181A5 (no) |
| CS (1) | CS200513B2 (no) |
| DD (1) | DD130932A5 (no) |
| DE (1) | DE2719351A1 (no) |
| DK (1) | DK199677A (no) |
| EG (1) | EG12889A (no) |
| ES (1) | ES469265A1 (no) |
| FI (1) | FI65624C (no) |
| FR (2) | FR2368471A1 (no) |
| GB (1) | GB1574950A (no) |
| GR (1) | GR63186B (no) |
| HU (1) | HU178199B (no) |
| IL (1) | IL51997A (no) |
| IN (1) | IN145672B (no) |
| NL (1) | NL7704993A (no) |
| NO (1) | NO145236C (no) |
| PL (2) | PL121491B1 (no) |
| RO (1) | RO72420A (no) |
| SE (1) | SE431087B (no) |
| SU (1) | SU795456A3 (no) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4218404A (en) * | 1976-05-06 | 1980-08-19 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | ω-Aminocarboxylic acid amides |
| HU180443B (en) * | 1979-04-02 | 1983-03-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing a pharmaceutical preparation with synergetic action against radiation |
| IT1190163B (it) * | 1986-01-13 | 1988-02-16 | Sigma Tau Ind Farmaceuti | Derivati fosforilalcanolammidici della l-carnitina e composizioni farmaceutiche che li contengono |
| JPS62199502A (ja) * | 1986-02-28 | 1987-09-03 | Suzuki Motor Co Ltd | ナツクルア−ム |
| JPS6397455A (ja) * | 1986-10-13 | 1988-04-28 | Honda Motor Co Ltd | 車両のブレ−キ装置 |
| JPS6398804U (no) * | 1986-12-19 | 1988-06-27 | ||
| US6096536A (en) * | 1990-07-06 | 2000-08-01 | University Of New Mexico | In vitro cell culture in media containing beta-alanyl-taurine or carbobenzoxy beta-alanyl-taurine |
| US5370868A (en) * | 1990-07-06 | 1994-12-06 | University Of New Mexico | Therapeutic use of vitaletheine modulators in neoplasia |
| JPH0459508U (no) * | 1990-09-29 | 1992-05-21 | ||
| US6007819A (en) | 1995-10-17 | 1999-12-28 | Dovetail Technologies, Inc. | Methods of inducing immunity using low molecular weight immune stimulants |
| US6762174B1 (en) | 1998-02-24 | 2004-07-13 | Dovetail Technologies, Inc. | Low molecular weight compounds administered together with anti-cancer agents to prevent or treat cancer and pharmaceutical compositions thereof |
| EP1059919A1 (en) | 1998-02-24 | 2000-12-20 | Dovetail Technologies, Inc. | Small molecules that increase the conversion of food to body weight gain |
| US20040019107A1 (en) | 2002-07-29 | 2004-01-29 | Floyd Taub | Homeopathic drug composition and methods of use thereof |
| EP1477493A1 (en) * | 2003-05-15 | 2004-11-17 | Bayer HealthCare AG | Isotope coded affinity tags |
| KR101443573B1 (ko) | 2006-10-12 | 2014-11-03 | 비에이치아이 리미티드 파트너쉽 | 3-아미노-1-프로판설폰산을 전달하기 위한 방법, 화합물, 조성물 및 비히클 |
| DE102009002239A1 (de) * | 2009-04-07 | 2010-10-14 | Evonik Röhm Gmbh | Verfahren zur kontinuierlichen Herstellung von Alkylamino(meth)acrylamiden |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2229744A (en) * | 1941-01-28 | Hnxchj-conh | ||
| BE758129A (fr) * | 1969-10-28 | 1971-04-01 | Bayer Ag | Sels d'acides 2-(beta-amino-propionamino)-alcane sulfoniques etleur utilisation comme composants de synthese anioniques dans la preparation dedispersions de polyurethanes sans agents emulsifiants |
| IL47149A (en) * | 1974-04-29 | 1979-05-31 | Chinoin Gyogyszer Es Vegyeszet | Amino acid derivatives,their preparation and pharmaceutical compositions containing them |
-
1976
- 1976-05-06 HU HU76CI1662A patent/HU178199B/hu unknown
-
1977
- 1977-04-30 DE DE19772719351 patent/DE2719351A1/de not_active Ceased
- 1977-05-02 US US05/792,917 patent/US4102948A/en not_active Expired - Lifetime
- 1977-05-02 AT AT308377A patent/AT353762B/de not_active IP Right Cessation
- 1977-05-03 IL IL51997A patent/IL51997A/xx unknown
- 1977-05-03 BG BG036190A patent/BG27739A3/xx unknown
- 1977-05-03 CS CS772896A patent/CS200513B2/cs unknown
- 1977-05-03 SE SE7705143A patent/SE431087B/xx not_active IP Right Cessation
- 1977-05-05 DD DD7700198775A patent/DD130932A5/xx unknown
- 1977-05-05 IN IN672/CAL/77A patent/IN145672B/en unknown
- 1977-05-05 GB GB18927/77A patent/GB1574950A/en not_active Expired
- 1977-05-05 AU AU24893/77A patent/AU508792B2/en not_active Expired
- 1977-05-05 DK DK199677A patent/DK199677A/da not_active Application Discontinuation
- 1977-05-05 NO NO771584A patent/NO145236C/no unknown
- 1977-05-05 CA CA277,811A patent/CA1089485A/en not_active Expired
- 1977-05-05 GR GR53376A patent/GR63186B/el unknown
- 1977-05-05 SU SU772478856A patent/SU795456A3/ru active
- 1977-05-05 CH CH563477A patent/CH638181A5/de not_active IP Right Cessation
- 1977-05-05 FI FI771425A patent/FI65624C/fi not_active IP Right Cessation
- 1977-05-05 RO RO7790234A patent/RO72420A/ro unknown
- 1977-05-06 FR FR7713900A patent/FR2368471A1/fr active Granted
- 1977-05-06 PL PL1977197928A patent/PL121491B1/pl unknown
- 1977-05-06 NL NL7704993A patent/NL7704993A/xx not_active Application Discontinuation
- 1977-05-06 AR AR267507A patent/AR212468A1/es active
- 1977-05-06 JP JP52051311A patent/JPS6055506B2/ja not_active Expired
- 1977-05-06 PL PL1977213795A patent/PL125548B1/pl unknown
- 1977-05-06 BE BE177343A patent/BE854347A/xx not_active IP Right Cessation
- 1977-05-07 EG EG265/77A patent/EG12889A/xx active
-
1978
- 1978-03-08 AR AR271308A patent/AR213748A1/es active
- 1978-04-28 ES ES469265A patent/ES469265A1/es not_active Expired
-
1980
- 1980-05-14 FR FR8010848A patent/FR2479833A1/fr active Granted
-
1984
- 1984-05-04 JP JP59088545A patent/JPS601126A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: CHINOIN GYOGUSZER ES VEGYESZETI TERMEKEK |