IT1190163B - Derivati fosforilalcanolammidici della l-carnitina e composizioni farmaceutiche che li contengono - Google Patents
Derivati fosforilalcanolammidici della l-carnitina e composizioni farmaceutiche che li contengonoInfo
- Publication number
- IT1190163B IT1190163B IT47524/86A IT4752486A IT1190163B IT 1190163 B IT1190163 B IT 1190163B IT 47524/86 A IT47524/86 A IT 47524/86A IT 4752486 A IT4752486 A IT 4752486A IT 1190163 B IT1190163 B IT 1190163B
- Authority
- IT
- Italy
- Prior art keywords
- carnitine
- derivatives
- pharmaceutical compositions
- compositions containing
- phosphorylalcanolamide
- Prior art date
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical class C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 Amide derivatives of L-carnitine Chemical class 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 abstract 1
- URXZXNYJPAJJOQ-UHFFFAOYSA-N Erucic acid Natural products CCCCCCC=CCCCCCCCCCCCC(O)=O URXZXNYJPAJJOQ-UHFFFAOYSA-N 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT47524/86A IT1190163B (it) | 1986-01-13 | 1986-01-13 | Derivati fosforilalcanolammidici della l-carnitina e composizioni farmaceutiche che li contengono |
| US07/000,397 US4784992A (en) | 1986-01-13 | 1987-01-05 | Phosphorylalkanolamide derivatives of L-carnitine and pharmaceutical compositions containing same |
| AT87830008T ATE43601T1 (de) | 1986-01-13 | 1987-01-12 | Phosphorylalkanolamid-derivate von l-carnitin und sie enthaltende arzneimittel. |
| ES87830008T ES2009856B3 (es) | 1986-01-13 | 1987-01-12 | Un procedimiento para producir fosforilalcanolamidas de l-carnitina. |
| EP87830008A EP0232227B1 (en) | 1986-01-13 | 1987-01-12 | Phosphorylalkanolamide derivatives of l-carnitine and pharmaceutical compositions containing same |
| DE8787830008T DE3760202D1 (en) | 1986-01-13 | 1987-01-12 | Phosphorylalkanolamide derivatives of l-carnitine and pharmaceutical compositions containing same |
| JP62005860A JPS62190190A (ja) | 1986-01-13 | 1987-01-13 | Ｌ−カルニチンのホスホリルアルカノ−ルアミド誘導体類およびその医薬組成物 |
| GR89400128T GR3000113T3 (en) | 1986-01-13 | 1989-07-24 | Phosphorylalkanolamide derivatives of l-carnitine and pharmaceutical compositions containing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT47524/86A IT1190163B (it) | 1986-01-13 | 1986-01-13 | Derivati fosforilalcanolammidici della l-carnitina e composizioni farmaceutiche che li contengono |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8647524A0 IT8647524A0 (it) | 1986-01-13 |
| IT1190163B true IT1190163B (it) | 1988-02-16 |
Family
ID=11260878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT47524/86A IT1190163B (it) | 1986-01-13 | 1986-01-13 | Derivati fosforilalcanolammidici della l-carnitina e composizioni farmaceutiche che li contengono |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4784992A (it) |
| EP (1) | EP0232227B1 (it) |
| JP (1) | JPS62190190A (it) |
| AT (1) | ATE43601T1 (it) |
| DE (1) | DE3760202D1 (it) |
| ES (1) | ES2009856B3 (it) |
| GR (1) | GR3000113T3 (it) |
| IT (1) | IT1190163B (it) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040053208A1 (en) * | 1995-08-29 | 2004-03-18 | V. I. TECHNOLOGIES, Inc. | Methods to selectively inactivate parasites in biological compositions |
| US6352695B1 (en) * | 1997-10-03 | 2002-03-05 | V.I. Technologies, Inc. | Methods and compositions for the selective modification of nucleic acids |
| US6093564A (en) * | 1997-10-03 | 2000-07-25 | V.I. Technologies, Inc. | Methods and compositions for the selective modification of nucleic acids |
| IT1299266B1 (it) * | 1998-05-15 | 2000-02-29 | Sigma Tau Ind Farmaceuti | Inibitori reversibili della carnitina palmitoil trasferasi |
| US6617100B2 (en) | 1998-09-25 | 2003-09-09 | V.I. Technologies, Inc. | Solid phase quenching systems |
| US6403359B1 (en) | 1998-09-25 | 2002-06-11 | V. I. TECHNOLOGIES, Inc. | Solid phase quenching systems |
| US20040019107A1 (en) | 2002-07-29 | 2004-01-29 | Floyd Taub | Homeopathic drug composition and methods of use thereof |
| US20050232911A1 (en) * | 2004-04-19 | 2005-10-20 | Schreiber Brian D | Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid |
| WO2012011572A1 (ja) * | 2010-07-23 | 2012-01-26 | 国立大学法人大阪大学 | 拡張不全型心不全治療薬 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4218404A (en) * | 1976-05-06 | 1980-08-19 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | ω-Aminocarboxylic acid amides |
| HU178199B (en) * | 1976-05-06 | 1982-03-28 | Chinoin Gyogyszer Es Vegyeszet | New process for producing amides of omega-amino-carboxylic acids |
| GB2058566A (en) * | 1979-09-21 | 1981-04-15 | Sigma Tau Ind Farmaceuti | Pharmaceutical composition comprising L-carnitine |
| IT1209564B (it) * | 1984-06-29 | 1989-08-30 | Magis Farmaceutici | Derivati della l-carnitina o di l-acil carnitina. |
-
1986
- 1986-01-13 IT IT47524/86A patent/IT1190163B/it active
-
1987
- 1987-01-05 US US07/000,397 patent/US4784992A/en not_active Expired - Fee Related
- 1987-01-12 DE DE8787830008T patent/DE3760202D1/de not_active Expired
- 1987-01-12 ES ES87830008T patent/ES2009856B3/es not_active Expired
- 1987-01-12 EP EP87830008A patent/EP0232227B1/en not_active Expired
- 1987-01-12 AT AT87830008T patent/ATE43601T1/de not_active IP Right Cessation
- 1987-01-13 JP JP62005860A patent/JPS62190190A/ja active Pending
-
1989
- 1989-07-24 GR GR89400128T patent/GR3000113T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62190190A (ja) | 1987-08-20 |
| DE3760202D1 (en) | 1989-07-06 |
| EP0232227B1 (en) | 1989-05-31 |
| ATE43601T1 (de) | 1989-06-15 |
| GR3000113T3 (en) | 1990-11-29 |
| US4784992A (en) | 1988-11-15 |
| EP0232227A1 (en) | 1987-08-12 |
| ES2009856B3 (es) | 1989-10-16 |
| IT8647524A0 (it) | 1986-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19941205 |