KR910014352A - 피리딘-2,4- 및-2,5-디카복실산의 디(니트록시알킬)아미드, 이의 제조방법 및 이의 용도 - Google Patents

피리딘-2,4- 및-2,5-디카복실산의 디(니트록시알킬)아미드, 이의 제조방법 및 이의 용도 Download PDF

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KR910014352A
KR910014352A KR1019910000412A KR910000412A KR910014352A KR 910014352 A KR910014352 A KR 910014352A KR 1019910000412 A KR1019910000412 A KR 1019910000412A KR 910000412 A KR910000412 A KR 910000412A KR 910014352 A KR910014352 A KR 910014352A
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compound
formula
collagen
salt
medicament
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KR1019910000412A
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바더 에케하르트
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오일러, 라피체
훽스트 아크티엔게젤샤프트
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Publication of KR910014352A publication Critical patent/KR910014352A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Transplantation (AREA)
  • Diabetes (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음

Description

피리딘-2.4-및-2,5-디카복실산의 디(니트록시알킬)아미드, 이의 제조방법 및 이의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 프롤린 하이드록실라제 및 리신 하이드록실라제를 억제하는 약제를 제조하기 위한 일반식(Ⅰ)의 피리딘-2,4- 및 -2,5-디카복실산의 디(니트록시알킬)아미드 또는 이의 생리학적으로 허용되는 염의 용도.
    상기식에서, R은 직쇄 또는 측쇄 C1-C4-알칸디일이다.
  2. 제1항에 있어서, R이 에틸렌 또는 프로필렌인 용도.
  3. 일반식(Ⅰ)의 화합물 또는 이의 생리학적으로 허용되는 염.
    상기식에서, R은 메틸렌, 프로필렌 또는 부틸렌이다.
  4. 제3항에 있어서, R이 메틸렌 또는 n-프로필렌인 일반식(Ⅰ)의 화합물.
  5. 제3항 또는 제4항에 있어서, 약제로서 사용하기 위한 화합물.
  6. 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 화합물과 반응시키거나, 일반식(Ⅳ)의 화합물을 질소화시키고, 이어서 필요한 경우, 반응 생성물을 이의 생리학적으로 허용되는 염으로 전환시킴을 특징으로 하여, 제3항에서 청구된 일반식(Ⅰ)의 화합물을 제조하는 방법.
    상기식에서, R은 제3항에서 정의한 바와 같고, Y는 할로겐, 하이드록실 또는 C1-C4-알콕시이거나, 카보닐 그룹과 함께 활성 에스테르 또는 혼합 무수물을 형성한다.
  7. 제3항 또는 제4항에 있어서, 프롤린 하이드록실라제 및 리신 하이드록실라제를 억제하기 위한 화합물.
  8. 제1항 내지 제4항중 어느 한 항에 있어서, 섬유 형성억제제 및 면역억제제로서 사용하기 위한 화합물.
  9. 제3항 또는 제4항에서 청구된 일반식(Ⅰ)의 화합물과 약제학적으로 허용되는 비히클을 함유하는 약제.
  10. 콜라겐 및 콜라겐-유사 물질의 대사 및 Clq의 생합성에 영향을 주기 위한 제1항 내지 제4항중 어느 한 항에서 청구된 일반식(Ⅰ)의 화합물 또는 이의 염의 용도.
  11. 콜라겐 및 콜라겐-유사 물질의 대사 장해 및 Clq의 생합성 장해를 치료하기 위한 제1항 내지 제4항중 어느 한 항에서 청구된 일반식(Ⅰ)의 화합물 또는 이의 염의 용도.
  12. 제1항 내지 제4항중 어느 한 항에서 청구된 일반식(Ⅰ)의 화합물 또는 이의 염을 약제에 첨가함을 특징으로 하여, 콜라겐 및 콜라겐-유사 물질의 대사 및 Clq의 생합성에 영향을 주기 위한 약제를 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910000412A 1990-01-16 1991-01-14 피리딘-2,4- 및-2,5-디카복실산의 디(니트록시알킬)아미드, 이의 제조방법 및 이의 용도 KR910014352A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4001002A DE4001002A1 (de) 1990-01-16 1990-01-16 Pyridin-2,4-und 2,5-dicarbonsaeuredi-(nitroxyalkyl)amide, verfahren zu ihrer herstellung sowie deren verwendung
DE4001002.3 1990-01-16

Publications (1)

Publication Number Publication Date
KR910014352A true KR910014352A (ko) 1991-08-31

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ID=6398117

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Application Number Title Priority Date Filing Date
KR1019910000412A KR910014352A (ko) 1990-01-16 1991-01-14 피리딘-2,4- 및-2,5-디카복실산의 디(니트록시알킬)아미드, 이의 제조방법 및 이의 용도

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Country Link
EP (1) EP0438795A1 (ko)
JP (1) JPH04330060A (ko)
KR (1) KR910014352A (ko)
CN (1) CN1053606A (ko)
AU (1) AU631285B2 (ko)
BR (1) BR9100159A (ko)
CA (1) CA2034206A1 (ko)
CS (1) CS7591A2 (ko)
DE (1) DE4001002A1 (ko)
FI (1) FI910177A (ko)
HU (1) HUT59102A (ko)
IE (1) IE910126A1 (ko)
IL (1) IL96941A0 (ko)
MA (1) MA22041A1 (ko)
MX (1) MX24143A (ko)
NO (1) NO910163L (ko)
NZ (1) NZ236766A (ko)
PT (1) PT96493A (ko)
ZA (1) ZA91291B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4020570A1 (de) 1990-06-28 1992-01-02 Hoechst Ag 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung
YU9492A (sh) * 1991-02-05 1995-03-27 Hoechst Ag. 2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje
EP0533130A1 (de) * 1991-09-19 1993-03-24 Hoechst Aktiengesellschaft 2-Hydroxymethylpyridine, die entsprechenden Pyridin-N-oxide und ihre Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung
EP0541042A1 (de) * 1991-11-05 1993-05-12 Hoechst Aktiengesellschaft Pyridin-2,4- und 2,5-dicarbonsäureamide und deren Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK145608C (da) * 1976-04-02 1983-07-11 Chugai Pharmaceutical Co Ltd Analogifremgangsmaade til fremstilling af salpetersyreesteren af n-(2-hydroxyethyl)nicotinamid
DE3432094A1 (de) * 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
DE3703959A1 (de) * 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen

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Publication number Publication date
IE910126A1 (en) 1991-07-17
FI910177A (fi) 1991-07-17
FI910177A0 (fi) 1991-01-14
PT96493A (pt) 1991-10-15
EP0438795A1 (de) 1991-07-31
AU631285B2 (en) 1992-11-19
MX24143A (es) 1993-05-01
CA2034206A1 (en) 1991-07-17
AU6936691A (en) 1991-07-18
NO910163L (no) 1991-07-17
NZ236766A (en) 1993-08-26
HU910109D0 (en) 1991-08-28
ZA91291B (en) 1991-09-25
MA22041A1 (fr) 1991-10-01
IL96941A0 (en) 1992-03-29
BR9100159A (pt) 1991-10-22
JPH04330060A (ja) 1992-11-18
DE4001002A1 (de) 1991-07-18
NO910163D0 (no) 1991-01-15
CN1053606A (zh) 1991-08-07
HUT59102A (en) 1992-04-28
CS7591A2 (en) 1991-09-15

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