YU9492A - 2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje - Google Patents
2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanjeInfo
- Publication number
- YU9492A YU9492A YU9492A YU9492A YU9492A YU 9492 A YU9492 A YU 9492A YU 9492 A YU9492 A YU 9492A YU 9492 A YU9492 A YU 9492A YU 9492 A YU9492 A YU 9492A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- pyridines
- tetrazolyl
- bis
- preparation
- hydroxylase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Predloženi pronalazak se odnosi na 2,4- i 2,5-bis-tetroazolimenih piridina kao i njihovih fiziološki prihvatljivih soli, zatim na postupak za njihovo dobijanje kao i na njihovu upotrebu kao farmaceutskih proizvoda tj. lekova. Pomenuta jedinjenja 2,4- i 2,5-bis-tetrazolinil piridina imaju opštu formulu I u kojoj je značenje za A: dok su brojna značenja za R data u patentnim zahtevima 1-9. Postupak za dobijanje jedinjenja opšte formule I, obuhvata sintezu jedinjenja opšte formule II sa NaN3 i NH4 CL u odgovarajućem organskom rastvaraču i potom supstitucijske reakcije radi uvodjenja željenih supstituenata. Navedena jedinjenja inhibiraju enzime prolin i lizinhidroksilaze i prouzrokuju selektivnu zaštitu biosinteze kolagena. upotrebljavaju se kao fibrosupresivi i imunosupresivi.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR940840A HRP940840B1 (en) | 1991-02-05 | 1994-10-26 | 2,4- and 2,5-bis-(tetrazolyl)pyridines, process for their preparation and their use as medicines |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4103372 | 1991-02-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU9492A true YU9492A (sh) | 1995-03-27 |
Family
ID=6424383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU9492A YU9492A (sh) | 1991-02-05 | 1992-01-30 | 2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US5482953A (sh) |
| EP (1) | EP0498334B1 (sh) |
| JP (1) | JPH0559041A (sh) |
| KR (1) | KR100214797B1 (sh) |
| AT (1) | ATE193288T1 (sh) |
| AU (1) | AU650511B2 (sh) |
| CA (1) | CA2060622A1 (sh) |
| CZ (1) | CZ283006B6 (sh) |
| DE (1) | DE59209838D1 (sh) |
| DK (1) | DK0498334T3 (sh) |
| ES (1) | ES2146581T3 (sh) |
| FI (1) | FI103117B (sh) |
| GR (1) | GR3033536T3 (sh) |
| HR (1) | HRP940840B1 (sh) |
| HU (1) | HUT61295A (sh) |
| IE (1) | IE920368A1 (sh) |
| IL (1) | IL100860A (sh) |
| MX (1) | MX9200492A (sh) |
| NO (1) | NO180446C (sh) |
| NZ (1) | NZ241505A (sh) |
| PT (1) | PT498334E (sh) |
| YU (1) | YU9492A (sh) |
| ZA (1) | ZA92788B (sh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ305460B6 (cs) * | 2013-05-06 | 2015-10-07 | Contipro Biotech S.R.O. | Způsob přípravy esteru 2-oxoglutarátu, přípravek obsahující ester 2-oxoglutarát a jeho použití |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3432094A1 (de) * | 1984-08-31 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase |
| DE3703963A1 (de) * | 1987-02-10 | 1988-08-18 | Hoechst Ag | Pyridin-2,4- und 2,,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben, sowie arzneimittel auf basis dieser verbindungen |
| DE3703959A1 (de) * | 1987-02-10 | 1988-08-18 | Hoechst Ag | Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen |
| US5238948A (en) * | 1987-02-10 | 1993-08-24 | Hoechst Aktiengesellschaft | Pyridine-2,4- and -2,5-dicarboxylic acid derivatives and medicaments based on these compounds |
| DE3703962A1 (de) * | 1987-02-10 | 1988-08-18 | Hoechst Ag | Pyridin-2,4- und 2,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen |
| EP0353668B1 (de) * | 1988-08-04 | 1994-10-19 | Hoechst Aktiengesellschaft | Verbessertes Verfahren zur Herstellung von N,N-Bis(alkoxyalkyl)-pyridin -2,4-dicarbonsäurediamiden |
| JPH02178263A (ja) * | 1988-12-27 | 1990-07-11 | Kaken Pharmaceut Co Ltd | アザアズレン誘導体、その製造法およびそれを有効成分とする抗アレルギー剤および抗炎症剤 |
| DE3924093A1 (de) * | 1989-07-20 | 1991-02-07 | Hoechst Ag | N,n'-bis(alkoxy-alkyl)-pyridin-2,4-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung |
| FR2655801B1 (fr) * | 1989-12-08 | 1992-03-13 | Charbonnages De France | Procede et dispositif de transmission de signaux video en milieu confine. |
| ZA91291B (en) * | 1990-01-16 | 1991-09-25 | Hoechst Ag | Di(nitroxyalkyl)amides of pyridine-2,4-and-2,5-dicarboxylic acids,a process for the preparation thereof,and the use thereof |
| DE4020570A1 (de) * | 1990-06-28 | 1992-01-02 | Hoechst Ag | 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung |
-
1992
- 1992-01-30 YU YU9492A patent/YU9492A/sh unknown
- 1992-02-01 KR KR1019920001589A patent/KR100214797B1/ko not_active IP Right Cessation
- 1992-02-03 NZ NZ241505A patent/NZ241505A/en unknown
- 1992-02-03 IL IL10086092A patent/IL100860A/en not_active IP Right Cessation
- 1992-02-03 EP EP92101709A patent/EP0498334B1/de not_active Expired - Lifetime
- 1992-02-03 PT PT92101709T patent/PT498334E/pt unknown
- 1992-02-03 DK DK92101709T patent/DK0498334T3/da active
- 1992-02-03 DE DE59209838T patent/DE59209838D1/de not_active Expired - Fee Related
- 1992-02-03 ES ES92101709T patent/ES2146581T3/es not_active Expired - Lifetime
- 1992-02-03 AT AT92101709T patent/ATE193288T1/de not_active IP Right Cessation
- 1992-02-03 FI FI920460A patent/FI103117B/fi active
- 1992-02-04 NO NO920462A patent/NO180446C/no not_active IP Right Cessation
- 1992-02-04 JP JP4018627A patent/JPH0559041A/ja active Pending
- 1992-02-04 ZA ZA92788A patent/ZA92788B/xx unknown
- 1992-02-04 MX MX9200492A patent/MX9200492A/es unknown
- 1992-02-04 HU HU9200336A patent/HUT61295A/hu unknown
- 1992-02-04 IE IE036892A patent/IE920368A1/en not_active Application Discontinuation
- 1992-02-04 AU AU10724/92A patent/AU650511B2/en not_active Ceased
- 1992-02-04 CA CA002060622A patent/CA2060622A1/en not_active Abandoned
- 1992-02-04 CZ CS92309A patent/CZ283006B6/cs not_active IP Right Cessation
-
1994
- 1994-01-21 US US08/183,786 patent/US5482953A/en not_active Expired - Fee Related
- 1994-10-26 HR HR940840A patent/HRP940840B1/xx not_active IP Right Cessation
-
1995
- 1995-06-05 US US08/465,326 patent/US5614537A/en not_active Expired - Fee Related
-
2000
- 2000-05-31 GR GR20000401228T patent/GR3033536T3/el not_active IP Right Cessation
Also Published As
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