KR950000141A - 피부병 치료용 약제조성물 제조를 위한 방향족산을 함유한 l- 카르니틴 o-에스테르의 용도 - Google Patents
피부병 치료용 약제조성물 제조를 위한 방향족산을 함유한 l- 카르니틴 o-에스테르의 용도 Download PDFInfo
- Publication number
- KR950000141A KR950000141A KR1019940012266A KR19940012266A KR950000141A KR 950000141 A KR950000141 A KR 950000141A KR 1019940012266 A KR1019940012266 A KR 1019940012266A KR 19940012266 A KR19940012266 A KR 19940012266A KR 950000141 A KR950000141 A KR 950000141A
- Authority
- KR
- South Korea
- Prior art keywords
- acid
- pharmaceutical composition
- carnitine
- composition according
- ester
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 13
- 208000017520 skin disease Diseases 0.000 title claims abstract 6
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title claims abstract 3
- 159000000032 aromatic acids Chemical class 0.000 title claims abstract 3
- 239000002253 acid Substances 0.000 claims abstract 10
- -1 ester compound Chemical class 0.000 claims abstract 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000002252 acyl group Chemical group 0.000 claims abstract 2
- 150000001450 anions Chemical class 0.000 claims abstract 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
- NDVRKEKNSBMTAX-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NDVRKEKNSBMTAX-BTVCFUMJSA-N 0.000 claims 1
- HZNQSWJZTWOTKM-UHFFFAOYSA-N 2,3,4-trimethoxybenzoic acid Chemical compound COC1=CC=C(C(O)=O)C(OC)=C1OC HZNQSWJZTWOTKM-UHFFFAOYSA-N 0.000 claims 1
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 208000001840 Dandruff Diseases 0.000 claims 1
- 206010020649 Hyperkeratosis Diseases 0.000 claims 1
- 102000011782 Keratins Human genes 0.000 claims 1
- 108010076876 Keratins Proteins 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 208000014417 Plantar hyperkeratosis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 229940009098 aspartate Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229960004889 salicylic acid Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 229910021653 sulphate ion Inorganic materials 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
본 발명은 피부병 치료용 약제조성물 제조를 위한 방향족산을 함유한 L-카르니틴 O-에스테르의 용도에 관한 것으로서, 더욱 상세하게는 국소투여에 적합한 약제조성물 제조를 위한 활성성분으로서의 다음 구조식(Ⅰ)로 표시되는 에스테르 화합물의 용도에 관한 것이다.
상기식에서, R은 방향족산의 아실그룹이고, X-는 약제학적으로 수용할 수 있는 산의 음이온이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 피부병 치료의 국소투여에 적합한 약제조성물 제조를 위한 다음 구조식(Ⅰ)로 표시되는 방향족산을 함유한 L-카르니틴 에스테르의 용도.상기식에서, R은 살리실산, 아세틸살리실산, 니코틴산 및 트리메톡시벤조산 중에서 선택된 방향족산의 아실그룹이고, X-는 약제학적으로 수용할 수 있는 산의 음이온이다.
- 제1항에 있어서, 상기 구조식(Ⅰ)로 표시되는 L-카르니틴 에스테르는 분자내 염의 형태인 것을 특징으로 하는 방향족산을 함유한 L-카르니틴 에스테르의 용도.
- 제1항에 있어서, 상기 X-는 염화물, 브롬화물, 오로트산염, 아스파르트산염의 산, 시트라산염의 산, 인산염의 산, 푸마르산염, 푸마르산염의 산, 락트산염, 말레산염, 말레산염의 산, 옥살산염의 산, 황산염의 산, 글루코스 인산염, 타르타르산염 및 타르타르산염의 산 중에서 선택되는 것을 특징으로 하는 방향족산을 함유한 L-카르니틴 에스테르의 용도.
- 다음 구조식(Ⅰ)로 표시되는 L-카르니틴 에스테르 O-에스테르 및 약제학적으로 수용할 수 있는 부형제로 구성되어 있는 피부병 치료의 국소투여에 적합한 약제조성물.상기식에서, R 및 X'는 상기 제1항에서 정의한 바와 같다.
- 제4항에 있어서, 상기 약제조성물은 어린선 및 건선의 치료에 사용되는 것을 특징으로 하는 약제조성물.
- 제4항에 있어서, 상기 약제조성물은 각화 결손에 의한 피부병 치료에 사용되는 것을 특징으로 하는 약제조성물.
- 제6항에 있어서, 상기 피부병은 비듬, 여드름, 손바닥 과각화증 또는 발바닥 과각화증인 것을 특징으로 하는 약제조성물.
- 제4항에 있어서, 상기 약제조성물은 용액, 로션, 연고 또는 크림 형태임을 특징으로 하는 약제조성물.
- 제4항에 있어서, 상기 약제조성물은 상기 구조식(Ⅰ)로 표시되는 L-카르니틴 에스테르 O-에스테르 화합물 중에서 선택된 1종 이상의 것을 0.01~20중량% 함유하는 것을 특징으로 하는 약제조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM93A000365 | 1993-06-02 | ||
| ITRM930365A IT1261696B (it) | 1993-06-02 | 1993-06-02 | Uso di esteri sull'ossidrile della l-carnitina con acidi aromatici perprodurre composizioni farmaceutiche per il trattamento di affezioni cutanee. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR950000141A true KR950000141A (ko) | 1995-01-03 |
Family
ID=11401791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019940012266A KR950000141A (ko) | 1993-06-02 | 1994-06-01 | 피부병 치료용 약제조성물 제조를 위한 방향족산을 함유한 l- 카르니틴 o-에스테르의 용도 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5639767A (ko) |
| EP (1) | EP0628308B1 (ko) |
| JP (1) | JPH07309820A (ko) |
| KR (1) | KR950000141A (ko) |
| AT (1) | ATE174216T1 (ko) |
| CA (1) | CA2124748A1 (ko) |
| DE (1) | DE69415081T2 (ko) |
| DK (1) | DK0628308T3 (ko) |
| ES (1) | ES2126674T3 (ko) |
| GR (1) | GR3029536T3 (ko) |
| IT (1) | IT1261696B (ko) |
| ZA (1) | ZA943808B (ko) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100783145B1 (ko) * | 2002-04-23 | 2007-12-07 | 삼성광주전자 주식회사 | 선회형 흡입구를 가지는 청소 로봇 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5833998A (en) * | 1995-11-06 | 1998-11-10 | The Procter & Gamble Company | Topical compositions for regulating the oily/shiny appearance of skin |
| IT1276253B1 (it) | 1995-12-15 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi |
| IT1291113B1 (it) * | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
| US6090848A (en) * | 1997-12-01 | 2000-07-18 | Sigma-Tau Healthscience S.P.A. | Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans |
| US5863940A (en) | 1997-12-01 | 1999-01-26 | Sigma-Tau Healthscience S.P.A. | Medicament and therapeutical method for treating idiopathic asthenozoospermia |
| PT951909E (pt) | 1998-03-19 | 2004-04-30 | Sigma Tau Ind Farmaceuti | Composicao combinada que contem uma l-carnitina ou uma alcanoil-l-carnitina um glicosaminoglicano e/ou um seu constituinte |
| DE10129502A1 (de) * | 2001-06-19 | 2003-01-09 | Beiersdorf Ag | Verwendung von Carnitin und/oder einem oder mehreren Acyl-Carnitinen zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Steigerung der Ceramidbiosynthese |
| DE10133200A1 (de) | 2001-07-07 | 2003-01-23 | Beiersdorf Ag | Carnitin enthaltende kosmetische und dermatologische Zubereitungen zur Behandlung und aktiven Prävention trockener Haut und anderer negativer Veränderungen der physiologischen Homöostase der gesunden Haut |
| ITRM20020055A1 (it) * | 2002-02-04 | 2003-08-04 | Aldo Fassi | Sali metallici di carnitine, integratori dietetici/nutritivi che li contengono e kit dietetici per contrastare disturbi sessuali in soggetti |
| ES2336995B1 (es) | 2008-10-13 | 2011-02-09 | Lipotec, S.A. | Composicion cosmetica o dermofarmaceutica para el cuidado de la piel,cuero cabelludo y uñas. |
| US9259343B2 (en) | 2012-07-06 | 2016-02-16 | Newman Technologies LLC | Device for mitigating plantar fasciitis |
| CN107540605B (zh) * | 2016-12-28 | 2020-03-06 | 宁波见睿新材料有限公司 | 用于头发或头皮护理的胆碱酯类化合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2354769A1 (fr) * | 1976-06-15 | 1978-01-13 | Tanabe Seiyaku Co | Derives de nicotinoylcarnitines, leur preparation et leurs utilisations therapeutiques |
| CH679856A5 (ko) * | 1990-07-04 | 1992-04-30 | Lonza Ag |
-
1993
- 1993-06-02 IT ITRM930365A patent/IT1261696B/it active IP Right Grant
-
1994
- 1994-05-25 DK DK94108016T patent/DK0628308T3/da active
- 1994-05-25 AT AT94108016T patent/ATE174216T1/de not_active IP Right Cessation
- 1994-05-25 DE DE69415081T patent/DE69415081T2/de not_active Expired - Fee Related
- 1994-05-25 ES ES94108016T patent/ES2126674T3/es not_active Expired - Lifetime
- 1994-05-25 EP EP94108016A patent/EP0628308B1/en not_active Expired - Lifetime
- 1994-05-31 CA CA002124748A patent/CA2124748A1/en not_active Abandoned
- 1994-06-01 ZA ZA943808A patent/ZA943808B/xx unknown
- 1994-06-01 KR KR1019940012266A patent/KR950000141A/ko not_active Application Discontinuation
- 1994-06-02 US US08/253,051 patent/US5639767A/en not_active Expired - Fee Related
- 1994-06-02 JP JP6121068A patent/JPH07309820A/ja active Pending
-
1999
- 1999-03-01 GR GR990400631T patent/GR3029536T3/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100783145B1 (ko) * | 2002-04-23 | 2007-12-07 | 삼성광주전자 주식회사 | 선회형 흡입구를 가지는 청소 로봇 |
Also Published As
| Publication number | Publication date |
|---|---|
| ITRM930365A1 (it) | 1994-12-02 |
| IT1261696B (it) | 1996-05-29 |
| DE69415081T2 (de) | 1999-04-29 |
| GR3029536T3 (en) | 1999-06-30 |
| ATE174216T1 (de) | 1998-12-15 |
| EP0628308B1 (en) | 1998-12-09 |
| DK0628308T3 (da) | 1999-08-16 |
| US5639767A (en) | 1997-06-17 |
| JPH07309820A (ja) | 1995-11-28 |
| ITRM930365A0 (it) | 1993-06-02 |
| DE69415081D1 (de) | 1999-01-21 |
| CA2124748A1 (en) | 1994-12-03 |
| EP0628308A1 (en) | 1994-12-14 |
| ES2126674T3 (es) | 1999-04-01 |
| ZA943808B (en) | 1995-01-30 |
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