FI64159C - Foerfarande foer framstaellning av oralt effektiva antiallergiska 11-oxo-11-h-pyrido(2,1-b)-kinazoliner - Google Patents

Foerfarande foer framstaellning av oralt effektiva antiallergiska 11-oxo-11-h-pyrido(2,1-b)-kinazoliner Download PDF

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Publication number
FI64159C
FI64159C FI763469A FI763469A FI64159C FI 64159 C FI64159 C FI 64159C FI 763469 A FI763469 A FI 763469A FI 763469 A FI763469 A FI 763469A FI 64159 C FI64159 C FI 64159C
Authority
FI
Finland
Prior art keywords
formula
compound
carboxyl
group
alkyl
Prior art date
Application number
FI763469A
Other languages
English (en)
Finnish (fi)
Other versions
FI64159B (fi
FI763469A (de
Inventor
Kurt Schromm
Anton Mentrup
Ernst-Otto Renth
Armin Fuegner
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of FI763469A publication Critical patent/FI763469A/fi
Publication of FI64159B publication Critical patent/FI64159B/fi
Application granted granted Critical
Publication of FI64159C publication Critical patent/FI64159C/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI763469A 1975-12-19 1976-12-02 Foerfarande foer framstaellning av oralt effektiva antiallergiska 11-oxo-11-h-pyrido(2,1-b)-kinazoliner FI64159C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2557425A DE2557425C2 (de) 1975-12-19 1975-12-19 11-Oxo-11-H-pyrido[2,1-b]-chinazolin-2-carbonsäure und ihre Salze, Verfahren zu ihrer Herstellung und Arzneimittel
DE2557425 1975-12-19

Publications (3)

Publication Number Publication Date
FI763469A FI763469A (de) 1977-06-20
FI64159B FI64159B (fi) 1983-06-30
FI64159C true FI64159C (fi) 1983-10-10

Family

ID=5964943

Family Applications (1)

Application Number Title Priority Date Filing Date
FI763469A FI64159C (fi) 1975-12-19 1976-12-02 Foerfarande foer framstaellning av oralt effektiva antiallergiska 11-oxo-11-h-pyrido(2,1-b)-kinazoliner

Country Status (36)

Country Link
US (2) US4083980A (de)
JP (1) JPS5831350B2 (de)
AT (1) AT352736B (de)
AU (1) AU513469B2 (de)
BE (1) BE849542A (de)
BG (3) BG25092A3 (de)
CA (1) CA1199914A (de)
CH (4) CH625522A5 (de)
CS (1) CS198222B2 (de)
DD (1) DD128812A5 (de)
DE (1) DE2557425C2 (de)
DK (1) DK149107C (de)
ES (3) ES454405A1 (de)
FI (1) FI64159C (de)
FR (1) FR2335229A1 (de)
GB (1) GB1572707A (de)
GR (1) GR62109B (de)
HK (1) HK12984A (de)
HU (1) HU172929B (de)
IE (1) IE45256B1 (de)
IL (1) IL51124A (de)
LU (1) LU76417A1 (de)
MX (1) MX4488E (de)
MY (1) MY8500078A (de)
NL (1) NL182535C (de)
NO (1) NO147450C (de)
NZ (1) NZ182915A (de)
PH (1) PH16310A (de)
PL (5) PL102308B1 (de)
PT (1) PT65981A (de)
RO (3) RO69411A (de)
SE (1) SE431456B (de)
SG (1) SG55483G (de)
SU (4) SU645571A3 (de)
YU (2) YU39048B (de)
ZA (1) ZA767490B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337255A (en) * 1977-07-29 1982-06-29 E. R. Squibb & Sons, Inc. Pyrazolo[1,5-c]quinazoline derivatives and related compounds
HU182009B (en) * 1977-08-19 1983-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted pirido-square bracket-1,2-a-square bracket closed-pyrimidines, pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines
DE2739020A1 (de) 1977-08-26 1979-03-01 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
US4348396A (en) * 1978-01-23 1982-09-07 Hoffmann-La Roche Inc. Substituted 11-oxo-11H-pyrido[2,1-b]quinazolines and method of inhibiting allergic reactions with them
US4168380A (en) * 1978-04-21 1979-09-18 Hoffmann-La Roche Inc. 7-Methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid
US4491587A (en) * 1978-05-05 1985-01-01 Mead Johnson & Company Tetrazole derivatives
US4223031A (en) * 1978-05-05 1980-09-16 Mead Johnson & Company Azolopyrimidinones
US4209620A (en) * 1978-06-19 1980-06-24 Bristol-Myers Company Substituted 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives having antiallergy activity
DE2845766A1 (de) * 1978-10-18 1980-04-30 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
DE3065963D1 (en) * 1979-01-24 1984-02-02 Warner Lambert Co Pyrazolo (5,1-b) quinazolin-9(4h)-one derivatives, process for their preparation and pharmaceutical compositions containing them
US4282360A (en) * 1979-10-12 1981-08-04 Hoffmann-La Roche Inc. 7-Methylthio or methylsulfinyl-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid
US4302585A (en) 1980-12-22 1981-11-24 American Home Products Corporation 3-Hydroxy-3-substituted phenylthiazolo[2,3-b]quinazoline-2-alkanoic acids and their lactones
US4395549A (en) 1981-10-02 1983-07-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 6-Hydrazono-pyrido[2,1-b] quinazoline-11 ones
DE3142728A1 (de) * 1981-10-28 1983-05-05 Basf Ag, 6700 Ludwigshafen Herbizide, enthaltend thiazolo(2,3-b)-chinazolone als wirkstoffe, und ihre verwendung zur beeinflussung des pflanzenwachstums
DE3142727A1 (de) * 1981-10-28 1983-05-05 Basf Ag, 6700 Ludwigshafen Thiazolo (2,3-b)-chinazolone, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des pflanzenwachstums
ES8406476A1 (es) * 1982-04-29 1984-07-01 Erba Farmitalia Procedimiento para preparar derivados cicloalifaticos condensados de pirido(1,2-a)pirimidinas sustituidas.
US4551460A (en) * 1982-05-10 1985-11-05 Hoffmann-La Roche Inc. Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis
US4455312A (en) * 1982-08-19 1984-06-19 Portnyagina Vera A 2-(o-Carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 and derivatives thereof, and application as antiphlogistics
DE3300477A1 (de) * 1983-01-08 1984-07-12 Boehringer Ingelheim KG, 6507 Ingelheim Neue heterocyclische verbindungen, ihre herstellung und verwendung
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
EP0142057A3 (de) * 1983-11-04 1988-03-30 F. Hoffmann-La Roche Ag Thiazolochinazolin-Derivate, ihre Herstellung und sie enthaltende pharmazeutische Zubereitungen
US4738964A (en) * 1984-05-30 1988-04-19 Pennwalt Corporation Method of suppressing the immune system comprising administering 5H-thiazolo[2,3-b]quinazoline-3(2H)-one
US4588812A (en) * 1984-05-30 1986-05-13 Pennwalt Corporation Substituted 2,3-dihydro-5H-thiazolo[2,3,-b]quinazoline derivatives
JPS61204475A (ja) * 1985-03-07 1986-09-10 松下電工株式会社 ２台収納立体ガレ−ジのパレツト落下防止装置
DE3634532A1 (de) * 1986-10-10 1988-04-14 Basf Ag Verfahren zur herstellung von thiazolo-(2,3-b)chinazolonen
DE3704203A1 (de) * 1987-02-11 1988-08-25 Boehringer Ingelheim Kg Verwendung von oxochinazolinderivaten bei der behandlung der hyperurikaemie
US4904667A (en) * 1989-02-24 1990-02-27 Ortho Pharmaceutical Corporation 1H-1,2,4-thiadiazolo(3,4-b)quinazolin-5-one-2,2-dioxides, and a method for increasing the cardiac output of a mammal with them
US6800651B2 (en) 2000-02-03 2004-10-05 Eli Lilly And Company Potentiators of glutamate receptors
WO2011130163A1 (en) 2010-04-12 2011-10-20 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US8765773B2 (en) 2010-10-18 2014-07-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US10183934B2 (en) 2015-02-02 2019-01-22 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors
WO2016126721A1 (en) 2015-02-02 2016-08-11 Forma Therapeutics, Inc. 3-aryl-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors
US10555935B2 (en) 2016-06-17 2020-02-11 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1242863A (en) * 1968-05-10 1971-08-18 Pharmacia As 2,3-DIHYDRO-5H-THIAZOLO[2,3-b]QUINAZOLINES AND PROCESSES FOR THE PREPARATION THEREOF
US3598823A (en) * 1969-05-28 1971-08-10 Sandoz Ag Tricyclic quinazolinones
CA984842A (en) 1972-02-28 1976-03-02 Charles M. Hall 1,4,6,9-tetrahydro-4,6-dioxopyrido-(3,2-g)-quinoline-2,8-dicarboxylic acid compounds
US3833588A (en) * 1972-04-25 1974-09-03 Sandoz Ag Unsaturated-substituted tricyclic quinazolinones
JPS5752352B2 (de) * 1974-02-28 1982-11-06
US4012387A (en) * 1975-09-18 1977-03-15 Warner-Lambert Company Benzo-[g]pyrido[2,1-b]quinazolinones
US4033961A (en) * 1975-10-07 1977-07-05 Warner-Lambert Company Pyrido[2-1-b]quinazolin-ones and their methods of preparation
US4142049A (en) * 1976-10-18 1979-02-27 Warner-Lambert Company Benzo[g]pyrido[2,1-b]quinazolinones
US4066767A (en) * 1976-11-01 1978-01-03 Warner-Lambert Company 8-(1H-Tetrazol-5-yl)-11H-pyrido[2,1-b]quinazolin-11-ones and method of treating bronchial asthma using them
DE2812585A1 (de) * 1977-03-24 1978-09-28 Hoffmann La Roche Chinazolin-derivate
DE2739020A1 (de) * 1977-08-26 1979-03-01 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
US4168380A (en) * 1978-04-21 1979-09-18 Hoffmann-La Roche Inc. 7-Methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid

Also Published As

Publication number Publication date
RO75248A (ro) 1980-11-30
NL182535C (nl) 1988-04-05
FI64159B (fi) 1983-06-30
FR2335229A1 (fr) 1977-07-15
ES464162A1 (es) 1978-09-01
SE7614258L (sv) 1977-06-20
FI763469A (de) 1977-06-20
ZA767490B (en) 1978-08-30
DK567376A (da) 1977-06-20
BG25093A3 (en) 1978-07-12
CA1199914A (en) 1986-01-28
IE45256B1 (en) 1982-07-28
DD128812A5 (de) 1977-12-14
IE45256L (en) 1977-06-19
SU645571A3 (ru) 1979-01-30
CH625522A5 (de) 1981-09-30
NZ182915A (en) 1979-07-11
DK149107C (da) 1986-06-09
YU39048B (en) 1984-02-29
NL7614013A (nl) 1977-06-21
DE2557425C2 (de) 1987-03-19
SU733516A3 (ru) 1980-05-05
PL111422B1 (en) 1980-08-30
YU115282A (en) 1983-12-31
BG24673A3 (en) 1978-04-12
ATA883976A (de) 1979-03-15
MY8500078A (en) 1985-12-31
NO764303L (de) 1977-06-21
CH625243A5 (de) 1981-09-15
FR2335229B1 (de) 1980-04-11
CH627754A5 (de) 1982-01-29
NO147450B (no) 1983-01-03
SG55483G (en) 1984-07-27
PL102308B1 (pl) 1979-03-31
PT65981A (pt) 1977-01-01
PL103556B1 (pl) 1979-06-30
LU76417A1 (de) 1978-01-18
US4332802A (en) 1982-06-01
ES464136A1 (es) 1978-09-01
ES454405A1 (es) 1978-01-16
NL182535B (nl) 1987-11-02
BG25092A3 (en) 1978-07-12
JPS5831350B2 (ja) 1983-07-05
JPS5277096A (en) 1977-06-29
GR62109B (en) 1979-02-26
IL51124A0 (en) 1977-02-28
DE2557425A1 (de) 1977-06-30
MX4488E (es) 1982-05-21
AU2069576A (en) 1978-06-22
AU513469B2 (en) 1980-12-04
BE849542A (fr) 1977-06-17
PL110780B1 (en) 1980-07-31
IL51124A (en) 1980-06-30
HK12984A (en) 1984-02-24
PL101141B1 (pl) 1978-12-30
CH631983A5 (de) 1982-09-15
RO69411A (ro) 1982-02-01
HU172929B (hu) 1979-01-28
GB1572707A (en) 1980-07-30
YU40078B (en) 1985-06-30
SE431456B (sv) 1984-02-06
US4083980A (en) 1978-04-11
YU308276A (en) 1982-08-31
RO75734A (ro) 1982-07-06
PH16310A (en) 1983-09-05
SU652894A3 (ru) 1979-03-15
SU784776A3 (ru) 1980-11-30
DK149107B (da) 1986-01-27
CS198222B2 (en) 1980-05-30
AT352736B (de) 1979-10-10
NO147450C (no) 1983-04-13

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Owner name: C.H. BOEHRINGER SOHN