FI63580C - Foerfarande foer rening av foerorenad klavulansyra och foer frmstaellning av rena klavulanatsalter - Google Patents

Foerfarande foer rening av foerorenad klavulansyra och foer frmstaellning av rena klavulanatsalter Download PDF

Info

Publication number
FI63580C
FI63580C FI760285A FI760285A FI63580C FI 63580 C FI63580 C FI 63580C FI 760285 A FI760285 A FI 760285A FI 760285 A FI760285 A FI 760285A FI 63580 C FI63580 C FI 63580C
Authority
FI
Finland
Prior art keywords
lithium
salt
water
clavulanic acid
clavulanate
Prior art date
Application number
FI760285A
Other languages
English (en)
Finnish (fi)
Other versions
FI760285A (it
FI63580B (fi
Inventor
Ian Dunlop Fleming
David Noble
Hazel Mary Noble
Wilfred Frank Wall
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB540975A external-priority patent/GB1543563A/en
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of FI760285A publication Critical patent/FI760285A/fi
Priority to FI802142A priority Critical patent/FI64600C/fi
Publication of FI63580B publication Critical patent/FI63580B/fi
Application granted granted Critical
Publication of FI63580C publication Critical patent/FI63580C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI760285A 1975-02-07 1976-02-06 Foerfarande foer rening av foerorenad klavulansyra och foer frmstaellning av rena klavulanatsalter FI63580C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI802142A FI64600C (fi) 1975-02-07 1980-07-03 Litiumklavulanat foer anvaendning vid rening av klavulansyra och dess derivat

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB540975 1975-02-07
GB540975A GB1543563A (en) 1975-02-07 1975-02-07 Beta-lactam antibiotic in purified form
GB1107675 1975-03-17
GB1107675 1975-03-17

Publications (3)

Publication Number Publication Date
FI760285A FI760285A (it) 1976-08-08
FI63580B FI63580B (fi) 1983-03-31
FI63580C true FI63580C (fi) 1983-07-11

Family

ID=26239868

Family Applications (1)

Application Number Title Priority Date Filing Date
FI760285A FI63580C (fi) 1975-02-07 1976-02-06 Foerfarande foer rening av foerorenad klavulansyra och foer frmstaellning av rena klavulanatsalter

Country Status (15)

Country Link
US (3) US4490294A (it)
JP (2) JPS51101994A (it)
AT (1) AT353409B (it)
AU (1) AU509313B2 (it)
CH (1) CH624956A5 (it)
DE (1) DE2604697A1 (it)
DK (1) DK141099B (it)
ES (1) ES444948A1 (it)
FI (1) FI63580C (it)
FR (1) FR2368276A1 (it)
IE (1) IE43790B1 (it)
IT (2) IT1059403B (it)
NL (1) NL7601227A (it)
SE (1) SE421796B (it)
YU (1) YU40452B (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
GB1542405A (en) * 1975-04-15 1979-03-21 Beecham Group Ltd Clavulanic acid derivatives
EP0002370B1 (en) * 1977-12-02 1983-05-11 Beecham Group Plc A process for the preparation of ether derivatives of clavulanic acid
EP0026044B1 (en) * 1979-08-24 1983-06-08 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
GB9702216D0 (en) * 1997-02-04 1997-03-26 Smithkline Beecham Plc Novel product
GB9702218D0 (en) * 1997-02-04 1997-03-26 Smithkline Beecham Plc Novel product
EP0867515B1 (en) * 1997-03-24 1999-12-08 CIPAN-Companhia Industrial Produtora De Antibioticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
JPH11254368A (ja) * 1998-03-12 1999-09-21 Central Motor Co Ltd 部材保持装置
WO2000001840A1 (en) * 1998-07-03 2000-01-13 Dsm N.V. Fermentation process to produce clavulanic acid at a low concentration of free amino acids
PT102181A (pt) * 1998-07-20 2000-01-31 Dsm Nv Processo melhorado para a producao de acido clavulanico
CN1468098A (zh) * 2000-10-05 2004-01-14 �ݰ¸Ƕ�ҩ�����޹�˾ 基本上无普伐他汀内酯和表普伐他汀的普伐他汀钠和包含普伐他汀钠的组合物
US20040072815A1 (en) * 2002-02-12 2004-04-15 Koppel Gary A. Antibiotic composition and method
KR100461278B1 (ko) * 2002-10-23 2004-12-10 현대자동차주식회사 용접 대상물의 위치규제 및 취출장치
WO2019068642A1 (en) 2017-10-02 2019-04-11 Metabolic Explorer PROCESS FOR PRODUCING ORGANIC ACID SALTS FROM A FERMENTATION BROTH

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754693A (fr) * 1969-08-12 1971-02-11 Lilly Co Eli Nouvel antibiotique et procede pour le preparer
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration

Also Published As

Publication number Publication date
IE43790B1 (en) 1981-06-03
DK49876A (it) 1976-08-08
NL7601227A (nl) 1976-08-10
US4490294A (en) 1984-12-25
FI760285A (it) 1976-08-08
YU40452B (en) 1986-02-28
US4490295A (en) 1984-12-25
DE2604697A1 (de) 1976-08-19
DE2604697C2 (it) 1992-10-29
SE7601337L (sv) 1976-11-03
SE421796B (sv) 1982-02-01
IE43790L (en) 1976-08-07
AU509313B2 (en) 1980-05-08
ATA83476A (de) 1979-04-15
FR2368276A1 (fr) 1978-05-19
AT353409B (de) 1979-11-12
FI63580B (fi) 1983-03-31
JPS51101994A (it) 1976-09-08
FR2368276B1 (it) 1979-03-16
YU29076A (en) 1982-08-31
DK141099B (da) 1980-01-14
IT1059403B (it) 1982-05-31
AU1089176A (en) 1977-08-11
JPH0222281A (ja) 1990-01-25
CH624956A5 (de) 1981-08-31
DK141099C (it) 1980-07-21
IT1066098B (it) 1985-03-04
ES444948A1 (es) 1977-08-16
US4367175A (en) 1983-01-04

Similar Documents

Publication Publication Date Title
FI63580C (fi) Foerfarande foer rening av foerorenad klavulansyra och foer frmstaellning av rena klavulanatsalter
JPS5946954B2 (ja) 抗生物質の製法
AU655718B2 (en) Novel alkylenediammonium diclavulanate derivatives, a process for the preparation thereof as well as the use thereof
US4144242A (en) Process for the purification of clavulanic acid
SU1003761A3 (ru) Способ получени антибиотика G-6302
JP2002535996A (ja) シュードモナス酸群を含む培養液からのシュードモナス酸ａの単離方法
US4517296A (en) Antibiotic acmimycin and its production
US2885433A (en) O-carbamyl-d-serine
US4530791A (en) β-Lactam antibiotics
FI64600C (fi) Litiumklavulanat foer anvaendning vid rening av klavulansyra och dess derivat
DK143570B (da) Fremgangsmaade til fremstilling af maytansinol maytanacin og eller maytansinolpropionat
JP2742586B2 (ja) Ｔａｎ−１０３０ａおよびその誘導体，これらの製造法ならびに用途
US4283492A (en) Production of antibiotics WS-3442 A, B, C, D and E, and their acyl derivatives
KR800001241B1 (ko) 클라블란산 항생물질의 정제방법
Perlman et al. Microbial production of vitamin B12 antimetabolites: II. 2-Amino-4-keto-3-methylpentanoic acids from bacillus cereus 439
SU1296009A3 (ru) Штамм @ @ 15118-продуцент антибиотического комплекса и способ получени антибиотического комплекса
DK146764B (da) Alkalimetalclavulanat til anvendelse som mellemprodukt ved fremstilling af clavulansyre eller andre derivater deraf, samt blanding til anvendelse ved fremstilling af clavulansyre eller derivater deraf
EP0659752B1 (en) Antibacterial and anti-tumor epoxide derivate dc 114-a1
JPH0123473B2 (it)
JPS62132848A (ja) ２，３−ジヒドロ−２−ジアゾ−３−オキソ安息香酸もしくはそのエステルならびにそれらの製造法
JPH0613499B2 (ja) パチュロリドおよびその製造法
CA1055415A (en) Enzymatic production of 7-(3-alkanesulfonamido phenyl-d-glycinamido)-3-desacetoxy cephalosporanic acid
SU1165680A1 (ru) Непланоцин @ или его производные в качестве промежуточных продуктов в синтезе непланоцина @
KR790001610B1 (ko) 항생물질 mm 13902의 제조방법
KR830002207B1 (ko) 7α-메톡시세팔로스포린 유도체의 제조방법

Legal Events

Date Code Title Description
MA Patent expired
MA Patent expired

Owner name: BEECHAM GROUP LTD