FI63407C - Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-2-furoyl)- 5-(2-tenoyl)- 5-(3-furoyl)- och 5-(3-tenoyl)- 21,dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karboxylsyraderivat - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-2-furoyl)- 5-(2-tenoyl)- 5-(3-furoyl)- och 5-(3-tenoyl)- 21,dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karboxylsyraderivat Download PDF

Info

Publication number
FI63407C
FI63407C FI772154A FI772154A FI63407C FI 63407 C FI63407 C FI 63407C FI 772154 A FI772154 A FI 772154A FI 772154 A FI772154 A FI 772154A FI 63407 C FI63407 C FI 63407C
Authority
FI
Finland
Prior art keywords
pyrrolo
pyrrole
dihydro
formula
acid
Prior art date
Application number
FI772154A
Other languages
English (en)
Finnish (fi)
Other versions
FI772154A (xx
FI63407B (fi
Inventor
Joseph M Muchowski
Arthur F Kluge
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/771,283 external-priority patent/US4087539A/en
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of FI772154A publication Critical patent/FI772154A/fi
Publication of FI63407B publication Critical patent/FI63407B/fi
Application granted granted Critical
Publication of FI63407C publication Critical patent/FI63407C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI772154A 1976-07-14 1977-07-11 Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-2-furoyl)- 5-(2-tenoyl)- 5-(3-furoyl)- och 5-(3-tenoyl)- 21,dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karboxylsyraderivat FI63407C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70485776A 1976-07-14 1976-07-14
US70485776 1976-07-14
US05/771,283 US4087539A (en) 1976-07-14 1977-02-23 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US77128377 1977-02-23

Publications (3)

Publication Number Publication Date
FI772154A FI772154A (xx) 1978-01-15
FI63407B FI63407B (fi) 1983-02-28
FI63407C true FI63407C (fi) 1983-06-10

Family

ID=27107392

Family Applications (1)

Application Number Title Priority Date Filing Date
FI772154A FI63407C (fi) 1976-07-14 1977-07-11 Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-2-furoyl)- 5-(2-tenoyl)- 5-(3-furoyl)- och 5-(3-tenoyl)- 21,dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karboxylsyraderivat

Country Status (26)

Country Link
JP (1) JPS539789A (xx)
AR (1) AR218631A1 (xx)
AU (1) AU513385B2 (xx)
CA (1) CA1100140A (xx)
CH (2) CH644861A5 (xx)
CS (1) CS208724B2 (xx)
DE (1) DE2731662A1 (xx)
DK (1) DK152652C (xx)
ES (2) ES460705A1 (xx)
FI (1) FI63407C (xx)
FR (1) FR2361396A1 (xx)
GB (1) GB1554076A (xx)
GR (1) GR61607B (xx)
HK (1) HK17581A (xx)
IE (1) IE45302B1 (xx)
IL (1) IL52492A (xx)
IT (1) IT1117314B (xx)
MY (1) MY8100371A (xx)
NL (1) NL7707652A (xx)
NO (1) NO147563C (xx)
NZ (1) NZ184611A (xx)
PL (1) PL111408B1 (xx)
PT (1) PT66779B (xx)
SE (1) SE434644B (xx)
SU (2) SU664566A3 (xx)
YU (2) YU43156B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097579A (en) * 1977-03-31 1978-06-27 Syntex (U.S.A.) Inc. 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
JPS5910589A (ja) * 1982-06-10 1984-01-20 メルク　エンド　カムパニー　インコーポレーテツド 抗炎症剤および鎮痛剤として新規な５−（ピロ−ル−２−オイル）−１，２−ジヒドロ−３Ｈ−ピロロ〔１，２−ａ〕ピロ−ル誘導体
HU198927B (en) * 1987-01-14 1989-12-28 Richter Gedeon Vegyeszet Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds

Also Published As

Publication number Publication date
AU513385B2 (en) 1980-11-27
FI772154A (xx) 1978-01-15
PT66779A (fr) 1977-08-01
NZ184611A (en) 1979-03-28
DK307677A (da) 1978-01-15
AU2697677A (en) 1979-01-18
IE45302L (en) 1978-01-14
YU47583A (en) 1984-06-30
PL111408B1 (en) 1980-08-30
ES460705A1 (es) 1979-10-01
PT66779B (fr) 1978-12-18
NO147563C (no) 1983-05-18
IL52492A (en) 1981-06-29
FI63407B (fi) 1983-02-28
JPS6254110B2 (xx) 1987-11-13
NO772493L (no) 1978-01-17
GB1554076A (en) 1979-10-17
CH651045A5 (en) 1985-08-30
YU43157B (en) 1989-04-30
CA1100140A (en) 1981-04-28
AR218631A1 (es) 1980-06-30
DE2731662A1 (de) 1978-01-19
FR2361396B1 (xx) 1981-11-27
IL52492A0 (en) 1977-10-31
SU793400A3 (ru) 1980-12-30
IE45302B1 (en) 1982-07-28
DK152652B (da) 1988-04-05
CS208724B2 (en) 1981-09-15
GR61607B (en) 1978-12-02
PL199602A1 (pl) 1979-01-29
HK17581A (en) 1981-05-08
ES470213A1 (es) 1979-09-16
SE434644B (sv) 1984-08-06
IT1117314B (it) 1986-02-17
JPS539789A (en) 1978-01-28
SU664566A3 (ru) 1979-05-25
DE2731662C2 (xx) 1989-11-09
CH644861A5 (en) 1984-08-31
MY8100371A (en) 1981-12-31
FR2361396A1 (fr) 1978-03-10
YU47683A (en) 1984-04-30
DK152652C (da) 1988-09-12
NL7707652A (nl) 1978-01-17
NO147563B (no) 1983-01-24
YU43156B (en) 1989-04-30
SE7708142L (sv) 1978-01-15

Similar Documents

Publication Publication Date Title
US4087539A (en) 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
JPS6254792B2 (xx)
NO874834L (no) Fremgangsmaate for fremstilling av terapeutisk aktive tienopyridinoner.
FI63407C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-2-furoyl)- 5-(2-tenoyl)- 5-(3-furoyl)- och 5-(3-tenoyl)- 21,dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karboxylsyraderivat
FI63406C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-entsoyl-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karboxylsyr adrivat
PL103100B1 (pl) Sposob wytwarzania nowych acyloaminopochodnych piecioczlonowych zwiazkow heterocyklicznych
PL145196B1 (en) Method of obtaining novel 2-ketoindolo-1-carbonamides
US6657070B2 (en) Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
AU619896B2 (en) Novel substituted thienopyrans as antihypertensive agents
EP0114632B1 (en) 5-(4-vinyl- or 4-ethynylbenzoyl)-1,2-dihydro-3h-pyrrolo-(1,2-a)-pyrrole-1-carboxylic acids and derivatives thereof
AU2009251195A1 (en) Production of chirally pure alpha-amino acids and n-sulfonyl alpha-amino acids
L Khokra et al. Rational Design and Synthesis of Biologically Active Disubstituted 2 (3H) Furanones and Pyrrolone Derivatives as Potent and Safer Non Steroidal Anti-inflammatory Agents
JP3878128B2 (ja) チエノピロリジノン
EP0011282B1 (de) Thienylbenzoesäurederivate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate auf Basis dieser Verbindungen
CS255887B2 (en) Process for preparing derivatives of 5,6-dihydro-4h-cyclopent/b/-6-thiophene
US5015656A (en) Organic compounds and their use as pharmaceuticals
IE60102B1 (en) New derivatives of 1-styrenesulphonyl-2-oxo-5-hydroxy pyrrolidine, the process and the intermediates for their preparation, their application as medicaments and the compositions containing them
DK152653B (da) Analogifremgangsmaade til fremstilling af (dl)-eller (l)-5-(2-furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- eller 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolooe1,2-aaapyrrol-1-carboxylsyreestere eller salte
FR2488257A1 (fr) Derives de benzazepine et leur utilisation en pharmacie
GB2320715A (en) Derivatives of Carboxyalkyl Azulenes and Azulene-1-Carboxylic Acid
CH644862A5 (en) 5-(2- and 3-furoyl)- and 5-(2- and 3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and their salts and esters
DK151336B (da) Analogifremgangsmaade til fremstilling af en (dl)- eller (l)-5-benzoyl-1,2-dihydro-3h-pyrrol(1,2-a)pyrrol-1-carboxylsyre
MXPA00009418A (en) PYRROLO[1,2-a]PYRAZINE sPLA2
EP0480692A2 (en) Substituted 4,5-dihydrothieno[2,3-b]thiophene-2-sulfonamides

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: SYNTEX (U.S.A.) INC.