FI62079C - Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(metoximetylfurylmetyl)-6,7-benzomorfaner och deras syraadditionssalter - Google Patents

Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(metoximetylfurylmetyl)-6,7-benzomorfaner och deras syraadditionssalter Download PDF

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Publication number
FI62079C
FI62079C FI3141/74A FI314174A FI62079C FI 62079 C FI62079 C FI 62079C FI 3141/74 A FI3141/74 A FI 3141/74A FI 314174 A FI314174 A FI 314174A FI 62079 C FI62079 C FI 62079C
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FI
Finland
Prior art keywords
group
methyl
formula
compounds
hydrogen atom
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Application number
FI3141/74A
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English (en)
Finnish (fi)
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FI62079B (fi
FI314174A (cs
Inventor
Herbert Merz
Adolf Langbein
Gerhard Walther
Klaus Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
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Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of FI314174A publication Critical patent/FI314174A/fi
Publication of FI62079B publication Critical patent/FI62079B/fi
Application granted granted Critical
Publication of FI62079C publication Critical patent/FI62079C/fi

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI3141/74A 1973-10-27 1974-10-25 Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(metoximetylfurylmetyl)-6,7-benzomorfaner och deras syraadditionssalter FI62079C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19732354002 DE2354002A1 (de) 1973-10-27 1973-10-27 Neue n-(methoxymethyl-furylmethyl)6,7-benzomorphane und -morphinane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
DE2354002 1973-10-27

Publications (3)

Publication Number Publication Date
FI314174A FI314174A (cs) 1975-04-28
FI62079B FI62079B (fi) 1982-07-30
FI62079C true FI62079C (fi) 1982-11-10

Family

ID=5896658

Family Applications (1)

Application Number Title Priority Date Filing Date
FI3141/74A FI62079C (fi) 1973-10-27 1974-10-25 Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(metoximetylfurylmetyl)-6,7-benzomorfaner och deras syraadditionssalter

Country Status (27)

Country Link
US (1) US3981874A (cs)
JP (1) JPS5738590B2 (cs)
AT (6) AT335632B (cs)
BE (1) BE821505A (cs)
BG (3) BG27902A3 (cs)
CA (1) CA1056377A (cs)
CH (6) CH609047A5 (cs)
CS (3) CS171194B2 (cs)
DD (1) DD115909A5 (cs)
DE (1) DE2354002A1 (cs)
DK (1) DK138325C (cs)
ES (6) ES431058A1 (cs)
FI (1) FI62079C (cs)
FR (1) FR2248838B1 (cs)
GB (1) GB1482552A (cs)
HU (1) HU176479B (cs)
IE (1) IE41528B1 (cs)
IL (1) IL45938A (cs)
NL (1) NL7413980A (cs)
NO (1) NO140859C (cs)
PH (1) PH11894A (cs)
PL (3) PL92086B1 (cs)
RO (5) RO65656A (cs)
SE (1) SE422791B (cs)
SU (6) SU510999A3 (cs)
YU (5) YU36949B (cs)
ZA (1) ZA746790B (cs)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1513961A (en) * 1975-02-25 1978-06-14 Acf Chemiefarma Nv 6,7-benzomorphans method for their preparation and intermediates
US4208523A (en) * 1978-11-30 1980-06-17 Sterling Drug Inc. 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl-lower-alkyl-hexahydro-2,6-methano-3-benzazocines
CL2008002199A1 (es) 2007-07-26 2009-10-23 Vitae Pharmaceuticals Inc Compuestos derivados de 1,3-oxazin-2-ona; composicion farmaceutica que comprende a dichos compuestos; y uso para tratar una enfermedad asociada con la actividad de la 11beta-hidroxiesteroide deshidrogenasa tipo 1 (11beta-hsd1) tales como dislipidemia, hiperlipidemia, hipertension, obesidad y enfermedad cardiovascular, entre otras.
AR069545A1 (es) * 2007-11-16 2010-02-03 Boehringer Ingelheim Pharma Derivados de aril y heteroarilcarbonilo de benzomorfanos y estructuras relacionadas, composiciones farmaceuticas que contienen dichos compuestos, obtencion de las mismas, su uso en el tratamiento de enfermedades mediadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa (hsd) 1 y
JP5490014B2 (ja) 2007-12-11 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
EP2252601B1 (en) 2008-01-24 2012-12-19 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009100872A1 (en) * 2008-02-12 2009-08-20 Boehringer Ingelheim International Gmbh Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
EP2254872A2 (en) 2008-02-15 2010-12-01 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CA2723034A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CL2009001058A1 (es) 2008-05-01 2010-09-10 Vitae Pharmaceuticals Inc Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras.
BRPI0911764A2 (pt) 2008-05-01 2015-10-06 Boehringer Ingelheim Int inibidores cíclicos de 11beta-hidroxiesteroide desigrogenase 1
AR071719A1 (es) 2008-05-13 2010-07-07 Boehringer Ingelheim Int Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion
US8114868B2 (en) 2008-07-25 2012-02-14 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
AR078887A1 (es) * 2009-11-06 2011-12-07 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen.
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
JP2014524438A (ja) 2011-08-17 2014-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インデノピリジン誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632591A (en) * 1968-07-19 1972-01-04 Sterling Drug Inc 1 2 3 4 5 6 - hexahydro-3-(cycloaliphatic or cycloaliphatic 11-dimethyl-2 alkyl)-66-methano-3-benzazocines
US3833595A (en) * 1968-12-26 1974-09-03 Sumitomo Chemical Co 2-aroylalkyl benzomorphans
CS166804B2 (cs) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim

Also Published As

Publication number Publication date
BG27903A3 (en) 1980-01-15
RO65657A (ro) 1980-06-15
AT335632B (de) 1977-03-25
NL7413980A (nl) 1975-04-29
CS171195B2 (cs) 1976-10-29
YU285474A (en) 1982-06-18
JPS5738590B2 (cs) 1982-08-16
ZA746790B (en) 1976-06-30
JPS5071679A (cs) 1975-06-13
RO65655A (ro) 1980-06-15
YU36949B (en) 1984-08-31
BG27902A3 (en) 1980-01-15
YU36951B (en) 1984-08-31
PL92053B1 (cs) 1977-03-31
NO140859C (no) 1979-11-28
ATA829074A (de) 1976-07-15
YU285274A (en) 1982-02-25
ATA828774A (de) 1976-07-15
YU36950B (en) 1984-08-31
FI62079B (fi) 1982-07-30
CH609048A5 (cs) 1979-02-15
DK138325C (da) 1979-01-22
NO140859B (no) 1979-08-20
ES431056A1 (es) 1976-10-16
SU508192A3 (ru) 1976-03-25
RO65656A (ro) 1980-06-15
PL92052B1 (cs) 1977-03-31
DK559874A (cs) 1975-06-23
IE41528B1 (en) 1980-01-30
ATA828674A (de) 1976-07-15
CH609046A5 (cs) 1979-02-15
ATA828874A (de) 1976-06-15
ES431057A1 (es) 1976-10-16
AT335633B (de) 1977-03-25
CH609340A5 (cs) 1979-02-28
ES431054A1 (es) 1976-10-16
FI314174A (cs) 1975-04-28
HU176479B (en) 1981-03-28
CS171194B2 (cs) 1976-10-29
FR2248838B1 (cs) 1977-11-04
ES431058A1 (es) 1976-10-16
IL45938A0 (en) 1974-12-31
CH609047A5 (cs) 1979-02-15
AT335631B (de) 1977-03-25
US3981874A (en) 1976-09-21
YU36519B (en) 1984-02-29
RO65658A (fr) 1979-07-15
BG27901A3 (bg) 1980-01-15
CS171196B2 (cs) 1976-10-29
YU285174A (en) 1982-06-18
FR2248838A1 (cs) 1975-05-23
AT336202B (de) 1977-04-25
CH609686A5 (cs) 1979-03-15
DD115909A5 (cs) 1975-10-20
ES431059A1 (es) 1976-10-16
CH609685A5 (cs) 1979-03-15
AT335634B (de) 1977-03-25
PL92086B1 (cs) 1977-03-31
GB1482552A (en) 1977-08-10
BE821505A (fr) 1975-04-25
ATA828974A (de) 1976-08-15
DE2354002A1 (de) 1975-05-07
NO743845L (cs) 1975-05-26
AT335076B (de) 1977-02-25
SE422791B (sv) 1982-03-29
SU512707A3 (ru) 1976-04-30
RO65659A (ro) 1980-06-15
IL45938A (en) 1977-12-30
PH11894A (en) 1978-08-29
SU511005A3 (ru) 1976-04-15
SU578870A3 (ru) 1977-10-30
CA1056377A (en) 1979-06-12
ES431055A1 (es) 1976-10-16
YU285374A (en) 1982-06-18
YU285674A (en) 1982-06-18
SE7413485L (cs) 1975-04-28
SU508193A3 (ru) 1976-03-25
DK138325B (da) 1978-08-14
SU510999A3 (ru) 1976-04-15
YU36952B (en) 1984-08-31
IE41528L (en) 1975-04-27
ATA828574A (de) 1976-07-15

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