RO65659A - Procedeu de preparare a unor n-(metoximetilfurilmetil)-6,7-benzomorfani-morfinani - Google Patents

Procedeu de preparare a unor n-(metoximetilfurilmetil)-6,7-benzomorfani-morfinani

Info

Publication number
RO65659A
RO65659A RO7480318A RO8031874A RO65659A RO 65659 A RO65659 A RO 65659A RO 7480318 A RO7480318 A RO 7480318A RO 8031874 A RO8031874 A RO 8031874A RO 65659 A RO65659 A RO 65659A
Authority
RO
Romania
Prior art keywords
morphinanes
benzomorphanes
preparation
urylmethyle
methoxymethylfurylmethyle
Prior art date
Application number
RO7480318A
Other languages
English (en)
French (fr)
Inventor
Herbert Merz
Adolf Langbein
Gerhard Walther
Klaus Stockhaus
Original Assignee
C.H. Boehringer Sohn,De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H. Boehringer Sohn,De filed Critical C.H. Boehringer Sohn,De
Publication of RO65659A publication Critical patent/RO65659A/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
RO7480318A 1973-10-27 1974-10-25 Procedeu de preparare a unor n-(metoximetilfurilmetil)-6,7-benzomorfani-morfinani RO65659A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19732354002 DE2354002A1 (de) 1973-10-27 1973-10-27 Neue n-(methoxymethyl-furylmethyl)6,7-benzomorphane und -morphinane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
RO65659A true RO65659A (ro) 1980-06-15

Family

ID=5896658

Family Applications (5)

Application Number Title Priority Date Filing Date
RO7480315A RO65656A (ro) 1973-10-27 1974-01-25 Procedeu de preparare a unor n-(metoximetilfurilmetil)-6,7-benzomorfani si morfinani
RO7480317A RO65658A (fr) 1973-10-27 1974-10-25 Procede pour la preparation des n-(methoxymethylfurylmethyle-6,7-benzomorphanes et morphinanes
RO7480318A RO65659A (ro) 1973-10-27 1974-10-25 Procedeu de preparare a unor n-(metoximetilfurilmetil)-6,7-benzomorfani-morfinani
RO7480314A RO65655A (ro) 1973-10-27 1974-10-25 Procedeu de preparare a unor n-(metoximetilfurilmetil)-6,7-benzomorfani si morfinani
RO7480316A RO65657A (ro) 1973-10-27 1974-10-25 Procedeu de preparare a unor n-metoximetilfurilmetil)-6,7-benzomorfani si morfani

Family Applications Before (2)

Application Number Title Priority Date Filing Date
RO7480315A RO65656A (ro) 1973-10-27 1974-01-25 Procedeu de preparare a unor n-(metoximetilfurilmetil)-6,7-benzomorfani si morfinani
RO7480317A RO65658A (fr) 1973-10-27 1974-10-25 Procede pour la preparation des n-(methoxymethylfurylmethyle-6,7-benzomorphanes et morphinanes

Family Applications After (2)

Application Number Title Priority Date Filing Date
RO7480314A RO65655A (ro) 1973-10-27 1974-10-25 Procedeu de preparare a unor n-(metoximetilfurilmetil)-6,7-benzomorfani si morfinani
RO7480316A RO65657A (ro) 1973-10-27 1974-10-25 Procedeu de preparare a unor n-metoximetilfurilmetil)-6,7-benzomorfani si morfani

Country Status (27)

Country Link
US (1) US3981874A (ro)
JP (1) JPS5738590B2 (ro)
AT (6) AT335634B (ro)
BE (1) BE821505A (ro)
BG (3) BG27901A3 (ro)
CA (1) CA1056377A (ro)
CH (6) CH609047A5 (ro)
CS (3) CS171194B2 (ro)
DD (1) DD115909A5 (ro)
DE (1) DE2354002A1 (ro)
DK (1) DK138325C (ro)
ES (6) ES431056A1 (ro)
FI (1) FI62079C (ro)
FR (1) FR2248838B1 (ro)
GB (1) GB1482552A (ro)
HU (1) HU176479B (ro)
IE (1) IE41528B1 (ro)
IL (1) IL45938A (ro)
NL (1) NL7413980A (ro)
NO (1) NO140859C (ro)
PH (1) PH11894A (ro)
PL (3) PL92086B1 (ro)
RO (5) RO65656A (ro)
SE (1) SE422791B (ro)
SU (6) SU510999A3 (ro)
YU (5) YU36950B (ro)
ZA (1) ZA746790B (ro)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1513961A (en) * 1975-02-25 1978-06-14 Acf Chemiefarma Nv 6,7-benzomorphans method for their preparation and intermediates
US4208523A (en) * 1978-11-30 1980-06-17 Sterling Drug Inc. 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl-lower-alkyl-hexahydro-2,6-methano-3-benzazocines
JP5451611B2 (ja) 2007-07-26 2014-03-26 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックインヒビター
CA2704628C (en) * 2007-11-16 2016-11-29 Boehringer Ingelheim International Gmbh Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja) 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター
US20110028445A1 (en) * 2008-02-12 2011-02-03 Boehringer Ingelheim International Gmbh Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5538365B2 (ja) 2008-05-01 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
CL2009001058A1 (es) 2008-05-01 2010-09-10 Vitae Pharmaceuticals Inc Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras.
PL2300461T3 (pl) 2008-05-01 2013-09-30 Vitae Pharmaceuticals Inc Cykliczne inhibitory dehydrogenazy 11beta-hydroksysteroidów 1
US8765780B2 (en) 2008-05-13 2014-07-01 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
CA2729998A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2687525B1 (en) 2008-07-25 2015-09-23 Boehringer Ingelheim International GmbH Cyclic inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
AR078887A1 (es) * 2009-11-06 2011-12-07 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen.
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
JP2014524438A (ja) 2011-08-17 2014-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インデノピリジン誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632591A (en) * 1968-07-19 1972-01-04 Sterling Drug Inc 1 2 3 4 5 6 - hexahydro-3-(cycloaliphatic or cycloaliphatic 11-dimethyl-2 alkyl)-66-methano-3-benzazocines
US3833595A (en) * 1968-12-26 1974-09-03 Sumitomo Chemical Co 2-aroylalkyl benzomorphans
CS166804B2 (ro) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim

Also Published As

Publication number Publication date
NO140859B (no) 1979-08-20
BG27902A3 (en) 1980-01-15
CH609686A5 (ro) 1979-03-15
AT335631B (de) 1977-03-25
YU285174A (en) 1982-06-18
YU36519B (en) 1984-02-29
FI314174A (ro) 1975-04-28
ZA746790B (en) 1976-06-30
DE2354002A1 (de) 1975-05-07
GB1482552A (en) 1977-08-10
IE41528B1 (en) 1980-01-30
FI62079C (fi) 1982-11-10
AT335633B (de) 1977-03-25
YU285674A (en) 1982-06-18
YU36949B (en) 1984-08-31
NO743845L (ro) 1975-05-26
FI62079B (fi) 1982-07-30
SE7413485L (ro) 1975-04-28
ES431059A1 (es) 1976-10-16
RO65658A (fr) 1979-07-15
PL92053B1 (ro) 1977-03-31
PL92086B1 (ro) 1977-03-31
SU578870A3 (ru) 1977-10-30
SU510999A3 (ru) 1976-04-15
PH11894A (en) 1978-08-29
ATA829074A (de) 1976-07-15
CS171196B2 (ro) 1976-10-29
HU176479B (en) 1981-03-28
SE422791B (sv) 1982-03-29
CA1056377A (en) 1979-06-12
ATA828674A (de) 1976-07-15
AT335634B (de) 1977-03-25
CS171195B2 (ro) 1976-10-29
IL45938A (en) 1977-12-30
ES431058A1 (es) 1976-10-16
CH609047A5 (ro) 1979-02-15
SU511005A3 (ru) 1976-04-15
ES431055A1 (es) 1976-10-16
YU285274A (en) 1982-02-25
YU36951B (en) 1984-08-31
DK138325C (da) 1979-01-22
DK559874A (ro) 1975-06-23
JPS5071679A (ro) 1975-06-13
CH609340A5 (ro) 1979-02-28
ATA828774A (de) 1976-07-15
AT336202B (de) 1977-04-25
AT335076B (de) 1977-02-25
BG27903A3 (en) 1980-01-15
SU512707A3 (ru) 1976-04-30
RO65657A (ro) 1980-06-15
ATA828974A (de) 1976-08-15
YU36952B (en) 1984-08-31
DK138325B (da) 1978-08-14
PL92052B1 (ro) 1977-03-31
YU285474A (en) 1982-06-18
ES431054A1 (es) 1976-10-16
RO65655A (ro) 1980-06-15
FR2248838A1 (ro) 1975-05-23
SU508192A3 (ru) 1976-03-25
FR2248838B1 (ro) 1977-11-04
ES431057A1 (es) 1976-10-16
NL7413980A (nl) 1975-04-29
US3981874A (en) 1976-09-21
IE41528L (en) 1975-04-27
DD115909A5 (ro) 1975-10-20
JPS5738590B2 (ro) 1982-08-16
AT335632B (de) 1977-03-25
CH609046A5 (ro) 1979-02-15
ATA828874A (de) 1976-06-15
NO140859C (no) 1979-11-28
RO65656A (ro) 1980-06-15
IL45938A0 (en) 1974-12-31
ES431056A1 (es) 1976-10-16
YU36950B (en) 1984-08-31
BG27901A3 (bg) 1980-01-15
CH609048A5 (ro) 1979-02-15
YU285374A (en) 1982-06-18
ATA828574A (de) 1976-07-15
BE821505A (fr) 1975-04-25
CH609685A5 (ro) 1979-03-15
CS171194B2 (ro) 1976-10-29
SU508193A3 (ru) 1976-03-25

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