FI62063C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-klor eller brom-fenon-0-(2-aminoetyl)-oximer - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-klor eller brom-fenon-0-(2-aminoetyl)-oximer Download PDFInfo
- Publication number
- FI62063C FI62063C FI760695A FI760695A FI62063C FI 62063 C FI62063 C FI 62063C FI 760695 A FI760695 A FI 760695A FI 760695 A FI760695 A FI 760695A FI 62063 C FI62063 C FI 62063C
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- FI
- Finland
- Prior art keywords
- formula
- hal
- compound
- methoxyethoxy
- aminoethyl
- Prior art date
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- -1 2-AMINOETHYL Chemical class 0.000 title claims description 50
- 239000000460 chlorine Substances 0.000 title claims description 17
- 238000000034 method Methods 0.000 title claims description 15
- 229910052801 chlorine Inorganic materials 0.000 title claims description 3
- 230000001225 therapeutic effect Effects 0.000 title claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 69
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims description 28
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 12
- 150000002923 oximes Chemical class 0.000 claims description 12
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 7
- 229910021529 ammonia Inorganic materials 0.000 claims description 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 5
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims description 5
- 239000012458 free base Substances 0.000 claims description 5
- 229910052802 copper Inorganic materials 0.000 claims description 4
- 239000010949 copper Substances 0.000 claims description 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
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- 229910052783 alkali metal Inorganic materials 0.000 claims description 3
- 150000001340 alkali metals Chemical class 0.000 claims description 3
- 125000005530 alkylenedioxy group Chemical group 0.000 claims description 3
- 239000002585 base Substances 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 125000003544 oxime group Chemical group 0.000 claims description 3
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- 125000006239 protecting group Chemical group 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims 3
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
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- YBVPWLHQQWQJAR-UHFFFAOYSA-N [Cl+].[Cu+] Chemical compound [Cl+].[Cu+] YBVPWLHQQWQJAR-UHFFFAOYSA-N 0.000 claims 1
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- JMANVNJQNLATNU-UHFFFAOYSA-N oxalonitrile Chemical group N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
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- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
- 230000004202 respiratory function Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- MLGCXEBRWGEOQX-UHFFFAOYSA-N tetradifon Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)C1=CC(Cl)=C(Cl)C=C1Cl MLGCXEBRWGEOQX-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- XKGLSKVNOSHTAD-UHFFFAOYSA-N valerophenone Chemical compound CCCCC(=O)C1=CC=CC=C1 XKGLSKVNOSHTAD-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
- C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/58—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
- C07C255/64—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7503312A NL7503312A (nl) | 1975-03-20 | 1975-03-20 | Verbindingen met antidepressieve werking. |
| NL7503312 | 1975-03-20 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI760695A FI760695A (xx) | 1976-09-21 |
| FI62063B FI62063B (fi) | 1982-07-30 |
| FI62063C true FI62063C (fi) | 1982-11-10 |
Family
ID=19823426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI760695A FI62063C (fi) | 1975-03-20 | 1976-03-17 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-klor eller brom-fenon-0-(2-aminoetyl)-oximer |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4086361A (xx) |
| JP (1) | JPS6055505B2 (xx) |
| AR (2) | AR211118A1 (xx) |
| AT (1) | AT340896B (xx) |
| AU (1) | AU505356B2 (xx) |
| BE (1) | BE839746A (xx) |
| CA (1) | CA1074813A (xx) |
| CH (3) | CH622501A5 (xx) |
| DD (1) | DD125686A5 (xx) |
| DE (1) | DE2609437A1 (xx) |
| DK (1) | DK143844C (xx) |
| ES (1) | ES446188A1 (xx) |
| FI (1) | FI62063C (xx) |
| FR (1) | FR2304334A1 (xx) |
| GB (1) | GB1531041A (xx) |
| GR (1) | GR59914B (xx) |
| HU (1) | HU171028B (xx) |
| IE (1) | IE43706B1 (xx) |
| IL (1) | IL49235A (xx) |
| IT (1) | IT1063061B (xx) |
| NL (1) | NL7503312A (xx) |
| PL (3) | PL100619B1 (xx) |
| SE (1) | SE425389B (xx) |
| SU (3) | SU668595A3 (xx) |
| YU (1) | YU70176A (xx) |
| ZA (1) | ZA761404B (xx) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3692835A (en) * | 1967-04-05 | 1972-09-19 | Jan Van Dijk | Pharmacologically active amino-ethyl oximes |
| JPH058165Y2 (xx) * | 1985-08-30 | 1993-03-02 | ||
| US4844908A (en) * | 1986-11-27 | 1989-07-04 | Duphar International Research B.V. | Method of preparing tablets with clovoxamine fumarate and tablets thus prepared |
| FR2639942B1 (fr) * | 1988-12-02 | 1991-03-29 | Sanofi Sa | Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant |
| EP1925610A1 (de) * | 2006-11-24 | 2008-05-28 | Bayer CropScience AG | Verfahren zur Herstellung von 2-Aminooxyethanol |
| DK3544420T3 (da) | 2016-11-24 | 2022-09-05 | Sigmadrugs Kutato Korlatolt Feleloessegue Tarsasag | Anvendelse af sammensætninger til organ-/vævskonservering |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3692835A (en) * | 1967-04-05 | 1972-09-19 | Jan Van Dijk | Pharmacologically active amino-ethyl oximes |
-
1975
- 1975-03-20 NL NL7503312A patent/NL7503312A/xx not_active Application Discontinuation
-
1976
- 1976-03-06 DE DE19762609437 patent/DE2609437A1/de active Granted
- 1976-03-08 ZA ZA761404A patent/ZA761404B/xx unknown
- 1976-03-15 AR AR262561A patent/AR211118A1/es active
- 1976-03-17 FI FI760695A patent/FI62063C/fi not_active IP Right Cessation
- 1976-03-17 AT AT195576A patent/AT340896B/de not_active IP Right Cessation
- 1976-03-17 IT IT21323/76A patent/IT1063061B/it active
- 1976-03-17 PL PL1976188004A patent/PL100619B1/pl unknown
- 1976-03-17 DK DK116076A patent/DK143844C/da not_active IP Right Cessation
- 1976-03-17 PL PL1976199553A patent/PL100616B1/xx unknown
- 1976-03-17 HU HU76PI00000511A patent/HU171028B/hu not_active IP Right Cessation
- 1976-03-17 GR GR50335A patent/GR59914B/el unknown
- 1976-03-17 IL IL49235A patent/IL49235A/xx unknown
- 1976-03-17 PL PL1976199552A patent/PL101949B1/pl unknown
- 1976-03-17 CA CA248,107A patent/CA1074813A/en not_active Expired
- 1976-03-17 SE SE7603340A patent/SE425389B/xx not_active IP Right Cessation
- 1976-03-17 GB GB10701/76A patent/GB1531041A/en not_active Expired
- 1976-03-17 SU SU762334811A patent/SU668595A3/ru active
- 1976-03-17 CH CH334376A patent/CH622501A5/de not_active IP Right Cessation
- 1976-03-18 IE IE565/76A patent/IE43706B1/en unknown
- 1976-03-18 YU YU00701/76A patent/YU70176A/xx unknown
- 1976-03-18 AU AU12144/76A patent/AU505356B2/en not_active Expired
- 1976-03-18 BE BE165318A patent/BE839746A/xx not_active IP Right Cessation
- 1976-03-18 DD DD191914A patent/DD125686A5/xx unknown
- 1976-03-18 ES ES446188A patent/ES446188A1/es not_active Expired
- 1976-03-19 FR FR7608017A patent/FR2304334A1/fr active Granted
- 1976-03-19 US US05/668,479 patent/US4086361A/en not_active Expired - Lifetime
- 1976-03-19 JP JP51029396A patent/JPS6055505B2/ja not_active Expired
- 1976-11-29 AR AR265659A patent/AR214986A1/es active
-
1977
- 1977-07-06 SU SU772499908A patent/SU645558A3/ru active
- 1977-07-06 SU SU772499557A patent/SU639448A3/ru active
-
1981
- 1981-01-19 CH CH32081A patent/CH628617A5/de not_active IP Right Cessation
- 1981-01-19 CH CH31981A patent/CH630895A5/de not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: DUPHAR INTERNATIONAL RESEARCH B.V |