FI61875C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara trifluormetylfenon-0-(2-aminoetyl)-oximer - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara trifluormetylfenon-0-(2-aminoetyl)-oximer Download PDFInfo
- Publication number
- FI61875C FI61875C FI760699A FI760699A FI61875C FI 61875 C FI61875 C FI 61875C FI 760699 A FI760699 A FI 760699A FI 760699 A FI760699 A FI 760699A FI 61875 C FI61875 C FI 61875C
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- FI
- Finland
- Prior art keywords
- formula
- compound
- aminoethyl
- oxime
- defined above
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- -1 2-AMINOETHYL Chemical class 0.000 title claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 72
- 238000000034 method Methods 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 15
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 8
- 150000002923 oximes Chemical class 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 229910052783 alkali metal Inorganic materials 0.000 claims description 5
- 150000001340 alkali metals Chemical class 0.000 claims description 5
- 229910021529 ammonia Inorganic materials 0.000 claims description 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 4
- 125000005530 alkylenedioxy group Chemical group 0.000 claims description 3
- 239000002585 base Substances 0.000 claims description 3
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims description 3
- 239000012458 free base Substances 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 125000003544 oxime group Chemical group 0.000 claims description 3
- 125000006239 protecting group Chemical group 0.000 claims description 3
- 125000004429 atom Chemical group 0.000 claims description 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical class 0.000 claims description 2
- 125000005905 mesyloxy group Chemical group 0.000 claims description 2
- 125000005424 tosyloxy group Chemical group S(=O)(=O)(C1=CC=C(C)C=C1)O* 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims 1
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- 150000004681 metal hydrides Chemical class 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 230000002474 noradrenergic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- LDCYZAJDBXYCGN-UHFFFAOYSA-N oxitriptan Natural products C1=C(O)C=C2C(CC(N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-UHFFFAOYSA-N 0.000 description 1
- YYROPELSRYBVMQ-UHFFFAOYSA-N p-toluenesulfonyl chloride Substances CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 238000001050 pharmacotherapy Methods 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229960002601 protriptyline Drugs 0.000 description 1
- BWPIARFWQZKAIA-UHFFFAOYSA-N protriptyline Chemical compound C1=CC2=CC=CC=C2C(CCCNC)C2=CC=CC=C21 BWPIARFWQZKAIA-UHFFFAOYSA-N 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 230000004202 respiratory function Effects 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- MLGCXEBRWGEOQX-UHFFFAOYSA-N tetradifon Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)C1=CC(Cl)=C(Cl)C=C1Cl MLGCXEBRWGEOQX-UHFFFAOYSA-N 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/58—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
- C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7503310 | 1975-03-20 | ||
| NL7503310A NL7503310A (nl) | 1975-03-20 | 1975-03-20 | Verbindingen met antidepressieve werking. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI760699A7 FI760699A7 (2) | 1976-09-21 |
| FI61875B FI61875B (fi) | 1982-06-30 |
| FI61875C true FI61875C (fi) | 1982-10-11 |
Family
ID=19823424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI760699A FI61875C (fi) | 1975-03-20 | 1976-03-17 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara trifluormetylfenon-0-(2-aminoetyl)-oximer |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4085225A (2) |
| JP (1) | JPS6026776B2 (2) |
| AR (2) | AR211011A1 (2) |
| AT (1) | AT340895B (2) |
| AU (1) | AU505358B2 (2) |
| BE (1) | BE839744A (2) |
| CA (1) | CA1076142A (2) |
| CH (4) | CH626057A5 (2) |
| DD (1) | DD128332A5 (2) |
| DE (1) | DE2610886A1 (2) |
| DK (1) | DK144942C (2) |
| ES (1) | ES446192A1 (2) |
| FI (1) | FI61875C (2) |
| FR (1) | FR2304336A1 (2) |
| GB (1) | GB1535226A (2) |
| GR (1) | GR60052B (2) |
| HU (1) | HU171030B (2) |
| IE (1) | IE43768B1 (2) |
| IL (1) | IL49238A (2) |
| IT (1) | IT1063064B (2) |
| MX (1) | MX9203723A (2) |
| NL (1) | NL7503310A (2) |
| PL (3) | PL101951B1 (2) |
| SE (1) | SE410312B (2) |
| SU (3) | SU635867A3 (2) |
| YU (1) | YU39345B (2) |
| ZA (1) | ZA761434B (2) |
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| IT1110460B (it) * | 1977-03-02 | 1985-12-23 | Ciba Geigy Ag | Prodotti che favoriscono la crescita delle piante e prodotti che proteggono le piante a base di eteri di ossime e di esteri di ossime loro preparazione e loro impiego |
| FR2639942B1 (fr) * | 1988-12-02 | 1991-03-29 | Sanofi Sa | Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant |
| US5665756A (en) * | 1994-08-03 | 1997-09-09 | Hoechst Marion Roussel, Inc. | Aminoalkyloximes useful in the treatment of depression and obsessive compulsive disorders |
| US6548084B2 (en) * | 1995-07-20 | 2003-04-15 | Smithkline Beecham Plc | Controlled release compositions |
| ATE192042T1 (de) * | 1995-08-16 | 2000-05-15 | Lilly Co Eli | Potenzierung von serotonin-wirkstoffresponz |
| IN182588B (2) | 1998-05-12 | 1999-05-08 | Sun Pharmaceutical Ind Ltd | |
| IE990406A1 (en) | 1999-05-20 | 2000-12-27 | Elan Corp Plc | Multiparticulate controlled release selective serotonin reuptake inhibitor formulations. |
| IN186677B (2) | 1999-11-12 | 2001-10-20 | Sun Pharmaceutical Ind Ltd | |
| US20080021085A1 (en) * | 2000-04-13 | 2008-01-24 | Mayo Foundation For Medical Education And Research | Method of reducing abeta42 and treating diseases |
| AU5702201A (en) * | 2000-04-13 | 2001-10-30 | Mayo Foundation | Abeta<sub>42</sub> lowering agents |
| WO2001080845A2 (en) * | 2000-04-24 | 2001-11-01 | Aryx Therapeutics | (2-aminoethyl) oxime derivatives for the treatment of depression |
| US7256191B2 (en) * | 2000-04-24 | 2007-08-14 | Aryx Therapeutics | Materials and methods for the treatment of depression |
| ES2666188T3 (es) * | 2001-10-12 | 2018-05-03 | Azevan Pharmaceuticals, Inc. | Antagonistas del v1a de vasopresina beta-lactámicos |
| EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
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| KR20060040676A (ko) * | 2003-07-11 | 2006-05-10 | 미리어드 제네틱스, 인크. | 알츠하이머병을 치료하기 위한 약제학적 방법, 투약 방법및 제형 |
| NZ545494A (en) | 2003-09-12 | 2009-10-30 | Pfizer | Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors |
| ATE473967T1 (de) * | 2003-11-26 | 2010-07-15 | Pfizer Prod Inc | Aminopyrazolderivate als gsk-3-inhibitoren |
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| KR20140045925A (ko) | 2011-03-17 | 2014-04-17 | 루핀 리미티드 | 선택적 세로토닌 재흡수 억제제의 방출조절형 약제학적 조성물 |
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| US9783492B2 (en) | 2013-04-03 | 2017-10-10 | Zcl Chemicals Limited | Process for the preparation of fluvoxamine maleate |
| CN106456578B (zh) | 2014-02-07 | 2020-02-18 | 匈牙利科学院大学及其他机构附属研究所 | Sigma-1受体激动剂化合物的用途 |
| NZ724718A (en) | 2014-03-28 | 2023-04-28 | Azevan Pharmaceuticals Inc | Compositions and methods for treating neurodegenerative diseases |
| US10828302B2 (en) | 2016-03-10 | 2020-11-10 | Janssen Pharmaceutica Nv | Methods of treating depression using orexin-2 receptor antagonists |
| ES2926179T3 (es) | 2016-11-24 | 2022-10-24 | Sigmadrugs Kutato Korlatolt Feleloessegue Tarsasag | Utilización de composiciones para la conservación de órganos/tejidos |
| WO2019055913A1 (en) | 2017-09-15 | 2019-03-21 | Azevan Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF BRAIN INJURY |
| EP3999058A4 (en) | 2019-07-19 | 2023-05-03 | Bioxcel Therapeutics, Inc. | NON-SEDATIVE DEXMEDETOMIDINE-BASED TREATMENT REGIMEN |
| US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3692835A (en) * | 1967-04-05 | 1972-09-19 | Jan Van Dijk | Pharmacologically active amino-ethyl oximes |
-
1975
- 1975-03-20 NL NL7503310A patent/NL7503310A/xx not_active Application Discontinuation
-
1976
- 1976-03-09 ZA ZA761434A patent/ZA761434B/xx unknown
- 1976-03-16 DE DE19762610886 patent/DE2610886A1/de active Granted
- 1976-03-17 CA CA248,102A patent/CA1076142A/en not_active Expired
- 1976-03-17 GB GB10703/76A patent/GB1535226A/en not_active Expired
- 1976-03-17 DK DK115976A patent/DK144942C/da not_active IP Right Cessation
- 1976-03-17 IT IT21320/76A patent/IT1063064B/it active Protection Beyond IP Right Term
- 1976-03-17 FI FI760699A patent/FI61875C/fi not_active IP Right Cessation
- 1976-03-17 PL PL1976199557A patent/PL101951B1/pl unknown
- 1976-03-17 PL PL1976199556A patent/PL100052B1/pl unknown
- 1976-03-17 SU SU762335241A patent/SU635867A3/ru active
- 1976-03-17 HU HU76PI00000513A patent/HU171030B/hu unknown
- 1976-03-17 AT AT195476A patent/AT340895B/de active Protection Beyond IP Right Term
- 1976-03-17 IL IL49238A patent/IL49238A/xx unknown
- 1976-03-17 DD DD7600191893A patent/DD128332A5/xx unknown
- 1976-03-17 PL PL1976188006A patent/PL100614B1/pl unknown
- 1976-03-17 SE SE7603341A patent/SE410312B/xx not_active IP Right Cessation
- 1976-03-17 CH CH334576A patent/CH626057A5/de active Protection Beyond IP Right Term
- 1976-03-17 GR GR50333A patent/GR60052B/el unknown
- 1976-03-18 AU AU12147/76A patent/AU505358B2/en not_active Expired
- 1976-03-18 YU YU714/76A patent/YU39345B/xx unknown
- 1976-03-18 ES ES446192A patent/ES446192A1/es not_active Expired
- 1976-03-18 BE BE165316A patent/BE839744A/xx not_active IP Right Cessation
- 1976-03-18 IE IE567/76A patent/IE43768B1/en not_active IP Right Cessation
- 1976-03-19 JP JP51029394A patent/JPS6026776B2/ja not_active Expired
- 1976-03-19 US US05/668,461 patent/US4085225A/en not_active Expired - Lifetime
- 1976-03-19 FR FR7608019A patent/FR2304336A1/fr active Granted
- 1976-03-22 AR AR262650A patent/AR211011A1/es active
- 1976-12-10 AR AR265801A patent/AR211153A1/es active
-
1977
- 1977-07-12 SU SU772503815A patent/SU620206A3/ru active
- 1977-07-12 SU SU772503814A patent/SU645559A3/ru active
-
1981
- 1981-03-06 CH CH153981A patent/CH629184A5/de not_active IP Right Cessation
- 1981-03-06 CH CH154081A patent/CH629477A5/de not_active IP Right Cessation
- 1981-03-06 CH CH154181A patent/CH629761A5/de not_active IP Right Cessation
-
1992
- 1992-06-29 MX MX9203723A patent/MX9203723A/es unknown
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