FI60354C - Foerfarande foer framstaellning av laekemedel i folieform - Google Patents
Foerfarande foer framstaellning av laekemedel i folieform Download PDFInfo
- Publication number
- FI60354C FI60354C FI751801A FI751801A FI60354C FI 60354 C FI60354 C FI 60354C FI 751801 A FI751801 A FI 751801A FI 751801 A FI751801 A FI 751801A FI 60354 C FI60354 C FI 60354C
- Authority
- FI
- Finland
- Prior art keywords
- film
- units
- hydroxypropylcellulose
- cellulose
- unit
- Prior art date
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 55
- 239000000203 mixture Substances 0.000 description 50
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 43
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 43
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 43
- 229920002678 cellulose Polymers 0.000 description 37
- 239000001913 cellulose Substances 0.000 description 37
- 238000002360 preparation method Methods 0.000 description 37
- 239000004480 active ingredient Substances 0.000 description 36
- 239000000243 solution Substances 0.000 description 36
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 32
- 229960002568 ethinylestradiol Drugs 0.000 description 32
- 229920000642 polymer Polymers 0.000 description 32
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 32
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 31
- 239000000725 suspension Substances 0.000 description 30
- 235000019441 ethanol Nutrition 0.000 description 27
- 229960004400 levonorgestrel Drugs 0.000 description 27
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 15
- 239000000843 powder Substances 0.000 description 12
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 description 10
- 229960001652 norethindrone acetate Drugs 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 239000013543 active substance Substances 0.000 description 8
- 229920002472 Starch Polymers 0.000 description 7
- 235000019698 starch Nutrition 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 6
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000000945 filler Substances 0.000 description 6
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 6
- 239000008107 starch Substances 0.000 description 6
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 description 5
- 239000008101 lactose Substances 0.000 description 5
- 229940099429 polyoxyl 40 stearate Drugs 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 229920002261 Corn starch Polymers 0.000 description 4
- 239000001856 Ethyl cellulose Substances 0.000 description 4
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 4
- 244000299461 Theobroma cacao Species 0.000 description 4
- 235000009470 Theobroma cacao Nutrition 0.000 description 4
- 239000008120 corn starch Substances 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 229920001249 ethyl cellulose Polymers 0.000 description 4
- 235000019325 ethyl cellulose Nutrition 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229920000609 methyl cellulose Polymers 0.000 description 4
- 239000001923 methylcellulose Substances 0.000 description 4
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 4
- 229940081974 saccharin Drugs 0.000 description 4
- 235000019204 saccharin Nutrition 0.000 description 4
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 4
- 229920002545 silicone oil Polymers 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 235000010216 calcium carbonate Nutrition 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- -1 hydroxyalkyl ethers Chemical class 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 229920002675 Polyoxyl Polymers 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000262 estrogen Substances 0.000 description 2
- 229940011871 estrogen Drugs 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- ZKUDBRCEOBOWLF-UHFFFAOYSA-N glisoxepide Chemical compound O1C(C)=CC(C(=O)NCCC=2C=CC(=CC=2)S(=O)(=O)NC(=O)NN2CCCCCC2)=N1 ZKUDBRCEOBOWLF-UHFFFAOYSA-N 0.000 description 2
- 229960003236 glisoxepide Drugs 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229940053934 norethindrone Drugs 0.000 description 2
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 2
- IUGYQRQAERSCNH-UHFFFAOYSA-M pivalate Chemical compound CC(C)(C)C([O-])=O IUGYQRQAERSCNH-UHFFFAOYSA-M 0.000 description 2
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 2
- 239000008389 polyethoxylated castor oil Substances 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 150000003456 sulfonamides Chemical class 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 239000003232 water-soluble binding agent Substances 0.000 description 2
- XLMXUUQMSMKFMH-UZRURVBFSA-N 2-hydroxyethyl (z,12r)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC(=O)OCCO XLMXUUQMSMKFMH-UZRURVBFSA-N 0.000 description 1
- JMIRNRNUUNDDMC-UHFFFAOYSA-N 5-methyl-2H-1,2-oxazole-5-carboxamide Chemical compound CC1(C=CNO1)C(=O)N JMIRNRNUUNDDMC-UHFFFAOYSA-N 0.000 description 1
- AGCFSBXXHKGFAI-UHFFFAOYSA-N 7-chloro-4-hydroxy-n-methyl-5-phenyl-1,4-benzodiazepin-2-amine Chemical compound C=12C=C(Cl)C=CC2=NC(NC)=CN(O)C=1C1=CC=CC=C1 AGCFSBXXHKGFAI-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- AGNOORJQCHFCAC-UHFFFAOYSA-O C=[NH+]C1O[C-]=NC1=O Chemical compound C=[NH+]C1O[C-]=NC1=O AGNOORJQCHFCAC-UHFFFAOYSA-O 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical class C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 241000224526 Trichomonas Species 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000011437 continuous method Methods 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 239000004173 sunset yellow FCF Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000004149 tartrazine Substances 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2432925 | 1974-07-05 | ||
| DE2432925A DE2432925C3 (de) | 1974-07-05 | 1974-07-05 | Folienförmige Arzneimittel |
| DE19742449865 DE2449865B2 (de) | 1974-10-17 | 1974-10-17 | Folienförmiges Arzneimittel |
| DE2449865 | 1974-10-17 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI751801A7 FI751801A7 (cs) | 1976-01-06 |
| FI60354B FI60354B (fi) | 1981-09-30 |
| FI60354C true FI60354C (fi) | 1982-01-11 |
Family
ID=25767384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI751801A FI60354C (fi) | 1974-07-05 | 1975-06-17 | Foerfarande foer framstaellning av laekemedel i folieform |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS6028810B2 (cs) |
| CA (1) | CA1067407A (cs) |
| CH (1) | CH625704A5 (cs) |
| DD (1) | DD122196A5 (cs) |
| DK (1) | DK143221C (cs) |
| EG (1) | EG11756A (cs) |
| FI (1) | FI60354C (cs) |
| FR (1) | FR2276811A1 (cs) |
| GB (1) | GB1510999A (cs) |
| IE (1) | IE42604B1 (cs) |
| IL (1) | IL47573A (cs) |
| IN (1) | IN142428B (cs) |
| NL (1) | NL186294C (cs) |
| NO (1) | NO752416L (cs) |
| PH (1) | PH18973A (cs) |
| RO (1) | RO68836A (cs) |
| SE (1) | SE413285B (cs) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU514195B2 (en) | 1975-12-15 | 1981-01-29 | F. Hoffmann-La Roche & Co. | Dosage form |
| US4332789A (en) | 1975-12-15 | 1982-06-01 | Hoffmann-La Roche Inc. | Pharmaceutical unit dosage forms |
| GB1601923A (en) * | 1977-06-09 | 1981-11-04 | Beecham Group Ltd | Sustained release compositions |
| IL59063A (en) * | 1979-01-11 | 1983-12-30 | Key Pharma | Polymeric diffusion matrix for release of pharmaceutical dosage |
| EP0063657A1 (en) * | 1981-04-29 | 1982-11-03 | Merck & Co. Inc. | Topical application of interferon inducers |
| JPS59222406A (ja) * | 1983-06-01 | 1984-12-14 | Teijin Ltd | 歯周疾患治療用製剤及びその製造法 |
| JPS6086576U (ja) * | 1983-11-15 | 1985-06-14 | 株式会社豊田自動織機製作所 | 流体噴射式織機の緯糸貯留装置における緯糸案内装置 |
| JPS61280423A (ja) * | 1985-06-05 | 1986-12-11 | Kiyuukiyuu Yakuhin Kogyo Kk | 口腔内粘膜貼付剤 |
| DE3601923A1 (de) * | 1986-01-23 | 1987-07-30 | Behringwerke Ag | Nasal applizierbares arzneimittel, verfahren zu seiner herstellung und seine verwendung |
| SE8602666D0 (sv) * | 1986-06-16 | 1986-06-16 | Leo Ab | Intravaginal devices |
| DE3630603A1 (de) * | 1986-09-09 | 1988-03-10 | Desitin Arzneimittel Gmbh | Darreichungs- und dosierungsform fuer arzneimittelwirkstoffe, reagentien oder dergleichen sowie verfahren zu deren herstellung |
| DE4018247A1 (de) * | 1990-06-07 | 1991-12-12 | Lohmann Therapie Syst Lts | Herstellungsverfahren fuer schnellzerfallende folienfoermige darreichungsformen |
| DE19549506C2 (de) * | 1995-03-07 | 1998-07-30 | Richard Prof Dr Sueverkruep | Darreichungsform zur äußerlichen Applikation und Verfahren zur Herstellung derselben |
| DE19646392A1 (de) * | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
| JP3460538B2 (ja) * | 1997-10-08 | 2003-10-27 | 救急薬品工業株式会社 | 速溶性フィルム製剤 |
| DE19745208A1 (de) * | 1997-10-13 | 1999-04-15 | Labtec Gmbh | Mundfilm |
| DE19856101A1 (de) * | 1998-12-04 | 2000-06-08 | Labtec Gmbh | Mundhöhlen-Matrixpflaster |
| AU5907300A (en) | 1999-07-02 | 2001-01-22 | Procter & Gamble Company, The | Compositions comprising organosiloxane resins for delivering xylitol to the oralcavity |
| US7666337B2 (en) | 2002-04-11 | 2010-02-23 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
| US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
| US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
| US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
| US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
| US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
| US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US20070281003A1 (en) | 2001-10-12 | 2007-12-06 | Fuisz Richard C | Polymer-Based Films and Drug Delivery Systems Made Therefrom |
| US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
| DE10207394B4 (de) * | 2002-02-21 | 2007-03-29 | Lts Lohmann Therapie-Systeme Ag | Geschmacksmaskierte oblatenförmige Arzneizubereitung |
| JP2004043450A (ja) * | 2002-05-16 | 2004-02-12 | Kyukyu Yakuhin Kogyo Kk | 速溶性フィルム状製剤 |
| CN100396332C (zh) * | 2002-05-16 | 2008-06-25 | 救急药品工业株式会社 | 速溶性膜剂 |
| US8524200B2 (en) | 2002-09-11 | 2013-09-03 | The Procter & Gamble Company | Tooth whitening products |
| ATE553746T1 (de) * | 2003-01-30 | 2012-05-15 | Monosolrx Llc | Verfahren zur herstellung eines dünnen films, thermolabile wirkstoffe enthaltend |
| DE10354894A1 (de) * | 2003-11-24 | 2005-07-07 | Hf Arzneimittelforschung Gmbh | Orale Formulierungen des Desoxypeganins und deren Anwendungen |
| DE102005003387A1 (de) * | 2004-09-01 | 2006-03-02 | LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH | Atrium Patch |
| CN101516331A (zh) | 2006-09-20 | 2009-08-26 | 莫诺索尔克斯有限公司 | 含有抗泡沫调味剂的可食用水溶性膜 |
| US20080260836A1 (en) * | 2007-04-18 | 2008-10-23 | Thomas James Boyd | Films Comprising a Plurality of Polymers |
| JP2010158173A (ja) * | 2009-01-06 | 2010-07-22 | Lintec Corp | 可食性フィルム、可食性フィルム用組成物及び可食性フィルム積層体の製造方法 |
| WO2010086989A1 (ja) | 2009-01-29 | 2010-08-05 | 日東電工株式会社 | 口腔内フィルム状基剤及び製剤 |
| JP5379499B2 (ja) * | 2009-01-29 | 2013-12-25 | リンテック株式会社 | 嚥下物包装体および可食性フィルム接合体 |
| JP5497358B2 (ja) * | 2009-07-28 | 2014-05-21 | リンテック株式会社 | 可食性積層フィルムおよびその製造方法 |
| JP5588688B2 (ja) * | 2010-01-28 | 2014-09-10 | 日東電工株式会社 | フィルム状製剤 |
| JP5466028B2 (ja) * | 2010-02-03 | 2014-04-09 | リンテック株式会社 | 可食性シート及び食品保持シート |
| JP5751868B2 (ja) | 2010-03-30 | 2015-07-22 | 日東電工株式会社 | フィルム状製剤及びその製造方法 |
| US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
| FR2968004B1 (fr) * | 2010-11-29 | 2013-06-28 | Sojasun Technologies | Films naturels biodegradables a base de co-produits issus de processus industriels de traitement de graines. |
| JP5841433B2 (ja) | 2012-01-11 | 2016-01-13 | 日東電工株式会社 | 口腔内フィルム状基剤及び製剤 |
| US10285915B2 (en) | 2012-10-17 | 2019-05-14 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
| US20180104183A1 (en) * | 2015-04-07 | 2018-04-19 | Nipro Corporation | Oral film preparation |
| US12427121B2 (en) | 2016-05-05 | 2025-09-30 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
| KR20190005199A (ko) | 2016-05-05 | 2019-01-15 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 강화된 전달 에프네프린 조성물 |
| US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
| US12433850B2 (en) | 2016-05-05 | 2025-10-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine and prodrug compositions |
| AU2018290925A1 (en) * | 2017-06-30 | 2020-01-16 | Allergan, Inc. | Dissolving film for delivery of a Clostridial derivative |
-
1975
- 1975-05-19 IN IN993/CAL/1975A patent/IN142428B/en unknown
- 1975-06-17 FI FI751801A patent/FI60354C/fi not_active IP Right Cessation
- 1975-06-24 JP JP50078601A patent/JPS6028810B2/ja not_active Expired
- 1975-06-26 IL IL47573A patent/IL47573A/xx unknown
- 1975-06-30 NL NLAANVRAGE7507785,A patent/NL186294C/xx not_active IP Right Cessation
- 1975-06-30 RO RO7582701A patent/RO68836A/ro unknown
- 1975-06-30 DK DK295075A patent/DK143221C/da not_active IP Right Cessation
- 1975-07-02 EG EG382A patent/EG11756A/xx active
- 1975-07-02 PH PH17340A patent/PH18973A/en unknown
- 1975-07-03 DD DD187079A patent/DD122196A5/xx unknown
- 1975-07-03 CH CH870075A patent/CH625704A5/de not_active IP Right Cessation
- 1975-07-03 NO NO752416A patent/NO752416L/no unknown
- 1975-07-03 SE SE7507659-6A patent/SE413285B/xx not_active IP Right Cessation
- 1975-07-03 IE IE1474/75A patent/IE42604B1/en unknown
- 1975-07-04 GB GB28252/75A patent/GB1510999A/en not_active Expired
- 1975-07-04 FR FR7521022A patent/FR2276811A1/fr active Granted
- 1975-07-04 CA CA230,802A patent/CA1067407A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK143221C (da) | 1981-11-30 |
| FR2276811A1 (fr) | 1976-01-30 |
| DD122196A5 (cs) | 1976-09-20 |
| JPS5129218A (en) | 1976-03-12 |
| IL47573A (en) | 1978-10-31 |
| NL7507785A (nl) | 1976-01-07 |
| NL186294B (nl) | 1990-06-01 |
| FI751801A7 (cs) | 1976-01-06 |
| DK143221B (da) | 1981-07-27 |
| CA1067407A (en) | 1979-12-04 |
| AU8252775A (en) | 1977-01-06 |
| NO752416L (cs) | 1976-01-06 |
| NL186294C (nl) | 1990-11-01 |
| IL47573A0 (en) | 1975-08-31 |
| RO68836A (ro) | 1980-07-15 |
| IN142428B (cs) | 1977-07-09 |
| GB1510999A (en) | 1978-05-17 |
| JPS6028810B2 (ja) | 1985-07-06 |
| SE7507659L (sv) | 1976-01-07 |
| CH625704A5 (en) | 1981-10-15 |
| FR2276811B1 (cs) | 1980-04-11 |
| IE42604L (en) | 1976-01-05 |
| PH18973A (en) | 1985-11-26 |
| IE42604B1 (en) | 1980-09-10 |
| FI60354B (fi) | 1981-09-30 |
| EG11756A (en) | 1977-11-30 |
| SE413285B (sv) | 1980-05-19 |
| DK295075A (da) | 1976-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: SCHERING AKTIENGESELLSCHAFT |