FI121075B - Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö - Google Patents

Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö Download PDF

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Publication number
FI121075B
FI121075B FI950628A FI950628A FI121075B FI 121075 B FI121075 B FI 121075B FI 950628 A FI950628 A FI 950628A FI 950628 A FI950628 A FI 950628A FI 121075 B FI121075 B FI 121075B
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FI
Finland
Prior art keywords
fungal cell
dna
leu
ser
gene
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FI950628A
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English (en)
Finnish (fi)
Swedish (sv)
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FI950628A (fi
FI950628A0 (fi
Inventor
Reinhard Fleer
Alain Fournier
Widmar Tanner
Sabine Strahl-Bolsinger
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Novozymes Biopharma Dk As
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Publication of FI950628A publication Critical patent/FI950628A/fi
Publication of FI950628A0 publication Critical patent/FI950628A0/fi
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI950628A 1992-08-14 1995-02-13 Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö FI121075B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4226971 1992-08-14
DE4226971A DE4226971C2 (de) 1992-08-14 1992-08-14 Modifizierte Pilzzellen und Verfahren zur Herstellung rekombinanter Produkte
PCT/EP1993/002179 WO1994004687A1 (en) 1992-08-14 1993-08-16 Modified fungal cells and method for producing recombinant products
EP9302179 1993-08-16

Publications (3)

Publication Number Publication Date
FI950628A FI950628A (fi) 1995-02-13
FI950628A0 FI950628A0 (fi) 1995-02-13
FI121075B true FI121075B (fi) 2010-06-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
FI950628A FI121075B (fi) 1992-08-14 1995-02-13 Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö

Country Status (13)

Country Link
US (1) US5714377A (de)
EP (1) EP0658203B1 (de)
JP (1) JP3630424B2 (de)
AT (1) ATE245701T1 (de)
AU (1) AU679935B2 (de)
CA (1) CA2140894C (de)
DE (3) DE4244915C2 (de)
ES (1) ES2203619T3 (de)
FI (1) FI121075B (de)
NO (1) NO320349B1 (de)
NZ (1) NZ255350A (de)
WO (1) WO1994004687A1 (de)
ZA (1) ZA935915B (de)

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US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
US20060084794A1 (en) * 2001-04-12 2006-04-20 Human Genome Sciences, Inc. Albumin fusion proteins
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US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
WO2003030821A2 (en) * 2001-10-05 2003-04-17 Human Genome Sciences, Inc. Albumin fusion proteins
EP2261250B1 (de) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin Fusionsproteine
WO2003059934A2 (en) * 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
WO2003066824A2 (en) 2002-02-07 2003-08-14 Aventis Behring Gmbh Albumin-fused kunitz domain peptides
AU2003274102B2 (en) * 2002-12-20 2007-01-25 Unilever Ip Holdings B.V. Preparation of antifreeze protein
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
US9057061B2 (en) 2003-12-23 2015-06-16 Novozymes Biopharma Dk A/S Gene expression technique
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
CA2628725A1 (en) * 2005-11-15 2007-05-31 Glycofi, Inc. Production of glycoproteins with reduced o-glycosylation
AU2012203729B2 (en) * 2005-11-22 2014-01-30 Glycofi, Inc Production of glycoproteins with reduced O-glycosylation
EP1816201A1 (de) * 2006-02-06 2007-08-08 CSL Behring GmbH Modifizierter Koagulationsfaktor VIIa mit verbesserter 'half-life'-Stabiltät
CN101605887B (zh) * 2006-05-16 2012-09-05 协和发酵麒麟株式会社 蛋白的高分泌生产方法
AU2007278994B2 (en) 2006-07-24 2013-08-15 Biorexis Pharmaceutical Corporation Exendin fusion proteins
GB0711424D0 (en) * 2007-06-13 2007-07-25 Novozymes Delta Ltd Recombinant transferrin mutants
CN101835801B (zh) 2007-08-08 2014-09-10 诺维信生物制药丹麦公司 转铁蛋白变体和偶联物
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
EP2245151B1 (de) 2008-02-20 2014-12-24 GlycoFi, Inc. Vektoren und hefestämme für die proteinproduktion
JP5731827B2 (ja) 2008-03-03 2015-06-10 グライコフィ， インコーポレイテッド 下等真核生物中での組換えタンパク質の表面ディスプレイ
MX2011001706A (es) 2008-08-12 2011-03-24 Glycofi Inc Vectores mejorados y cepas de levadura para produccion de proteina: sobreexpresion de ca2+ atpasa.
US9120871B2 (en) 2009-01-23 2015-09-01 Novo Nordisk A/S Process for preparing FGF21 with low degree of O-glycosylation
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Also Published As

Publication number Publication date
AU679935B2 (en) 1997-07-17
ZA935915B (en) 1995-04-13
NO320349B1 (no) 2005-11-28
CA2140894C (en) 2010-03-02
FI950628A (fi) 1995-02-13
NZ255350A (en) 1996-11-26
EP0658203A1 (de) 1995-06-21
ES2203619T3 (es) 2004-04-16
NO950534L (no) 1995-04-05
DE4244915C2 (de) 1998-12-03
CA2140894A1 (en) 1994-03-03
FI950628A0 (fi) 1995-02-13
JPH08500975A (ja) 1996-02-06
DE4226971C2 (de) 1997-01-16
NO950534D0 (no) 1995-02-13
US5714377A (en) 1998-02-03
AU4948293A (en) 1994-03-15
WO1994004687A1 (en) 1994-03-03
DE4226971A1 (de) 1994-02-17
ATE245701T1 (de) 2003-08-15
DE69333112D1 (de) 2003-08-28
JP3630424B2 (ja) 2005-03-16
EP0658203B1 (de) 2003-07-23
DE69333112T2 (de) 2004-06-09

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