NO950534D0 - Modufiserte soppceller og fremgangsmåter for fremstilling av rekombinante produkter - Google Patents

Modufiserte soppceller og fremgangsmåter for fremstilling av rekombinante produkter

Info

Publication number
NO950534D0
NO950534D0 NO950534A NO950534A NO950534D0 NO 950534 D0 NO950534 D0 NO 950534D0 NO 950534 A NO950534 A NO 950534A NO 950534 A NO950534 A NO 950534A NO 950534 D0 NO950534 D0 NO 950534D0
Authority
NO
Norway
Prior art keywords
pct
recombinant products
fungal cells
methods
producing recombinant
Prior art date
Application number
NO950534A
Other languages
English (en)
Other versions
NO950534L (no
NO320349B1 (no
Inventor
Widmar Tanner
Sabine Strahl-Bolsinger
Reinhard Fleer
Alain Fournier
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NO950534D0 publication Critical patent/NO950534D0/no
Publication of NO950534L publication Critical patent/NO950534L/no
Publication of NO320349B1 publication Critical patent/NO320349B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO19950534A 1992-08-14 1995-02-13 Modufiserte soppceller, fremgangsmate for fremstilling av rekombinante produkter, DNA-molekyl og anvendelse av slike. NO320349B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4226971A DE4226971C2 (de) 1992-08-14 1992-08-14 Modifizierte Pilzzellen und Verfahren zur Herstellung rekombinanter Produkte
PCT/EP1993/002179 WO1994004687A1 (en) 1992-08-14 1993-08-16 Modified fungal cells and method for producing recombinant products

Publications (3)

Publication Number Publication Date
NO950534D0 true NO950534D0 (no) 1995-02-13
NO950534L NO950534L (no) 1995-04-05
NO320349B1 NO320349B1 (no) 2005-11-28

Family

ID=6465579

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19950534A NO320349B1 (no) 1992-08-14 1995-02-13 Modufiserte soppceller, fremgangsmate for fremstilling av rekombinante produkter, DNA-molekyl og anvendelse av slike.

Country Status (13)

Country Link
US (1) US5714377A (no)
EP (1) EP0658203B1 (no)
JP (1) JP3630424B2 (no)
AT (1) ATE245701T1 (no)
AU (1) AU679935B2 (no)
CA (1) CA2140894C (no)
DE (3) DE4226971C2 (no)
ES (1) ES2203619T3 (no)
FI (1) FI121075B (no)
NO (1) NO320349B1 (no)
NZ (1) NZ255350A (no)
WO (1) WO1994004687A1 (no)
ZA (1) ZA935915B (no)

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US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
JPH08173170A (ja) * 1994-05-25 1996-07-09 Kirin Brewery Co Ltd キャンディダ・ユティリス酵母の形質転換系、およびそれによる異種遺伝子の発現
EP0826054B1 (en) * 1995-05-18 2003-12-17 Genencor International, Inc. Expression of glycosyltransferase in aspergillus
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GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
AU2007200859A1 (en) * 1999-01-30 2007-03-22 Novozymes Delta Limited Process
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
AU2001266557A1 (en) * 2000-04-12 2001-10-23 Human Genome Sciences, Inc. Albumin fusion proteins
US20020068325A1 (en) * 2000-12-05 2002-06-06 Ng Davis T.W. Methods and compositions for highly efficient production of heterologous proteins in yeast
US20050054051A1 (en) * 2001-04-12 2005-03-10 Human Genome Sciences, Inc. Albumin fusion proteins
US20050244931A1 (en) * 2001-04-12 2005-11-03 Human Genome Sciences, Inc. Albumin fusion proteins
US20060084794A1 (en) * 2001-04-12 2006-04-20 Human Genome Sciences, Inc. Albumin fusion proteins
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
CA2383556A1 (en) * 2001-05-16 2002-11-16 Pharmacia & Upjohn Company High-efficiency assay for protein mannosyl transferases
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
AU2002332041A1 (en) * 2001-10-05 2003-04-22 Human Genome Sciences, Inc. Albumin fusion proteins
EP2990417A1 (en) 2001-12-21 2016-03-02 Human Genome Sciences, Inc. Albumin insulin fusion protein
AU2002364587A1 (en) * 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
KR20040095217A (ko) 2002-02-07 2004-11-12 델타 바이오테크놀로지 리미티드 알부민-융합 항-혈관신생 펩타이드
PT1573017E (pt) * 2002-12-20 2008-10-16 Unilever Nv Preparação de uma proteína anticongelante
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
EP2330200B1 (en) 2004-12-23 2017-04-05 Albumedix A/S Gene expression technique
CN101365783B (zh) * 2005-11-15 2013-07-17 格利科菲公司 具有降低的o-糖基化的糖蛋白的产生
AU2012203729B2 (en) * 2005-11-22 2014-01-30 Glycofi, Inc Production of glycoproteins with reduced O-glycosylation
EP1816201A1 (en) * 2006-02-06 2007-08-08 CSL Behring GmbH Modified coagulation factor VIIa with extended half-life
WO2007132949A1 (ja) 2006-05-16 2007-11-22 National Institute Of Advanced Industrial Science And Technology タンパク質の高分泌生産方法
KR101193722B1 (ko) 2006-07-24 2013-01-11 바이오렉시스 파마슈티칼 코포레이션 엑센딘 융합 단백질
GB0711424D0 (en) * 2007-06-13 2007-07-25 Novozymes Delta Ltd Recombinant transferrin mutants
EP2594583A1 (en) 2007-08-08 2013-05-22 Novozymes Biopharma DK A/S Transferrin variants and conugates
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
WO2009105357A1 (en) 2008-02-20 2009-08-27 Glycofi, Inc. Vectors and yeast strains for protein production
CA2715212A1 (en) 2008-03-03 2009-09-11 Glycofi, Inc. Surface display of recombinant proteins in lower eukaryotes
WO2010019487A1 (en) * 2008-08-12 2010-02-18 Glycofi, Inc. Improved vectors and yeast strains for protein production: ca2+ atpase overexpression
US9120871B2 (en) 2009-01-23 2015-09-01 Novo Nordisk A/S Process for preparing FGF21 with low degree of O-glycosylation
DK2393834T3 (da) 2009-02-06 2013-06-24 Novozymes Biopharma Dk As Fremgangsmåde til oprensning
CN102317315A (zh) 2009-02-11 2012-01-11 诺维信生物制药丹麦公司 白蛋白变体和缀合物
AU2010218139B2 (en) 2009-02-25 2012-11-01 Merck Sharp & Dohme Corp. Metabolic engineering of a galactose assimilation pathway in the glycoengineered yeast Pichia pastoris
CA2776241A1 (en) 2009-10-30 2011-05-05 Novozymes Biopharma Dk A/S Albumin variants
MX2012004994A (es) 2009-10-30 2012-06-12 Merck Sharp & Dohme Metodo para producir proteinas terapeuticas en pichia pastoris que carecen de actividad de dipeptidil aminopeptidasa.
MX2012009349A (es) * 2010-02-10 2013-02-11 Biocon Ltd Metodo para reducir glucosilacion de proteinas, procedimientos y proteinas de los mismos.
US8715963B2 (en) 2010-02-24 2014-05-06 Merck Sharp & Dohme Corp. Method for increasing N-glycosylation site occupancy on therapeutic glycoproteins produced in Pichia pastoris
KR20130070576A (ko) 2010-04-09 2013-06-27 노보자임스 바이오파마 디케이 에이/에스 알부민 유도체 및 변이체
CN103080130B (zh) 2010-05-27 2016-08-17 默沙东公司 制备具有改进特性的抗体的方法
JP5885191B2 (ja) 2011-01-04 2016-03-15 国立研究開発法人産業技術総合研究所 糖鎖改変酵母及びそれを用いた糖タンパク質の製造方法
EP2678440B1 (en) 2011-02-25 2018-05-23 Merck Sharp & Dohme Corp. Yeast strain for the production of proteins with modified o-glycosylation
EP2714732A4 (en) 2011-05-25 2014-12-10 Merck Sharp & Dohme PROCESS FOR PREPARING FC-CONTAINING POLYPEPTIDES WITH IMPROVED PROPERTIES
EP2780364A2 (en) 2011-11-18 2014-09-24 Eleven Biotherapeutics, Inc. Proteins with improved half-life and other properties
PL2825556T3 (pl) 2012-03-16 2018-10-31 Albumedix A/S Warianty albuminy
JP6487328B2 (ja) 2012-11-08 2019-03-20 アルブミディクス リミティド アルブミン変異体
EP3004156A1 (en) 2013-06-07 2016-04-13 Novo Nordisk A/S Method for making mature insulin polypeptides
EP3016970B1 (en) 2013-07-04 2019-05-22 Glykos Finland Oy O-mannosyltransferase deficient filamentous fungal cells and methods of use thereof
WO2016012468A1 (en) 2014-07-21 2016-01-28 Novartis Ag Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
US10633428B2 (en) 2015-08-20 2020-04-28 Albumedix Ltd Albumin variants and conjugates

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Publication number Priority date Publication date Assignee Title
BG38165A3 (en) * 1977-11-08 1985-10-15 Genentech, Inc. Method for preparing recombinant cloning vector suitable for transformation of microbial receptor
IT1203758B (it) * 1986-03-27 1989-02-23 Univ Roma Vettori di clonazione e di espressione di geni eterologhi in lieviti e lieviti trasformati con tali vettori
US4929553A (en) * 1987-05-29 1990-05-29 Canadian Patents & Development Ltd. Protease for specific processing of secreted proteins
FR2649991B2 (fr) * 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
FR2655660B1 (fr) * 1989-12-11 1992-03-20 Rhone Poulenc Sante Nouveaux polypeptides, sequences d'adn permettant leur expression, procede de preparation et leur utilisation.

Also Published As

Publication number Publication date
US5714377A (en) 1998-02-03
CA2140894C (en) 2010-03-02
DE69333112T2 (de) 2004-06-09
ES2203619T3 (es) 2004-04-16
CA2140894A1 (en) 1994-03-03
AU4948293A (en) 1994-03-15
FI950628A (fi) 1995-02-13
FI950628A0 (fi) 1995-02-13
DE4226971A1 (de) 1994-02-17
NZ255350A (en) 1996-11-26
NO950534L (no) 1995-04-05
AU679935B2 (en) 1997-07-17
NO320349B1 (no) 2005-11-28
JP3630424B2 (ja) 2005-03-16
DE4244915C2 (de) 1998-12-03
JPH08500975A (ja) 1996-02-06
EP0658203B1 (en) 2003-07-23
DE69333112D1 (de) 2003-08-28
WO1994004687A1 (en) 1994-03-03
DE4226971C2 (de) 1997-01-16
ZA935915B (en) 1995-04-13
EP0658203A1 (en) 1995-06-21
FI121075B (fi) 2010-06-30
ATE245701T1 (de) 2003-08-15

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