FI950628A0 - Modifioidut sienisolut ja menetelmä rekombinanttituotteiden tuottamiseksi - Google Patents

Modifioidut sienisolut ja menetelmä rekombinanttituotteiden tuottamiseksi

Info

Publication number
FI950628A0
FI950628A0 FI950628A FI950628A FI950628A0 FI 950628 A0 FI950628 A0 FI 950628A0 FI 950628 A FI950628 A FI 950628A FI 950628 A FI950628 A FI 950628A FI 950628 A0 FI950628 A0 FI 950628A0
Authority
FI
Finland
Prior art keywords
pct
recombinant products
fungal cells
producing recombinant
cells
Prior art date
Application number
FI950628A
Other languages
English (en)
Swedish (sv)
Other versions
FI950628A (fi
FI121075B (fi
Inventor
Widmar Tanner
Sabine Strahl-Bolsinger
Reinhard Fleer
Alain Fournier
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of FI950628A publication Critical patent/FI950628A/fi
Publication of FI950628A0 publication Critical patent/FI950628A0/fi
Application granted granted Critical
Publication of FI121075B publication Critical patent/FI121075B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI950628A 1992-08-14 1995-02-13 Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö FI121075B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4226971 1992-08-14
DE4226971A DE4226971C2 (de) 1992-08-14 1992-08-14 Modifizierte Pilzzellen und Verfahren zur Herstellung rekombinanter Produkte
PCT/EP1993/002179 WO1994004687A1 (en) 1992-08-14 1993-08-16 Modified fungal cells and method for producing recombinant products
EP9302179 1993-08-16

Publications (3)

Publication Number Publication Date
FI950628A FI950628A (fi) 1995-02-13
FI950628A0 true FI950628A0 (fi) 1995-02-13
FI121075B FI121075B (fi) 2010-06-30

Family

ID=6465579

Family Applications (1)

Application Number Title Priority Date Filing Date
FI950628A FI121075B (fi) 1992-08-14 1995-02-13 Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö

Country Status (13)

Country Link
US (1) US5714377A (fi)
EP (1) EP0658203B1 (fi)
JP (1) JP3630424B2 (fi)
AT (1) ATE245701T1 (fi)
AU (1) AU679935B2 (fi)
CA (1) CA2140894C (fi)
DE (3) DE4226971C2 (fi)
ES (1) ES2203619T3 (fi)
FI (1) FI121075B (fi)
NO (1) NO320349B1 (fi)
NZ (1) NZ255350A (fi)
WO (1) WO1994004687A1 (fi)
ZA (1) ZA935915B (fi)

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US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
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DE69631127T2 (de) * 1995-05-18 2004-07-08 Genencor International, Inc., Palo Alto Glykosyltransferase expression in aspergillus
GB9526733D0 (en) * 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
AU2007200859A1 (en) * 1999-01-30 2007-03-22 Novozymes Delta Limited Process
US6926898B2 (en) * 2000-04-12 2005-08-09 Human Genome Sciences, Inc. Albumin fusion proteins
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
EP1379667A2 (en) * 2000-12-05 2004-01-14 The Penn State Research Foundation Methods and compositions for highly efficient production of heterologous proteins in yeast
US20050244931A1 (en) * 2001-04-12 2005-11-03 Human Genome Sciences, Inc. Albumin fusion proteins
US20050054051A1 (en) * 2001-04-12 2005-03-10 Human Genome Sciences, Inc. Albumin fusion proteins
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
US20060084794A1 (en) * 2001-04-12 2006-04-20 Human Genome Sciences, Inc. Albumin fusion proteins
CA2383556A1 (en) * 2001-05-16 2002-11-16 Pharmacia & Upjohn Company High-efficiency assay for protein mannosyl transferases
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
WO2003030821A2 (en) * 2001-10-05 2003-04-17 Human Genome Sciences, Inc. Albumin fusion proteins
ES2500918T3 (es) * 2001-12-21 2014-10-01 Human Genome Sciences, Inc. Proteínas de fusión de albúmina e interferón beta
EP1463752A4 (en) * 2001-12-21 2005-07-13 Human Genome Sciences Inc ALBUMIN FUSION PROTEINS
JP2005516607A (ja) 2002-02-07 2005-06-09 デルタ バイオテクノロジー リミテッド Ｈｉｖ阻害タンパク質
BRPI0315943B1 (pt) * 2002-12-20 2019-07-09 Unilever N.V. Método para a produção de proteína anticongelante
US9057061B2 (en) 2003-12-23 2015-06-16 Novozymes Biopharma Dk A/S Gene expression technique
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
US8206949B2 (en) * 2005-11-15 2012-06-26 Glycofi, Inc. Production of glycoproteins with reduced O-glycosylation
AU2012203729B2 (en) * 2005-11-22 2014-01-30 Glycofi, Inc Production of glycoproteins with reduced O-glycosylation
EP1816201A1 (en) * 2006-02-06 2007-08-08 CSL Behring GmbH Modified coagulation factor VIIa with extended half-life
CN101605887B (zh) * 2006-05-16 2012-09-05 协和发酵麒麟株式会社 蛋白的高分泌生产方法
WO2008012629A2 (en) 2006-07-24 2008-01-31 Biorexis Pharmaceutical Corporation Exendin fusion proteins
GB0711424D0 (en) * 2007-06-13 2007-07-25 Novozymes Delta Ltd Recombinant transferrin mutants
CA2695830A1 (en) 2007-08-08 2009-02-12 Novozymes Biopharma Dk A/S Transferrin variants and conjugates
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
EP2245151B1 (en) 2008-02-20 2014-12-24 GlycoFi, Inc. Vectors and yeast strains for protein production
CA2715212A1 (en) * 2008-03-03 2009-09-11 Glycofi, Inc. Surface display of recombinant proteins in lower eukaryotes
MX2011001706A (es) 2008-08-12 2011-03-24 Glycofi Inc Vectores mejorados y cepas de levadura para produccion de proteina: sobreexpresion de ca2+ atpasa.
US9120871B2 (en) 2009-01-23 2015-09-01 Novo Nordisk A/S Process for preparing FGF21 with low degree of O-glycosylation
JP2012516878A (ja) 2009-02-06 2012-07-26 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ 精製プロセス
EP3243835B1 (en) 2009-02-11 2024-04-10 Albumedix Ltd Albumin variants and conjugates
CN102333872B (zh) 2009-02-25 2014-07-09 默沙东公司 在糖工程化的酵母巴斯德毕赤酵母中对半乳糖同化途径的代谢工程化
CA2776241A1 (en) 2009-10-30 2011-05-05 Novozymes Biopharma Dk A/S Albumin variants
CN102725396A (zh) 2009-10-30 2012-10-10 默沙东公司 在缺乏二肽基氨肽酶活性的巴斯德毕赤酵母中生产治疗性蛋白的方法
CN103003438B (zh) * 2010-02-10 2016-01-20 拜康有限公司 减少蛋白质糖基化的方法和过程及其蛋白质
US8715963B2 (en) 2010-02-24 2014-05-06 Merck Sharp & Dohme Corp. Method for increasing N-glycosylation site occupancy on therapeutic glycoproteins produced in Pichia pastoris
WO2011124718A1 (en) 2010-04-09 2011-10-13 Novozymes A/S Albumin derivatives and variants
WO2011149999A2 (en) 2010-05-27 2011-12-01 Merck Sharp & Dohme Corp. Method for preparing antibodies having improved properties
JP5885191B2 (ja) 2011-01-04 2016-03-15 国立研究開発法人産業技術総合研究所 糖鎖改変酵母及びそれを用いた糖タンパク質の製造方法
JP2014518608A (ja) 2011-02-25 2014-08-07 メルク・シャープ・アンド・ドーム・コーポレーション 修飾ｏ−グリコシル化を有するタンパク質の製造のための酵母株
CA2834589A1 (en) 2011-05-25 2012-11-29 Merck Sharp & Dohme Corp. Method for preparing fc-containing polypeptides having improved properties
EP2780364A2 (en) 2011-11-18 2014-09-24 Eleven Biotherapeutics, Inc. Proteins with improved half-life and other properties
US9944691B2 (en) 2012-03-16 2018-04-17 Albumedix A/S Albumin variants
US20140128326A1 (en) 2012-11-08 2014-05-08 Novozymes Biopharma Dk A/S Albumin variants
EP3004156A1 (en) 2013-06-07 2016-04-13 Novo Nordisk A/S Method for making mature insulin polypeptides
SI3016970T1 (sl) 2013-07-04 2019-08-30 Glykos Finland Oy Nitaste glivične celice brez O-manoziltransferaze in postopki za uporabo le-teh
WO2016012468A1 (en) 2014-07-21 2016-01-28 Novartis Ag Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
BR112018003179A2 (pt) 2015-08-20 2018-09-25 Albumedix As conjugados e variantes de albumina

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU257278A (en) * 1977-11-08 1984-02-29 Genentech Inc Process for obtaining a recombinat clone carrier
IT1203758B (it) * 1986-03-27 1989-02-23 Univ Roma Vettori di clonazione e di espressione di geni eterologhi in lieviti e lieviti trasformati con tali vettori
US4929553A (en) * 1987-05-29 1990-05-29 Canadian Patents & Development Ltd. Protease for specific processing of secreted proteins
FR2649991B2 (fr) * 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
FR2655660B1 (fr) * 1989-12-11 1992-03-20 Rhone Poulenc Sante Nouveaux polypeptides, sequences d'adn permettant leur expression, procede de preparation et leur utilisation.

Also Published As

Publication number Publication date
NO950534D0 (no) 1995-02-13
WO1994004687A1 (en) 1994-03-03
NO320349B1 (no) 2005-11-28
ATE245701T1 (de) 2003-08-15
EP0658203B1 (en) 2003-07-23
JP3630424B2 (ja) 2005-03-16
ZA935915B (en) 1995-04-13
FI950628A (fi) 1995-02-13
ES2203619T3 (es) 2004-04-16
DE4244915C2 (de) 1998-12-03
EP0658203A1 (en) 1995-06-21
AU679935B2 (en) 1997-07-17
DE69333112D1 (de) 2003-08-28
JPH08500975A (ja) 1996-02-06
DE4226971C2 (de) 1997-01-16
FI121075B (fi) 2010-06-30
US5714377A (en) 1998-02-03
CA2140894A1 (en) 1994-03-03
DE4226971A1 (de) 1994-02-17
DE69333112T2 (de) 2004-06-09
NO950534L (no) 1995-04-05
CA2140894C (en) 2010-03-02
AU4948293A (en) 1994-03-15
NZ255350A (en) 1996-11-26

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