NO950534L - Modufiserte soppceller og fremgangsmåter for fremstilling av rekombinante produkter - Google Patents

Modufiserte soppceller og fremgangsmåter for fremstilling av rekombinante produkter

Info

Publication number
NO950534L
NO950534L NO950534A NO950534A NO950534L NO 950534 L NO950534 L NO 950534L NO 950534 A NO950534 A NO 950534A NO 950534 A NO950534 A NO 950534A NO 950534 L NO950534 L NO 950534L
Authority
NO
Norway
Prior art keywords
pct
recombinant products
fungal cells
methods
producing recombinant
Prior art date
Application number
NO950534A
Other languages
English (en)
Other versions
NO950534D0 (no
NO320349B1 (no
Inventor
Widmar Tanner
Sabine Strahl-Bolsinger
Reinhard Fleer
Alain Fournier
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NO950534D0 publication Critical patent/NO950534D0/no
Publication of NO950534L publication Critical patent/NO950534L/no
Publication of NO320349B1 publication Critical patent/NO320349B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
NO19950534A 1992-08-14 1995-02-13 Modufiserte soppceller, fremgangsmate for fremstilling av rekombinante produkter, DNA-molekyl og anvendelse av slike. NO320349B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4226971A DE4226971C2 (de) 1992-08-14 1992-08-14 Modifizierte Pilzzellen und Verfahren zur Herstellung rekombinanter Produkte
PCT/EP1993/002179 WO1994004687A1 (en) 1992-08-14 1993-08-16 Modified fungal cells and method for producing recombinant products

Publications (3)

Publication Number Publication Date
NO950534D0 NO950534D0 (no) 1995-02-13
NO950534L true NO950534L (no) 1995-04-05
NO320349B1 NO320349B1 (no) 2005-11-28

Family

ID=6465579

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19950534A NO320349B1 (no) 1992-08-14 1995-02-13 Modufiserte soppceller, fremgangsmate for fremstilling av rekombinante produkter, DNA-molekyl og anvendelse av slike.

Country Status (13)

Country Link
US (1) US5714377A (no)
EP (1) EP0658203B1 (no)
JP (1) JP3630424B2 (no)
AT (1) ATE245701T1 (no)
AU (1) AU679935B2 (no)
CA (1) CA2140894C (no)
DE (3) DE4226971C2 (no)
ES (1) ES2203619T3 (no)
FI (1) FI121075B (no)
NO (1) NO320349B1 (no)
NZ (1) NZ255350A (no)
WO (1) WO1994004687A1 (no)
ZA (1) ZA935915B (no)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
JPH08173170A (ja) * 1994-05-25 1996-07-09 Kirin Brewery Co Ltd キャンディダ・ユティリス酵母の形質転換系、およびそれによる異種遺伝子の発現
CA2221271A1 (en) * 1995-05-18 1996-11-21 Genencor International, Inc. Expression of glycosyltransferase in aspergillus
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
AU2007200859A1 (en) * 1999-01-30 2007-03-22 Novozymes Delta Limited Process
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
CA2747325A1 (en) 2000-04-12 2001-10-25 Human Genome Sciences, Inc. Albumin fusion proteins
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
MXPA03004853A (es) * 2000-12-05 2005-02-14 Penn State Res Found Metodos y composiciones para produccion sumamente eficiente de proteinas heterologas en levadura.
US20050244931A1 (en) * 2001-04-12 2005-11-03 Human Genome Sciences, Inc. Albumin fusion proteins
US20060084794A1 (en) * 2001-04-12 2006-04-20 Human Genome Sciences, Inc. Albumin fusion proteins
US20050054051A1 (en) * 2001-04-12 2005-03-10 Human Genome Sciences, Inc. Albumin fusion proteins
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
CA2383556A1 (en) * 2001-05-16 2002-11-16 Pharmacia & Upjohn Company High-efficiency assay for protein mannosyl transferases
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
AU2002332041A1 (en) * 2001-10-05 2003-04-22 Human Genome Sciences, Inc. Albumin fusion proteins
ES2425738T3 (es) 2001-12-21 2013-10-17 Human Genome Sciences, Inc. Proteínas de fusión de la albúmina
EP1463752A4 (en) * 2001-12-21 2005-07-13 Human Genome Sciences Inc ALBUMIN FUSION PROTEINS
CN101166762A (zh) 2002-02-07 2008-04-23 达尔塔生物技术有限公司 白蛋白融合的Kunitz结构域肽
BRPI0315943B1 (pt) * 2002-12-20 2019-07-09 Unilever N.V. Método para a produção de proteína anticongelante
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
EP1831375B1 (en) 2004-12-23 2014-07-16 Novozymes Biopharma DK A/S Gene expression technique
EP1954815B1 (en) * 2005-11-15 2015-02-25 GlycoFi, Inc. Production of glycoproteins with reduced o-glycosylation
AU2012203729B2 (en) * 2005-11-22 2014-01-30 Glycofi, Inc Production of glycoproteins with reduced O-glycosylation
EP1816201A1 (en) * 2006-02-06 2007-08-08 CSL Behring GmbH Modified coagulation factor VIIa with extended half-life
ES2553162T3 (es) 2006-05-16 2015-12-04 Daiichi Sankyo Company, Limited Método de producción de alta secreción de proteínas
AU2007278994B2 (en) 2006-07-24 2013-08-15 Biorexis Pharmaceutical Corporation Exendin fusion proteins
GB0711424D0 (en) * 2007-06-13 2007-07-25 Novozymes Delta Ltd Recombinant transferrin mutants
EP2594583A1 (en) 2007-08-08 2013-05-22 Novozymes Biopharma DK A/S Transferrin variants and conugates
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
EP2245151B1 (en) 2008-02-20 2014-12-24 GlycoFi, Inc. Vectors and yeast strains for protein production
WO2009111183A1 (en) 2008-03-03 2009-09-11 Glycofi, Inc. Surface display of recombinant proteins in lower eukaryotes
AU2009282228A1 (en) * 2008-08-12 2010-02-18 Glycofi, Inc. Improved vectors and yeast strains for protein production: Ca2+ ATPase overexpression
US9120871B2 (en) 2009-01-23 2015-09-01 Novo Nordisk A/S Process for preparing FGF21 with low degree of O-glycosylation
CN102369213A (zh) 2009-02-06 2012-03-07 诺维信生物制药丹麦公司 纯化方法
JP5936112B2 (ja) 2009-02-11 2016-06-15 アルブミディクス アクティーゼルスカブ アルブミン変異体及び複合体
JP2012518419A (ja) 2009-02-25 2012-08-16 メルク・シャープ・エンド・ドーム・コーポレイション 糖操作酵母ピチア・パストリスにおけるガラクトース同化経路の代謝操作
EP2494030A4 (en) 2009-10-30 2013-03-27 Merck Sharp & Dohme METHOD FOR THE PRODUCTION OF THERAPEUTIC PROTEINS IN PICHIA PASTORIS WITHOUT DIPEPTIDYL-AMINOPEPTIDASE ACTIVITY
MX2012004793A (es) 2009-10-30 2012-07-20 Novozymes Biopharma Dk As Variantes de albumina.
JP5860413B2 (ja) * 2010-02-10 2016-02-16 バイオコン リミテッド タンパク質のグリコシル化を低下させる方法、その産生方法およびタンパク質
US8715963B2 (en) 2010-02-24 2014-05-06 Merck Sharp & Dohme Corp. Method for increasing N-glycosylation site occupancy on therapeutic glycoproteins produced in Pichia pastoris
CN106977608A (zh) 2010-04-09 2017-07-25 阿尔布麦狄克斯公司 白蛋白衍生物和变体
JP5956982B2 (ja) 2010-05-27 2016-07-27 メルク・シャープ・エンド・ドーム・コーポレイション 改善された特性を有する抗体の製造方法
JP5885191B2 (ja) 2011-01-04 2016-03-15 国立研究開発法人産業技術総合研究所 糖鎖改変酵母及びそれを用いた糖タンパク質の製造方法
JP2014518608A (ja) 2011-02-25 2014-08-07 メルク・シャープ・アンド・ドーム・コーポレーション 修飾ｏ−グリコシル化を有するタンパク質の製造のための酵母株
CA2834589A1 (en) 2011-05-25 2012-11-29 Merck Sharp & Dohme Corp. Method for preparing fc-containing polypeptides having improved properties
WO2013075066A2 (en) 2011-11-18 2013-05-23 Eleven Biotherapeutics, Inc. Proteins with improved half-life and other properties
EP2825556B1 (en) 2012-03-16 2018-01-03 Albumedix A/S Albumin variants
CA2890766A1 (en) 2012-11-08 2014-05-15 Novozymes Biopharma Dk A/S Albumin variants
JP2016521701A (ja) 2013-06-07 2016-07-25 ノヴォ ノルディスク アー／エス 成熟インスリンポリペプチドを作製するための方法
BR112015032695A2 (pt) 2013-07-04 2017-10-24 Glykos Finland Oy células de fungos filamentosos deficientes em o-manosiltransferase e métodos de uso das mesmas
US10513724B2 (en) 2014-07-21 2019-12-24 Glykos Finland Oy Production of glycoproteins with mammalian-like N-glycans in filamentous fungi
EP3337816B1 (en) 2015-08-20 2024-02-14 Albumedix Ltd Albumin variants and conjugates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2007676B (en) * 1977-11-08 1982-09-08 Genentech Inc Method and means for microbial polypeptide expression
IT1203758B (it) * 1986-03-27 1989-02-23 Univ Roma Vettori di clonazione e di espressione di geni eterologhi in lieviti e lieviti trasformati con tali vettori
US4929553A (en) * 1987-05-29 1990-05-29 Canadian Patents & Development Ltd. Protease for specific processing of secreted proteins
FR2649991B2 (fr) * 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
FR2655660B1 (fr) * 1989-12-11 1992-03-20 Rhone Poulenc Sante Nouveaux polypeptides, sequences d'adn permettant leur expression, procede de preparation et leur utilisation.

Also Published As

Publication number Publication date
WO1994004687A1 (en) 1994-03-03
JPH08500975A (ja) 1996-02-06
DE4226971A1 (de) 1994-02-17
AU4948293A (en) 1994-03-15
DE4226971C2 (de) 1997-01-16
EP0658203B1 (en) 2003-07-23
FI121075B (fi) 2010-06-30
ATE245701T1 (de) 2003-08-15
AU679935B2 (en) 1997-07-17
JP3630424B2 (ja) 2005-03-16
CA2140894C (en) 2010-03-02
CA2140894A1 (en) 1994-03-03
FI950628A (fi) 1995-02-13
US5714377A (en) 1998-02-03
ES2203619T3 (es) 2004-04-16
NO950534D0 (no) 1995-02-13
DE4244915C2 (de) 1998-12-03
DE69333112T2 (de) 2004-06-09
ZA935915B (en) 1995-04-13
NZ255350A (en) 1996-11-26
EP0658203A1 (en) 1995-06-21
FI950628A0 (fi) 1995-02-13
NO320349B1 (no) 2005-11-28
DE69333112D1 (de) 2003-08-28

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Legal Events

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