ZA935915B - Modified fungal cells and method for producing recombinant products - Google Patents

Modified fungal cells and method for producing recombinant products

Info

Publication number
ZA935915B
ZA935915B ZA935915A ZA935915A ZA935915B ZA 935915 B ZA935915 B ZA 935915B ZA 935915 A ZA935915 A ZA 935915A ZA 935915 A ZA935915 A ZA 935915A ZA 935915 B ZA935915 B ZA 935915B
Authority
ZA
South Africa
Prior art keywords
pct
recombinant products
fungal cells
producing recombinant
cells
Prior art date
Application number
ZA935915A
Other languages
English (en)
Inventor
Widmar Tanner
Sabine Strahl-Bolsinger
Reinhard Fleer
Alan Fournier
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of ZA935915B publication Critical patent/ZA935915B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA935915A 1992-08-14 1993-08-13 Modified fungal cells and method for producing recombinant products ZA935915B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4226971A DE4226971C2 (de) 1992-08-14 1992-08-14 Modifizierte Pilzzellen und Verfahren zur Herstellung rekombinanter Produkte

Publications (1)

Publication Number Publication Date
ZA935915B true ZA935915B (en) 1995-04-13

Family

ID=6465579

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA935915A ZA935915B (en) 1992-08-14 1993-08-13 Modified fungal cells and method for producing recombinant products

Country Status (13)

Country Link
US (1) US5714377A (no)
EP (1) EP0658203B1 (no)
JP (1) JP3630424B2 (no)
AT (1) ATE245701T1 (no)
AU (1) AU679935B2 (no)
CA (1) CA2140894C (no)
DE (3) DE4226971C2 (no)
ES (1) ES2203619T3 (no)
FI (1) FI121075B (no)
NO (1) NO320349B1 (no)
NZ (1) NZ255350A (no)
WO (1) WO1994004687A1 (no)
ZA (1) ZA935915B (no)

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US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
CA2431013A1 (en) * 2000-12-05 2002-06-13 The Penn State Research Foundation Methods and compositions for highly efficient production of heterologous proteins in yeast
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
US20060084794A1 (en) * 2001-04-12 2006-04-20 Human Genome Sciences, Inc. Albumin fusion proteins
US20050054051A1 (en) * 2001-04-12 2005-03-10 Human Genome Sciences, Inc. Albumin fusion proteins
US20050244931A1 (en) * 2001-04-12 2005-11-03 Human Genome Sciences, Inc. Albumin fusion proteins
CA2383556A1 (en) * 2001-05-16 2002-11-16 Pharmacia & Upjohn Company High-efficiency assay for protein mannosyl transferases
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
WO2003030821A2 (en) * 2001-10-05 2003-04-17 Human Genome Sciences, Inc. Albumin fusion proteins
AU2002364587A1 (en) * 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
CA2471363C (en) * 2001-12-21 2014-02-11 Human Genome Sciences, Inc. Albumin fusion proteins
JP2005530484A (ja) 2002-02-07 2005-10-13 デルタ バイオテクノロジー リミテッド アルブミン融合抗血管形成ペプチド
CN100383251C (zh) * 2002-12-20 2008-04-23 荷兰联合利华有限公司 抗冻蛋白的制备
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
EP1831375B1 (en) 2004-12-23 2014-07-16 Novozymes Biopharma DK A/S Gene expression technique
AU2006316838B2 (en) 2005-11-15 2012-04-12 Glycofi, Inc Production of glycoproteins with reduced O-glycosylation
AU2012203729B2 (en) * 2005-11-22 2014-01-30 Glycofi, Inc Production of glycoproteins with reduced O-glycosylation
EP1816201A1 (en) * 2006-02-06 2007-08-08 CSL Behring GmbH Modified coagulation factor VIIa with extended half-life
AU2007250735A1 (en) * 2006-05-16 2007-11-22 Daiichi Sankyo Company, Limited Method for high-level secretory production of protein
EP2046826B1 (en) 2006-07-24 2011-09-14 Biorexis Pharmaceutical Corporation Exendin fusion proteins
GB0711424D0 (en) * 2007-06-13 2007-07-25 Novozymes Delta Ltd Recombinant transferrin mutants
JP2010535484A (ja) 2007-08-08 2010-11-25 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ トランスフェリン変異体と複合体
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
CN101945998B (zh) 2008-02-20 2013-09-18 格利科菲公司 用于蛋白生产的载体和酵母菌株
WO2009111183A1 (en) 2008-03-03 2009-09-11 Glycofi, Inc. Surface display of recombinant proteins in lower eukaryotes
AU2009282228A1 (en) * 2008-08-12 2010-02-18 Glycofi, Inc. Improved vectors and yeast strains for protein production: Ca2+ ATPase overexpression
US9120871B2 (en) 2009-01-23 2015-09-01 Novo Nordisk A/S Process for preparing FGF21 with low degree of O-glycosylation
EP2617733A1 (en) 2009-02-06 2013-07-24 Novozymes Biopharma DK A/S Purification process
EP2396347B1 (en) 2009-02-11 2017-04-12 Albumedix A/S Albumin variants and conjugates
EP2401378B1 (en) 2009-02-25 2013-08-14 Merck Sharp & Dohme Corp. Metabolic engineering of a galactose assimilation pathway in the glycoengineered yeast pichia pastoris
AU2010313492B2 (en) 2009-10-30 2014-05-29 Merck Sharp & Dohme Corp. Method for producing therapeutic proteins in Pichia pastoris lacking dipeptidyl aminopeptidase activity
CN102741280B (zh) 2009-10-30 2015-12-02 诺维信生物制药丹麦公司 白蛋白变体
JP5860413B2 (ja) * 2010-02-10 2016-02-16 バイオコン リミテッド タンパク質のグリコシル化を低下させる方法、その産生方法およびタンパク質
RU2012140429A (ru) 2010-02-24 2014-03-27 Мерк Шарп Энд Домэ Корп. Способ увеличения занятости участков n-ликозилирования на терапевтических гликопротеинах, продуцируемых в p pastoris
US10233228B2 (en) 2010-04-09 2019-03-19 Albumedix Ltd Albumin derivatives and variants
CA2799595C (en) 2010-05-27 2022-08-16 Merck Sharp & Dohme Corp. Method for preparing antibodies having improved properties
JP5885191B2 (ja) 2011-01-04 2016-03-15 国立研究開発法人産業技術総合研究所 糖鎖改変酵母及びそれを用いた糖タンパク質の製造方法
KR20140114278A (ko) 2011-02-25 2014-09-26 머크 샤프 앤드 돔 코포레이션 변형된 ｏ-글리코실화를 갖는 단백질의 생산을 위한 효모 균주
KR20140028013A (ko) 2011-05-25 2014-03-07 머크 샤프 앤드 돔 코포레이션 개선된 특성을 갖는 Fc-함유 폴리펩티드를 제조하는 방법
EP2780364A2 (en) 2011-11-18 2014-09-24 Eleven Biotherapeutics, Inc. Proteins with improved half-life and other properties
AU2013234299B2 (en) 2012-03-16 2017-06-22 Albumedix Ltd. Albumin variants
GB2512156A (en) 2012-11-08 2014-09-24 Novozymes Biopharma Dk As Albumin variants
EP3004156A1 (en) 2013-06-07 2016-04-13 Novo Nordisk A/S Method for making mature insulin polypeptides
KR102111078B1 (ko) 2013-07-04 2020-05-18 노파르티스 아게 O-만노실트랜스퍼라제 결핍 사상균 세포 및 이의 이용 방법
CA2954974A1 (en) 2014-07-21 2016-01-28 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
JP7007261B2 (ja) 2015-08-20 2022-01-24 アルブミディクス リミティド アルブミン変異体及びコンジュゲート

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AT373279B (de) * 1977-11-08 1984-01-10 Genentech Inc Verfahren zur herstellung eines rekombinationsclonbildungstraegers
IT1203758B (it) * 1986-03-27 1989-02-23 Univ Roma Vettori di clonazione e di espressione di geni eterologhi in lieviti e lieviti trasformati con tali vettori
US4929553A (en) * 1987-05-29 1990-05-29 Canadian Patents & Development Ltd. Protease for specific processing of secreted proteins
FR2649991B2 (fr) * 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
FR2655660B1 (fr) * 1989-12-11 1992-03-20 Rhone Poulenc Sante Nouveaux polypeptides, sequences d'adn permettant leur expression, procede de preparation et leur utilisation.

Also Published As

Publication number Publication date
AU679935B2 (en) 1997-07-17
FI950628A0 (fi) 1995-02-13
DE4226971A1 (de) 1994-02-17
AU4948293A (en) 1994-03-15
JP3630424B2 (ja) 2005-03-16
CA2140894A1 (en) 1994-03-03
DE69333112D1 (de) 2003-08-28
DE4244915C2 (de) 1998-12-03
CA2140894C (en) 2010-03-02
US5714377A (en) 1998-02-03
NZ255350A (en) 1996-11-26
JPH08500975A (ja) 1996-02-06
NO950534D0 (no) 1995-02-13
EP0658203A1 (en) 1995-06-21
WO1994004687A1 (en) 1994-03-03
NO950534L (no) 1995-04-05
FI121075B (fi) 2010-06-30
ATE245701T1 (de) 2003-08-15
EP0658203B1 (en) 2003-07-23
ES2203619T3 (es) 2004-04-16
DE69333112T2 (de) 2004-06-09
FI950628A (fi) 1995-02-13
DE4226971C2 (de) 1997-01-16
NO320349B1 (no) 2005-11-28

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