HUP9903959A2 - Csonkított vérlemezke-aktiváló faktor acetilhidroláz - Google Patents

Csonkított vérlemezke-aktiváló faktor acetilhidroláz

Info

Publication number
HUP9903959A2
HUP9903959A2 HU9903959A HUP9903959A HUP9903959A2 HU P9903959 A2 HUP9903959 A2 HU P9903959A2 HU 9903959 A HU9903959 A HU 9903959A HU P9903959 A HUP9903959 A HU P9903959A HU P9903959 A2 HUP9903959 A2 HU P9903959A2
Authority
HU
Hungary
Prior art keywords
paf
polypeptide
variant
fragment
dna
Prior art date
Application number
HU9903959A
Other languages
English (en)
Inventor
Lawrance S. Cousens
Christine D. Eberhardt
Patrick Gray
Larry W. Tjoelker
Hai Le Trong
Cheryl L. Wilder
Original Assignee
Icos Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corporation filed Critical Icos Corporation
Publication of HUP9903959A2 publication Critical patent/HUP9903959A2/hu
Publication of HUP9903959A3 publication Critical patent/HUP9903959A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01047—1-Alkyl-2-acetylglycerophosphocholine esterase (3.1.1.47), i.e. platelet-activating factor acetylhydrolase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Otolaryngology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A találmány tárgyát a hűmán vérplazma vérlemezke-aktiváló faktőracetilhidrőlázt kódőló tisztítőtt és izőlált pőlineűkleőtidők képezik.A találmány tárgyát képezik tővábbá a vérlemezke-aktiváló faktőracetilhidrőláz termékek rekőmbináns előállítási eljárásáhőz szükségesanyagők és eljárásők is, amik a patőlógiás gyűladásős eseményekszabályőzásában elvárhatóan hasznősak. ŕ
HU9903959A 1997-08-13 1997-08-13 Truncated platelet-activating factor acetylhydrolase HUP9903959A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1997/014212 WO1999009147A1 (en) 1997-08-13 1997-08-13 Truncated platelet-activating factor acetylhydrolase

Publications (2)

Publication Number Publication Date
HUP9903959A2 true HUP9903959A2 (hu) 2000-03-28
HUP9903959A3 HUP9903959A3 (en) 2002-01-28

Family

ID=22261441

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903959A HUP9903959A3 (en) 1997-08-13 1997-08-13 Truncated platelet-activating factor acetylhydrolase

Country Status (12)

Country Link
EP (1) EP0948605A1 (hu)
JP (1) JP2001502163A (hu)
AU (1) AU751594B2 (hu)
BR (1) BR9711882A (hu)
CA (1) CA2267994C (hu)
CZ (1) CZ297603B6 (hu)
HU (1) HUP9903959A3 (hu)
IL (3) IL129262A0 (hu)
NO (1) NO326968B1 (hu)
PL (1) PL190532B1 (hu)
SK (1) SK286518B6 (hu)
WO (1) WO1999009147A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0974663A1 (en) 1993-06-25 2000-01-26 Smithkline Beecham Plc Lipoprotein associated phospholipase A2, inhibitors thereof and use of same in diagnosis and therapy
CA2398683A1 (en) * 2000-01-20 2001-07-26 Genome Therapeutics Corporation Rapid determination of gene structure using cdna sequence
CN103891709A (zh) * 2012-12-24 2014-07-02 深圳先进技术研究院 细胞冻存液及细胞冻存方法
CN112575057B (zh) * 2020-12-11 2021-07-30 深圳上泰生物工程有限公司 一种组合物及其在检测脂蛋白相关磷脂酶a2活性中的应用
WO2022120784A1 (zh) * 2020-12-11 2022-06-16 深圳上泰生物工程有限公司 一种组合物及其在检测脂蛋白相关磷脂酶a2活性中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0974663A1 (en) * 1993-06-25 2000-01-26 Smithkline Beecham Plc Lipoprotein associated phospholipase A2, inhibitors thereof and use of same in diagnosis and therapy
ATE315655T1 (de) * 1993-10-06 2006-02-15 Icos Corp Acethylhydrolase des plättchen aktivierenden faktors
JPH11514228A (ja) * 1995-09-29 1999-12-07 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー リポ蛋白結合ホスホリパーゼＡ２（Ｌｐ−ＰＬＡ２）ＰＡＦアセチルヒドロラーゼに対して配列相同性を有する化合物
JP2002515728A (ja) * 1995-09-29 2002-05-28 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 新規用途

Also Published As

Publication number Publication date
CA2267994A1 (en) 1999-02-25
BR9711882A (pt) 1999-09-21
WO1999009147A1 (en) 1999-02-25
NO991717L (no) 1999-06-11
IL129262A (en) 2006-06-11
CA2267994C (en) 2005-04-12
IL129262A0 (en) 2000-02-17
JP2001502163A (ja) 2001-02-20
HUP9903959A3 (en) 2002-01-28
PL332833A1 (en) 1999-10-11
CZ297603B6 (cs) 2007-02-07
NO326968B1 (no) 2009-03-23
SK47399A3 (en) 2000-11-07
AU751594B2 (en) 2002-08-22
PL190532B1 (pl) 2005-12-30
IL173867A0 (en) 2006-07-05
EP0948605A1 (en) 1999-10-13
CZ124199A3 (cs) 2000-06-14
AU3978297A (en) 1999-03-08
NO991717D0 (no) 1999-04-12
SK286518B6 (sk) 2008-12-05

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Legal Events

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FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished