CA2267994A1 - Truncated platelet-activating factor acetylhydrolase - Google Patents

Truncated platelet-activating factor acetylhydrolase

Info

Publication number
CA2267994A1
CA2267994A1 CA002267994A CA2267994A CA2267994A1 CA 2267994 A1 CA2267994 A1 CA 2267994A1 CA 002267994 A CA002267994 A CA 002267994A CA 2267994 A CA2267994 A CA 2267994A CA 2267994 A1 CA2267994 A1 CA 2267994A1
Authority
CA
Canada
Prior art keywords
activating factor
factor acetylhydrolase
platelet
truncated
truncated platelet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002267994A
Other languages
French (fr)
Other versions
CA2267994C (en
Inventor
Lawrence S. Cousens
Christine D. Eberhardt
Patrick Gray
Hai Le Trong
Larry W. Tjoelker
Cheryl L. Wilder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icos Corp
Original Assignee
Icos Corporation
Lawrence S. Cousens
Christine D. Eberhardt
Patrick Gray
Hai Le Trong
Larry W. Tjoelker
Cheryl L. Wilder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corporation, Lawrence S. Cousens, Christine D. Eberhardt, Patrick Gray, Hai Le Trong, Larry W. Tjoelker, Cheryl L. Wilder filed Critical Icos Corporation
Publication of CA2267994A1 publication Critical patent/CA2267994A1/en
Application granted granted Critical
Publication of CA2267994C publication Critical patent/CA2267994C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01047—1-Alkyl-2-acetylglycerophosphocholine esterase (3.1.1.47), i.e. platelet-activating factor acetylhydrolase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.
CA002267994A 1997-08-13 1997-08-13 Truncated platelet-activating factor acetylhydrolase Expired - Lifetime CA2267994C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1997/014212 WO1999009147A1 (en) 1997-08-13 1997-08-13 Truncated platelet-activating factor acetylhydrolase

Publications (2)

Publication Number Publication Date
CA2267994A1 true CA2267994A1 (en) 1999-02-25
CA2267994C CA2267994C (en) 2005-04-12

Family

ID=22261441

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002267994A Expired - Lifetime CA2267994C (en) 1997-08-13 1997-08-13 Truncated platelet-activating factor acetylhydrolase

Country Status (12)

Country Link
EP (1) EP0948605A1 (en)
JP (1) JP2001502163A (en)
AU (1) AU751594B2 (en)
BR (1) BR9711882A (en)
CA (1) CA2267994C (en)
CZ (1) CZ297603B6 (en)
HU (1) HUP9903959A3 (en)
IL (3) IL129262A0 (en)
NO (1) NO326968B1 (en)
PL (1) PL190532B1 (en)
SK (1) SK286518B6 (en)
WO (1) WO1999009147A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69423436T2 (en) 1993-06-25 2000-09-07 Smithkline Beecham Plc PHOSPHOLIPASE A2 TIED TO LIPOPROTEIN, INHIBITORS THEREOF AND THEIR USE FOR DIAGNOSIS AND THERAPY
EP1294943A2 (en) * 2000-01-20 2003-03-26 Genome Therapeutics Corporation RAPID DETERMINATION OF GENE STRUCTURE USING cDNA SEQUENCE
CN103891709A (en) * 2012-12-24 2014-07-02 深圳先进技术研究院 Cell cryopreservation liquid and cell cryopreservation method
WO2022120784A1 (en) * 2020-12-11 2022-06-16 深圳上泰生物工程有限公司 Composition and application thereof in detecting activity of lipoprotein-related phospholipase a2
CN112575057B (en) * 2020-12-11 2021-07-30 深圳上泰生物工程有限公司 Composition and application thereof in detecting activity of lipoprotein-associated phospholipase A2

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69423436T2 (en) * 1993-06-25 2000-09-07 Smithkline Beecham Plc PHOSPHOLIPASE A2 TIED TO LIPOPROTEIN, INHIBITORS THEREOF AND THEIR USE FOR DIAGNOSIS AND THERAPY
ES2159573T3 (en) * 1993-10-06 2001-10-16 Icos Corp ACETILHIDROLASA OF THE PLATE ACTIVATOR FACTOR.
WO1997012984A1 (en) * 1995-09-29 1997-04-10 Smithkline Beecham Plc COMPOUND HAVING SEQUENCE HOMOLOGY WITH LIPOPROTEIN ASSOCIATED PHOSPHOLIPASE A2 (Lp-PLA2)/PAF ACETYL HYDROLASE
JP2002515728A (en) * 1995-09-29 2002-05-28 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー New applications

Also Published As

Publication number Publication date
NO991717D0 (en) 1999-04-12
CZ124199A3 (en) 2000-06-14
SK286518B6 (en) 2008-12-05
IL129262A (en) 2006-06-11
NO326968B1 (en) 2009-03-23
JP2001502163A (en) 2001-02-20
CZ297603B6 (en) 2007-02-07
PL190532B1 (en) 2005-12-30
IL173867A0 (en) 2006-07-05
PL332833A1 (en) 1999-10-11
SK47399A3 (en) 2000-11-07
BR9711882A (en) 1999-09-21
IL129262A0 (en) 2000-02-17
EP0948605A1 (en) 1999-10-13
AU751594B2 (en) 2002-08-22
WO1999009147A1 (en) 1999-02-25
NO991717L (en) 1999-06-11
CA2267994C (en) 2005-04-12
HUP9903959A2 (en) 2000-03-28
HUP9903959A3 (en) 2002-01-28
AU3978297A (en) 1999-03-08

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170814