FI120259B - Menetelmä epoksidin valmistamiseksi - Google Patents

Menetelmä epoksidin valmistamiseksi Download PDF

Info

Publication number
FI120259B
FI120259B FI963452A FI963452A FI120259B FI 120259 B FI120259 B FI 120259B FI 963452 A FI963452 A FI 963452A FI 963452 A FI963452 A FI 963452A FI 120259 B FI120259 B FI 120259B
Authority
FI
Finland
Prior art keywords
allyl
formula
acetonide
epoxide
equivalent
Prior art date
Application number
FI963452A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963452A0 (fi
FI963452A (fi
Inventor
David Askin
Kan K Eng
Peter E Maligres
Paul J Reider
Kai Rossen
Ralph P Volante
Veena Upadhyay
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22764868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI120259(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI963452A0 publication Critical patent/FI963452A0/fi
Publication of FI963452A publication Critical patent/FI963452A/fi
Application granted granted Critical
Publication of FI120259B publication Critical patent/FI120259B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FI963452A 1994-03-04 1996-09-03 Menetelmä epoksidin valmistamiseksi FI120259B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20607494A 1994-03-04 1994-03-04
US20607494 1994-03-04
PCT/US1995/002347 WO1995023797A1 (fr) 1994-03-04 1995-02-27 Procede de fabrication d'un epoxyde
US9502347 1995-02-27

Publications (3)

Publication Number Publication Date
FI963452A0 FI963452A0 (fi) 1996-09-03
FI963452A FI963452A (fi) 1996-09-03
FI120259B true FI120259B (fi) 2009-08-31

Family

ID=22764868

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963452A FI120259B (fi) 1994-03-04 1996-09-03 Menetelmä epoksidin valmistamiseksi

Country Status (25)

Country Link
EP (1) EP0748319B1 (fr)
JP (1) JP3871705B2 (fr)
KR (1) KR100387741B1 (fr)
CN (1) CN1066728C (fr)
AT (1) ATE210662T1 (fr)
AU (1) AU690231B2 (fr)
BR (1) BR9506977A (fr)
CA (1) CA2183976C (fr)
CZ (1) CZ291816B6 (fr)
DE (1) DE69524578T2 (fr)
DK (1) DK0748319T3 (fr)
ES (1) ES2167419T3 (fr)
FI (1) FI120259B (fr)
HR (1) HRP950096B1 (fr)
HU (1) HU222750B1 (fr)
MX (1) MX9603871A (fr)
NZ (1) NZ281866A (fr)
PT (1) PT748319E (fr)
RO (1) RO117696B1 (fr)
RU (1) RU2137769C1 (fr)
SK (1) SK283067B6 (fr)
TW (1) TW380137B (fr)
UA (1) UA45968C2 (fr)
WO (1) WO1995023797A1 (fr)
YU (1) YU49010B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728840A (en) * 1994-03-04 1998-03-17 Merck & Co., Inc. Process for making an epoxide
TW415948B (en) * 1995-10-30 2000-12-21 Merck & Co Inc Process for synthesizing epoxide and halohydrin
US5981759A (en) * 1997-06-20 1999-11-09 Merck & Co., Inc. Process for indinavir intermediate
PL1948678T3 (pl) 2005-11-09 2013-09-30 Onyx Therapeutics Inc Związki do hamowania enzymów
DK2041158T3 (da) 2006-06-19 2013-06-24 Onyx Therapeutics Inc Peptid-epoxidketoner til proteasom inhibering
KR20150131405A (ko) 2007-10-04 2015-11-24 오닉스 세라퓨틱스, 인크. 결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성
EP2349313A4 (fr) 2008-10-21 2012-08-29 Onyx Therapeutics Inc Thérapie de combinaison avec des peptides époxycétones
AR075899A1 (es) 2009-03-20 2011-05-04 Onyx Therapeutics Inc Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
US8853147B2 (en) 2009-11-13 2014-10-07 Onyx Therapeutics, Inc. Use of peptide epoxyketones for metastasis suppression
MX2012010017A (es) 2010-03-01 2012-10-01 Onyx Therapeutics Inc Compuestos de para la inhibicion de inmunoproteasomas.
CN103025730A (zh) * 2010-04-30 2013-04-03 印第安纳大学研究及科技有限公司 制备利奈唑胺的方法
US20140105921A1 (en) 2012-07-09 2014-04-17 Onyx Therapeutics, Inc. Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
CN104692987B (zh) * 2015-01-22 2017-05-17 北京大学 卤代醇及其衍生物的廉价高效合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2072237A1 (fr) * 1991-07-02 1993-01-03 Merck & Co., Inc. Production stereoselective de composes hydroxyamide obtenus a partir d'–-aminoepoxydes chiraux
DK0541168T3 (da) * 1991-11-08 1998-05-11 Merck & Co Inc HIV-proteaseinhibitorer, som er egnede til behandling af AIDS

Also Published As

Publication number Publication date
EP0748319B1 (fr) 2001-12-12
UA45968C2 (uk) 2002-05-15
RU2137769C1 (ru) 1999-09-20
HU222750B1 (hu) 2003-09-29
HU9602412D0 (en) 1996-11-28
SK112296A3 (en) 1997-02-05
RO117696B1 (ro) 2002-06-28
DE69524578D1 (de) 2002-01-24
AU1882895A (en) 1995-09-18
DE69524578T2 (de) 2002-07-18
AU690231B2 (en) 1998-04-23
HRP950096B1 (en) 2002-06-30
EP0748319A1 (fr) 1996-12-18
BR9506977A (pt) 1997-09-02
YU14595A (sh) 1997-12-05
MX9603871A (es) 1997-07-31
ATE210662T1 (de) 2001-12-15
CN1066728C (zh) 2001-06-06
HRP950096A2 (en) 1997-06-30
JPH09509929A (ja) 1997-10-07
SK283067B6 (sk) 2003-02-04
NZ281866A (en) 1998-05-27
TW380137B (en) 2000-01-21
CZ254396A3 (en) 1997-01-15
CA2183976A1 (fr) 1995-09-08
ES2167419T3 (es) 2002-05-16
PT748319E (pt) 2002-05-31
JP3871705B2 (ja) 2007-01-24
CZ291816B6 (cs) 2003-06-18
WO1995023797A1 (fr) 1995-09-08
FI963452A0 (fi) 1996-09-03
CA2183976C (fr) 2005-02-01
CN1146768A (zh) 1997-04-02
FI963452A (fi) 1996-09-03
KR970701714A (ko) 1997-04-12
HUT75611A (en) 1997-05-28
DK0748319T3 (da) 2002-03-18
YU49010B (sh) 2003-04-30
KR100387741B1 (ko) 2003-10-04

Similar Documents

Publication Publication Date Title
CN108718527B (zh) 用于制备化合物的方法
US20120283434A1 (en) Process for the preparation of rivaroxaban and intermediates thereof
FI120259B (fi) Menetelmä epoksidin valmistamiseksi
EP3152191B1 (fr) Procédé amélioré de production de promédicaments à base de duocarmycine
WO2022214645A1 (fr) Procédés et intermédiaires pour la préparation de rélugolix
AU676079B2 (en) Process for making HIV protease inhibitors
EP0708763B1 (fr) Procede de preparation d'inhibiteurs de protease de vih
AU681499B2 (en) Regiospecific process to make cis-1-amino-2-alkanol from epoxide
DE69813886T2 (de) Naphthalin derivate
US5728840A (en) Process for making an epoxide
CZ266196A3 (cs) Regioselektivní způsob výroby cis-1-amino-2-indanolu
Kato et al. Synthesis of 6‐amino‐1‐benzyl‐4‐methylhexahydro‐1H‐1, 4‐diazepine
JP2014125458A (ja) 光学活性ベンズアミド誘導体の製造方法
CA2167183C (fr) Methode pour l'obtention d'inhibiteurs de la protease du vih
KR100393744B1 (ko) 1,2,3,9-테트라하이드로-9-메틸-3-[(2-메틸-1h-이미다졸-1-일)메틸]-4h-카바졸-4-온의 제조방법
KR20020081771A (ko) 신규의 아지리딘 유도체 및 그 제조방법
ITMI20011435A1 (it) Procedimento per la produzione di benzossazine e nuove benzossasine

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 120259

Country of ref document: FI

PC Transfer of assignment of patent

Owner name: MERCK SHARP & DOHME CORP.

Free format text: MERCK SHARP & DOHME CORP.

MM Patent lapsed