DE69524578T2 - Verfahren zur herstellung von epoxiden - Google Patents

Verfahren zur herstellung von epoxiden

Info

Publication number
DE69524578T2
DE69524578T2 DE69524578T DE69524578T DE69524578T2 DE 69524578 T2 DE69524578 T2 DE 69524578T2 DE 69524578 T DE69524578 T DE 69524578T DE 69524578 T DE69524578 T DE 69524578T DE 69524578 T2 DE69524578 T2 DE 69524578T2
Authority
DE
Germany
Prior art keywords
epoxies
producing
epoxide
renin
proteases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69524578T
Other languages
English (en)
Other versions
DE69524578D1 (de
Inventor
David Askin
K Eng
E Maligres
J Reider
Kai Rossen
P Volante
Veena Upadhyay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22764868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69524578(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69524578D1 publication Critical patent/DE69524578D1/de
Publication of DE69524578T2 publication Critical patent/DE69524578T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69524578T 1994-03-04 1995-02-27 Verfahren zur herstellung von epoxiden Expired - Lifetime DE69524578T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20607494A 1994-03-04 1994-03-04
PCT/US1995/002347 WO1995023797A1 (en) 1994-03-04 1995-02-27 Process for making an epoxide

Publications (2)

Publication Number Publication Date
DE69524578D1 DE69524578D1 (de) 2002-01-24
DE69524578T2 true DE69524578T2 (de) 2002-07-18

Family

ID=22764868

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69524578T Expired - Lifetime DE69524578T2 (de) 1994-03-04 1995-02-27 Verfahren zur herstellung von epoxiden

Country Status (25)

Country Link
EP (1) EP0748319B1 (de)
JP (1) JP3871705B2 (de)
KR (1) KR100387741B1 (de)
CN (1) CN1066728C (de)
AT (1) ATE210662T1 (de)
AU (1) AU690231B2 (de)
BR (1) BR9506977A (de)
CA (1) CA2183976C (de)
CZ (1) CZ291816B6 (de)
DE (1) DE69524578T2 (de)
DK (1) DK0748319T3 (de)
ES (1) ES2167419T3 (de)
FI (1) FI120259B (de)
HR (1) HRP950096B1 (de)
HU (1) HU222750B1 (de)
MX (1) MX9603871A (de)
NZ (1) NZ281866A (de)
PT (1) PT748319E (de)
RO (1) RO117696B1 (de)
RU (1) RU2137769C1 (de)
SK (1) SK283067B6 (de)
TW (1) TW380137B (de)
UA (1) UA45968C2 (de)
WO (1) WO1995023797A1 (de)
YU (1) YU49010B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728840A (en) * 1994-03-04 1998-03-17 Merck & Co., Inc. Process for making an epoxide
TW415948B (en) * 1995-10-30 2000-12-21 Merck & Co Inc Process for synthesizing epoxide and halohydrin
US5981759A (en) * 1997-06-20 1999-11-09 Merck & Co., Inc. Process for indinavir intermediate
BRPI0618468A2 (pt) 2005-11-09 2011-08-30 Proteolix Inc compostos para inibição de enzima
WO2007149512A2 (en) 2006-06-19 2007-12-27 Proteolix, Inc. Peptide epoxyketones for pr0teas0me inhibition
MY166950A (en) * 2007-10-04 2018-07-25 Onyx Therapeutics Inc Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
EP3090737A1 (de) 2008-10-21 2016-11-09 Onyx Therapeutics, Inc. Kombinationstherapie mit peptidepoxyketonen
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
US8853147B2 (en) 2009-11-13 2014-10-07 Onyx Therapeutics, Inc. Use of peptide epoxyketones for metastasis suppression
MA34133B1 (fr) 2010-03-01 2013-04-03 Onyx Therapeutics Inc Composes pour inhibiteurs de l'immunoproteasome
WO2011137222A1 (en) * 2010-04-30 2011-11-03 Indiana University Research And Technology Corporation Processes for preparing linezolid
TW201414751A (zh) 2012-07-09 2014-04-16 歐尼克斯治療公司 肽環氧酮蛋白酶抑制劑之前驅藥物
CN104692987B (zh) * 2015-01-22 2017-05-17 北京大学 卤代醇及其衍生物的廉价高效合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2072237A1 (en) * 1991-07-02 1993-01-03 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral –-amino epoxides
ES2112880T3 (es) * 1991-11-08 1998-04-16 Merck & Co Inc Inhibidores de la proteasa de vih utiles para el tratamiento del sida.

Also Published As

Publication number Publication date
NZ281866A (en) 1998-05-27
AU1882895A (en) 1995-09-18
CA2183976C (en) 2005-02-01
CZ291816B6 (cs) 2003-06-18
FI120259B (fi) 2009-08-31
CA2183976A1 (en) 1995-09-08
FI963452A0 (fi) 1996-09-03
SK283067B6 (sk) 2003-02-04
DK0748319T3 (da) 2002-03-18
PT748319E (pt) 2002-05-31
CN1146768A (zh) 1997-04-02
JPH09509929A (ja) 1997-10-07
YU49010B (sh) 2003-04-30
KR100387741B1 (ko) 2003-10-04
HUT75611A (en) 1997-05-28
HU9602412D0 (en) 1996-11-28
RO117696B1 (ro) 2002-06-28
TW380137B (en) 2000-01-21
RU2137769C1 (ru) 1999-09-20
YU14595A (sh) 1997-12-05
UA45968C2 (uk) 2002-05-15
BR9506977A (pt) 1997-09-02
EP0748319A1 (de) 1996-12-18
HRP950096B1 (en) 2002-06-30
ES2167419T3 (es) 2002-05-16
JP3871705B2 (ja) 2007-01-24
FI963452A (fi) 1996-09-03
HRP950096A2 (en) 1997-06-30
ATE210662T1 (de) 2001-12-15
EP0748319B1 (de) 2001-12-12
KR970701714A (ko) 1997-04-12
HU222750B1 (hu) 2003-09-29
MX9603871A (es) 1997-07-31
DE69524578D1 (de) 2002-01-24
AU690231B2 (en) 1998-04-23
CZ254396A3 (en) 1997-01-15
CN1066728C (zh) 2001-06-06
WO1995023797A1 (en) 1995-09-08
SK112296A3 (en) 1997-02-05

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