YU14595A - Postupak za dobijanje epoksida - Google Patents

Postupak za dobijanje epoksida

Info

Publication number
YU14595A
YU14595A YU14595A YU14595A YU14595A YU 14595 A YU14595 A YU 14595A YU 14595 A YU14595 A YU 14595A YU 14595 A YU14595 A YU 14595A YU 14595 A YU14595 A YU 14595A
Authority
YU
Yugoslavia
Prior art keywords
epoxide
procedure
obtaining
obtaining epoxide
renin
Prior art date
Application number
YU14595A
Other languages
English (en)
Other versions
YU49010B (sh
Inventor
D. Askin
K. eng. Kan
P. Maligres
P. Reider
K. Rossen
R. Volante
V. Upadhyay
Original Assignee
Merck And Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22764868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU14595(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck And Co. Inc. filed Critical Merck And Co. Inc.
Publication of YU14595A publication Critical patent/YU14595A/sh
Publication of YU49010B publication Critical patent/YU49010B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Postupak za sintetizovanje epoksida formule koji se sastoji od najmanje, obrazovanja halohidrina iz alii acetonid reagensa, a zatim bazom-indukovane ciklizacije, proizvod eppksid I je korisan kao intermedijar za sintezu inhibitora renina ili HIV proteaze ili drugih proteaza.
YU14595A 1994-03-04 1995-03-03 Postupak za sintetizovanje epoksida YU49010B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20607494A 1994-03-04 1994-03-04

Publications (2)

Publication Number Publication Date
YU14595A true YU14595A (sh) 1997-12-05
YU49010B YU49010B (sh) 2003-04-30

Family

ID=22764868

Family Applications (1)

Application Number Title Priority Date Filing Date
YU14595A YU49010B (sh) 1994-03-04 1995-03-03 Postupak za sintetizovanje epoksida

Country Status (25)

Country Link
EP (1) EP0748319B1 (sh)
JP (1) JP3871705B2 (sh)
KR (1) KR100387741B1 (sh)
CN (1) CN1066728C (sh)
AT (1) ATE210662T1 (sh)
AU (1) AU690231B2 (sh)
BR (1) BR9506977A (sh)
CA (1) CA2183976C (sh)
CZ (1) CZ291816B6 (sh)
DE (1) DE69524578T2 (sh)
DK (1) DK0748319T3 (sh)
ES (1) ES2167419T3 (sh)
FI (1) FI120259B (sh)
HR (1) HRP950096B1 (sh)
HU (1) HU222750B1 (sh)
MX (1) MX9603871A (sh)
NZ (1) NZ281866A (sh)
PT (1) PT748319E (sh)
RO (1) RO117696B1 (sh)
RU (1) RU2137769C1 (sh)
SK (1) SK283067B6 (sh)
TW (1) TW380137B (sh)
UA (1) UA45968C2 (sh)
WO (1) WO1995023797A1 (sh)
YU (1) YU49010B (sh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728840A (en) * 1994-03-04 1998-03-17 Merck & Co., Inc. Process for making an epoxide
TW415948B (en) * 1995-10-30 2000-12-21 Merck & Co Inc Process for synthesizing epoxide and halohydrin
US5981759A (en) * 1997-06-20 1999-11-09 Merck & Co., Inc. Process for indinavir intermediate
EP1948678B1 (en) 2005-11-09 2013-05-01 Onyx Therapeutics, Inc. Compounds for enzyme inhibition
AU2007261345B2 (en) 2006-06-19 2012-02-23 Onyx Therapeutics, Inc. Peptide epoxyketones for proteasome inhibition
MX2010003732A (es) 2007-10-04 2010-08-09 Onyx Therapeutics Inc Inhibidores de peptido cetona epoxi de proteasa cristalina y la sintesis de ceto-epoxidos de aminoacido.
MX2011004225A (es) 2008-10-21 2011-06-21 Onyx Therapeutics Inc Terapia de combinacion con epoxicetonas peptidicas.
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
EP2498793B1 (en) 2009-11-13 2019-07-10 Onyx Therapeutics, Inc. Oprozomib for use in metastasis suppression
KR20130075723A (ko) 2010-03-01 2013-07-05 오닉스 세라퓨틱스, 인크. 면역프로테아좀 저해를 위한 화합물
CA2798101A1 (en) * 2010-04-30 2011-11-03 Indiana University Research And Technology Corporation Processes for preparing linezolid
UY34897A (es) 2012-07-09 2014-01-31 Onyx Therapeutics Inc Profarmacos de inhibidores peptidicos de expoxi cetona proteasa
CN104692987B (zh) * 2015-01-22 2017-05-17 北京大学 卤代醇及其衍生物的廉价高效合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2072237A1 (en) * 1991-07-02 1993-01-03 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral –-amino epoxides
DK0541168T3 (da) * 1991-11-08 1998-05-11 Merck & Co Inc HIV-proteaseinhibitorer, som er egnede til behandling af AIDS

Also Published As

Publication number Publication date
CA2183976C (en) 2005-02-01
CZ291816B6 (cs) 2003-06-18
CZ254396A3 (en) 1997-01-15
CN1146768A (zh) 1997-04-02
BR9506977A (pt) 1997-09-02
FI120259B (fi) 2009-08-31
HRP950096B1 (en) 2002-06-30
FI963452A0 (fi) 1996-09-03
AU1882895A (en) 1995-09-18
CN1066728C (zh) 2001-06-06
AU690231B2 (en) 1998-04-23
NZ281866A (en) 1998-05-27
HUT75611A (en) 1997-05-28
FI963452A (fi) 1996-09-03
TW380137B (en) 2000-01-21
RU2137769C1 (ru) 1999-09-20
DE69524578T2 (de) 2002-07-18
RO117696B1 (ro) 2002-06-28
ATE210662T1 (de) 2001-12-15
ES2167419T3 (es) 2002-05-16
MX9603871A (es) 1997-07-31
UA45968C2 (uk) 2002-05-15
YU49010B (sh) 2003-04-30
SK112296A3 (en) 1997-02-05
JP3871705B2 (ja) 2007-01-24
PT748319E (pt) 2002-05-31
KR970701714A (ko) 1997-04-12
DE69524578D1 (de) 2002-01-24
CA2183976A1 (en) 1995-09-08
EP0748319A1 (en) 1996-12-18
EP0748319B1 (en) 2001-12-12
HU9602412D0 (en) 1996-11-28
HRP950096A2 (en) 1997-06-30
KR100387741B1 (ko) 2003-10-04
SK283067B6 (sk) 2003-02-04
JPH09509929A (ja) 1997-10-07
DK0748319T3 (da) 2002-03-18
HU222750B1 (hu) 2003-09-29
WO1995023797A1 (en) 1995-09-08

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