PT748319E - Processo para fabrico de um epoxido - Google Patents

Processo para fabrico de um epoxido

Info

Publication number
PT748319E
PT748319E PT95911105T PT95911105T PT748319E PT 748319 E PT748319 E PT 748319E PT 95911105 T PT95911105 T PT 95911105T PT 95911105 T PT95911105 T PT 95911105T PT 748319 E PT748319 E PT 748319E
Authority
PT
Portugal
Prior art keywords
epoxide
manufacture
renin
proteases
synthesizing
Prior art date
Application number
PT95911105T
Other languages
English (en)
Inventor
Peter E Maligres
David Askin
Ralph P Volante
Kan K Eng
Paul J Reider
Kai Rossen
Veena Upadhyay
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22764868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT748319(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PT748319E publication Critical patent/PT748319E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT95911105T 1994-03-04 1995-02-27 Processo para fabrico de um epoxido PT748319E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20607494A 1994-03-04 1994-03-04

Publications (1)

Publication Number Publication Date
PT748319E true PT748319E (pt) 2002-05-31

Family

ID=22764868

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95911105T PT748319E (pt) 1994-03-04 1995-02-27 Processo para fabrico de um epoxido

Country Status (25)

Country Link
EP (1) EP0748319B1 (pt)
JP (1) JP3871705B2 (pt)
KR (1) KR100387741B1 (pt)
CN (1) CN1066728C (pt)
AT (1) ATE210662T1 (pt)
AU (1) AU690231B2 (pt)
BR (1) BR9506977A (pt)
CA (1) CA2183976C (pt)
CZ (1) CZ291816B6 (pt)
DE (1) DE69524578T2 (pt)
DK (1) DK0748319T3 (pt)
ES (1) ES2167419T3 (pt)
FI (1) FI120259B (pt)
HR (1) HRP950096B1 (pt)
HU (1) HU222750B1 (pt)
MX (1) MX9603871A (pt)
NZ (1) NZ281866A (pt)
PT (1) PT748319E (pt)
RO (1) RO117696B1 (pt)
RU (1) RU2137769C1 (pt)
SK (1) SK283067B6 (pt)
TW (1) TW380137B (pt)
UA (1) UA45968C2 (pt)
WO (1) WO1995023797A1 (pt)
YU (1) YU49010B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728840A (en) * 1994-03-04 1998-03-17 Merck & Co., Inc. Process for making an epoxide
TW415948B (en) * 1995-10-30 2000-12-21 Merck & Co Inc Process for synthesizing epoxide and halohydrin
US5981759A (en) * 1997-06-20 1999-11-09 Merck & Co., Inc. Process for indinavir intermediate
MY145757A (en) 2005-11-09 2012-04-13 Proteolix Inc Compounds for enzyme inhibition
SI2041158T1 (sl) 2006-06-19 2013-09-30 Onyx Therapeutics, Inc. Peptidni epoksiketoni za inhibicijo proteasomov
DK2207791T4 (da) 2007-10-04 2019-10-07 Onyx Therapeutics Inc Krystallinske peptidepoxyketon-proteasehæmmere og syntese af aminosyreketoepoxider
ES2617560T3 (es) 2008-10-21 2017-06-19 Onyx Therapeutics, Inc. Combinación del inhibidor del proteasoma de epoxicetona peptídica carfilzomib con melfalán para su uso en el tratamiento del mieloma múltiple
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
JP5919196B2 (ja) 2009-11-13 2016-05-18 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 転移抑制のためのペプチドエポキシケトンの使用
WO2011109355A1 (en) 2010-03-01 2011-09-09 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
JP5865898B2 (ja) * 2010-04-30 2016-02-17 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ リネゾリドを調製するためのプロセス
US9309283B2 (en) 2012-07-09 2016-04-12 Onyx Therapeutics, Inc. Prodrugs of peptide epoxy ketone protease inhibitors
CN104692987B (zh) * 2015-01-22 2017-05-17 北京大学 卤代醇及其衍生物的廉价高效合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2072237A1 (en) * 1991-07-02 1993-01-03 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral –-amino epoxides
CA2195027C (en) * 1991-11-08 2000-01-11 Joseph P. Vacca Hiv protease inhibitors useful for the treatment of aids

Also Published As

Publication number Publication date
CN1066728C (zh) 2001-06-06
WO1995023797A1 (en) 1995-09-08
SK112296A3 (en) 1997-02-05
YU14595A (sh) 1997-12-05
ES2167419T3 (es) 2002-05-16
KR100387741B1 (ko) 2003-10-04
RU2137769C1 (ru) 1999-09-20
BR9506977A (pt) 1997-09-02
HU222750B1 (hu) 2003-09-29
NZ281866A (en) 1998-05-27
MX9603871A (es) 1997-07-31
DK0748319T3 (da) 2002-03-18
EP0748319B1 (en) 2001-12-12
ATE210662T1 (de) 2001-12-15
FI963452A (fi) 1996-09-03
DE69524578T2 (de) 2002-07-18
FI120259B (fi) 2009-08-31
FI963452A0 (fi) 1996-09-03
TW380137B (en) 2000-01-21
RO117696B1 (ro) 2002-06-28
HU9602412D0 (en) 1996-11-28
AU690231B2 (en) 1998-04-23
AU1882895A (en) 1995-09-18
HRP950096A2 (en) 1997-06-30
JPH09509929A (ja) 1997-10-07
HRP950096B1 (en) 2002-06-30
EP0748319A1 (en) 1996-12-18
CA2183976A1 (en) 1995-09-08
HUT75611A (en) 1997-05-28
SK283067B6 (sk) 2003-02-04
CZ291816B6 (cs) 2003-06-18
CN1146768A (zh) 1997-04-02
CA2183976C (en) 2005-02-01
JP3871705B2 (ja) 2007-01-24
UA45968C2 (uk) 2002-05-15
DE69524578D1 (de) 2002-01-24
KR970701714A (ko) 1997-04-12
YU49010B (sh) 2003-04-30
CZ254396A3 (en) 1997-01-15

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